• Biomolecules & Therapeutics
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• 제25권5호
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• pp.545-552
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• 2017

Increasing concern is being given to the association between risk of cancer and exposure to low-dose bisphenol A (BPA), especially in young-aged population. In this study, we investigated the effects of repeated oral treatment of low to high dose BPA in juvenile Sprague-Dawley rats. Exposing juvenile rats to BPA (0, 0.5, 5, 50, and 250 mg/kg oral gavage) from post-natal day 9 for 90 days resulted in higher food intakes and increased body weights in biphasic dose-effect relationship. Male mammary glands were atrophied at high dose, which coincided with sexual pre-maturation of females. Notably, proliferative changes with altered cell foci and focal inflammation were observed around bile ducts in the liver of all BPA-dosed groups in males, which achieved statistical significance from 0.5 mg/kg (ANOVA, Dunnett's test, p<0.05). Toxicokinetic analysis revealed that systemic exposure to BPA was greater at early age (e.g., 210-fold in $C_{max}$, and 26-fold in AUC at 50 mg/kg in male on day 1 over day 90) and in females (e.g., 4-fold in $C_{max}$ and 1.6-fold in AUC at 50 mg/kg vs. male on day 1), which might have stemmed from either age- or gender-dependent differences in metabolic capacity. These results may serve as evidence for the association between risk of cancer and exposure to low-dose BPA, especially in young children, as well as for varying toxicity of xenobiotics in different age and gender groups.

• Journal of Preventive Medicine and Public Health
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• 제50권6호
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• pp.401-410
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• 2017

Objectives: The purpose of this study was to examine the associations of childbirth, breastfeeding, and their interaction with breast cancer (BC) risk reduction, and to evaluate the heterogeneity in the BC risk reduction effects of these factors by menopause, hormone receptor (HR) status, and pathological subtype. Methods: BC patients aged 40+ from the Korean Breast Cancer Registry in 2004-2012 and controls from the Health Examinee cohort participants were included in this study after 1:1 matching (12 889 pairs) by age and enrollment year. BC risk according to childbirth, breast-feeding, and their interaction was calculated in logistic regression models using odds ratios (ORs) and 95% confidence intervals (CIs). Results: BC risk decreased with childbirth (3+ childbirths relative to 1 childbirth: OR, 0.66; 95% CI, 0.56 to 0.78 and OR, 0.80; 95% CI, 0.68 to 0.95 in postmenopausal and premenopausal women, respectively); and the degree of risk reduction by the number of children was heterogeneous according to menopausal status (p-heterogeneity=0.04), HR status (p-heterogeneity<0.001), and pathological subtype (p-heterogeneity<0.001); whereas breastfeeding for 1-12 months showed a heterogeneous association with BC risk according to menopausal status, with risk reduction only in premenopausal women (p-heterogeneity<0.05). The combination of 2 more childbirths and breastfeeding for ${\geq}13$ months had a much stronger BC risk reduction of 49% (OR, 0.51; 95% CI, 0.45 to 0.58). Conclusions: This study suggests that the combination of longer breastfeeding and more childbirths reduces BC risk more strongly, and that women who experience both 2 or more childbirths and breastfeed for ${\geq}13$ months can reduce their BC risk by about 50%.

• 한국산학기술학회논문지
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• 제19권8호
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• pp.230-238
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• 2018

본 연구는 울산광역시 노인에 대해 구군별 공원 형태와 공원내부 요소들이 실외에서 얼마나 자주 나와서 걷는지에 대한 걷기 일 수에 미치는 영향을 검증하여, 울산광역시 노인 건강증진을 위한 도시개발 및 물리적 환경개선과 발전에 대한 정책적 제언을 하는 것에 목적이 있다. 지역사회건강조사 2015년 원시데이터를 이용하여 울산광역시의 65세 이상 노인 1,274명을 대상자로 선정하였다. 울산광역시 5개 구군에 따른 지역 수준 요인 변수가 걷기 일 수에 영향을 미치는 요인을 파악하기 위하여 위계적 선형 모형으로 다수준 분석을 시행하였다. 노인의 걷기 일 수에 영향을 미치는 지역 수준 요인은 체육시설이 많으면 걷기 일 수가 증가하였고, 어린이가 주로 이용하는 유희시설이 많으면 노인의 걷기 일 수가 감소하였다. 울산광역시 내에서 중구의 경우는 공원 개수와 공원 면적이 많음에도 걷기 일 수가 낮았고, 북구의 경우는 공원 개수와 공원 면적이 적음에도 걷기 일 수가 높았다. 울산광역시 중구의 노인은 걷기 촉진을 위한 건강증진 사업이 필요할 것으로 생각되며, 울산광역시 북구의 노인은 걷기 좋은 환경을 만들어주는 것이 필요할 것으로 생각된다.

