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Stimulants Medication of Attention-Deficit Hyperactivity Disorder (주의력결핍 과잉행동장애에서 정신자극제를 이용한 약물치료)

  • Yang, Young-Hui;Yoo, Hee-Jeong
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.19 no.2
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    • pp.61-71
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    • 2008
  • Attention-deficit hyperactivity disorder (ADHD) is characterized by inattention, hyperactivity, impulsiveness and problems in other higher cognitive processes such as executive function deficits. Currently, there are many treatment modalities, of which pharmacotherapy is the most strongly supported by scientific and clinical evidence. Stimulants, which are first choice in the pharmacological treatment of ADHD, block dopamine reuptake by binding the dopamine transporter and so increasing the concentration of dopamine in synaptic clefts. Stimulants are effective in improving core ADHD symptoms, as well as the nonspecific symptoms, such as aggressiveness and oppositional behavior. Frequently reported short-term adverse effects are decreased appetite, sleep disturbance, headache, dizziness and irritability. Although questions have been raised about the long-term side effects of stimulants, including growth suppression, cardiovascular events, and abuse potential, there is no clear evidence to support these concerns.

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CFHT: another opportunity for Korean Astronomy?

  • Veillet, Christian
    • The Bulletin of The Korean Astronomical Society
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    • v.36 no.2
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    • pp.125.1-125.1
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    • 2011
  • After a short description of the observatory, this presentation will highlight some of the most recent scientific achievements based on CFHT observations and how they benefit from the current instrumentation and novel observing modes proposed to the CFHT users. We will then move to the mid-term future with the development of new spectroscopic capabilities (visible wide-field FTS or near-IR spectro-polarimetry) and the study of a novel wide-field imager in the visible using Ground-Layer AO to provide unprecedented image quality on a large field of view. As an option for the long-term future, the concept of a next generation 10-m class telescope to replace the current CFHT 3.6-m will be described. An emphasis will be given on how CFHT is slowly morphing into an Asia-Pacific Rim observatory and on the role the Korean community could play in such an endeavor, from immediate access to first-class astronomical data to partnering with other nations in exciting developments.

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Concepts of Integrative Medicine and its Relationship with TKM (Traditional Korean Medicine) (통합의학의 개념 및 한의학과의 관계)

  • Lee, Tae-Hyung;Kim, Nam-Il
    • Korean Journal of Oriental Medicine
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    • v.17 no.3
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    • pp.35-42
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    • 2011
  • Objectives : The terms, CAM and Integrative Medicine, have been often used to conceptualize relation between TKM and western medicine in Korea. But both terms often lead to confusion since the backgrounds of those were not being properly discussed. Methods : We researched the concepts of CAM and Integrative Medicine through the changes in definitions and research methods. Results : Although modern medical verification of CAM showed some results through scientific researches, there existed certain limitations. The term Integrative Medicine newly emerged for this reason. The rise of the new term came to criticize existing research methodologies such as RCTs or SRs. However in Korea, Integrative Medicine has often been misunderstood as a unification of two different medical systems. Conclusions : Thus, in future research of relationship between TKM and western medicine, debates on plausibility & philosophical background of TKM, and research methodology are indispensable.

Free vibration of cross-ply laminated plates based on higher-order shear deformation theory

  • Javed, Saira;Viswanathan, K.K.;Izyan, M.D. Nurul;Aziz, Z.A.;Lee, J.H.
    • Steel and Composite Structures
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    • v.26 no.4
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    • pp.473-484
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    • 2018
  • Free vibration of cross-ply laminated plates using a higher-order shear deformation theory is studied. The arbitrary number of layers is oriented in symmetric and anti-symmetric manners. The plate kinematics are based on higher-order shear deformation theory (HSDT) and the vibrational behaviour of multi-layered plates are analysed under simply supported boundary conditions. The differential equations are obtained in terms of displacement and rotational functions by substituting the stress-strain relations and strain-displacement relations in the governing equations and separable method is adopted for these functions to get a set of ordinary differential equations in term of single variable, which are coupled. These displacement and rotational functions are approximated using cubic and quantic splines which results in to the system of algebraic equations with unknown spline coefficients. Incurring the boundary conditions with the algebraic equations, a generalized eigen value problem is obtained. This eigen value problem is solved numerically to find the eigen frequency parameter and associated eigenvectors which are the spline coefficients.The material properties of Kevlar-49/epoxy, Graphite/Epoxy and E-glass epoxy are used to show the parametric effects of the plates aspect ratio, side-to-thickness ratio, stacking sequence, number of lamina and ply orientations on the frequency parameter of the plate. The current results are verified with those results obtained in the previous work and the new results are presented in tables and graphs.

