• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3735-3742
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• 2013

Background: Cardamom (Elettaria cardamom), also known as "Queen of Spices", has been traditionally used as a culinary ingredient due to its pleasant aroma and taste. In addition to this role, studies on cardamom have demonstrated cancer chemopreventive potential in in vitro and in vivo systems. Nevertheless, the precise poly-pharmacological nature of naturally occurring chemo-preventive compounds in cardamom has still not been fully demystified. Methods:In this study, an effort has been made to identify the proapoptopic, anti-inflammatory, anti-proliferative, anti-invasive and anti-angiogenic targets of Cardamom's bioactive principles (eucalyptol, alpha-pinene, beta-pinene, d-limonene and geraniol) by employing a dual reverse virtual screening protocol. Experimentally proven target information of the bioactive principles was annotated from bioassay databases and compared with the virtually screened set of targets to evaluate the reliability of the computational identification. To study the molecular interaction pattern of the anti-tumor action, molecular docking simulation was performed with Auto Dock Pyrx. Interaction studies of binding pose of eucalyptol with Caspase 3 were conducted to obtain an insight into the interacting amino acids and their inter-molecular bondings. Results:A prioritized list of target proteins associated with multiple forms of cancer and ranked by their Fit Score (Pharm Mapper) and descending 3D score (Reverse Screen 3D) were obtained from the two independent inverse screening platforms. Molecular docking studies exploring the bioactive principle targeted action revealed that H- bonds and electrostatic interactions forms the chief contributing factor in inter-molecular interactions associated with anti-tumor activity. Eucalyptol binds to the Caspase 3 with a specific framework that is well-suited for nucleophilic attacks by polar residues inside the Caspase 3 catalytic site. Conclusion:This study revealed vital information about the poly-pharmacological anti-tumor mode-of-action of essential oils in cardamom. In addition, a probabilistic set of anti-tumor targets for cardamom was generated, which can be further confirmed by in vivo and in vitro experiments.

• Korean Journal of Plant Tissue Culture
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• v.24 no.2
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• pp.113-117
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• 1997

Simple sequence repeats (SSR) are widely dispersed throughout eukaryotic genomes, highly polymorphic, and easily typed using polymerase chain reaction (PCR). The objective of this study was to determine the polymorphism of different Chlamydomonas reinhartdtii strains and to determine the mode of inheritance of the SSR locus in Chlamydomonas. A genomic DNA library of C. reinhardtii was constructed and screened with a radiolabeled $(AC)_{11}$ probe for the selection of (CA/GT)n repeat clone. Selected clone was seqeuenced, and PCR primer set flanking (CA/GT)n sequence was constructed. PCR was used to specifically amplify the SSR locus from multiple isolates of C. reinhardtii. The locus was polymorphic in some of the C. reinhardtii isolates. However, the locus was amplified only 4 of 6 isolates of C. reinhardtii, not in other 2 isolates of C. reinhardtii, suggesting that this locus is not extensively conserved. A simple Mendelian inheritance pattern was found, which showed 2:2 segregation in the tetrads resulting from a cross between C. reinhardtii and C. smithii. Our results suggest that this simple sequence repeat DNA polymorphism will be useful for identity testing, population studies, linkage analysis, and genome mapping in Chlamydomonas.

• Journal of the Korean Society for Precision Engineering
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• v.7 no.3
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• pp.26-36
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• 1990

This paper describes the Computer Aided Design (CAD) of dies for direct hot extrusion of structural shapes such as Z's and U's from aluminum alloys. A simple analysis of the direct extrusion process is developed and used to formulate a disign procedure for determining the optimal shape of the extrusion dies. A computer software system has been developed to design flat-faced dies for non-lubricated hot extrusion process. This software is a system of computer programs which are written to logical design procedure. Computer programs are based on empirical and analytical relationships, as well as on established knowledge based system. In the interactive mode of operation, the reaults at various tages of the design process are plotted on a screen. At any stage, the designer can interact with the computer to change or modify the design, based on his experience. The output from the program is (a) the design of the flat-faced die, (b) information on extrusion load, reduction ratio, and other process variables, etc. The implementation of this CAD system is expected to (a) provide scientific basis and rationalize the die design procedure, (b) optimize extrusion variables to maximize yield and production rate, (c) improve utilization of existing press capacity, etc.

