• 제목/요약/키워드: Saikosaponin

검색결과 57건 처리시간 0.052초

자호(紫胡) 사이코사포닌 정량분석방법(定量分析方法) 비교(比較) (Comparison of Analytical Methods for Saikosaponins in Bupleurum falcatum L.)

  • 김관수;이승택;성낙술;이정일;채영암
    • 한국약용작물학회지
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    • 제3권3호
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    • pp.226-232
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    • 1995
  • 자호(紫胡) saikosaponin정량(定量)에 대한 추출방법(抽出方法) 및 기기분석조건별(器機分析條件別) 비교분석시험(比較分析試驗)결과는 다음과 같다. 1. HPLC를 이용한 시호 사포닌 정량은 산처리하는 방법에서 무처리 방법보다 분석시간이 더 단축되었다. 2. 추출방법상 상온추출이 수율이 높으나 가온 환류추출에 의해 분석시간이 짧고 양호한 크로마토그람을 얻을 수 있었다. 3. 시호 사포닌 분석시 HPTLC법이 HPLC법보다 대량신속측면에서 양호하나 신뢰도가 떨어졌다. 4. 따라서 시호 사포닌의 추출 및 분석은 가온환류추출과 산처리하는 분석방법이 신속한 분석방법으로 적당하였으며, 성분육종을 위한 간이검정기술로서는TLC 이용 분석이 유리할 것으로 생각되었다.

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증숙에 따른 소시호탕의 활성 변화 (Enhancement of Bioactivity of Sosihotang with Steaming Process)

  • 원진배;마진열;양혜진;이보형;윤보라;마충제
    • 생약학회지
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    • 제42권3호
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    • pp.271-275
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    • 2011
  • Sosihotang is a herbal medicine traditionally used to treat chronic liver disease. This study was performed to investigate the effect of steaming Sosihotang at a $121^{\circ}C$ on its major compounds and neuroprotective activity. We evaluated quantitative changes of 6 major compounds in Soshihotang, saikosaponin A, homogentisic acid, baicalin, ginsenoside $Rg_3$, glycyrrhizin and 6-gingerol using HPLC-DAD. After steaming produce, saikosaponin A, homogentisic acid, baicalin, glycyrrhizin and 6-gingerol in Sosihotang were decreased and ginsenoside $Rg_3$ was increased. The neuroprotective activity of steamed Sosihotang was determined by MTT assay, comparing to Sosihotang. The steamed sosihotang showed a higher neuroprotective activity than Sosihotang. In conclusion, steam produce could improve neuroprotective activity of Soshihotang.

시호(柴胡) 사포닌류(Saikosaponins)의 약리작용(I) -Acetaminophen에 의한 약물대사계의 변화 및 간독성에 미친 영향- (Pharmacologic Activities of Saikosaponins(I) -Effects on Drug Metabolizing Enzymes Modification and Liver Toxicities due to Acetaminophen-)

  • 이정식;이정규;최종원
    • 생약학회지
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    • 제24권1호
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    • pp.69-77
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    • 1993
  • Saikosaponins, originally isolated from Bupleuri Radix, were reported to exhibit diverse biological activities especially concerning with liver function. To elucidate the mode of protective action of saikosaponins on liver injury due to the acetaminophen administration, effects on drug metabolizing enzymes system and some transferase activities were checked. As the result, activities of transferase were shown to be strengthened by saikosaponin treatments significantly.

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동백종실(Camellia japonica L.)과 유박의 일반성분, 사포닌 및 아미노산 조성 (Proximate, Saponin and Amino Acid Compositions in Camellia (Camellia japonica L.) Seeds and Defatted Camellia Seeds)

  • 강성구;김용두;최옥자
    • 한국식품영양과학회지
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    • 제27권2호
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    • pp.227-231
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    • 1998
  • To furnish basic data for the utilizatin of camellia(Camellia japonica L.) seeds as a raw material of industrial products, major chemical components of camellia and defatted camellia seeds were investigated. The moisture, crude ash, crude fat and crude protein contents of camellia seeds were 4.06%, 1.83%, 65.75% and 8.44%, respectively. Defatted camellia seeds indicates that it contains 10.31% moisture, 5.28% crude ash and 17.49% crude protein while no crude fat was detected. The curde ginseng saponin, crude saikosaponin and red ginseng saponin contents of camellia seeds were 108.0mg%, 0.4mg% and 40.3mg%, respectively. Total amino acid contents of camellia seeds and defatted camellia seeds were 7,851mg% and 13,002mg%, respectively, and the major amino acids were glutamic acid, arginine, aspartic acid and leucine. The ratio of essential/total amino acid of camellia seeds was 0.29.

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