• 가정과삶의질연구
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• 제30권2호
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• pp.137-152
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• 2012

The graying of populations is emerging as an international issue around the world, and this is a problem that is rapidly advancing in Korea as well, signaling the need for financial preparations for the aged. For this purpose, various retirement pension systems are being employed as preparatory measures for the nation's elderly. Using data from 1474 people in the 2007 panel study of National Security for the Retired, the present work attempts to look at satisfaction rates with regard to public pension receipts for the national pension and special occupational pensions according to general characteristics and factors related to the preparation for an aging society. Satisfaction with retirement pension receipts according to the type of pension was high for special occupation retirement pensions, individual retirement pensions and the national retirement pension, in that order. Looking at satisfaction rates based on the general characteristics of pension recipients, the study revealed that for the national pension, satisfaction was highest for groups with above-average physical and psychological health, groups who think appropriate living expenses for the elderly are lower, groups in which a partner also earns income, and groups who had amply prepared for their expected living expenses in later life. Regarding special occupation retirement pensions, satisfaction was high for groups over the age of 70, groups with good psychological health, and groups sufficiently prepared for their living expenses in later expenses, compared to groups for which these factors did not apply. In terms of the relative influences impacting retirement pension recipient satisfaction, satisfaction with the national pension was highest when the primary source to cover elderly living expenses was a resource other than income earned by the recipient and their partner and/or income received from children. Concerning special occupation retirement pensions, satisfaction was highest among those whose education terminated before middle school, and for those in good physical health. Based on the above results, it is vital that plans exist for preparing sufficiently for the living expenses of the elderly and for facilitating the physical and psychological health of pension recipients. Plans are also necessary to, ensure that citizens are provided with easily accessible educational programs and activities regarding general installment savings and deposits, stocks and bonds, real estate investments, individual retirement pensions, private insurance, severance pay pensions, and public pensions.

• 농촌의학ㆍ지역보건
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• 제22권2호
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• pp.277-293
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• 1997

This study was conducted to provide basic materials required to enforce and develop welfare policies, as well as the health system, for the aged, by surveying the status of health care utilized by the daily increasing old population and the importance of receiving physical therapy. Data that need in this research was gathered from over ages of 65, during the period from Jan 4, 1996 to Jan 31, using the inquiries previously made by geriatric researchers and through literatures investigator by this writer. The data were analyzed by $X^2$, Z-test, Likert scale. The findings were as follows : 1) General characteristics of subjects. People in the age group between 65 and 69 were 55.6% and the highest number, while male were 37% and female 63%. Analysis of income group disclosed 60.6% whose monthly income, including the pocket money given by children, was less than 200,000 won. 91.1% of the elderly people surveyed owned houses; only 36.4% live with spouses; while 15.6% live alone. 2) Characteristics with respect to utilization of health care institution. 56% of the total medical institutions used by the elderly people were clinics and the rates of chronic disease and musculoskeletal disease were 73.2%. 3) Characteristics with respect to approach of health care institution. 45.1% of the respondent stated it took 20 minutes to arrive at hospital, and bus accounted for 48.6% of all transportation means used to go to hospital. 4) Degree of cognition with respect to the rights of geriatric patients. (1) There is no financial support from the government for geriatric patients(71.4%). (2) Government financial support is needed for geriatric patients(95.3%). (3) Have never been regionally surveyed or called upon for interviews with respect to treatment desire and problems relating to geriatric patients(87.2%). (4) Health and medical policies for geriatric patients must be established rapidly(98.4). (5) Expansion and construction of specialized medical facilities for geriatric patients such as elderly hospital and medical center are needed(90.2%). (6) Government's welfare policies for the elderly people is insufficient(82.0%) 5) Degree of cognition on importance of physical therapy with respect to geriatric patient. (1) Physical therapy is considered most effective in treating geriatric patients(82.9%). (2) Physical therapists specializing in only elderly people must be need of separately(76.2%). (3) It is desirable for medical specialists to visit geriatric patients at home to provide physical therapy(82.9%). (4) Hospitals specializing in physical therapy for geriatric patient are required(85.6%). Based on the result for this research, the following suggestions are presented to facilitate the utilization of health care institution for the welfare of geriatric patients. Medical facilities such as elderly hospital and geriatric patient's medical center specializing in elderly people must be constructed as early as possible; and home-visiting physical therapist system must be important to treat chronic geriatric patients; our government must establish policies to provide the old ages with means for the health care and curing chronic diseases, and carry out the plans of reasonable distribution and effective untilization of medical resources.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.2369-2378
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• 2012