• Transactions of the Korean Society of Automotive Engineers
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• v.21 no.3
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• pp.82-87
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• 2013

In this work, the 1L grade integrated metal DOC/DPF filter that can install in engine manifold position was developed to investigate the effect of platinum-coating amount of filter on the improvement of filter activation temperature and reduction of particulate matter (PM). This filter was installed in 2.9L CI engine which meets the EURO-4 emission regulation. Tests for PM reduction efficiency of filter were conducted under ND-13 mode with full-load test condition. It was revealed that the time to reach the activation temperature of metal filter ($280^{\circ}C$) was shorter as the amount of platinum-coating increased. This short activation time can be helpful for the reduction of CO and HC emissions during cold start condition. At the same time, PM reduced as the coating amount increased. The reduction percentage of $DOC_{40}$, $DOC_{20}$, and $DOC_0$ were 96.7% (2.34 mg/kW'h), 95.1% (3.47 mg/kW'h), and 94.5% (3.69 mg/kW'h) compared to previous result (71.4 mg/kW'h), respectively.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2004.11a
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• pp.181-190
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• 2004

The docking and in silico ligand screening procedures can select small sets of lead -like candidates from large libraries of either commercially or synthetically available compounds; however, the vast number of such molecules make the potential size of this task enormous. To accelerate the discovery of drugs to inhibit several targets, we have exploited massively distributed computing to screen compound libraries virtually. The Korea@HOME project was launched in Feb. 2002, and one year later, more than 1200 PC's have been recruited. This has created a 31 -gigaflop machine that has already provided more than 1400 hours of CPU time. It has all owed databases of millions of compounds to be screened against protein targets in a matter of days. Now, the virtual screening software suitable for distributed environments is developed by BMD. It has been evaluated in terms of the accuracy of the scoring function and the search algorithm for the correct binding mode.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.26 no.11
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• pp.1622-1629
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• 2002

To enhance isothermal characteristics of glass-farming surface, a rectangular parallelepiped heat pipes was fabricated, tested, and analyzed. The working fluid was sodium and the wall material was stainless steel 304. The dimension of the heat pipe was 210 (L) $\times$ 140(W) $\times$ 92(H)mm. A lattice structure covered with screen mesh was inserted to promote return of working fluid. The bottom side of heat pipe was heated electrically and the top side was cooled by liquid circulation. The temperature distribution at the bottom surface was of major concern and was monitored to determine isothermal characteristics. A frozen start-up of rectangular parallelepiped liquid metal heat pipe was tested. The operating mode of the sodium heat pipe was affected by the temperature of cooling zone, input heat flux, and the operating temperature of heat pipe. The heat pipe operated in a normal fashion as long as the heat flux was over 5.78W/cm$^2$, and the inside wall temperature of condenser part was above 95$^{\circ}C$ The maximum temperature difference at the bottom surface was observed to be 32$^{\circ}C$ when the operating temperature of the heat pipe was operating normally around 50$0^{\circ}C$. The result showed that a sodium heat pipe was very effective in reducing significantly the temperature difference in the glass-forming surface.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.40 no.6
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• pp.78-86
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• 2003

When we transformed from Monochrome-data to Color-data in text mode, we used hardware-method to design the circuit which is convertible in real time. We saved color information in every screens that can make screen in Color Palette ROM and it is also generated 8bit. lower 4bit assign foreground color and upper 4bit can design to have background color. We have Address Reduction ROM to remove repeated address and reduce volume of Color Palette ROM to 1/16. Besides, we have many D-FF to save address, data and page information temporarily after that, we have management process 8 times through counter in real time. Finally, we chose either foreground color or background color in multiplex and established color information was sended to the color video controller. Thus, you can use it as a good interface when yow transfer many control devices with Monochrome display (ex, LCD Monitor) into devices with Color display.

