• Journal of Integrative Natural Science
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• v.3 no.1
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• pp.49-53
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• 2010

Molecular docking is a critical event which mostly forms Van der waals complex in molecular recognition. Since the majority of developed drugs are small molecules, docking them into proteins has been a prime concern in drug discovery community. Since the binding pose space is too vast to cover completely, many search algorithms such as genetic algorithm, Monte Carlo, simulated annealing, distance geometry have been developed. Proper evaluation of the quality of binding is an essential problem. Scoring functions derived from force fields handle the ligand binding prediction with the use of potential energies and sometimes in combination with solvation and entropy contributions. Knowledge-based scoring functions are based on atom pair potentials derived from structural databases. Forces and potentials are collected from known protein-ligand complexes to get a score for their binding affinities (e.g. PME). Empirical scoring functions are derived from training sets of protein-ligand complexes with determined affinity data. Because non of any single scoring function performs generally better than others, some other approaches have been tried. Although numerous scoring functions have been developed to locate the correct binding poses, it still remains a major hurdle to derive an accurate scoring function for general targets. Recently, consensus scoring functions and target specific scoring functions have been studied to overcome the current limitations.

• Journal of the Korean Institute of Intelligent Systems
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• v.19 no.5
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• pp.629-634
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• 2009

In real-time system application, the feature extraction and scoring algorithm for classification of the passive sonar target has the following problems: it requires an accurate and efficient feature extraction method because it is very difficult to distinguish the features of the propeller shaft rate (PSR) and the blade rate (BR) from the frequency spectrum in real-time, it requires a robust and effective feature scoring method because the classification database (DB) composed of extracted features is noised and incomplete, and further, it requires an easy design procedure in terms of structures and parameters. To solve these problems, an intelligent feature extraction and scoring algorithm using the evolution strategy (ES) and the fuzzy theory is proposed here. To verify the performance of the proposed algorithm, a passive sonar target classification is performed in real-time. Simulation results show that the proposed algorithm effectively solves sonar classification problems in real-time.

• International Journal of Aeronautical and Space Sciences
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• v.17 no.2
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• pp.204-213
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• 2016

A differential game theory based approach is used to develop an automated maneuver generation algorithm for Within Visual Range (WVR) air-to-air combat of unmanned combat aerial vehicles (UCAVs). The algorithm follows hierarchical decisionmaking structure and performs scoring function matrix calculation based on differential game theory to find the optimal maneuvers against dynamic and challenging combat situation. The score, implying how much air superiority the UCAV has, is computed from the predicted relative geometry, relative distance and velocity of two aircrafts. Security strategy is applied at the decision-making step. Additionally, a barrier function is implemented to keep the airplanes above the altitude lower bound. To shorten the simulation time to make the algorithm more real-time, a moving horizon method is implemented. An F-16 pseudo 6-DOF model is used for realistic simulation. The combat maneuver generation algorithm is verified through three dimensional simulations.

• Journal of the Korea Society of Computer and Information
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• v.10 no.6 s.38
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• pp.279-286
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• 2005

The objective of this study is to suggest a credit scoring model of a capital company's customers by integration of multiple classifiers using genetic algorithm. For this purpose , an integrated model is derived in two phases. In first phase, three types of classifiers MLP (Multi-Layered Perceptron), RBF (Radial Basis Function) and linear models - are trained, in which each type has three ones respectively so htat we have nine classifiers totally. In second phase, genetic algorithm is applied twice for integration of classifiers. That is, after htree models are derived from each group, a final one is from these three, In result, our suggested model shows a superior accuracy to any single ones.

• Journal of Korea Society of Industrial Information Systems
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• v.4 no.2
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• pp.39-43
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• 1999

We consider generalized exponential regression model with randomly censored data and propose a modified Fisher scoring method which estimates the model parameters. For this, the likelihood equations are derived and then the estimating algorithm is developed. We illustrate the proposed method using a real data.

• Journal of Information Processing Systems
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• v.11 no.2
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• pp.173-183
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• 2015

At present, it is simple to the electronic commerce credit scoring model, as a brush credit phenomenon in E-commerce has emerged. This phenomenon affects the judgment of consumers and hinders the rapid development of E-commerce. In this paper, that E-commerce credit evaluation model that uses a Gaussian density function is put forward by density test and the analysis for the anomalies of E-commerce credit rating, it can be fond out the abnormal point in credit scoring, these points were calculated by nonlinear credit scoring algorithm, thus it can effectively improve the current E-commerce credit score, and enhance the accuracy of E-commerce credit score.