Objectives: To assess knowledge of HPV and attitudes towards HPV vaccination among the general female population, government officials, and healthcare providers in China to assist the development of an effective national HPV vaccination program. Methods: A cross-sectional epidemiologic survey was conducted across 21 urban and rural sites in China using a short questionnaire. 763 government officials, 760 healthcare providers, and 11,681 women aged 15-59 years were included in the final analysis. Data were analyzed using standard descriptive statistics and logistic regression. Results: Knowledge of HPV among the general female population was low; only 24% had heard of HPV. Less than 20% of healthcare providers recognized sexually na$\ddot{i}$ve women as the most appropriate population for HPV vaccination. There was high acceptance of the HPV vaccine for all categories of respondents. Only 6% of women were willing to pay more than US $300 for the vaccine. Conclusions: Aggressive education is necessary to increase knowledge of HPV and its vaccine. Further proof of vaccine safety and efficacy and government subsidies combined with increased awareness could facilitate development and implementation of HPV vaccination in China.

• 구강회복응용과학지
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• 제28권1호
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• pp.47-56
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• 2012

입술은 사람의 인상을 결정하는 중요한 부분중의 하나이다. 본 연구는 두부계측방사선사진을 이용하여 구호흡자와 비호흡자의 입술두께를 비교하여 구호흡과 하순 두께 변화와의 연관성을 알아보았다. 8세~18세인 아동 및 청소년 436명을 대상으로 두부방사선계측사진을 조사하였다. 전체 조사대상자를 구호흡 그룹과 비호흡 그룹으로만 나누어서 평균과 표준편차를 구한 결과 구호흡 그룹의 하순/상순 비율은 $1.13{\pm}0.14$, 비호흡 그룹의 하순/상순 비율은 $1.02{\pm}0.14$로 나타났다. Skeletal class에 따라 구분한 그룹의 각각의 평균과 표준편차를 살펴보면 skeletal class I은 $1.05{\pm}0.09$, skeletal class II는 $1.20{\pm}0.12$, skeletal class III는 $0.97{\pm}0.11$로 나타났다. 호흡양상에 따라 비교하였을 때 비호흡을 하는 그룹보다 구호흡을 하는 그룹에서 하순/상순 비율이 더 큰 값을 나타내어 하순의 두께가 더 두꺼운 양상을 보였다. Skeletal class에 따라서 비교하였을 때는 skeletal class II 그룹에서 하순/상순 비율이 가장 큰 값을 나타내어 하순의 두께가 가장 두꺼운 양상을 보였다.

• 치위생과학회지
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• 제16권5호
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• pp.349-354
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• 2016

2015년 실시한 국민구강실태조사에 따르면 우리나라 만 12세 아동들의 우식경험영구치지수(DMFT index)는 1.9로 주요 OECD 국가들의 평균인 1.6에 거의 근접한 것으로 조사되었다. 본 연구의 목적은 인접면 우식증의 진단에 있어 새로 개발된 $Qraypen^{TM}$의 효능을 기존의 방법인 시진 및 구내 치근단 방사선 사진과 비교 평가하고, 임상 적용 시의 문제점을 파악하여 차후 $Qraypen^{TM}$에 필요한 개선안을 제시함과 아울러 치아우식증의 예방 및 초기 우식증 재광화 방법에 대한 기초 연구자료를 마련하고자 하였다. 학교 구강검진을 목적으로 내원한 학령기의 혼합치열을 가진 32명의 어린이들을 대상으로 구강검진 2회, 구치부 치근단 방사선 필름 판독 2회 그리고 구치부 인접면 $Qraypen^{TM}$ 이미지 판독 2회를 실시하고 비교한 결과 $Qraypen^{TM}$ 영상은 변연융선이 파괴되지 않은 유구치의 인접면 우식증의 탐지에 효과적이었다. 또한 방사선 촬영 결과와 비교해 보니 차이가 없음을 확인하였다. 그러나 인접면 우식증이 상아질까지 진행되어 병소가 성숙하여야 뚜렷한 붉은색 형광을 관찰할 수 있었기에 우식 병소의 진행 정도와 붉은색 형광 발생의 관련성을 확인하기 위해서는 향후 발치된 치아를 사용하여 조직학적 검사를 병행한 추가적인 연구가 필요할 것으로 생각된다. 본 연구 결과 $Qraypen^{TM}$은 유구치의 육안으로 보이지 않은 인접면 우식증을 탐지하는 데 도움을 줄 수 있는 유용하고 간편한 보조장비가 될 수 있을 것으로 기대된다.

