• Tuberculosis and Respiratory Diseases
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• 제58권2호
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• pp.174-178
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• 2005

기관지 정맥류는 기관지 정맥압이 상승하는 승모판 협착증이나 폐정맥 폐쇄증에서 이차적으로 발생할 수 있다. 기관지 정맥류는 주로 좌측 주기관지에서 관찰되며, 드물지만 기관지 정맥류의 파열로 대량 객혈이 가능하고 사망할 수도 있다. 저자들은 중증 승모판 협착증 환자에서 동반된 기관지 정맥류를 기관지내시경에서 우연히 관찰하였고 승모판치환술 후 기관지 정맥류가 호전되어 이를 문헌고찰과 함께 보고하는 바이다.

• 재활복지공학회논문지
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• 제2권1호
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• pp.51-56
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• 2009

본 연구는 데이터 마이닝 기법 중 하나인 순차규칙 모델링을 활용해 뇌경색증 환자의 진단을 분석함으로써 뇌경색증의 선행질환과 합병증을 파악하고 이를 최소화할 수 있는 중재 개발에 기초자료를 제공하고자 시도되었다. 뇌경색증 환자의 진단 관련 데이터는 대구에 위치한 A 의료원에서 2000년에서 2007년 사이 뇌경색증으로 진단받은 환자의 관련 데이터를 추출하여 일괄분석을 위해 데이터마트를 구축하였다. 대상 의료 기관에서 총 2,267명이 뇌경색증을 진단 받았고 추출된 진단 데이터는 총 32,692건이었다. 데이터 분석은 Clementine 12.0의 순차규칙 모델링을 이용하였고 8개의 의미 있는 규칙이 발견되었다. 본 연구 결과는 2차 뇌경색 발생 예방 프로그램 개발 및 뇌경색증 환자의 합병증 예방 중재 개발의 기초자료로 활용할 수 있을 것으로 기대된다.

• Journal of Oral Medicine and Pain
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• 제45권1호
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• pp.12-16
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• 2020

Chronic otitis media (COM) is a chronic inflammatory disease which affects the middle ear, mastoid cavity. It presents hearing loss, ear pain, dizziness, headache, temporomandibular joint (TMJ) inflammation and intracranial complication. Intracranial complications such as skull base osteomyelitis (SBO) may occur secondary to COM due to transmission of infection by a number of possible routes. SBO is an uncommon condition with a significant morbidity and mortality if not treated in the early stages. We report a-67-year-old male patient with diabetes and untreated COM who presented atypical severe TMJ, periorbital and postmandibular pain. By computerized tomography (CT), magnetic resonance imaging (MRI) and whole body bone scan (WBBS), he was diagnosed with SBO spreading from untreated COM via infective arthritis of TMJ. Through this case, we suggest proper utilization of diagnostic imaging, especially CT or MRI for the early detection of SBO in the case of COM accompanying with the greater risk of infection developments such as diabetes.

• Journal of Chest Surgery
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• 제32권7호
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• pp.686-689
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• 1999

하행 괴사성 종격동염은 구강인두와 경부 염증의 드문 합병증 중의 하나로서, 높은 사망률과 합병증 등을 낮추기 위해 조기에 적극적이고 효과적인 수술적 배농술이 필요하다. 39세 남자 환자가 연하통, 경부 종창, 연하곤란 및 호흡곤란으로 내원하여 촬영한 경부 CT상 편도주위농 양과 인두 후부 및 주위의 농양이 발견되어 이비인후과에서 경부절개를 통한 배농술을 시행하였다. 1차 수 술 이후에 발열, 양측 견갑통이 재발하였으며 재촬영한 경부 및 흉부 CT에서 종격동 농양이 발견되어 경부 배농술과 더불어 개흉술을 통한 종격동 배농술을 시행하였다. 수술시에 시행한 종격동 농양과 농흉, 그리고 객담으로부터의 균배양 결과 Klebsiella pneumona로 밝혀졌다. 2차 수술후 환자는 호전되어 술후 85일째 퇴원 할 수 있었다. 결론적으로 CT촬영으로 하행 괴사성 종격동염을 조기에 진단하고 경부 배농술 뿐만 아니라 개흉술을 통한 광범위하고 효과적인 배농술이 환자의 생존율을 높이는데 도움이 되리라 본다.

