• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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• 제9권1호
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• pp.25-32
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• 2003

오늘날 사람들의 많은 관심을 끌고 있는 생명 공학 분야에서, 가상 검색은 컴퓨터에서 가상적으로 시뮬레이션을 수행함으로서 특정 질병에 관여하는 물질을 널다 빠르게 추출하여 신약을 설계하는 방법이다. 본 논문에서는 지역적으로 분산된 유휴 또는 전략적 자원을 이용하여 가상 검색을 효과적으로 수행할 수 있는 분산 시스템인 DVSF(Distributed Virtual Screening Facilities)를 소개한다. DVSF는 중소규모의 실험실이 가지고 있는 유휴 자원을 이용하여 최소한의 비용으로 효과적인 신약 개발을 위한 환경을 구성할 수 있도록 개발되었다.

• Archives of Pharmacal Research
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• 제23권3호
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• pp.246-251
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• 2000

In most tissues, apoptosis plays a pivotal role in normal development and for regulating cell number, thus inappropriate apoptosis underlies a variety of diseases. Caspase-3 is one of a family of caspases that are mainly involved in the apoptotic signal transduction pathway, where caspase-3 acts as an effect molecule to proteolytically cleave intracellular substrates that are necessary for maintaining cell survival. Recent evidences show that apoptotic cell death can be blocked by inhibiting caspase-3, suggesting its inhibitors have potential to be therapeutic drugs for the diseases related with inappropriate apoptosis. We have established a screening system to search caspase-3 inhibitors from chemical libraries stocked in our institute. The enzyme assay is configured entirely in 96-well format, which is easily adapted for high throughput screening. Before performing mass screening, 80 in-house compounds were screened as a preliminary experiment, and we found that morin hydrate inhibited caspase-3 by 66.4 % at the final concentration of 20 ${\mu}g/m{\ell}$.

• 한국콘텐츠학회논문지
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• 제6권5호
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• pp.56-65
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• 2006

게임심의제도는 거의 모든 국가에서 운영되는데, 각 국가의 커뮤니케이션 정책에 따라 그 운영형태는 각각 상이하다. 본고에서는 주요 국가의 게임심의제도를 표현의 자유, 콘텐츠 완전공개, 청소년보호/산업 진흥의 균형이라는 세 측면에서 비교분석하였다. 그 결과 미국, 유럽, 일본 등의 제도가 커뮤니케이션 정책의 기본원칙들을 충실히 지키는 편이었으며, 우리나라와 남아공, 호주 등은 아직 개선되어야 할 점이 많이 나타났다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8595-8598
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• 2016

Background: Decision making modalities for screening for many cancer conditions and different stages have become increasingly complex. Computer-based risk assessment systems facilitate scheduling and decision making and support the delivery of cancer screening services. The aim of this article was to survey electronic risk assessment system as an appropriate tool for the prevention of cancer. Materials and Methods: A qualitative design was used involving 21 face-to-face interviews. Interviewing involved asking questions and getting answers from exclusive managers of cancer screening. Of the participants 6 were female and 15 were male, and ages ranged from 32 to 78 years. The study was based on a grounded theory approach and the tool was a semi-structured interview. Results: Researchers studied 5 dimensions, comprising electronic guideline standards of colorectal cancer screening, work flow of clinical and genetic activities, pathways of colorectal cancer screening and functionality of computer based guidelines and barriers. Electronic guideline standards of colorectal cancer screening were described in the s3 categories of content standard, telecommunications and technical standards and nomenclature and classification standards. According to the participations' views, workflow and genetic pathways of colorectal cancer screening were identified. Conclusions: The study demonstrated an effective role of computer-guided consultation for screening management. Electronic based systems facilitate real-time decision making during a clinical interaction. Electronic pathways have been applied for clinical and genetic decision support, workflow management, update recommendation and resource estimates. A suitable technical and clinical infrastructure is an integral part of clinical practice guidline of screening. As a conclusion, it is recommended to consider the necessity of architecture assessment and also integration standards.

