• Journal of Korean Medicine Rehabilitation
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• v.20 no.4
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• pp.33-49
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• 2010

Objectives : This study was designed to elucidate the anti-pathogenetic and curative effects of Gyehyeoldeungbokhap-bang(Jixietengfuge-fang, GCP) on Type II collagen-induced arthritis(CIA) in mice. Methods : In experiment, twenty four mices were divided into non-treated normal group(n=6), bovine type II collagen-induced control group(n=6), collagen immunized and treated two group medicated with extract of GCP(concentration of extraction: 200 mg/kg n=6, 400 mg/kg n=6) for 4 weeks after collagen immunization, Various experimental such as arthritis, incidence, index, total cell number of spleen, total cell number of peripheral lymph node(PLN), paw joint total cell number, analysis on the percentage of immunofluorescent cells of spleen in CIA induced mice, effects of inflammatory gene expression in spleen, PLN and paw joint of CIA mice, production of cytokine(IFN-${\gamma}$, IL-4, TNF-${\alpha}$, IL-6), analysis of rheumatoid factor(anti-collagen lgG, lgM level in serum) and histopathological study on the paw joint. The arthritis index, incidence were measured a week over 4 weeks after second boosting. Total cell number of spleen, peripheral lymph node, paw joint were measure after performed experiment over 7 weeks. Concentration of cytokine and rheumatoid factor in serum were measured after experiment finished. Histopathological study on the paw joint was measured after 40 days medicated with extract of GCP. Results : 1. Incidence of arthritis and index of arthritis were significantly decreased in treated group with 400 mg/kg. 2. Total cell number of spleen, PLN and paw joint were significantly decreased in treated group. 3. Analysis on the percentage of immunofluorescent cells of spleen in CIA induced mice were significantly controled compare with control group. 4. Effects of inflammatory gene expression in spleen, PLN and paw joint of CIA induced mice were significantly controled compare with control group. 5. IFN-${\gamma}$, IL-6, TNF-${\alpha}$, concentration($pg/m{\ell}$) in serum of treated group was significantly decreased compare with control group. But IL-4 was significantly increased. 6. lgM and lgG concentration($pg/m{\ell}$) in serum of treated group was significantly decreased compare with control group. 7. Histopathologically, suppurative and destructive lesion of synovial membrane, articular cartilage and subchondral bony tissue in treated group were alleviated compare with those of control group. Conclusions : Based on the results described above, it might be consider that Gyehyeoldeungbokhap-bang(Jixietengfuge-fang, GCP) has antiarthritic and analgesic effects and also inhibitory effects on the progression of collagen-induced arthritis mice.

• Journal of the East Asian Society of Dietary Life
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• v.13 no.1
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• pp.56-63
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• 2003

The dough fermentation and the quality of bread prepared with different kinds of water such as distilled water, tap water and diluted hot spring water(SW) from Gyungsan Sipan hot spring were investigated. Content of total soluble solid in the hot spring water was 8,765 ppm and contents of Na, Ca, Mg and K as major elements was 2,296, 287, 65 and 8 ppm, respectively. Content of Fe, Cu, Co, F, Zn, Al, S, Mo, Se and Si as minor elements was in the range of 0.002~5.2 ppm. The pH(6.95~7.68) of the dough prepared with diluted hot spring water(I, 55 times; II, 4 times; III, 2 times) was higher than that of distilled water. The dough volume after the 1st fermentation was expecially lower in the III, but the volume of the dough prepared with III adjusted pH to 5.5 was higher than that of the control. The hardness and the strength were higher than those of the control, but the scores were love. than those of the control in case of pH adjustment(pH 5.5). The cohesiveness was also lower than that of the control in the bread with diluted hot spring water. Softness and stickiness of the bread(III) were hisher than those of the control. But overall acceptability was the highest in the II.

• The Korean Journal of Physiology
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• v.29 no.2
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• pp.279-289
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• 1995

This study was designed 1) to develop a hypertensive animal model in which the blood pressures (BPs) of symmetric regions (right and left upper extremities) are significantly different and 2) to test the effect of BP per se on the contractility and endothelium-dependent relaxation of vascular smooth muscle. Rabbits were anesthetized with sodium pentobarbital and ventilated with room air via animal respirator. The transverse aorta was exposed through the left second intercostal space and the lumen of the aorta was narrowed partially by ligation using 3-0 silk and a probe at a point between the origins of the brachiocephalic trunk and the left subclavian artery. Four to eight weeks postoperatively, BPs were measured in the carotid artery as the high BP area (proximal to coactation site) and in the femoral artery as the low BP area (distal to coarctation site). In the animal model, pressure-overload hypertension was developed and the BP of the right subclavian artery was higher than that of the left subclavian artery. The concentrations of circulating epinephrine, norepinephrine, angiotensin I, and angiotensin II were measured. The right and left subclavian arteries and their branches were used for isometric tension recording in organ baths and their responsiveness to phenylephrine, serotonin, acetylcholine, and sodium nitroprusside were examined. The BPs of carotid and femoral artery in control animals were $116{\pm} 12/75{\pm}9\;mmHg (mean ${\pm}SEM$) and $130{\pm}16/68{\pm}9\;mmHg$ respectively, while those of carotid and femoral artery in the hypetensive animals were $172{\pm}6/111{\pm}10\;mmHg$ and 136{\pm} 4/100 {\pm}9\;mmHg$ respectively. There were no significant differences in the concentrations of circulating epinephrine, norepinephrine, angiotensin I, and angiotensin II between controls and the animal models. No significant differences were found in the vascular sensitivities to phenylephrine and serotonin between the high pressure-exposed vessels and the low pressure-exposed vessels. However, the endothelium-dependent relaxation to acetylcholine and nitroprusside-induced relaxation showed significant differences between the high pressure-exposed and the low pressure-exposed subclavian arteries. From the above results, we suggest that the contractility of vascular smooth muscle is unchanged by the elevated pressure per se. However, the endothelium-dependent relaxation to acetylcholine and the nitroprusside-induced relaxation are attenuated by pressure.

