• 사상체질의학회지
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• 제35권4호
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• pp.10-22
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• 2023

Objectives The aim of this study is to explore the mechanism of action and target diseases of Sasang constitutional prescriptions using a multiscale interactome approach. Methods The compound and target information of Sasang constitutional prescriptions were retrieved from various databases such as the TM-MC, STITCH, and TTD. Key targets for Sasang constitutional prescriptions were identified by selecting the top 100 targets based on the number of simple paths within the constructed network. Diffusion profiles for Sasang constitutional prescriptions and diseases were calculated based on a biased random walk algorithm. Potential diseases and key mechanisms of Sasang constitutional prescriptions were identified by analyzing diffusion profiles. Results We identified 144 Sasang constitutional prescriptions and their targets, finding 80 herbs with effective biological targets. A cluster analysis based on selecting up to 100 key targets for each prescription revealed a more cohesive grouping of prescriptions according to Sasang constitution. We then predicted potential diseases for 62 Sasang constitutional prescriptions using diffusion profiles calculated on a multiscale interactome. Finally, our analysis of diffusion profiles revealed key targets and biological functions of prescriptions in obesity and diabetes. Conclusions This study demonstrates the effectiveness of a multiscale interactome approach in elucidating the complex mechanisms and potential therapeutic applications of prescriptions in Sasang constitutional medicine.

• 사상체질의학회지
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• 제29권2호
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• pp.73-82
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• 2017

Objective The purpose of this study was to provide appropriate methods of taking decoction in Sasang Constitutional Medicine. Methods We investigated the methods of taking decoction written in Lee Je-ma's writings such as "Donguisusebowon(東醫壽世保元)", "Donguisusebowon-Sasangchobongwon(東醫壽世保元四象草本卷)", "Dongmuyoogo(東武遺稿)" and several papers which related to methods of taking decoction. Results and Conclusions The effects of decoction can be affected by the methods of taking decoction. Therefore, when administering decoction of Sasang Constitutional Medicine to the patient, we should consider the stages of disease and condition of patient. This paper shows the appropriate methods of taking decoction in Sasang Constitutional Medicine. Further studies should be needed to find out the appropriate administration methods of various dosage forms.

• 대한한의정보학회지
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• 제21권2호
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• pp.11-23
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• 2015

Objectives : Through a comparative study between Sasang constitutional medicine and Syndrome identification and treatment medicine about the theory of diagnosis, the theory of herbal medicine, the theory of prescription, the theory of acupuncture and constitutional medicine to put forward a complementary perfect solution which has good clinical utility. Methods : We compared and sorted out the textbook of Korean Sasang constitutional medicine which named Sasang medicine, and also the textbook of Chinese TCM which was including Basic theory of TCM, Diagnostics of TCM, Science of Chinese materia medica, Pharmacology of traditional Chinese medical formulae, Science of acupuncture and moxibustion, Constitution of TCM, and also related papers. Results : (1) Through a comparative study between Sasang constitutional medicine and Syndrome identification and treatment medicine about diagnosis, herbal medicine, prescription and acupuncture, Sasang constitutional medicine is a medical system which gives priority to balance of organs, when Syndrome identification and treatment medicine is a medical system that gives priority to improve symptom. (2) The prescriptions of Sasang constitutional medicine are used for the treatment of basic pathogenesis in the chronic stage of the disease, which can recover vital qi, when Syndrome identification and treatment medicine are used for the treatment of stage pathogenesis in the acute stage of the disease, which can get rid of pathogenic factors. (3) There are two kind of complementary perfect solution between Sasang constitutional medicine and Syndrome identification and treatment medicine. One perfect complementary medicine is that Sasang constitutional medicine plays a major role when Syndrome identification and treatment medicine plays a supporting role. The other one is that Syndrome identification and treatment medicine plays a major role when Sasang constitutional medicine plays a supporting role. It determined by the usual symptoms and the symptoms now, vital qi and pathogenic factors, symptom and the root cause, acute stage and chronic stage, and the state of pathogenesis. Conclusion : A new perfect complementary medicine can be created which is based on the setting that Sasang constitutional medicine primarily treat the usual symptoms, vital qi, the root cause, chronic stage and basic pathogenesis when Syndrome identification and treatment medicine primarily treat the symptoms now, pathogenic factors, symptom, acute stage and stage pathogenesis.

• 사상체질의학회지
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• 제34권3호
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• pp.50-68
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• 2022

Objectives The purpose of this study is to review the current Sasang constitutional research on obesity and to provide basic data for further development in the direction of better research. Methods Clinical research articles on obesity of the Sasang Constitutional Medicine were extracted from five database. Published year, published journals, and subjects of studies were classified. Clinical methods for the classification of Sasang type and diagnostic criteria for obesity were summarized. Results A total of 36 selected research articles were published from 1998 to 2020. And 20 articles(55.6%) have been published in Journal of Sasang Constitutional Medicine and Journal of Oriental Rehabilitation Medicine. Most of the clinical study subjects were studies that identified independent factors that were correlated with obesity by Sasang constitution type. But these studies have not sufficiently reflected the distinctive characteristics of Sasang Constitution Medicine. Discussion Through this study, it was confirmed to the necessity of developing new research designs for obesity by Sasang constitution and researching on obesity treatment through improvement of symptoms by using the already developed questionnaires that have proven reliability and validity, away from the research biased towards Taeeumin and Taeeumin's prescription. If additional research based on this study is accompanied, it is expected that it can be utilized in typed obesity treatment fields.

