• 대한족부족관절학회지
• /
• 제15권2호
• /
• pp.51-57
• /
• 2011

Pilon fractures involving distal tibia remain one of the most difficult therapeutic challenges that confront the orthopedic surgeons because of associated soft tissue injury is common. To introduce and describe the diagnosis, current treatment, results and complications of the pilon fractures. In initial assessment, the correct evaluation of the fracture type through radiographic checkup and examination of the soft tissue envelope is needed to decide appropriate treatment planning of pilon fractures. Even though Ruedi and Allgower reported 74% good and excellent results with primary open reduction and internal fixation, recently the second staged treatment of pilon fractures is preferred to orthopedic traumatologist because of the soft tissue problem is common after primary open reduction and internal fixation. The components of the first stage are focused primarily on stabilization of the soft tissue envelope. If fibula is fractured, fibular open reduction and internal fixation is integral part of initial management for reducing the majority of tibial deformities. Ankle-spanning temporary external fixator is used to restore limb alignment and displaced intraarticular fragments through ligamentotaxis and distraction. And the second stage, definitive open reduction and internal fixation of the tibial component, is undertaken when the soft tissue injury has resolved and no infection sign is seen on pin site of external fixator. The goals of definitive internal fixation should include absolute stability and interfragmentary compression of reduced articular segments, stable fixation of the articular segment to the tibial diaphysis, and restoration of coronal, transverse, and sagittal plane alignments. The location, rigidity, and kinds of the implants are based on each individual fractures. The conventional plate fixation has more advantages in anatomical reduction of intraarticular fractures than locking compression plate. But it has more complications as infection, delayed union and nonunion. The locking compression plate fixation provides greater stability and lesser wound problem than conventional implants. But the locking compression plate remains poorly defined for intraarticular fractures of the distal tibia. Active, active assisted, passive range of motion of the ankle is recommended when postoperative rehabilitation is started. Splinting with the foot in neutral is continued until suture is removed at the 2~3 weeks and weight bearing is delayed for approximately 12 weeks. The recognition of the soft tissue injury has evolved as a critical component of the management of pilon fractures. At this point, the second staged treatment of pilon fractures is good treatment option because of it is designed to promote recovery of the soft tissue envelope in first stage operation and get a good result in definitive reduction and stabilization of the articular surface and axial alignment in second stage operation.

• 한국산학기술학회논문지
• /
• 제21권5호
• /
• pp.565-576
• /
• 2020

본 연구에서는 캐나다에 거주하는 재외국민을 대상으로 한국과 캐나다에서의 1차 의료기관 이용 경험을 토대로 한국과 캐나다 의료기관 만족도를 비교·분석하기 위한 목적으로 수행되었다. 설문조사를 기초로 대응표본 T 검정, ANOVA분석, 일반선형분석모형을 이용해 자료를 분석하였다. 본 연구의 주요 분석 결과는 다음과 같다. 첫째, 한국의료에 대한 종합적인 만족도는 캐나다 보다 높았다. 둘째, 한국의료만족도는 성, 연령, 교육수준, 거주 지역에 무관하게 안정적이었다. 셋째, 한국의료에 대한 항목별 만족도가 캐나다의료에 대한 만족도 보다 높았다. 넷째, 특히 치료기술 및 수준, 진료예약 신속성 등에서 만족도가 높았으나 진료비용 측면에서는 만족도가 낮았다. 다섯째, 의사기술 및 실력에 대한 신뢰는 높았으나 충분한 상담 및 설명 측면에서는 유의한 차이가 없었다. 여섯째, 한국의사는 캐나다 의사에 비해 진료수입을 늘리기 위해 진료회수를 늘리는 경향이 있다고 인식하고 있었다. 세부적인 분석결과 우리나라 1차 의료가 캐나다에 비해 충분히 경쟁력을 가지고 있으나 1차 의료 의사의 환자면담 및 설명의무, 수입조절을 위한 유인행위, 진료비용 등은 개선될 필요가 있다는 결론에 도달하였다.

