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The Analysis of 40Hz Event-Related Potentials in Schizophrenia (정신분열병 환자에서 40Hz 뇌 사건관련전위에 관한 연구 : 분석 방법론적 측면)

  • Youn, Tak;Park, Hae-Jeong;Kang, Do-Hyung;Kim, Myung-Sun;Kim, Jae-Jin;Kwon, Jun Soo
    • Korean Journal of Biological Psychiatry
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    • v.8 no.2
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    • pp.251-257
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    • 2001
  • Backgrounds : Gamma band oscillatory activity is considered to be related to cognitive functions and illustrates that the concept of event-related oscillations bridges the gap between single neurons and neural assemblies. An event-related gamma oscillation is the time-locked responses of specific frequency, and can be identified by computing the amplitude frequency characteristics of the averaged event-related potentials(ERPs) after stimulation. Objectives : We purposed to present experimental paradigm to investigate ${\gamma}$-band oscillation activities from the recording of ERPs by using auditory oddball paradigm and investigate the difference of ${\gamma}$-band activity between schizophrenia and normal controls. Methods : The ERPs resulting from auditory stimuli with oddball paradigm in a group of schizophrenics(n=11), and also a group of age-, sex-, and handedness matched normal controls, were recorded by 128 channel EEG. The ${\gamma}$-band oscillatory activities were calculated by using time-frequency wavelet decomposition of the signal between 20 and 80Hz. The ${\gamma}$-band oscillatory activities of both groups were compared by t-test. Results : The ${\gamma}$-band oscillatory of the leads Fz, Cz, and Pz of both groups were represented well in the time-frequency maps. Significant increases of the ${\gamma}$-band activity in normal controls compared with schizophrenics were observed around 160 msec, 350 msec, and 800 msec after stimulation. Conclusions : Our results suggested that the increment in ${\gamma}$-band oscillatory activity during cognitive operations and decreased ${\gamma}$-band activity in schizophrenics may be associated with the cognitive dysfunctions and the pathophysiology of the schizophrenia.

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Measurement of Respiratory Motion Signals for Respiratory Gating Radiation Therapy (호흡동조 방사선치료를 위한 호흡 움직임 신호 측정)

  • Chung, Jin-Beom;Chung, Won-Kyun;Kim, Yon-Lae;Lee, Jeong-Woo;Suh, Tae-Suk
    • Proceedings of the Korean Society of Medical Physics Conference
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    • 2005.04a
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    • pp.59-63
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    • 2005
  • Respiration motion causes movement of internal structures in the thorax and abdomen, making accurate delivery of radiation therapy to tumors in those areas a challenge. Accounting for such motion during treatment, therefore, has the potential to reduce margins drawn around the clinical target volume (CTV), resulting in a lower dose to normal tissues (e.g., lung and liver) and thus a lower risk of treatment induced complications. Among the techniques that explicitly account for intrafraction motion are breath-hold, respiration gating, and 4D or tumor-tracking techniques. Respiration gating methods periodically turn the beam on when the patient's respiration signal is in a certain part of the respiratory cycle (generally end-inhale or end-exhale). These techniques require acquisition of some form of respiration motion signal (infrared reflective markers, spirometry, strain gauge, thermistor, video tracking of chest outlines and fluoroscopic tracking of implanted markers are some of the techniques employed to date), which is assumed to be correlated with internal anatomy motion. In preliminary study for the respiratory gating radiation therapy, we performed to measurement of this respiration motion signal. In order to measure the respiratory motion signals of patient, respiration measurement system (RMS) was composed with three sensor (spirometer, thermistor, and belt transducer), 4 channel data acquisition system and mobile computer. For two patients, we performed to evaluation of respiratory cycle and shape with RMS. We observed under this system that respiratory cycle is generally periodic but asymmetric, with the majority of time spent. As expected, RMS traced patient's respiration each other well and be easily handled for application.