• 대한간호학회지
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• 제29권2호
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• pp.258-270
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• 1999

This study was carried out to offer the basic data for more qualitative lives of the middle-aged women through their health maintenance and control. So, the researcher reviewed and analyzed the health problems of the middle-aged women, the differences of main symptoms in each subject, positive ratcs in screening tests, the difference of screening tests with age and the correlation of obesity and blood pressure with screening tests. All subjects were 218 women(40-59years) who had a check-up at a comprehensive health check-up center in K University Hospital in Seoul from July 1, 1998 to August 31. 1998. Questionaires were developed to get subjects, general characteristics. main symptoms, medical examination and diagnosed disease by the researcher referring through the questionaires of comprehensive health check-up center and the medical recorders were used as a tool of study. The researcher analyzed the data with SPSS PC+ ; the distribution of the subjects, general characteristics and main symptoms with percentage : the difference between main symptoms and screening tests with X$^2$-test, ANOVA. The results are as follows. 1) Among the age distribution, most were 40-45 years old and unemployed. 2) The most common complaints were indigestion in digestive system, cough in respiratory system, heart beat in cardiovascular system, general sweat in endocrine system. edema in urinary system, easy bruise in hematologic system, backache in musculoskeletal system, headache in psychoneurologic system, lochia in gynecology, itch in dermatology system, eye ball pain in visual system and tinnitus in auditory system. 3) In main symptoms according to age, the 40-45 age group had a higher rate of complaints in digestive system and gynecology than other age group ; the 46-49 age group in endocrine system. 4) The main symptoms according to diagnosis had no difference statistically. 5) The screening tests which showed high rates of abnormality were mammography(the highest), abdominal ultrasonography, upper gastrointestinal series/gastrofiberscopy, PFT. In all age group the highest rate of abnormality was seen in mammography. 6) In screening tests according to age. the 46-49 age group showed higher positive rates of pap smear, blood sugar test, urine test than any other age group ; the 50-55 age group showerd higher positive rates of obesity, BP, chest X-ray, abdominal ultrasonography, ESR, SGOT, CRP and urine micro. 7) In correlation of obesity with screening test, the obesity group showed higher positive rates of blood pressure, chest X-ray, abdominal ultrasonography, HCT and CRP than the normal weight group. 8) In correlation of blood pressure with screening test, the hypertension group showed higher positive rate of obesity, chest X-ray, abdominal ultrasonography, pap smear and blood sugar than the normal blood pressure group. In conculusion, the middle-aged women have various physical symptoms and affected by age. The obesity and BP have an important effect on the health of the middle aged women. Therefore, this study is considered significant as data for qualitative lives of the middle-aged women playing an important part of family health care by catching of their health problem complaints for prevention of disease and promotion of health.

• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2607-2612
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• 2014

Background: Cancer screening rates in Japan are much lower than those in Western countries. This study evaluated the relationship between cancer screening rates and strategies used to improve screening rates, and determined which strategy is the most effective. Materials and Methods: All municipalities are responsible for conducting gastric, lung, colorectal, cervical, and breast cancer screenings in Japan. Of the 1,746 municipalities in total, 92-99% were included in the analyses for each cancer screening. Using national data in 2009, the correlations between cancer screening rates and strategies for improving screening rates of all municipalities, both large (populations of over 30,000) and small (populations of under 30,000), were determined. The strategies used were as follows: sending personal invitation letters, personal visits by community health workers, use of a clinical setting for screening, and free screening. Results: Of all four strategies used to improve cancer screening rates, sending personal invitation letters had the highest correlations with all screening rates, with the exception of breast cancer screening. The partial correlation coefficients linking this strategy with the screening rates in all municipalities were 0.28, 0.32, 0.30, and 0.26 for gastric, lung, colorectal, and cervical cancer screening, respectively. In large municipalities, the correlations between the number of examinees in a clinical setting and the screening rates were also relatively high, particularly for cervical cancer screening (r=0.41). Conclusions: Sending personal invitation letters appears to be particularly effective in improving cancer screening rates in all municipalities. All municipalities should implement a system that sends personal invitation letters for cancer screening. In large municipalities, increasing the availability of screening in a clinical setting is also effective in improving cancer screening rates.

