• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2004년도 춘계학술발표대회
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• pp.625-628
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• 2004

GVM(General Virtual Machine)은 무선 단말기 상에서 동적인 응용프로그램을 실행할 수 있는 가상 기계(Virtual Machine) 플랫폼이다. 가상 기계를 이용한 응용프로그램의 실행은 플랫폼 독립적인 실행이 가능하며 또한 효과적인 다운로드 솔루션을 통한 동적인 실행이 가능하다. GVM은 SGS 파일을 다운로드 받아 실행되는 시스템이므로, 성능의 저하없이 실행되기 위해서는 효율적인 최적화와 실행 시스템이 요구된다. 본 논문은 SGS 파일이 시스템 리소스의 제한이 큰 무선 단말기 상에서 보다 효율적으로 실행되기 위해서 SAL 코드에 대한 최적화를 수행하였다. SAL 코드 최적화 단계를 수행한 GS 파일은 부분적으로 SGS 파일의 최적화를 가져와 전체 SGS 파일의 크기를 줄이고, 실행될 때 수행 속도 면에서 좀 더 빠른 실행 속도를 가지게 된다. 존재하는 최적화 방법론에 관한 연구를 통하여 SAL 코드의 특성을 고려한 최적화 방법론을 제시하고, 최적화된 SAL 코드를 생성하기 위한 코드 최적화기에 관하여 설계하고 구현하였다.

• 비파괴검사학회지
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• 제24권5호
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• pp.465-475
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• 2004

본 논문은 두 편으로 구성된 스마트 능동 레이어(smart active layer, SAL) 센서 개발에 관한 첫 번째 논문으로, 구조 내에 발생하는 균열 및 손상에 의한 탄성파 검출을 위한 SAL 센서의 이론 및 개념을 연구하였다. 본 SAL 센서의 개발을 위해, 첫째, 탄성파의 기본 이론을 고찰하였고, 둘째, 이론적 토대 위에 단일 압전 disc의 유한요소해석법(finite element analysis, FEA)을 이용하여 탄성파 검출 센서로서의 가능성을 검증하였고, 셋째, 몇 종류의 압전 disc 센서와 상용 음향방출(acoustic emission, AE) 센서를 연필심 파괴시험을 통해 상호 성능을 비교하여 실험적으로 그 가능성을 확인하였다. 또한 수 개의 센서를 일정한 거리로 분포시켜서 구조물 결함의 효과적 검출 및 위치 표정이 가능한 스마트능동레이어 센서의 개념연구를 수행하였다.

• Journal of Microbiology and Biotechnology
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• 제30권1호
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• pp.38-43
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• 2020

Hand, foot, and mouth disease (HFMD) is caused by enterovirus 71 (EV71) in infants and children under six years of age. HFMD is characterized by fever, mouth ulcers, and vesicular rashes on the palms and feet. EV71 also causes severe neurological manifestations, such as brainstem encephalitis and aseptic meningitis. Recently, frequent outbreaks of EV71 have occurred in the Asia-Pacific region, but currently, no effective antiviral drugs have been developed to treat the disease. In this study, we investigated the antiviral effect of salvianolic acid B (SalB) on EV71. SalB is a major component of the Salvia miltiorrhiza root and has been shown to be an effective treatment for subarachnoid hemorrhages and myocardial infarctions. HeLa cells were cultured in 12-well plates and treated with SalB (100 or 10 ㎍/ml) and 10⁶ PFU/ml of EV71. SalB treatment (100 ㎍/ml) significantly decreased the cleavage of the eukaryotic eIF4G1 protein and reduced the expression of the EV71 capsid protein VP1. In addition, SalB treatment showed a dramatic decrease in viral infection, measured by immunofluorescence staining. The Akt signaling pathway, a key component of cell survival and proliferation, was significantly increased in EV71-infected HeLa cells treated with 100 ㎍/ml SalB. RT-PCR results showed that the mRNA for anti-apoptotic protein Bcl-2 and the cell cycle regulator Cyclin-D1 were significantly increased by SalB treatment. These results indicate that SalB activates Akt/PKB signaling and inhibits apoptosis in infected HeLa cells. Taken together, these results suggest that SalB could be used to develop a new therapeutic drug for EV71-induced HFMD.