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Spatial and Seasonal Patterns of Polychaete Community During the Reclamation and Dredging Activities for the Construction of the Pohang Steel Mill Company in Kwangyang Bay, Korea (광양제철소 건설을 위한 매립과 준설공사 기간중 저서 다모류 군집의 공간 및 계절 변화)

  • JUNG Rae-Hong;HONG Jae-Sang;LEE Jae-Hac
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.30 no.5
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    • pp.730-743
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    • 1997
  • Community structure and distribution patterns of benthic polychaetes were studied in Aug. 1983 and Feb. 1984 in Kwangyang Bay, Korea. During the study period, the large-scale reclamation and dredging operations were taking place. Polychaetes were composed of 76 species with a mean density of $342\;ind.{\cdot}m^{-2}$ during the summer 1983 and 77 species with a mean density of $437\;ind.{\cdot}m^{-2}$ during the winter 1984. Community structure indices were applied to the seasonal data. The stations influenced by the Seomjin river are characterized by a low species number and low diversity, while the stations located in channel regions represent high species richness and highdiversity. The inner bay stations showed the intermediate level in terms of species richness and diversity. On the basis of taxa composition and abundance in summer, the cluster analysis indicated that the study area was divided into live regions. The main factors that govern the polychaete distributions appeared to be the fresh water run-off and bottom sediment composition. However, a slight difference was observed in winter community, and changes in composition of the dominant species were found from Lagis bocki and Chone teres to Glycinde gurjanovae and Heteromastus filiformis. As a result, the broad scale reclamation and dredging activities may have played a role in changes of the polychaete community structure and the dominant species composition in Kwangyang Bay.

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ON THE MORPHOLOGY OF POST-LARVAL AND YOUNG STAGES OF OMOBRANCHUS ELEGANS(STEINDACHNER) (앞동갈베도라치 Omobranchus elegans (STEINDACHNER)의 자치어기의 형태)

  • KIM Yong Uk
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.12 no.4
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    • pp.297-303
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    • 1979
  • Early morphological changes of Omobranchus slogans (STEINDACHNER) (Family Blennidae) were studied based on the samples of 125 individuals collected from Changseon channel of Nam-hae in June 1973 and May 1979. Descriptions were made with particular emphasis on developmental changes of supraorbital region, fin rays, development of chromatophores and the preopercular spine. In the early stages the lateral profile of the supraorbital region is perpendicular to tile sagittal plane, however, in the later stages it becomes curved. In the early stage of 5.55 mm in total length the number of soft rays of dorsal fin is 18, and that of the anal fin 15. Ventral fin first appears as a premoidal proturberance. It fully developes into a fin composed of two soft rays in the stages of 12.9 mm in total length. The caudal fin rays first appear in the ventral part and in the stages of 6.15 mm in total length it gets one or two soft rays which bear 1-2 segments. In the later stages each ray bears more than 5 segments. Melanophores first appear as two black spots on the central part of the head. They are distributed on the opercle and the antero-dorsal surface of the trunk in the stage of 18mm in total length. At this stage the general chromatophore. pattern is identical to the adult stage. The anal fin bears melanophores at the basal part of the rays, and it is one of the remarkable morphological characters of this species. In early stages the preopercular spine develops reaching the basal part of the pectoral fin. In the later stages of 15 mm in total length relative length of the spine decreases to total length, and ie reaches only the distal margin of the opercular.

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Evaluation of Car Prototype using CAVE-like Systems (케이브 기반 자동차 시제품 평가)

  • 고희동;안희갑;김진욱;김종국;송재복;어홍준;윤명환;우인수;박연동
    • Science of Emotion and Sensibility
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    • v.5 no.4
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    • pp.77-84
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    • 2002
  • In this paper, we propose the NAVER, a general framework for multipurpose virtual environments, and introduce the case study of evaluating car prototypes using cave-like systems. As a framework to implement variant applications in virtual environment, NAVER is extensible, reconfigurable and scalable. NAVER consists of several external modules (Render Server, Control Server and Device Server), which communicate each other to share states and user-provided data and to perform their own functions. NAVER supports its own scripting language based on XML which allows a user to define variant interactions between objects in virtual environments as well as describe the scenario of an application. We used NAVER to implement the system for evaluating car prototyes in a CAVE-like virtual environment system. The CAVE-like virtual environment system at KIST consists three side screens and a floor screen (each of them is a square with side of 2.2m), four CRT projectors displays stereoscopic images to the screens, a haptic armmaster, and a 5.1 channel sound system. The system can provide a sense of reality by displaying auditory and tactile senses as well as visual images at the same time. We evaluate car prototypes in a CAVE-like system in which a user can observe, touch and manipulate the virtual installation of car interior.