• 한국수학교육학회지시리즈A:수학교육
• /
• 제47권2호
• /
• pp.197-219
• /
• 2008

Unlike ordinary situations, deifinitions play a very important role in mathematics education in schools. Mathematical concepts have been mainly acquired by given definitions. However, according to didactical intentions, mathematics education in schools has employed mathematical concepts and definitions with less strict forms than those in pure mathematics. This research mainly discusses definitions used in geometry (promising) course in primary schools to cope with possibilities of creating misconception due to this didactical transformation. After analyzing problems with potential misconceptions, a survey was conducted $\underline{with}$ 80 primary school teachers in Jeju to investigate their recognitions in meaning of mathematical concepts in geometry and attitudes toward teaching. Most of the respondents answered they taught their students while they knew well about mathematical definitions in geometry but the respondents sometimes confused mathematical concepts of polygons and circles. Also, they were aware of problems in current mathematics textbooks which have explained figures in small topics (classes). Here, several suggestions are proposed as follows from analyzing teachers' recognitions and researches in mathematical viewpoints of definitions (promising) in geometric figures which have been adopted by current mathematics textbooks in primary schools from the seventh educational curriculum. First, when primary school students in their detailed operational stage studying figures, they tend to experience $\underline{a}$ collision between concept images acquired from activities to find out promising and concept images formed through promising. Therefore, a teaching method is required to lessen possibility of misconceptions. That is, there should be a communication method between defining conceptual definitions and Images. Second, we need to consider how geometric figures and their elements in primary school textbooks are connected with fundamental terminologies laying the foundation for geometrical definitions and more logical approaches should be adopted. Third, the consistency with studying geometric figures should be considered. Fourth, sorting activities about problems in coined words related to figures and way and time of their introductions should be emphasized. In primary schools mathematics curriculum, geometry has played a crucial role in increasing mathematical ways of thoughts. Hence, being introduced by parts from viewpoints of relational understanding should be emphasized more in textbooks and teachers should teach students after restructuring this. Mathematics teachers should help their students not only learn conceptual definitions of geometric figures in their courses well but also advance to rigid mathematical definitions. Therefore, that's why mathematics teachers should know meanings of concepts clearly and accurately.

• 대한치과교정학회지
• /
• 제30권1호
• /
• pp.43-52
• /
• 2000

반안면 왜소증 (Hemifacial microsomia) 은 선천성 악안면기형 중 발생빈도가 두 번째로 높은 질환으로서, 상, 하악골 뿐만이 아니라 외이나 중이, 두개의 일부, 협부 연조직, 안면신경, 근육 등의 복합적인 부위를 침범하는 광범위한 선천성 기형으로서, 환자에 따라 그 정도의 차이는 있으나 성장에 따라 교합면 경사와 함께 이환 측으로 안면 비대칭의 정도가 점점 심화되는 특징을 가진다. 반안면 왜소증에서 치아와 관련된 증상으로는 치아 성숙도의 차이, 치아 수의 감소, 맹출지 연, 법랑질 저형성증 등이 보고된 바 있다. 치아는 악골의 크기나 형태와 밀접한 연관을 가지고 발육하기 때문에, 반안면 왜소증 환자의 경우 치아 발육에서 변화가 발생되기 쉬울 것으로 생각된다. 이에 저자들은 한국인 편측성 반안면 왜소증 환자의 이환 측과 비이환 측에서 상, 하악 유치와 영구치의 크기와 형태 차이 여부를 조사하기 위하여 본 연구를 시행하였다. 서울대학교병원 교정과에 내원하였던 편측성 반안면 왜소증 환자 34명 (남자 18명, 여자 15명, 초진시 평균연령 5세 11개월)을 연구대상으로 선정하였다. 이들의 각 치아별 근원심과 협설측 폭경 을 계측한 후, 평균 및 표준편차를 계산하고 paired t-test로 통계 처리하여 다음과 같은 결과를 얻었다. 1. 상, 하악 유치와 영구치의 이환 측과 비이환 측의 근원심 폭경 비교에서 이환 측의 하악 제 2 유구치와 하악 제1 영구 대구치가 비이환 측에 비하여 작게 나타났으며 통계학적 유의차를 보였다. 이것은 하악 전치부와 제 1유구치의 근원심 폭경에서 통계학적으로 유의성있는 차이를 보이지 않았음과 연관지어볼 때, 이환측 하악의 최후방 구치에서 근원심 폭경 감소의 경향 (gradient of severity)이 크다고 할 수 있다. 2. 상, 하악 유치와 영구치의 이환 측과 비이환 측의 협설측 폭경 비교에서 모든 치아에서 통계학적 유의차를 볼 수 없었지만, 이환 측의 하악 유치와 영구치의 협설측 폭경이 비이환 측에 비하여 보상적으로 다소 큰 값을 나타내는 경향이 있었다. 본 연구는 반안면 왜소증에 의하여 영향을 받은 하악골의 이한측 치아, 특히 최후방 구치, 의 크기와 형태 이상이 발생될 가능성이 있다는 것을 보여주었다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권8호
• /
• pp.3645-3649
• /
• 2014