Systematic review of the effect of coenzyme Q10 on antioxidant capacity while focused on evaluation of claims for health functional food (건강기능식품의 기능성을 중심으로 한 코엔자임Q10의 항산화 기능성에 대한 체계적 고찰)

  • Kim, Ji Yeon;Jeong, Sewon;Paek, Ju Eun;Kim, Joohee;Kwak, Jin Sook;Lee, Yoon Jung;Kang, Tae Seok;Kwon, Oran
    • Journal of Nutrition and Health
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    • v.46 no.3
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    • pp.218-225
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    • 2013
  • Although the functional ingredient has been evaluated by the Korea Food and Drug Administration (KFDA) based on scientific evidence, the levels of scientific evidence and consistency of the results might vary according to emerging data. Therefore, periodic re-evaluation may be needed for some functional ingredients. In this study, we re-evaluated scientific evidence for the antioxidant activity of coenzyme Q10 as a functional ingredient in health functional food. Literature searches were conducted using the Medline and Cochrane, KISS, and IBIDS databases for the years 1955-2010 with the search term of coenzyme Q10 in combination with antioxidant. The search was limited to human studies published in Korean, English, and Japanese. Using the KFDA's evidence based evaluation system for scientific evaluation of health claims, 33 human studies were identified and reviewed in order to evaluate the strength of the evidence supporting a relation between coenzyme Q10 and antioxidant activity. Among 33 studies, significant effects for antioxidant activities were reported in 22 studies and their daily intake amount was 60 to 300 mg. Based on this systematic review, we concluded that there was possible evidence to support a relation between coenzyme Q10 intake and antioxidant activities. However, because inconsistent results have recently been reported, future studies should be monitored.

Nuclear magnetic resonance-based metabolomics analysis and characteristics of beef in different fattening periods

  • Jeong, Jin Young;Baek, Youl-Chang;Ji, Sang Yun;Oh, Young Kyun;Cho, Soohyun;Seo, Hyun-Woo;Kim, Minseok;Lee, Hyun-Jeong
    • Journal of Animal Science and Technology
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    • v.62 no.3
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    • pp.321-333
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    • 2020
  • Beef quality is influenced by the fattening period. Therefore, meat metabolomics profiles from the different fattening periods (e.g., short-term vs. long-term) were analyzed for identify potential indicators using nuclear magnetic resonance. Additionally, blood, free fatty acid, sensory, and mineral compositions in Korean steers were determined. Blood, free fatty acid, and mineral concentrations showed significant differences between short-term and long-term groups that were fed different diets. However, there were no sensory differences in the two fattening groups. Additionally, the metabolic profiles of meats were clearly separated based on multivariate orthogonal partial least square discriminant analysis. Six metabolites of variable importance in the projection plot were identified and showed high sensitivity as candidate markers for meat characteristics. In particular, lactate, carnosine, and creatine could be directly linked to scientific indicators of the fattening stage (31 vs. 28 mo) of meat. Our findings suggest that the metabolomics approach could be a powerful method for the detection of novel signatures underlying the managing period of beef.

Review on Studies about Greenhouse Gas Reduction Scenarios toward 2050 in Developed Countries and Implications (선진국의 2050년 온실가스 저감 시나리오에 관한 연구 동향과 시사점)

  • Park, Nyun-Bae
    • Journal of Environmental Policy
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    • v.5 no.3
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    • pp.57-78
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    • 2006
  • Now post 2012 greenhouse gas reduction commitment being discussed, studies about long-term GHG reduction scenarios toward 2050 have actively been worked separately from 5 years short-term approach. In this paper, background, temperature target, $CO_2$ concentration target, national emission target, and approach of long-term reduction scenarios toward 2050 particularly in European countries such as UK, Germany, France, Netherlands et al. are reviewed. After comparing GDP and emission indices between Developed (European) countries and Korea, some implications of long-term GHG reduction scenarios are deduced. Acting early owing to uncertainty in climate change impact and technology development rather than delaying reduction activity owing to scientific uncertainty in climate change is needed. Providing our society's vision of climate change and government's explicit direction through long-term GHG reduction target setting toward 2050 and economic units' preparing for those are needed.