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Effects of Suaeda asparagoides MIQ extracts on mice ileal motility (마우스 회장 운동에 대한 나문재 (Suaeda asparagoides MIQ) 추출물의 효과)

  • Song, Jae-Chan;Park, Chang-Hee;Kim, Hyun-Tak;Endale, Mehari;Rhee, Man-Hee;Park, Seung-Chun;Kim, Kil-Soo;Kim, Tae-Wan
    • Korean Journal of Veterinary Research
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    • v.46 no.4
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    • pp.323-326
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    • 2006
  • Suaeda (S.) asparagoides $M_{IQ}$, one of the halophyte groups, has been used as a folk remedy for digestive disturbances in Korea. However, its pharmacological activity on gastrointestinal motility has not been reported yet. In this study, the effects of this halophyte extracts with various solvent fractions (ethanol, hexane, chloroform, ethyl acetate, butanol, and water) on mice ileal spontaneous motility was examined. All solvent fractions at the concentration of $100{\mu}g/ml$ showed inhibitory actions on spontaneous motility of ileum with the potency order of water > 70% ethanol > hexane ${\gg}$ chloroform ${\geq}$ butanol ${\geq}$ ethyl acetate, respectively. In addition, the water fraction of extracts from S. asparagoides $M_{IQ}$ (WFSA) dose-dependently ($1-100{\mu}g/ml$) inhibited the amplitude of spontaneous phasic contraction and area under the contractile curve (AUC). The inhibitory effect of water fraction at the concentration of $10{\mu}g/ml$ was not affected by tetrodotoxin (TTX), $Na^+$ channel blocker ($1{\mu}M$), and $N^w$-nitro-L-arginine Methyl Ester (L-NAME), nitric oxide synthase inhibitor ($100{\mu}M$). However, cyclopiazonic acid (CPA, $10{\mu}M$), inhibitor of sarcoplasmic reticulum $Ca^{2+}$-ATPase, almost blocked the inhibitory effects of WFSA ($10{\mu}g/ml$) on the spontaneous phasic contraction of mouse ileum. But, CPA did not inhibit the lowering basal tone effects of WFSA. The result of this study showed that various extracts of S. asparagoides $M_{IQ}$ induce inhibitory effects on spontaneous contraction of mice ileal segments. More over, the polar solvent fractions were shown to be more potent than non-polar solvent fractions. The effects of S. asparagoides $M_{IQ}$ extracts are not mediated by nerve or nitric oxide. The inhibitory effects of WFSA at least partially mediated by sarcoplasmic reticulum $Ca^{2+}$-ATPase. However, further study is required to determine the exact pharmacological mechanisms of this halophyte on its gastrointestinal motility inhibitory effects.

A Study of the noise level in hospital and the Count-Measure against the noise (병실내 소음도와 환자와의 관계)

  • Kim, Myung-Ho;Cha, Il-Whan
    • Journal of Preventive Medicine and Public Health
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    • v.6 no.1
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    • pp.43-49
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    • 1973
  • In this study noise source in a ward at four general hospitals in Seoul area has been investigated and analysed. The degree of reaction against noise by 171 randomly has also been examined. The results of the study have shown that the source of noise is the speakers of wired broadcasting or from visiting guests in two hospitals located in residential area. The patients at the two other hospitals located at commercial site have been suffered more from traffic noise. However, because of their separated living at hospital from their ordinary houselife, sixty one percent of the inpatients have wished a music sound of around 60 dB (A). After having considered the results of the investigation and wishes of the inpatients, following suggestions have been made: 1. Reduce the number of guests or their length of stay. 2. Wired broadcasting system should be substitued by wireless one, or if it's unavoidable, it should be used in office rooms only. 3. Since the stops and starts of vehicles induce much noise, Seoul City Government be requested to prepare an appropriate administrative measure for the vehicles around hospital area and it should prevent the establishment of new hospitals along high way site. 4. By using earphone, inpatients can choose a wireless channel according to each individual's taste. This through the masking effect, would cover up the noise source. 5. Rooms along the streets should be utilized as offices, otherwise double windows should be set up for inpatient's wards.