• Asian-Australasian Journal of Animal Sciences
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• 제14권3호
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• pp.346-350
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• 2001

The present study was designed to evaluate the usefulness of Sauropus. androgynus leaf (SAL) meal on reducing fat accumulation in broiler chickens. Eighty unsexed broiler chickens were allocated to four treatment groups with five replicates of four chickens each. SAL meal supplementation had no effect on body, leg, back, breast, wing, liver and heart weights, carcass protein, moisture and ash contents (p>0.05). Broilers fed diets supplemented with 30 g of SAL meal had lower feed intake with better feed conversion ratio (p<0.05) than did the control chickens. SAL supplementation at all levels significantly reduced fat accumulation in abdomen region, and liver (p<0.01), and in carcass (p<0.05). Higher SAL supplementation resulted in lower fat accumulation in the carcass ($r^{2}=0.94$; p<0.01), abdomen ($r^{2}=0.99$; p<0.01) and liver ($r^{2}=0.98$; p<0.01). The current study showed that a 30 g supplementation of SAL meal to the broiler diet was effective to improve feed conversion ratio without reducing body weight. SAL meal supplementation to the diet reduce fat accumulation in broiler chickens.

• 한국임상수의학회지
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• 제37권2호
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• pp.75-81
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• 2020

The objective of the present study was to evaluate the effectiveness of autoligation techniques for castrating healthy male small breed dogs. Forty dogs were divided into four groups, with 10 in each group, based on maturity and the surgical technique used: 1) immature dogs aged less than 1 year, with autoligation of the spermatic cord via a scrotal approach (SAL) as the surgical technique (SAL-IM); 2) mature dogs aged 1 year or older, with the same SAL surgical technique (SAL-M); 3) immature dogs aged less than 1 year, with double ligation of the spermatic cord with an absorbable suture via a prescrotal approach (PDL) as the surgical technique (PDL-IM); and 4) mature dogs aged 1 year or older, with the same PDL surgical technique (PDL-M). The effectiveness of the surgical technique was evaluated by comparing the operating time and complications between these four groups. The significant decreases in operating times were found in SAL-IM and SAL-M compared with those of PDL-IM and PDL-M (p < 0.01 and p < 0.01). Regardless of maturity, the SAL surgical technique reduced operating time by approximately 69.5% compared with the PDL surgical technique. When the complication severities were scored, the results showed no significant differences among the four group. The autoligation technique for castration in healthy male small breed dogs is considered to be effective because the operating time consuming is less than conventional techniques.

• BMB Reports
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• 제49권1호
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• pp.45-50
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• 2016

Salsolinol (SAL), a compound derived from dopamine metabolism, is the most probable neurotoxin involved in the pathogenesis of Parkinson's disease (PD). In this study, we investigated the modification and inactivation of human ceruloplasmin (hCP) induced by SAL. Incubation of hCP with SAL increased the protein aggregation and enzyme inactivation in a dose-dependent manner. Reactive oxygen species scavengers and copper chelators inhibited the SAL-mediated hCP modification and inactivation. The formation of dityrosine was detected in SAL-mediated hCP aggregates. Amino acid analysis post the exposure of hCP to SAL revealed that aspartate, histidine, lysine, threonine and tyrosine residues were particularly sensitive. Since hCP is a major copper transport protein, oxidative damage of hCP by SAL may induce perturbation of the copper transport system, which subsequently leads to deleterious conditions in cells. This study of the mechanism by which ceruloplasmin is modified by salsolinol may provide an explanation for the deterioration of organs under neurodegenerative disorders such as PD. [BMB Reports 2016; 49(1): 45-50]

• 비파괴검사학회지
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• 제24권5호
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• pp.476-486
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• 2004

본 논문은 두 편으로 구성된 스마트능동레이어 (smart active layer, SAL) 센서 개발에 관한 두 번째 것이다. 이미 첫 번째 논문에서 언급되었지만, 구조물 건전성 감시 (structural health monitoring, SHM)는 구조물 안전 감시의 비용과 편리성을 개선하기 위한 방법으로서, 산업현장에서 그 응용이 점차 증가하는 새로운 기술이며, 최근 실제 응용을 하기 위한 스마트 센서의 개발 및 연구가 매우 활발하다. 본 논문에서는 첫 번째 논문에 기술된 SAL 센서의 이론 및 개념 연구에 이어서 실제 제작 및 적용연구에 관해 기술한다. 본 연구에서는 탄성파 감지를 위한 스마트 압전 센서 SAL을 개발하였는데, 압전 소자, 전자기파 차폐층 (EMI shielding lave.) 및 보호 층(protection layer)으로 구성되었다. 보호층에 일정 간격으로 분포된 압전 센서가 부착되고, 이들을 전기적으로 연결하는 회로층이 위치하고 있다. 모두 4종류의 SAL 센서가 설계, 제작 및 시험되었으며 이에 대해 상세히 기술하고 있다. 본 연구를 통해 SAL 센서는 SHM의 수행과 탄성파에 의한 손상 위치를 표정하는데 적용 가능할 것으로 예상된다.