• Economic and Environmental Geology
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• v.37 no.2
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• pp.245-253
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• 2004

The 36km-long Daebo-Campo coast has a well-developed marine terraces divided to six steps by elevation of paleoshoreline : 0.5 m(T1), 10 m(T2), 30 m(T3), 40 m(T4), 60 m(T5) and 75 m(T6). The 2$^{nd}$ and 3$^{nd}$ platforms in Daebo to Guryongpo are wider and more distinctive than those of Guryongpo to Gampo. The 3$^{nd}$ terrace of 30 m high is subdivided to two flights as lower(T3b) and upper(T3a) by old sea cliff. Platform age is unclear because of coral fossil free. However, the terrace age could be determined with convergent OSL ages from beach sediments on 2$^{nd}$ step(T2). OSL ages of the terrace of 10 m high range in 60-70 ka. It reveals that the 2$^{nd}$ -step platform correlates to Oxygen Isotope Time scale, substage 5a(ca. 80 ka), and that uplift rate is ca. 0.19 m/ka for 2$^{nd}$ terrace at Daebo-Campo coast. If considering equivalent uplift rate for all terraces since the Late Pleistocene, the 3$^{rd}$ and 4$^{th}$ terraces would be 5e substage and 7 stage. The 30 m-high terrace provides a good indicator for uplift at Daebo-Gampo coast since 125,000 yrs(MIS 5e). It suggests that the local neotectonic deformation might cause an optional uplift rate of ca. 0.19 m/ka along the SE coast of Korea.

• The Korean Journal of Quaternary Research
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• v.20 no.2
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• pp.51-57
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• 2006

Terrace stratigraphy of the southeastern coastal areas of Korea is reappraised on the basis of terrace mapping and geochronology. Coastal terraces are divided into uHT ($90{\sim}130\;m$), HT ($63{\sim}86m$), MT ($36{\sim}55\;m$), and LT ($8{\sim}25\;m$) according to altitude. Among these, the Lower Terrace I is interpreted to have formed during MIS 5e based on Tephras Aso-4 (MIS 5c), Ata(MIS 5d or 5e) and OSL data. The age of Lower Terrace II is thought to be MIS 5a based on tephras and OSL data. The uplift rate in the SE part of Korea during the formation of the Lower Terrace (i.e. the MIS 5) ranges from 0.08 to 0.25 mm/yr and averages as 0.15 mm/yr. Such value is quite small in comparison to that of Japan, Taiwan or many other tectonically active areas in the world.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.9
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• pp.255-261
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• 2019

This trial was conducted to determine the optimal supplementation level of Hermetia illucens (HI) on the growth performance, the apparent total tract retention of nutrients and the economic efficiency in weaning pigs. A total of 192 weaned pigs ($Landrace{\times}Yorkshire{\times}Duroc$; $6.51{\pm}0.15kg$) were randomly allotted to 4 treatments and 6 replicates on the basis of their initial body weight. The dietary treatments included a corn-soybean meal based diet supplemented with 0, 1, 2 or 3% HI. There were no significantly effects between the treatments in phases I, II and overall. But average daily gain was significant and linearly increased when HI was added to the diet in the overall group. Although digestibility of dry matter (DM) was increased by adding HI, digestibility responses were not observed by supplying HI in phase I. Also, all the parameters of economic efficiency were not significantly different according to the level of HI. The results showed that HI had beneficial effects on growth performance and digestibility of dry matter. However, there were no effects on economic efficiency by using HI in weaning pig diets.