• 대한골관절종양학회지
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• 제1권1호
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• pp.52-59
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• 1995

Metastatic cancer is the most common tumor of the skeleton. The prevalence of pathologic fracture may increase as patient survival is prolonged by improved cancer therapy. With recent advances in orthopaedic procedure and medical management of terminal cancer patients, it is generally agreed that aggressive treatment should be undertaken for patient with pathologic fracture secondary to metastatic disease, and a team approach should be utilized. The authors have reviewed twenty cases of pathologic fracture of the long bone due to metastatic tumor treated in the Department of Orthopedic Surgery, Yonsei University College of Medicine, from April 1989 to April 1994 and the following results were obtained. 1. The mean age at surgery was 58.4 years (ranged from 24years to 86years) and among 20 cases, 10 cases were male and the others were female. 2. The most frequent site of pathologic fracture in long bone is femur(15 cases, 75%), and followed by humerus(4 cases, 20%), tibia(1 case). 3. The frequently encountered primary tumors that metastases to long bone are those of the lung(7 cases, 35%), breast(4 cases, 20%), and prostate(2 cases, 10%). 4. The operative procedure was performed by resection of the tumor mass extensively, and we used polymethylmetacrylate for filling the dead space after resection, in all cases. 5. The mean survival period after operation is 9.2 months(ranged from 1 month to 4 years and 9 month). 6. The results of postoperative pain relief status were graded as fair to excellent in 17 cases(85%).

• 대한한의학회지
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• 제27권4호
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• pp.182-190
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• 2006

Objective : Based on immunological mechanisms, this study examined whether subcutaneous (s.c.) injection of Clematis mandshurica Maxim. water extract (CMA) has anti-inflammatory effects, and its effect on $TNF-{\alpha}$, IL-1 and IL-10 release from synoviocytes on adjuvant arthritis (AA) in the rat. Methods : Complete Freund's adjuvant was used to induce AA in rats. Synoviocytes were separated by the method of collagenase and DNase digestion Synoviocytes proliferation was assayed by 3-(4, 5 dimethylthiazol 2 yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. $TNF-{\alpha}$, IL-1 and interleukin-10 (IL-10) production of synoviocytes was measured with ELISA. The expression of IL-10 mRNA of synoviocytes was determined using RT PCR. Results : There were significant secondary inflammatory reactions in AA rats, accompanied by the decrease of body and immune organs weight simultaneously. Synoviocytes proliferation of AA rats significantly increased, and the levels of $TNF-{\alpha}$ and IL-1 in supernatants of synoviocytes in AA rats were also elevated compared with the sham group. The administration of CMA (2, 5, 10 mg/kg, s.c.) reduced the above changes significantly. In contrast to $TNF-{\alpha}$ and IL-1, IL-10 production and the level of its mRNA of synoviocytes in AA rats apparently decreased. CMA (2, 5, 10 mg/kg, s.c.) markedly increased IL-10 in synoviocytes at protein and transcription level. Conclusion : The results indicate that CMA has a beneficial effect on rat AA due to modulating inflammatory cytokine production of synoviocytes, which play a crucial role in the pathogenesis of this disease.

• 한국학교ㆍ지역보건교육학회지
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• 제11권1호
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• pp.67-78
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• 2010

Background & Objectives: Current trend is that funding agencies require investigators to share their data with others. However, there is limited guidance how to access and utilize the shared data. We sought to determine what common data sharing practices in U.S.A. are, what data-related to adolescent health are freely available, and how we deal with the large dataset adopting the complex study design. Methods: The study included only research data-related to adolescent health which was collected in USA and unlimitedly accessible through the internet. Only the raw data, not aggregated, was considered for the study. Major keywords for web search were "adolescent", "children", "health", and "school". Results: Current approaches for public health data sharing lacked of common standards and varied largely due to the data's complex nature, large size, local expertise and internal procedures. Some common data sharing practices are unlimited access, formal screened access, restricted access, and informal exclusive access. The Inter-University Consortium for Political and Social Research and the Center for Disease Control and Prevention were the best data depository. "Data on the net" was search engine for the website providing data freely available. Six datasets related to adolescent health freely available were identified. The importance and methods of incorporating complex research design into analysis was discussed. Conclusion: There have been various attempts to standardize process for open access and open data using the information technology concept. However, it may not be easy for researchers to adapt themselves to this high technology. Therefore, guidance provided by this study may help researchers enhance the accessibility to and the utilization of the open source data.