• Korean Journal of Radiology
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• 제21권9호
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• pp.1027-1035
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• 2020

Objective: To assess the appropriate follow-up interval, and rate and timepoint of cancer detection in women with Breast Imaging Reporting and Data System (BI-RADS) 3 lesions on screening ultrasonography (US) according to the type of institution. Materials and Methods: A total of 1451 asymptomatic women who had negative or benign findings on screening mammogram, BI-RADS 3 assessment on screening US, and at least 6 months of follow-up were included. The median follow-up interval was 30.8 months (range, 6.8-52.9 months). The cancer detection rate, cancer detection timepoint, risk factors, and clinicopathological characteristics were compared between the screening and tertiary centers. Nominal variables were compared using the chi-square or Fisher's exact test and continuous variables were compared using the independent t test or Mann-Whitney U test. Results: In 1451 women, 19 cancers (1.3%) were detected; two (0.1%) were diagnosed at 6 months and 17 (1.2%) were diagnosed after 12.3 months. The malignancy rates were both 1.3% in the screening (9 of 699) and tertiary (10 of 752) centers. In the screening center, all nine cancers were invasive cancers and diagnosed after 12.3 months. In the tertiary center, two were ductal carcinomas in situ and eight were invasive cancers. Two of the invasive cancers were diagnosed at 6 months and the remaining eight cancers newly developed after 13.1 months. Conclusion: One-year follow-up rather than 6-month follow-up may be suitable for BI-RADS 3 lesions on screening US found in screening centers. However, more caution is needed regarding similar findings in tertiary centers where 6-month follow-up may be more appropriate.

• 한국해안해양공학회지
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• 제15권4호
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• pp.224-231
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• 2003

본 논문에서는 부유식 방파제와 잠제의 단점을 보완하고 장점을 활용하기 위하여 부유식방파제와 잠제를 혼합한 혼합형 방파제에 의한 파랑 차단 성능을 2차원 유한요소법에 의해 검토하고 있다. 혼합형 방파제의 경우 부유식 방파제 또는 잠제를 단독으로 사용하였을 때 보다 우수한 파랑 차단 성능을 보였고, 단파 및 비교적 장파에서도 우수한 파랑 차단 성능을 보여 파랑의 일부 주기에 국한되지 않고 넓은 주기 영역에서의 파랑 차단 성능이 우수함이 나타났다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2005년도 제36회 하계학술대회 논문집 A
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• pp.335-337
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• 2005

The purpose of this work is to explain techniques achieved while developing a transient stability program which is suitable to Korean power system, and to add a module for contingency screening. It concentrates on the development of Contingency Screening Module. In this thesis, a fast contingency screening algorithm SIME(Single Machin Equivalent), which is one of the Hybrid methods for the transient stability assessment is used to develop the contingency screening module. The proposed module is applied to a KEPCO system, and simulation results obtained from the program are compared to those of commercial programs.

• 디지털융복합연구
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• 제10권9호
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• pp.397-407
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• 2012

본 연구에서는 대전지역 일개 건강검진센터의 디지털화된 국민건강보험 건강검진 수검 자료를 이용하여 국민건강보험 검진환자를 효율적으로 관리할 수 있는 방안을 제시하고자 하였다. 이를 위해 대전지역 일개 건강검진센터의 2002년부터 2011년까지 10년간의 국민건강보험 건강검진 수검 자료를 수집하였으며, 수집된 자료를 이용하여 국민건강보험 검진환자의 재검진 예측모형, 민간검진 예측모형, 위암검진 예측모형을 개발하였다. 예측모형 개발 결과 연령, 거주지, 단체 또는 개인 검진 여부, 이전 국민건강보험 건강검진 횟수 등이 국민건강보험 재검진, 민간검진, 위암검진에 유의한 영향을 미치는 것으로 나타났다. 개발된 예측모형을 토대로 재검진, 민간검진, 위암검진 확률 로직을 산출하여 대전지역 일개 건강검진센터의 시스템에 적용할 수 있는 방안을 마련하였다. 국민건강보험 건강검진 환자관리 시스템을 토대로 맞춤형 서비스를 제공한다면 건강검진센터 운영의 효율화에 크게 이바지 할 수 있을 것이다.