• Journal of the korean academy of Pediatric Dentistry
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• v.50 no.3
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• pp.277-291
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• 2023

This study aimed to compare the effects of applying different types of dentin bonding agents (DBAs) on tooth and on the sealing ability of CSC in regenerative endodontic procedures (REPs). Specimens were made from 120 human first premolars and categorized into the following groups based on the presence and the type of DBA: Group I, no bonding; Group II, One-Step; Group III, Clearfil SE Bond; and Group IV, Single Bond Universal. Subsequently, the groups were categorized into Subgroup a and Subgroup b, in which Endocem MTA^® Premixed Regular and Biodentine were used, respectively. The CIE L^*a^*b^* on the photos taken prior to TAP placement (S0), 1 week after TAP placement (S1), 2 weeks after TAP placement (S2), 4 weeks after TAP placement (S3) and 2 weeks after CSC placement (S4) was used to assess discoloration. The samples were submerged in a 2% methylene blue solution and magnified by 30 times under a stereomicroscope to assess microleakage. The application of DBA during REP reduced crown discoloration, while Biodentine showed minimal discoloration with or without DBA and regardless of the DBA type. Additionally, the application of DBA did not increase microleakage.

• Toxicological Research
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• v.32 no.4
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• pp.301-309
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• 2016

Due to undesirable hazardous interactions with biological systems, this investigation was undertaken to evaluate the effect of chronic exposure to silver on certain biochemical and some oxidative stress parameters with histopathological examination of brain, as well as the possible protective role of selenium and/or vitamin E as nutritional supplements. Thirty six male rats were divided into six groups of six each: the first group used as a control group. Group II given both vitamin E (400 mg/kg) of diet and selenium (Se) (1 mg/L) in their drinking water. Group III given silver as silver nitrate ($AgNO_3$) (20 mg/L). Group IV given vitamin E and $AgNO_3$. Group V given both $AgNO_3$ and selenium. Group VI given $AgNO_3$, vitamin E and Se. The animals were in the same exposure conditions for 3 months. According to the results which have been obtained; there was an increase in serum lactate dehydrogenase (LDH), lipase activities and cholesterol level, a decrease in serum total protein, calcium and alkaline phosphatase (ALP) activity in Ag-intoxicated rats. Moreover, the findings showed that $Ag^+$ ions affected antioxidant defense system by decreasing superoxide dismutase (SOD) activity and increasing vitamin E concentration with a high level of malondialdehyde (MDA) in brain tissue. The histological examination also exhibited some nervous tissue alterations including hemorrhage and cytoplasm vacuolization. However, the co-administration of selenium and/or vitamin E ameliorated the biochemical parameters and restored the histological alterations. In conclusion, this study indicated that silver could cause harmful effects in animal body and these effects can be more toxic in high concentrations or prolonged time exposure to this metal. However, selenium and vitamin E act as powerful antioxidants which may exercise adverse effect against the toxicity of this metal.

• Journal of the Korean Society of Clothing and Textiles
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• v.35 no.12
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• pp.1418-1424
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• 2011

This study proposes the suggested amount of clothing (SAC) and examines the preferred amount of clothing (PAC) for thermal comfort in mild cold conditions. Six male and nine female college students were systematically exposed to mild cold conditions by reducing the amount of clothing (Step I, 1.2clo ${\rightarrow}$ Step II, 1.0clo ${\rightarrow}$ Step III, 0.8clo ${\rightarrow}$ Step IV, 0.7clo). The subjects were then asked to adjust the amount of clothing to attain overall thermal comfort until they maintained thermal comfort for 10 minutes without changing the amount of clothing (Step V). The experiment was carried out in a climatic chamber at $19.5^{\circ}C$, 50%R.H. Body composition was measured and individual cold climate adaptability was surveyed before starting the experiment. Rectal temperature ($T^{re}$), skin temperature ($T_{sk}$), and oxygen consumption ($\dot{V}O_2$) were measured and the overall thermal sensation was voted in each step. PAC was obtained from the garments weight selected by each subject in Step V. SAC was proposed based on the change of oxygen consumption (${\Delta}\dot{V}O_2$). As a result, males showed higher $\bar{T}_{sk}$ and greater $O_2$ than females (p<.01). SAC obtained from $\dot{V}O_2$ were 652.0 (SE 3.9) g/$m^2$ for males and 766.0 (SE 2.5) g/$m^2$ for females and it was significantly different between groups (p<.01). PAC of males and females were 1.6 and 1.5 times heavier than SAC. In conclusion, females were more sensitive to the cold stress and recommended larger amount of clothing than males.

• Journal of The Geomorphological Association of Korea
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• v.19 no.3
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• pp.97-108
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• 2012

During the last few decades, the ever-increasing knowledge of coastal morphogenic processes has made marine terraces the most recognizable, widespread and scientifically reliable records to determine both qualitatively and quantitatively the vertical movements that have affected the tectonically active coastal regions during the Quaternary. This study first aims to address the marine terrace records from Suje-ri to Suryum-ri along the coast of Gyeongju, SE Korea. Eight distinct flights of terraces, including HH YC, elevated up to 160 m above present sea level have been mapped along the coast of the study areas, and are designated $L_{II}$ to HH YC from the youngest to oldest. Based on the elevation of paleo-shoreline and inferred formation age for HH YC uplift rate since the middle Pleistocene has been estimated at 0.23 mm/year. Establishing the nature and timing of the uplift history derived from marine terraces provide a better understanding of neotectonic framework for explain enigmatic, complex landscape evolution in the Korean peninsula.