• 생명과학회지
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• 제22권9호
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• pp.1145-1151
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• 2012

아스피린과 아스피린의 deacetylated form인 sodium salicylate (NaSal)은 대장암, 폐암 및 유방암을 비롯한 다양한 암의 항암제 활성을 나타내는 것으로 잘 알려져 있다. A549 폐암 세포주에 저농도의 NaSal과 genistein을 함께 복합 처리시 상승작용에 의해 세포사멸을 증가시켜서 NaSal에 의한 암억제 효과를 증대시킴을 이미 밝힌바 있다. 본 연구에서는 A549가 아닌 다른 암세포주와 in vitro solid tumor model인 multicellular spheroids (MTS)을 이용하여 NaSal과 genistein 복합처리 효과를 조사하였다. NaSal/genistein 복합 처리시 A549 세포주와 마찬가지로 HCT116 세포주에서도 세포사멸이 유도되었지만, MCF-7 세포주에서는 유도되지 않았다. 흥미롭게도, MCF-7 세포주는 MTS로 배양되는 동안 NaSal/genistein 복합 처리에 의해 세포 죽음을 나타내었다. 세포 죽음의 형태는 MCF-7 MTS의 발달 단계에 따라 세포사멸 또는 세포괴사로 나타났다. MCF-7 MTS에서의 세포사멸은 불완전한 양상을 보였다. 즉 염색체가 응축되고 쪼개지지만, 핵막은 여전히 관찰되었다. 이상의 연구 결과 NaSal/genistein 복합처리는 MCF-7 MTS 배양 system에서 불완전한 세포사멸과 세포괴사를 일으킴을 알 수 있었다.

• 대한본초학회지
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• 제33권1호
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• pp.17-26
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• 2018

Objective : In this study, we investigated the effect of SAL5(mixing extracts of Schisandra chinensis Baillon, Artemisia capillaris Thunb., and Aloe vera Linne) on chronic ethanol-induced fatty liver model. Methods : Sprague-Dawley male rats were fed Liber-DeCarli (normal), ethanol liquid diet (control), SAL5 (200 mg/kg). We administrated the SAL5 on chronic ethanol-induced fatty liver model for 5 weeks. We measured alkaline phosphtase (ALP), alanine transminase (ALT), aspartate transminase (AST) and ${\gamma}-glutamyl$ transpeptase (${\gamma}-GTP$) in serum and triglyceride (TG), superoxide dismutase (SOD), catalase, glutathione (GSH) and malondialdehyde (MDA) level in liver. Liver histopathology was examined by Hematoxylin-eosin and Oil red O staining of the fixed liver tissues. Real-time PCR was performed to measure the mRNA expression of inflammatory cytokines and MMP-2, MMP-9. Results : SAL5 administration resulted in significantly decreased liver marker enzymes activities of alanine transminase (ALT), ${\gamma}-glutamyl$ transpeptase (${\gamma}-GTP$) in serum and triglyceride (TG) activities in liver. The control group decreased the activities of superoxide dismutase (SOD), catalase (CAT) with the reduced level of glutathione (GSH) in liver. On the other hand, SAL5 group increased the activities of SOD, CAT and the level of GSH. SAL5 delayed the development of an alcoholic fatty liver by reversing fat accumulation in the liver, as evidenced in histological observations. The gene expression of mRNA were significantly decreased at the $IL-1{\beta}$, $TNF-{\alpha}$, NOS-II and MMP-2 by SAL5. Conclusions : These results indicate that SAL5 might have protective effect chronic ethanol-induced fatty liver models.

• 한국환경성돌연변이발암원학회지
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• 제21권1호
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• pp.30-33
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• 2001

Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, SAL), a dopaminergic isoquinoline neurotoxin, has been implicated to contribute the etiology of Parkinson's disease and neuropathology of chronic alcoholism. In our previous results, SAL was reported to have the mutagenicity and clastogenicity not in bacteria but in mammalian cells, and its genotoxic potential was known to be potentiated in the presence of rat liver S-9 fraction. This may indicate that some metabolite(s) of SAL was involved in the mutagenic potentials. To investigate the SAL metabolites, the metabolism studies of SAL were conducted in vitro rat liver S-9 fraction and in vivo using rats by high performance liquid chromatography and gas chromatography/mass spectrometry. The methylated metabolite of SAL was found in urine of rats, while the same methylating form of metabolite was not produced from the in vitro metabolism system using rat liver S-9 fraction.