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Prediction Oil and Gas Throughput Using Deep Learning

  • Sangseop Lim
    • Journal of the Korea Society of Computer and Information
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    • v.28 no.5
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    • pp.155-161
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    • 2023
  • 97.5% of our country's exports and 87.2% of imports are transported by sea, making ports an important component of the Korean economy. To efficiently operate these ports, it is necessary to improve the short-term prediction of port water volume through scientific research methods. Previous research has mainly focused on long-term prediction for large-scale infrastructure investment and has largely concentrated on container port water volume. In this study, short-term predictions for petroleum and liquefied gas cargo water volume were performed for Ulsan Port, one of the representative petroleum ports in Korea, and the prediction performance was confirmed using the deep learning model LSTM (Long Short Term Memory). The results of this study are expected to provide evidence for improving the efficiency of port operations by increasing the accuracy of demand predictions for petroleum and liquefied gas cargo water volume. Additionally, the possibility of using LSTM for predicting not only container port water volume but also petroleum and liquefied gas cargo water volume was confirmed, and it is expected to be applicable to future generalized studies through further research.

Stability of the growth process at pulling large alkali halide single crystals

  • V.I. Goriletsky;S.K. Bondarenko;M.M. Smirnov;V.I. Sumin;K.V. Shakhova;V.S. Suzdal;V.A. Kuznetzov
    • Journal of the Korean Crystal Growth and Crystal Technology
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    • v.13 no.1
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    • pp.5-14
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    • 2003
  • Principles of a novel pulse growing method are described. The method realized in the crystal growing on a seed from melts under raw melt feeding provided a more reliable control of the crystallization process when producing large alkali halide crystals. The slow natural convection of the melt in the crucible at a constant melt level is intensified by rotating the crucible, while the crystal rotation favors a more symmetrical distribution of thermal stresses over the crystal cross-section. Optimum rotation parameters for the crucible and crystal have been determined. The spatial position oi the solid/liquid phase interface relatively to the melt surface, heaters and the crucible elements are considered. Basing on that consideration, a novel criterion is stated, that is, the immersion extent of the crystallization front (CF) convex toward the melt. When the crystal grows at a <> CF immersion, the raised CF may tear off from the melt partially or completely due to its weight. This results in avoid formation in the crystal. Experimental data on the radial crystal growth speed are discussed. This speed defines the formation of a gas phase layer at the crystal surface. The layer thickness il a function of time a temperature at specific values of pressure in the furnace and the free melt surface dimensions in the gap between the crystal and crucible wall. Analytical expressions have been derived for the impurity component mass transfer at the steady-state growth stage describing two independent processes, the impurity mass transfer along the <> path and its transit along the <> one. The heater (and thus the melt) temperature variation is inherent in any control system. It has been shown that when random temperature changes occur causing its lowering at a rate exceeding $0.5^{\circ}C/min$, a kind of the CF decoration by foreign impurities or by gas bubbles takes place. Short-term temperature changes at one heater or both result in local (i.e., at the front) redistribution of the preset axial growth speed.

Implications of the 'Sontanda' Phenomenon of Scientists for Science Education: Focusing on Ian Hacking's Creation of Phenomena (과학자의 '손탄다' 현상이 과학교육에 주는 함의 -이언 해킹의 현상의 창조를 중심으로-)

  • Choi, Jinhyeon;Jeon, Sang-Hak
    • Journal of The Korean Association For Science Education
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    • v.42 no.2
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    • pp.253-264
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    • 2022
  • The purpose of this study is to examine the practice of scientists from the perspective of Ian Hacking's 'creation of phenomena'. Scientific phenomena, according to Hacking, are regular and do not exist in nature without the intervention of scientists or experimental tools. This study tries to derive scientific educational meaning by analyzing the thoughts and episodes of the 'Sontanda (inter-individual variability)' phenomenon experienced by four life scientists. The Sontanda phenomenon is a common term used by scientists to describe phenomena in which findings do not appear consistently even when studies are carried out using the same experimental procedure and materials. The following four educational implications were discovered as a result of the research. First, we confirmed the importance of embodied knowledge, or non-verbal knowledge, which solves issues by making appropriate judgments and reactions at all times, rather than simply becoming accustomed to the experimental method. This argues that propositional knowledge and non-verbal knowledge should be handled equally in order to provide students with a practical scientific inquiry. Second, we tried to reconsider the picture of the experiment. The phenomenon revealed in the interviews of scientists is rare, and it takes a long time to stabilize the phenomenon. On the other hand, the image of school experiments is always positive and consistent, necessitating a shift in perspective. Third, the precise meaning of scientific practice could be confirmed. This study confirms that scientists use their knowledge effectively in line with the circumstances, and we examined strategies to apply scientific practice to school instruction based on this. Finally, by provoking uncertainty, the Sontanda phenomena may give students with an opportunity to engage in meaningful scientific involvement. By breaking away from the cookbook experiment, this study expects school experimental education to help in efforts to experience scientific practice.