• BMB Reports
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• v.39 no.4
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• pp.441-447
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• 2006

Abuse of drugs can elicit compulsive drug seeking behaviors upon repeated administration, and ultimately leads to the phenomenon of addiction. We developed a procedure for the standardization of microarray gene expression data of rat brain in drug addiction and stored them in a single integrated database system, focusing on more effective data processing and interpretation. Another characteristic of the present database is that it has a systematic flexibility for statistical analysis and linking with other databases. Basically, we adopt an intelligent SQL querying system, as the foundation of our DB, in order to set up an interactive module which can automatically read the raw gene expression data in the standardized format. We maximize the usability of this DB, helping users study significant gene expression and identify biological function of the genes through integrated up-to-date gene information such as GO annotation and metabolic pathway. For collecting the latest information of selected gene from the database, we also set up the local BLAST search engine and non-redundant sequence database updated by NCBI server on a daily basis. We find that the present database is a useful query interface and data-mining tool, specifically for finding out the genes related to drug addiction. We apply this system to the identification and characterization of methamphetamine-induced genes' behavior in rat brain.

• The Journal of the Korea Contents Association
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• v.17 no.11
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• pp.389-397
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• 2017

Recently semantic web document is produced and added in repository in a cloud computing environment and requires an intelligent semantic agent for analytical classification of documents and information retrieval. The traditional methods of information retrieval uses keyword for query and delivers a document list returned by the search. Users carry a heavy workload for examination of contents because a former method of the information retrieval don't provide a lot of semantic similarity information. To solve these problems, we suggest a key word frequency and concept matching based semantic clustering model using hadoop and NoSQL to improve classification accuracy of the similarity. Implementation of our suggested technique in a cloud computing environment offers the ability to classify and discover similar document with improved accuracy of the classification. This suggested model is expected to be use in the semantic web retrieval system construction that can make it more flexible in retrieving proper document.

• The Journal of the Korea Contents Association
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• v.17 no.11
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• pp.600-608
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• 2017

Recently data growth rates are growing exponentially according to the rapid expansion of internet. Since users need some of all the information, they carry a heavy workload for examination and discovery of the necessary contents. Therefore information retrieval must provide hierarchical class information and the priority of examination through the evaluation of similarity on query and documents. In this paper we propose an Multi-class support vector machines model based clustering for hierarchical document categorization that make semantic search possible considering the word co-occurrence measures. A combination of hierarchical document categorization and SVM classifier gives high performance for analytical classification of web documents that increase exponentially according to extension of document hierarchy. More information retrieval systems are expected to use our proposed model in their developments and can perform a accurate and rapid information retrieval service.

• Proceedings of the Korea Contents Association Conference
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• 2007.11a
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• pp.595-598
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• 2007

Vast amount of XML documents raise interests in how they will be used and how far their usage can be expanded. This paper has two central goals: 1) easy and fast retrieval of XML documents or relevant elements; and 2) efficient and stable management of large-size XML documents. The keys to develop such a practical system are how to segment a large XML document to smaller fragments and how to store them. In order to achieve these goals, we designed SCOF(Service-centric Object Fragmentation) model, which is a semi-decomposition method based on conversion rules provided by XML database managers. Keyword-based search using SCOF model then retrieves the specific elements or attributes of XML documents, just as typical XML query language does. Even though this approach needs the wisdom of managers in XML document collection, SCOF model makes it efficient both retrieval and management of massive XML documents.

• Journal of KIISE:Software and Applications
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• v.29 no.3
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• pp.145-155
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• 2002

In content-based image retrieval (CBIR), most conventional approaches assume a linear relationship between different features and require users themselves to assign the appropriate weights to each feature. However, the linear relationship assumed between the features is too restricted to accurately represent high-level concepts and the intricacies of human perception. In this paper, a neural network-based image retrieval (NNIR) model is proposed. It has been developed based on a human-computer interaction approach to CBIR using a radial basis function network (RBFN). By using the RBFN, this approach determines the nonlinear relationship between features and it allows the user to select an initial query image and search incrementally the target images via relevance feedback so that more accurate similarity comparison between images can be supported. The experiment was performed to calculate the level of recall and precision based on a database that contains 1,015 images and consists of 145 classes. The experimental results showed that the recall and level of the proposed approach were 93.45% and 80.61% respectively, which is superior than precision the existing approaches such as the linearly combining approach, the rank-based method, and the backpropagation algorithm-based method.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.22 no.2
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• pp.205-214
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• 1997