• Archives of Plastic Surgery
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• 제35권5호
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• pp.615-618
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• 2008

Purpose: Pyoderma gangrenosum is a rare cutaneous ulcerative disease. First described in 1930, the condition is characterized by progressive ulceration with deeply undermined purple-red edge. The lower extremities are most commonly affected but other parts of the skin and mucous membranes may also be involved. Although medical treatments with topical wound therapy are commonly used, surgical intervention is still controversial. In this paper, we report an atypical case of pyoderma gangrenosum which was characterized by extensive soft tissue breakdown. Methods: A 27-year-old male patient was referred to our institution with a $7{\times}8cm$ sized deeply undermined ulceration with pus-like discharge and fever. Incision and drainage was performed at another clinic 3 days prior to admission to our institution. After a thorough physical examination and the MRI review, a diagnosis of necrotizing faciitis was made. Accordingly, fasciotomy and debridement was performed. However, the wound enlarged progressively and the patient remained highly febrile for 9 days after the treatment. Septic screening did not reveal any occult infection. After a secondary review of the case, the initial diagnosis of necrotizing fasciitis was rejected and changed to pyoderma gangrenosum. With the use of dexamethasone intravenously, the wound improved dramatically and the fever was eliminated. Steroid mediation was tapered with duration of 1 month. The wound was stabilized and subsequently covered with split-thickness skin graft. Results: Split-thickness skin grafting with 1 : 1.5 mesh was successfully taken. Conclusion: Initial clinical features of pyoderma gangrenosum are very similar to that of necrotizing fasciitis. High fever and progressive ulceration with severe pain could invite earlier surgical approach. The advancing wound margins (the well defined violaceous, undermined border and necrotic ulcer base) and lack of isolation of pathogenic organism was used to make the correct diagnosis of pyoderma gangrenosum. We achieved a good result with proper medication and split-thickness skin graft.

• Journal of Chest Surgery
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• 제53권6호
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• pp.361-367
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• 2020

Background: Malignant primary cardiac tumors are extremely rare, but have a poor prognosis. This study evaluated the surgical outcomes of patients with this disease. Methods: Forty patients who underwent surgery for malignant primary cardiac tumors between January 1998 and December 2018 were enrolled. Participants were divided into 3 groups based on resection margins (R0, 14 patients; R1, 11 patients; and R2, 11 patients) and their surgical outcomes were compared. Heart transplantation was performed in 4 patients with unresectable tumors. Results: Early mortality was reported in 2 cases (5%) due to postoperative bleeding and cerebral hemorrhage secondary to brain metastasis. The 1- and 2-year survival rates were 67.5% and 42.5%, respectively. The median survival time of the patients was 20.3 months (range, 9.2-37.6 months). The median survival time was 48.7, 20.3, and 4.8 months in patients with R0, R1, and R2 resections, respectively (p=0.023). Tumor recurrence occurred in 21 patients (61.7%), including 4 cases of local recurrence and 17 cases of distant metastasis. In patients who underwent heart transplantation, the median survival time was 29.5 months, with 3 cases of distant metastasis. Conclusion: Although surgery for malignant primary cardiac tumors has a poor prognosis, complete resection of the tumor may improve surgical outcomes.

• 대한한의학방제학회지
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• 제8권1호
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• pp.257-279
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• 2000

Allergic contact dermatitis is a common skin disease resulting from specific immunologic to topically applied various allergen. After Dinitrochlorobenzene (DNCB) secondary sensitization, the ICR mice administered Rhemanniae radix extract (RRE) was observed to ascerstain the effect of RRE on allergic contact dermatitis. Purpose of this study was to investigate contact hypersensitivity assay, abdominal skin morphologic changes. Including mast cells and cell-surface glycoconjugates. The change of interleukin 2 (IL-2) receptor (CD25R). ICAM in abdominal skin, lymph node of inguinal region, and electro microscope-morphologic changes of abdominal skin. The results of this study were as follows: 1. The contact hypersensitivity assay, the ear swelling in the RRE had lesser probability than in the ACD Group. 2. In the general morphologic change of skin, hyperplasia of keratinocytes, distribution of vasculogenesis and epidermal lymphocytes infiltration were decreased in the RRE group compared with the ACD group. In epidermal basal layer and prickle layer, cell damage was decreased in the RRE group compared with the group painted with ACD. 3. MasT-cell in dermis was decreased in the RRE group compared with the group painted with DNCB. 4. Distribution of interlukin-2 Receptior positive cell and ICAM positive cell in dermis was decreased in the RRE Group compared with the ACD group. 5. Distribution of helper T-lymphocyte and cytotoxic T-lymphocite in inguinal nodes was decreased in the RRE group, and was observed well in paracortical area and cortical cord. 6. Distribution of apoptotic cell was appeared in the RRE group compared with the ACD group, in skin, dermis. in inguinal nodes, paracortical area observed well. With above results, the restarint of immunosuppression occuring in Allergic contact dermatitis is resulted in the slow progress the effect of Allergic contact dermatitis, and it is thought that ithis fact has a series of relation with apoptosis.