• 대한감각통합치료학회지
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• 제15권1호
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• pp.33-45
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• 2017

목적 : 본 연구는 비숙면군 대학생의 감각처리특성과 수면의 질의 상관관계를 알아보고자 한다. 연구방법 : 부산광역시, 경상남도, 대구광역시, 그리고 경상북도에 소재한 6개 대학의 만 18세~25세 대학생 191명을 대상으로 하였다. 연구도구는 한글판 청소년/성인 감각 프로파일(Adolescent/Adults Sensory Profile; AASP)과 피츠버그 수면의 질 지수(Pittsburgh Sleep Quality Index; PSQI)를 사용하였다. 분석방법은 감각처리특성과 수면의 질의 관계를 알아보기 위해 Pearson 상관분석을 사용하였다. 결과 : 본 연구의 참가자들 중 비숙면군에서 감각처리특성과 수면의 질의 상관관계검증 결과, 등록 저하, 감각 민감성, 감각 회피, 감각 추구의 모든 감각특성이 수면의 질 항목 중 수면 방해와 정적 상관관계를 나타냈다. 수면의 질 항목 중 주간 기능장애는 등록 저하와 감각 민감성과 정적 상관관계를 나타냈다. 결론 : 대학생의 수면장애와 감각처리특성을 이해하는데 도움을 제공하며, 관련 연구의 기초 자료로 사용할 수 있다. 앞으로 대학생만이 아니라 아동, 성인, 노인을 대상으로 수면과 감각처리특성에 관한 연구가 필요하리라 생각된다.

• 한국식생활문화학회지
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• 제4권1호
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• pp.83-94
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• 1989

A secondary survey was conducted of 503 customers, to investigate eating out behaviours at five fast food restaurants of Youido apartment compound in Seoul, in April of 1988. The results are summarized as follows: The majority, 84% of customers, were aged 14 to 30, consisting of junior and senior high school children, college students and company employees. In contrast to the previous survey of 1986, in which no elderly customers were found, a small number of elderly customers were observed in this study. The reasons given by customers for patronizing fast food restaurants were the following, from most to least frequent: 'convenient', 'allows for companionship', 'the pleasant place to eat', 'dining equipment and tableware are hygienic', 'to be able to stay as long as I want', and 'foods rapidly served'. Only 24.2% of the customers purchased the fast foods for a full meal, 38.3% purchased the foods for snacking, and others purchased ice cream only or drink only. The majority of the customers ate the purchased foods at the fast food restaurants. However, a limited number of female customers preferred to take the packed fast foods to their homes. Taste preference was a major factor in food selection from available menu items, among the younger customers; whereas customers over 30 years old were concerned with nutritive balance. Fried chicken, pizza, rolled rice with laver, ice cream, and juice were high on the list of liked foods; in contrast, lower preference was for fish burger, doughnut, spaghetti, Chajang noodles and chili beans. The survey discovered that the preference for fried chicken, pizza, and salad had increased compared to the previous survey of 1986. Preference by food nationality was highest for Korean food, then Western food, Chinese food, and Japanese food, in that order. Customers offered suggestions for better fast food service, such as lowering the price; greater variety in the menu; developing fast foods from the traditional Korean foods; and increasing the proportion of vegetables and fruits on the fast food menu. The customers, in particular, emphasized a need for the development of Korean traditional beverage of malt drink and persimmon punch, as well as mungbean pan cakes and sweet- spicy rice noodles (docbokki), as fast foods.