The aim of this study was to evaluate the efficacy of third-line combined androgen blockade (CAB) therapy for castration-resistant prostate cancer that relapsed after primary and second-line CAB. We retrospectively reviewed the medical records of 52 patients who received first-, second-, and third-line CAB therapy (medical or surgical castration, plus steroidal antiandrogen of chlormadinone acetate, or nonsteroidal antiandrogen of flutamide or bicalutamide). For cumulative analysis, we searched the PubMed database and identified a total of 50 cases published in English. Including our cases, this provided a total of 102 cases for analysis. In our study cohort, 11 cases (21.2%) achieved more than 50% reduction of serum prostate-specific antigen (PSA) on initiation of third-line CAB. We found that third-line CAB with nonsteroidal antiandrogen after second-line CAB with steroidal antiandrogen exhibited favorable results, with a positive response in six of 13 patients (46.2%). Cumulative analysis findings were comparable. Regarding the timing of third-line CAB administration, 15 patients had started at a PSA equal to or less than 4.0 ng/ml, and eight of them (53.3%) showed a positive response to treatment, compared to only three of 37 patients (8.1%) whose PSA at the initiation of third-line therapy was higher than 4.0 ng/ml (p<0.001). We conclude that third-line CAB with nonsteroidal antiandrogen would be particularly useful for patients whose cancer progressed after second-line CAB with steroidal antiandrogen. The timing of treatment seems to be important because the higher the PSA at the start of third-line therapy, the lower the PSA response rate.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권5호
• /
• pp.2221-2224
• /
• 2014

Objective: To explore the relationship between expressions of cell adhesion molecules CD44 v6 and E-cadherin (E-cad) and lymphatic metastasis in non-small cell lung cancer (NSCLC). Materials and Methods: Eightyseven tissue samples obtained from patients with primary NSCLC were collected in our hospital from Dec., 2007 to Dec., 2012, and the expressions of CD44 v6 and E-cad gene proteins in these samples were detected by immunohistochemical method. Results: In the tissue without lymphatic metastasis, the positive expression rate of CD44 v6 was significantly lower, whereas the normal expression rate of E-cad was notably higher than that with lymphatic metastasis (55.6% vs. 78.4%, 47.2% vs. 21.6%), and both differences had statistical significance (P<0.05). Besides, CD44 v6 and E-cad expressions had a significant correlation in the NSCLC tissue with lymphatic metastasis (P<0.05). Conclusions: The positive expression of CD44 v6 and abnormal expression of E-cad may play a very important role in promoting lymphatic metastasis of NSCLC, with synergistic effect. Hence, detection of CD44 v6 and E-cad expressions is conductive to judging the lymphatic metastasis in NSCLC.

• 대한치과교정학회지
• /
• 제15권1호
• /
• pp.67-74
• /
• 1985

The primary objective of this study is to make the prediction percentile tabulation of the sun of mesiodistal width of the unerupted permanent canines and premolars derived from the sum of mesiodistal width of the erupted permanent mandibular incisors in Korean population. The subjects were 316 individuals with normal occlusion aged 11 to 23 years. The sum of mesiodistal width of mandibular incisors, and the sum of mesiodistal width of maxillary canine, first and second premolars, and the sum of mandibular canine, first and second premolars were measured from the dental cast models using the sliding caliper (Mitutoyo Co.). From the study, the results are as follows: 1. The sum of M-D width of mandibular incisors and the sum of M-D width of maxillary canines, first and second premolars, and the sum of M-D width of mandibular canine, first and second premolars were smaller than those of American Caucasians and Negros. 2. The correlation coefficient between the sum of M-D width of mandibular incisors and that of maxillary or mandibular canines, first and second premolars was found to be 0.598 and 0.586, respectively. 3. The regression constants were determined to evaluate the sum of M-D width of the unerupted permanent canines and premolars derived from the sum of M-D width of the erupted permanent incisors. 4. The prediction percentile tabulation were made in an attempt to predict the total M-D width of the unerupted permanent canines and premolars derived from the total M-D width of the erupted permanent mandibular incisors.

• Journal of Gynecologic Oncology
• /
• 제29권6호
• /
• pp.89.1-89.8
• /
• 2018

Objective: Highly effective chemotherapy for patients with low-risk gestational trophoblastic neoplasia (GTN) is associated with almost a 100% cure rate. However, 20%-30% of patients treated with chemotherapy need to change their regimens due to severe adverse events (SAEs) or drug resistance. We examined the treatment outcomes of second-line chemotherapy for patients with low-risk GTN. Methods: Between 1980 and 2015, 281 patients with low-risk GTN were treated. Of these 281 patients, 178 patients were primarily treated with 5-day intramuscular methotrexate (MTX; n=114) or 5-day drip infusion etoposide (ETP; n=64). We examined the remission rates, the drug change rates, and the outcomes of second-line chemotherapy. Results: The primary remission rates and drug resistant rates of 5-day ETP were significantly higher (p<0.001) and significantly lower (p=0.002) than those of 5-day MTX, respectively. Forty-seven patients (26.4%) required a change in their chemotherapy regimen due to the SAEs (n=16) and drug resistance (n=31), respectively. Of these 47 patients failed the first-line regimen, 39 patients (39/47, 82.9%) were re-treated with single-agent chemotherapy, and 35 patients (35/39, 89.7%) achieved remission. Four patients failed second-line, single-agent chemotherapy and eight patients (17.0%) who failed first-line regimens were treated with combined or multi-agent chemotherapy and achieved remission. Conclusions: Patients with low-risk GTN were usually treated with single-agent chemotherapy, while 20%-30% patients had to change their chemotherapy regimen due to SAEs or drug resistance. The second-line regimens of single-agent chemotherapy were effective; however, there were several patients who needed multiple agents and combined chemotherapy to achieve remission.