• Journal of Nutrition and Health
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• v.37 no.8
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• pp.675-687
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• 2004

This study is designed to assess the prevalence at risk of malnutrition according to the Mini Nutritional Assessment (MNA) and evaluate the factors influencing on the nutritional risk of the elderly. Three hundred and nine elderly (110 men and 199 women: mean age =74.1) who participated in meal service in the Chung-buk province were investigated. Mean MNA total score was 21.9 and women had significantly lower MNA scores than men (respectively, 21.5 and 22.8). In the mean time mean MNA-SF (Short Form) score was 10.7, respectively 10.6 for the women and 11.0 for the men, with the difference being statistically significant. The MNA classified 33% of the elderly as well-nourished, 61.7% as at risk of malnutrition and 5.3% as overt malnourished. However, MNA-SF categorized the examinees 40.2% as good and 59.8% at nutritional risk. Those who identified as malnourished elderly had significantly lower mean BMI, mid-arm and calf circumference, poorer functional abilities (ADL, IADL) , lower MAR and food habits scores, and higher number of nutrient $\leq$ 75% of RDA than those with at risk of malnutrition and well nourished. Also socioeconomic status such as educational level, self-rated economic status, poverty level, and marital status significantly influenced nutritional status. Similar effect was observed in self-rated nutritional status and health status, dental status, appetite change according to MNA score. Stepwise multiple regression analysis indicated that weight loss was the most predictive item in the total MNA and MNA-SF score. It was found that items such as mobility, living status (home vs institution) , mode of feeding, and pressure sores were inappropriate for assessment of the elderly who are able to participate meal service program. Also, some modifications of items in MNA are needed in order to apply to Korean elderly. Even though the MNA seems to be an useful tool to screen those old people at risk of malnourished, a lot of work is still to be done with this assessment tool to secure its reliability.

• Journal of Korean Society of Forest Science
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• v.88 no.1
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• pp.63-72
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• 1999

In this study, a relational database program to manage the data involved in forest planning was developed in such a way to simulate the whole process of 'Younglim' planning in Korean National Forest System. Using the pull-down menu system of various functions required for developing 'Younglim' plan, the database program can handle the data of forest inventory, 10-year working plans, annual working plans and the history of forest operations automatically and simultaneously. The model was designed to run under the environment of Korean version of Windows 95. Visual Basic 5.0 was used as the basic tool for programming and Microsoft ACCESS as the basic engine of the database system. In this paper, the process of designing the structure of database program following the process of 'Younglim' plan and the structure of the model are discussed. In addition, the functions of menu system are presented using the screen-mode output windows of the model.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.47 no.2
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• pp.68-76
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• 2010

Touch-enabled technology is increasingly being accepted as a main communication interface between human and computers. However, conventional touchscreen technologies, such as resistive overlay, capacitive overlay, and SAW(Surface Acoustic Wave), are not cost-effective for large screens. As an alternative to the conventional methods, we introduce a newly emerging method, an optical imaging touchscreen which is much simpler and more cost-effective. Despite its attractive benefits, optical imaging touchscreen has to overcome some problems, such as heavy computational complexity, intermittent ghost points, and over-sensitivity, to be commercially used. Therefore, we designed a hardware controller for signal processing and multi-coordinate computation, and proposed Infrared-blocked DA(Dark Area) manipulation as a solution. While the entire optical touch control took 34ms with a 32-bit microprocessor, the designed hardware controller can manage 2 valid coordinates at 200fps and also reduce energy consumption of infrared diodes from 1.8Wh to 0.0072Wh.