• 제목/요약/키워드: School-public health

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RPSA Gene Mutants Associated with Risk of Colorectal Cancer among the Chinese Population

  • Zhang, Shan-Chun;Jin, Wen;Liu, Hui;Jin, Ming-Juan;Chen, Ze-Xin;Ding, Zhe-Yuan;Zheng, Shuang-Shuang;Wang, Li-Juan;Yu, Yun-Xian;Chen, Kun
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권12호
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    • pp.7127-7131
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    • 2013

  • The primary aim of this study was to evaluate the relationship of single nucleotide polymorphisms (SNPs) in ribosomal protein SA (RPSA) gene with colorectal cancer (CRC). A case-control study including 388 controls and 387 patients with CRC was conducted in a Chinese population. Information about socio-demography and living behavior factors was collected by a structured questionnaire. Three SNPs (rs2133579, rs2269349, rs7641291) in RPSA gene were genotyped by Illumina SnapShot method. Multiple logistic regression models were used for assessing the joint effects between tea consumption and SNPs on CRC. The subjects with rs2269349 CC genotype had a decreased risk for CRC (OR=0.60; 95%CI = 0.37-0.99), compared with TT/CT genotype after adjustment for covariates. A similar association of rs2269349 with rectal cancer was observed (OR=0.49; 95%CI=0.24-1.00). Further analyses indicated that this SNP could modify the protective effect of tea drinking on CRC. Among the subjects with rs2269349 TT/CT or rs2133579 AA/GA, there was a marginal significantly lower risk of CRC (OR and 95%CI: 0.63 and 0.39-1.01 for rs2269349; 0.64 and 0.40-1.02 for rs2133579) in tea-drinking subjects in comparison to non-tea-drinking subjects. Mutants in the RPSA gene might be associated with genetic susceptibility to CRC and influence the protective effect of tea consumption in the Chinese population.

  • https://doi.org/10.7314/APJCP.2013.14.12.7127 인용 PDF KSCI

한국인의 사회경제적 불평등에 따른 주관적 건강수준의 차이와 건강행태 기여요인 분석 (Socioeconomic Inequity in Self-Rated Health Status and Contribution of Health Behavioral Factors in Korea)

  • 김민경;정우진;임승지;윤수진;이자경;김은경;고난주
    • Journal of Preventive Medicine and Public Health
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    • 제43권1호
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    • pp.50-61
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    • 2010

  • Objectives: The study is investigated socioeconomic variations in self-rated health status and contribution of health behavioral factors in Korea. Methods: A nationally representative sample (2,800 men and 3,230 women aged 20-64 years) from the 2005 Korea National Health and Nutrition Surveys was analyzed using logistic regression. Results: Self-rated health was lower among lower socioeconomic groups compared with higher socioeconomic groups, with gender being irrelevant. This association was attenuated when health behavioral and socio-demographic factors were adjusted. When each health behavioral factor was considered separately, mediators such as smoking in men, and stress or exercise in women explained a large part of the decreased socioeconomic health inequalities. Conclusions: In Korea, subjective health inequalities arise from different socioeconomic status, but this difference is decreased by health behavioral factors. Therefore, socioeconomic inequity in self-rated health status can be corrected more effectively by promotional health behaviors.

  • https://doi.org/10.3961/jpmph.2010.43.1.50 인용 PDF KSCI