• Applied Microscopy
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• v.51
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• pp.4.1-4.12
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• 2021

Fluorescence in situ hybridization (FISH) is a technique to visualize specific DNA/RNA sequences within the cell nuclei and provide the presence, location and structural integrity of genes on chromosomes. A confocal Whole Slide Imaging (WSI) scanner technology has superior depth resolution compared to wide-field fluorescence imaging. Confocal WSI has the ability to perform serial optical sections with specimen imaging, which is critical for 3D tissue reconstruction for volumetric spatial analysis. The standard clinical manual scoring for FISH is labor-intensive, time-consuming and subjective. Application of multi-gene FISH analysis alongside 3D imaging, significantly increase the level of complexity required for an accurate 3D analysis. Therefore, the purpose of this study is to establish automated 3D FISH scoring for z-stack images from confocal WSI scanner. The algorithm and the application we developed, SHIMARIS PAFQ, successfully employs 3D calculations for clear individual cell nuclei segmentation, gene signals detection and distribution of break-apart probes signal patterns, including standard break-apart, and variant patterns due to truncation, and deletion, etc. The analysis was accurate and precise when compared with ground truth clinical manual counting and scoring reported in ten lymphoma and solid tumors cases. The algorithm and the application we developed, SHIMARIS PAFQ, is objective and more efficient than the conventional procedure. It enables the automated counting of more nuclei, precisely detecting additional abnormal signal variations in nuclei patterns and analyzes gigabyte multi-layer stacking imaging data of tissue samples from patients. Currently, we are developing a deep learning algorithm for automated tumor area detection to be integrated with SHIMARIS PAFQ.

• The Mathematical Education
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• v.63 no.2
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• pp.165-186
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• 2024

Despite the growing attention on artificial intelligence-based automated scoring technology as a support method for the introduction of descriptive items in school environments and large-scale assessments, there is a noticeable lack of foundational research in mathematics compared to other subjects. This study developed an automated scoring model for two descriptive items in first-year middle school mathematics using the Random Forest algorithm, evaluated its performance, and explored ways to enhance this performance. The accuracy of the final models for the two items was found to be between 0.95 to 1.00 and 0.73 to 0.89, respectively, which is relatively high compared to automated scoring models in other subjects. We discovered that the strategic selection of the number of evaluation categories, taking into account the amount of data, is crucial for the effective development and performance of automated scoring models. Additionally, text preprocessing by mathematics education experts proved effective in improving both the performance and interpretability of the automated scoring model. Selecting a vectorization method that matches the characteristics of the items and data was identified as one way to enhance model performance. Furthermore, we confirmed that oversampling is a useful method to supplement performance in situations where practical limitations hinder balanced data collection. To enhance educational utility, further research is needed on how to utilize feature importance derived from the Random Forest-based automated scoring model to generate useful information for teaching and learning, such as feedback. This study is significant as foundational research in the field of mathematics descriptive automatic scoring, and there is a need for various subsequent studies through close collaboration between AI experts and math education experts.

• Proceedings of the Korea Inteligent Information System Society Conference
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• 2001.01a
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• pp.128-132
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• 2001

In this paper, we evaluate and contrast four neural network rule extraction approaches for credit scoring. Experiments are carried our on three real life credit scoring data sets. Both the continuous and the discretised versions of all data sets are analysed The rule extraction algorithms, Neurolonear, Neurorule. Trepan and Nefclass, have different characteristics, with respect to their perception of the neural network and their way of representing the generated rules or knowledge. It is shown that Neurolinear, Neurorule and Trepan are able to extract very concise rule sets or trees with a high predictive accuracy when compared to classical decision tree(rule) induction algorithms like C4.5(rules). Especially Neurorule extracted easy to understand and powerful propositional if -then rules for all discretised data sets. Hence, the Neurorule algorithm may offer a viable alternative for rule generation and knowledge discovery in the domain of credit scoring.

• The Journal of the Acoustical Society of Korea
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• v.13 no.2E
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• pp.58-67
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• 1994

Hidden Markov Model (HMM)-based algorithms have been used successfully in many speech recognition systems, especially large vocabulary systems. Although general purpose processors can be employed for the system, they inevitably suffer from the computational complexity and enormous data. Therefore, it is essential for real-time speech recognition to develop specialized hardware to accelerate the recognition steps. This paper concerns with a real-time implementation of an isolated word recognition system based on HMM. The speech recognition system consists of a host computer (PC), a DSP board, and a prototype Viterbi scoring board. The DSP board extracts feature vectors of speech signal. The Viterbi scoring board has been implemented using three field-programmable gate array chips. It employs a hardware-efficient Viterbi scoring architecture and performs the Viterbi algorithm for HMM-based speech recognition. At the clock rate of 10 MHz, the system can update about 100,000 states within a single frame of 10ms.