• 대한소아치과학회지
• /
• 제27권1호
• /
• pp.122-134
• /
• 2000

각화치은, 부착치은의 폭경, 치은열구의 깊이에 대해 성인에서는 많은 연구가 있었으나 아동에서의 연구는 드물었기 때문에, 유치열기, 혼합치열기 및 영구치열기의 모든 치아에 대하여 아동의 협측 각화치은 및 부착치은의 폭경과 치은열구 깊이에 대한 정상치를 구하고, 악골의 발육 및 치아의 맹출과의 관련성을 고찰하며, 점막치은 문제의 발현빈도를 조사하고자 하였다. 결론은 다음과 같다. 1. 유치열의 부착치은 폭경은 상악 유측절치 및 유견치에서 각각 3.50mm, 3.55mm로 최대값을, 하악 제1유구치에서 1.34mm로 최소값을 나타내었다. 영구치열의 경우에는 상악 측절치에서 3.00mm로 최대값을, 하악 제1소구치에서 0.55mm로 최소값을 나타내었다. 상하악 동명치아 비교시 상악 치아가 하악 치아보다 더 큰 값을 나타내었고, 남녀간 차이에는 특별한 규칙이 발견되지는 않았다. 2. 연령증가에 따른 부착치은 폭경의 변화 양상은 유치열의 경우 유견치, 제1유구치, 제2유구치에서 6세부터 증가하였다. 영구치의 경우 남자에서는 하악 중절치와 상악 제 1대구치의 측정값만이 연령에 따른 증가 추세를 나타냈으나(p<0.05), 여자에서는 상하악 중절치 측절치 및 상악 제1대구치에서 통계적으로 유의성 있는 각화치은 폭경의 증가 추세를 관찰할 수 있었다(p<0.05). 3. 치아교대기에서 부착치은 폭경의 차이는 남자 상악 중절치를 제외한 모든 경우에 유치에서의 측정값이 영구치에서의 측정값보다 큰 것으로 나타났다(p<0.05). 4. 6제부터 12세까지는 각화치은의 폭경과 치은열구의 깊이는 대부분 유치 초기값보다 그 계승영구치 최종값이 더 높은 값을 나타냈으나(p<0.05), 부착치은의 폭경에서는 유치 초기와 그 계승영구치 최종값사이에 통계적으로 유의성 있는 차이가 나타나지 않았다. 5. 점막치은 문제 발현 빈도는 남녀에 상관없이 유치열은 상하악 제 1유구치가, 영구치열은 상하악 모두 제 1소구치가 최고치를 나타냈으며 유치에서보다 그 대응 계승영구치에서 그 빈도가 더욱 높게 나타났다. 연령증가에 따라 점막치은 문제의 발현 빈도는 유치열, 영구치열에서 모두 감소하였으나, 하악 제1유구치, 하악 영구 견치, 제1, 제2소구치의 경우 연령의 증가와 상관없이 비슷하게 유지되거나 증가하는 경향을 보였다.

• 한국안전학회지
• /
• 제22권4호
• /
• pp.20-25
• /
• 2007

Instrument transformers are a safe measurement device designed to measure high voltage and large current. A current transformer(CT) is a type of instrument transformer designed to provide a current in its secondary winding proportional to the current flowing in its primary. It is commonly used in metering and protective relaying in the electrical power industry where it facilitates the safe measurement of large current. But, care must be taken that the secondary of a current transformer is not disconnected from its load while current is flowing in the primary, as this will produce a dangerously high voltage across the open secondary, and may permanently affect the accuracy of the transformer. Especially, industrial disaster such as an electric shock and/or a burn accident occurs occasionally by disregard of warning or attention. In this paper, we developed the detector for open of current transformer secondary terminal, and which was tested by the Korea Electrotechnology Research Institute. Test results show that Current Transformer secondary Open Detector(CTOD) interrupted within one second electronically when the 2nd terminal of current transformer opened.