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Surface Apatite Growth of NaOH and SBF Treated CP-Ti, Ti-6Al-4V and ECAP-Ti (NaOH처리와 SBF침적에 따른 CP-Ti, Ti-6Al-4V 및 ECAP-Ti의 표면 아파타이트 성장)

  • Oh Seok-Jin;Ruy Jae-Gyeoung;Lee Seung-Woo;Kim Yun-Jong;Han Man-So;Kim Chang-Hyu
    • Korean Journal of Materials Research
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    • v.14 no.12
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    • pp.893-899
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    • 2004
  • Even though Ti-6Al-4V has gained popularity as an implant material, the possible dissolution of Al and V ions in body fluids remains a matter of concern. Though commercially pure Ti (Cp-Ti) overcomes this problem, the mechanical strength of pure titanium remains very low. Thus, in this experiment Cp-Ti was processed by Equal channel angular processing (ECAP), in order to increase the mechanical strength. The biocompatibility of ECAP-Ti, Cp-Ti and Ti-6Al-4V was examined by the apatite formation on each sample surface, after treating the surface with 5M NaOH and soaking in Simulated body fluids (SBF). Initially, the samples were mechanically polished on silicone carbide paper (#2000). The polished samples were treated with 5M NaOH solution at $60^{\circ}C$ for 24 hours. The NaOH treated samples were washed gently with distill water and dried at $40^{\circ}C$ for 1 day. The dried samples were heat treated in air at $600^{\circ}C$ for 1 hour. The surface morphology of these samples were studied using SEM and XRD. The SEM studies showed network of pores in all samples. The XRD showed oxide layer formation on Cp-Ti and Ti-6Al-4V. samples. However the oxide layer in ECAP-Ti was not substantial. These samples were immersed in SBF, kept at $36.5^{\circ}C$ for seven days period. At the end of 7 days, the apatite formation was confirmed only on Cp-Ti and was not observed in Ti-6Al-4V and ECAP-Ti. These observations of apatite formation relate to the fact that Cp-Ti showed greater oxide layer than other samples. The apatite examined was confirmed as tricalcium phosphate (TCP) using EDS and XRD.

Better Use of Technological Advances in Communication of Information (농업기상정보교환에 있어 첨단기술의 효율적 활용)

  • Elijah Mukhala;Malgorzata, Keinska-Kasprzak
    • Korean Journal of Agricultural and Forest Meteorology
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    • v.6 no.2
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    • pp.85-93
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    • 2004
  • In recent years, technology has advanced so much, especially in the developed world, such that its application in development activities may be lagging behind. The lag between technological advances and its application affects agrometeorological science as well. This paper discusses technological advances that may be better used to communicate agrometeorological information. It is important to bear in mind that technological advances are only channels of communication that may be used to speed up the transference of information from the source to the user. The paper begins with a review of the definitions of 'communication' to put the discussion into context. After reviewing several papers, in simple terms, communication can be defined as the sharing of meaning. The paper also looks at operational communications channels and comes to a conclusion that operational communications channels are pretty much universal irrespective of the development level of a country, although some are more easily accessible in some parts of the world than others. The common communications channels include: newspapers, farming papers, radio, television, fax, email, mobile phones (SMS) and Internet web sites. As part of technological advances, mobile phones are becoming increasingly useful all over the world. In order to make better use of this technology, it is important far those that will use this technology to understand how the technology works, not necessarily in detail, but to be able to operate the technology and obtain the data they need. When it comes to constraints, communication of agrometeorological information requires a substantial amount of resources and it is generally expensive especially when sophisticated models must be operated.

Reliability improvement of an ion-measuring system using FET sensor array (FET 센서 어레이를 이용한 이온 측정 시스템의 신뢰도 개선)

  • Choi, Jung-Tae;Lee, Seung-Hyup;Kim, Young-Jin;Lee, Young-Chul;Cho, Byung-Woog;Sohn, Byung-Ki
    • Journal of Sensor Science and Technology
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    • v.8 no.4
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    • pp.341-346
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    • 1999
  • In general cases, compared with glass electrode, FET type electrolyte sensors have many advantages. But the drift, memory effect and the poor reproducibility of the FET type electrolyte sensor cause the decrease of the reliability in the measurement system. To improve the reliability, an ion-measuring system using FET type electrolyte sensor array with 8 sensors has been developed. Developed system employed the electronic switchs to connect a signal detecting circuit with 8 sensor array and the system can measure ion concentration of 4 different type electrolyte($H^+$, $Na^+$, $K^+$, $Ca^{2+}$). The signal processing algorithm with insertion sorting method was adopted to enhance the reliability. We measured 3 different ion($H^+$, $Na^+$, $K^+$) to evaluate the performance of developed system. The results show that the designed signal processing algorithm can reduce the error range in comparison with a simple arithmetic mean and the developed system has a good reliability over the previous single channel sensor system.

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