Combined Treatment of Sodium Salicylate and Genistein Induces Incomplete Apoptosis and Necrosis in MCF-7 Multicellular Tumor Spheroids
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Lee, Su-Yeon
(Department of Molecular Biology, College of Natural Sciences, Pusan National University)
Kim, Cho-Hee (Department of Molecular Biology, College of Natural Sciences, Pusan National University) Jeon, Hyun-Min (Department of Molecular Biology, College of Natural Sciences, Pusan National University) Ju, Min-Kyung (Department of Molecular Biology, College of Natural Sciences, Pusan National University) Kim, Min-Young (Department of Molecular Biology, College of Natural Sciences, Pusan National University) Jeong, Eui-Kyong (Department of Molecular Biology, College of Natural Sciences, Pusan National University) Park, Hye-Gyeong (Nanobiotechnology Center, Pusan National University) Kang, Ho-Sung (Department of Molecular Biology, College of Natural Sciences, Pusan National University) |
1 | Amann, R. and Peskar, B. A. 2002. Anti-inflammatory effects of aspirin and sodium salicylate. Eur. J. Pharmacol. 447, 1-9. DOI ScienceOn |
2 | Bellosillo, B., Pique, M., Barragan, M., Castano, E., Villamor, N., Colomer, D., Montserrat, E., Pons, G. and Gil, J. 1998. Aspirin and salicylate induce apoptosis and activation of caspases in B-cell chronic lymphocytic leukemia cells. Blood 92, 1406-1414. |
3 | Dikshit, P., Chatterjee, M., Goswami, A., Mishra, A. and Jana, N. R. 2006. Aspirin induces apoptosis through the inhibition of proteasome function. J. Biol. Chem. 281, 29228-29235. DOI ScienceOn |
4 | Dixon, R. A. and Ferreira, D. 2002. Genistein. Phytochemistry 60, 205-211. DOI ScienceOn |
5 | Flossmann, E. and Rothwell, P. M. 2007. Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies. Lancet 369, 1603-1613. DOI |
6 | Garg, A. K., Buchholz, T. A. and Aggarwal, B. B. 2005. Chemosensitization and radiosensitization of tumors by plant polyphenols. Antioxid. Redox Signal. 7, 1630-1647. DOI |
7 | Golstein, P. and Kroemer, G. 2007. Cell death by necrosis: towards a molecular definition. Trends Biochem. Sci. 32, 37-43. DOI |
8 | Horning, J. L., Sahoo, S. K., Vijayaraghavalu, S., Dimitrijevic, S., Vasir, J. K., Jain, T. K., Panda, A. K. and Labhasetwar, V. 2008. 3-D tumor model for in vitro evaluation of anticancer drugs. Mol. Pharm. 5, 849-862. DOI |
9 | Ivascu, A. and Kubbies, M. 2007. Diversity of cell-mediated adhesions in breast cancer spheroids. Int. J. Oncol. 31, 1403-1413. |
10 | Jeong, E. K., Lee, S. Y., Jeon, H. M., Ju, M. K., Kim, C. H. and Kang, H. S. 2010. Role of extracellular signal-regulated kinase (ERK)1/2 in multicellular resistance to docetaxel in MCF-7 cells. Int. J. Oncol. 37, 655-661. |
11 | Kim, C. H., Jeon, H. M., Lee, S. Y., Ju, M. K., Moon, J. Y., Park, H. G., Yoo, M. A., Choi, B. T., Yook, J. I., Lim, S. C., Han, S. I. and Kang, H. S. 2011. Implication of snail in metabolic stress-induced necrosis. PLoS One 6, e18000. DOI |
12 | Kim, C. H., Kim, M. Y., Moon, J. Y., Hwang, J. W., Lee, S. Y., Joo, Y. M., Han, S. I., Park, H. G. and Kang, H. S. 2008. Implication of NAG-1 in synergistic induction of apoptosis by combined treatment of sodium salicylate and PI3K/MEK1/2 inhibitors in A549 human lung adenocarcinoma cells. Biochem. Pharmacol. 75, 1751-1760. DOI |
13 | Klampfer, L., Cammenga, J., Wisniewski, H. G. and Nimer, S. D. 1999. Sodium salicylate activates caspases and induces apoptosis of myeloid leukemia cell lines. Blood 93, 2386-2394. |
14 | Law, B. K., Waltner-Law, M. E., Entingh, A. J., Chytil, A., Aakre, M. E., Norgaard, P. and Moses, H. L. 2000. Salicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-myc, cyclin D1, cyclin A, and proliferating cell nuclear antigen. J. Biol. Chem. 275, 38261-38267. DOI |
15 | Lee, E. J., Park, H. G. and Kang, H. S. 2003. Sodium salicylate induces apoptosis in HCT116 colorectal cancer cells through activation of p38MAPK. Int. J. Oncol. 23, 503-508. |
16 | Ruchaud, S., Korfali, N., Villa, P., Kottke, T. J., Dingwall, C., Kaufmann, S. H. and Earnshaw, W. C. 2002. Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation. Embo J. 21, 1967-1977. DOI ScienceOn |
17 | Lee, S. Y., Jeong, E. K., Jeon, H. M., Ju, M. K., Kim, C. H., Park, H. G. and Kang, H. S. 2011. HMGB1 Switches Alkylating DNA Damage-Induced Apoptosis to Necrosis. J. Life Sci. 21, 953-960. DOI |
18 | Lotze, M. T. and Tracey, K. J. 2005. High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat. Rev. Immunol. 5, 331-342. DOI |
19 | Marra, D. E., Simoncini, T. and Liao, J. K. 2000. Inhibition of vascular smooth muscle cell proliferation by sodium salicylate mediated by upregulation of p21(Waf1) and p27(Kip1). Circulation 102, 2124-2130. DOI |
20 | Scaffidi, P., Misteli, T. and Bianchi, M. E. 2002. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418, 191-195. DOI ScienceOn |
21 | Tomes, L., Emberley, E., Niu, Y., Troup, S., Pastorek, J., Strange, K., Harris, A. and Watson, P. H. 2003. Necrosis and hypoxia in invasive breast carcinoma. Breast Cancer Res. Treat. 81, 61-69. DOI |
22 | Ulrich, C. M., Bigler, J. and Potter, J. D. 2006. Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics. Nat. Rev. Cancer 6, 130-140. DOI |
23 | Vakkila, J. and Lotze, M. T. 2004. Inflammation and necrosis promote tumour growth. Nat. Rev. Immunol. 4, 641-648. DOI |
24 | Yeh, T. C., Chiang, P. C., Li, T. K., Hsu, J. L., Lin, C. J., Wang, S. W., Peng, C. Y. and Guh, J. H. 2007. Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insult. Biochem. Pharmacol. 73, 782-792. DOI |
25 | Zong, W. X. and Thompson, C. B. 2006. Necrotic death as a cell fate. Genes Dev. 20, 1-15. DOI |
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