In this paper, we suggest a cache mechanism to improve the speed fo query processing in distributed directory environment. For this, request and result and result about objects in remote site are store in the cache of local site. A cache mechanism developed through six phases; 1) Cached information which stored in distributed directory system is classified as application data, system data and meta data. 2) Cache system architecture is designed according to classified information. 3) Cache schema are designed for each cache information. 4) Least-TTL algorithms which use the weighted value of geograpical information and access frquency for replacements are developed for datacaches(application cache, system cache). 5) Operational algorithms are developed for meta data cache which has meta data tree. This tree is based on the information of past queries and improves the speed ofquery processing by reducing the scope of search space. 6) Finally, performance evaluations are performed by comparing with proposed cache mechanism and other mechanisms.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.18
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• pp.8191-8196
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• 2016

Inhibition of EGFR-EGF interactions forms an important therapeutic rationale in treatment of non-small cell lung carcinoma. Established inhibitors have been successful in reducing proliferative processes observed in NSCLC, however patients suffer serious side effects. Considering the narrow therapeutic window of present EGFR inhibitors, the present study centred on identifying high efficacy EGFR inhibitors through structure based virtual screening strategies. Established inhibitors - Afatinib, Dacomitinib, Erlotinib, Lapatinib, Rociletinib formed parent compounds to retrieve similar compounds by linear fingerprint based tanimoto search with a threshold of 90%. The compounds (parents and respective similars) were docked at the EGF binding cleft of EGFR. Patch dock supervised protein-protein interactions were established between EGF and ligand (query and similar) bound and free states of EGFR. Compounds ADS103317, AKOS024836912, AGN-PC-0MXVWT, GNF-Pf-3539, SCHEMBL15205939 were retrieved respectively similar to Afatinib, Dacomitinib, Erlotinib, Lapatinib, Rociletinib. Compound-AGN-PC-0MXVWT akin to Erlotinib showed highest affinity against EGFR amongst all the compounds (parent and similar) assessed in the study. Further, AGN-PC-0MXVWT brought about significant blocking of EGFR-EGF interactions in addition showed appreciable ADMET properties and pharmacophoric features. In the study, we report AGN-PC-0MXVWT to be an efficient and high efficacy inhibitor of EGFR-EGF interactions identified through computational approaches.

• Spatial Information Research
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• v.12 no.1
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• pp.57-71
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• 2004

In this study about construction of land consulting information system the system is constructed for the support be rapidly and efficiently of decision making information. Supporting decision making is be sure need when build in land or change form and character of land, that kind of variety land law, conditions of buying land location, distribution of land answering to the development purpose and buying and selling or lease of land. So that land consulting information system can be query, search, identity and analysis for the decision making elements using the computer. The system an another name ALGOSA far the improved extent of legal in ability of system. Like this where spread of system is by company as well as private person, it's company kinds of real estate business, survey and civil designer's office, architectural designer's office and professional1y land development company of great many all over the country.

• The Journal of Society for e-Business Studies
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• v.10 no.3
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• pp.111-134
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• 2005

Knowledge management is a core factor to achieve competitive advantage and improve the business performance. New information technology is also a core factor enabling the innovation of knowledge management. Semantic Web of which the goal is to realize machine-processable Web can't help affecting the knowledge management. Therefore, we empirically analyze the relationship between user's dissatisfaction and barriers or limitations of knowledge management and present methods allowing Semantic Web to overcome the limitations and to support knowledge management processes. Based on a questionnaire survey of 222 respondents, we found that the limitations of system qualities such as user inconvenience of knowledge management systems, search and integration limitations, and the limitations of knowledge qualities such as inappropriateness and untrust significantly affected the user dissatisfaction of knowledge management systems. Finally, we suggest a conceptual model of knowledge management systems of which components are resources, metadata, ontologies, and user & query layers.

• Journal of KIISE:Databases
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• v.29 no.3
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• pp.193-206
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• 2002

In this paper, we design and implement an efficient bulk-loading algorithm for CIR-Tree. Bulk-loading techniques increase node utilization, improve query performance and reduce index construction time. The CIR-tree has variable size of internal node entries since it only maintains minimal dimensions to decriminate child nodes. This property increases fan-out of internal nodes and improves search performance. Even though several bulk-loading algorithms for multi/high-dimensional index structures have been proposed, we cannot apple them to CIR-tree because of the variable size of internal node entries. In this paper, we propose an efficient bulk- loading algorithm for CIR-tree that improves the existing bulk-loading algorithm and accomodates the property of CIR-tree. We also implement it on a storage system MiDAS-III and show superiority of our algorithm through various experiments.