• 사상체질의학회지
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• 제27권3호
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• pp.366-377
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• 2015

Objectives This study was designed to report diagnosis and treatment by Sasang Constitutional Medicine to the patients with Oro-facial Dyskinesia. Methods These two patients were diagnosed as Soyangin and Taeeumin according to the result of Sasang constitutional diagnosis, and treated by Sasang constitutional medications and acupuncture. The progress was evaluated with the Global Assessment Scale (GAS). Result Oro-facial Dyskinesia was almost disappeared in each patients. the one patient was cured with Chongshimyeonja-tang and Yuldahanso-tang, and the other was cured with Hyeungbangjihwang-tang. Conclusion We can treat Oro-facial Dyskinesia whose cause is mostly idiopathic with the diagnosis and treatment of Sasang Constitutional Medicine.

• 사상체질의학회지
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• 제17권3호
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• pp.128-134
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• 2005

1. Objectives The primary purpose of this case is to report that a Taeurnin patients with Chorea originated after Cerebral infarction was treated with 'Yeoldahanso-tang(熱多寒少湯)' and then her symptoms improved 2. Methods We diagnosed her as Chorea originated after Cerebral infarction. So we treated her with 'Yeoldahanso-tang(熱多寒少湯)'. 3. Results After we treated her with 'Yeoldahanso-tang(熱多寒少湯)', her symptoms improved. 4. Conclusions 'Yeoldahanso-tang(熱多寒少湯)' may have an effect on Treatment Chorea originated after Cerebral infarction of Taeurnin.

• 사상체질의학회지
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• 제20권1호
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• pp.24-33
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• 2008

1. Objectives We analyze Doctor-Patient Relationship in anthropological medicine, medical sociology Oriental Medicine and find out solutions about problems of Modern Medicine which are dehumanized through the meaning of Doctor-Patient Relationship in Sasang Constitutional Medicine. 2. Methods We consider various studies which are related with doctor-patient relationship from models of the Doctor-Patient Relationship, anthropological medicine, medical sociology and Oriental Medicine. And we compare and analyze Sasang Constitutional Medicine's meaning of doctor and patient through Sasang Constitutional Medicine's view of treatment and philosophy. 3. Results and Conclusions 1) In various studies, Doctor-Patient Relationship have been dualistic perspective which is divided into doctor and patient, and lay emphasis on relationship between them. 2) In Sasang Constitutional Medicine, anyone might be a patient because they are human being, anyone might be a doctor as cure their own disease. In other words, doctor and patient are not separated but united. A point of regarding human is the core of illness and cure can present new direction that solves problems of dualistic perspective Modern Medicine.

• 사상체질의학회지
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• 제13권3호
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• pp.121-125
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• 2001

This case is about 68-year-old woman patient, who suffered from 'fever of unknown origin, abdominal distension and diarrhea'. She was diagnosed as Taeumin and diarrhea as that of 'The Interior Disease of Taeumin'. So she was given Galgeunhaegitang and had gotten better in her symptoms.

• 사상체질의학회지
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• 제27권1호
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• pp.138-148
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• 2015

Objectives This study was conducted in order to analyze the distribution of Sasang constitution, herbmed, exterior-interior disease and concomitant symptoms of 36 facial nerve paralysis patients. Methods A clinical study was done on 36 patients, treated as facial nerve paralysis. Sasang constitution specialist diagnosed their constitution and gave prescription. Degree of improvement was evaluated by assessment scale or change of patient's complaint. Results 1) Distribution of sasang constituion : Taeeumin 21 patients, Soyangin 8 patients, Soeumin 7 patients. 2) Distribution of exterior-interior disease : Taeeumin and Soeumin were diagnosed as interior disease more than exterior disease, Soyangin was reverse. 3) Hyeongbangdojeok-san and Hyeongbangjihwang-tang (Soyangin), Galgeunhaegi-tang(Taeeumin) and Gwakhyangjeonggi-san(Soeumin) were used the most in each sasang constitution. 4) Seventeen patients had concomitant symptoms : digestive disorder, sleep disorder, tinnitus, hypertension, diplopia, itching, gout, neck-shoulder pain, constipation and dizziness. Conclusions Patients had different Sasang constitution and in the same Sasang constitution, they had different symptomatology.

• 대한한의학회지
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• 제26권1호
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• pp.59-70
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• 2005

Objective: Tumor necrosis factor-a $(TNF-{\alpha})$, a potent immuno-modulator and pro-inflammatory cytokine, has been implicated in many pathological processes. In this study, the author examined whether promoter region polymorphism in the $TNF-{\alpha}$a gene at position-308 affect the odds of cerebral infarction (CI) and whether genetic risk is enhanced by sasang constitutional classification. Methods: 212 CI patients and 610 healthy controls were genotyped and determined according to sasang constitutional classification. The amplified genotypes were analyzed on $8\%$ polyacrylamide gel. The alleles were visualized by ethidium bromide staining. Primers for $TNF-{\alpha}$ were designed to incorporate a polymorphic site at a position -308 bp of the $TNF-{\alpha}$ gene into an NcoI restriction site. Restriction digests generated products of 87 and 20 bp for G allele and 107 bp for A allele. Results : A significant decrease was found for the $TNF-{\alpha}$ A allele in CI patients compared with controls (P=0.033, odds ratio, O.R.: 0.622). However, there was no significant association between $TNF-{\alpha}$ polymorphism and sasang constitution in CI patients. Conclusion: My finding suggests that $TNF-{\alpha}$promoter region polymorphism is responsible for susceptibility to CI in Koreans.