• Safety and Health at Work
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• v.2 no.2
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• pp.135-147
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• 2011

Objectives: The purpose of this study was to evaluate cancer risks in the Korean semiconductor industry. Methods: A retrospective cohort study was performed in eight semiconductor factories between 1998 and 2008. The number of subjects was 113,443 for mortality and 108,443 for incidence. Standardized mortality ratios (SMR) and standardized incidence ratios (SIR) were calculated. Results: The SMR of leukemia was 0.39 (95% Confidence Interval 0.08-1.14) in males (2 cases) and 1.37 (0.55-2.81) in females (7 cases). The SMR of non-Hodgkin's lymphoma (NHL) was 1.33 (0.43-3.09, 5 cases) in males and 2.5 (0.68-6.40, 4 cases) in females. The SIR of leukemia was 0.69 (0.30-1.37, 8 cases) in males and 1.28 (0.61-2.36, 10 cases) in females. The SIR of NHL in females was 2.31 (1.23-3.95, 13 cases) and that of thyroid cancer in males was 2.11 (1.49-2.89, 38 cases). The excess incidence of NHL was significant in female assembly operators [SIR=3.15 (1.02-7.36, 5 cases)], but not significant in fabrication workers. The SIR of NHL in the group working for 1-5 years was higher than the SIR of NHL for those working for more than five years. The excess incidence of male thyroid cancer was observed in both office and manufacturing workers. Conclusion: There was no significant increase of leukemia in the Korean semiconductor industry. However, the incidence of NHL in females and thyroid cancer in males were significantly increased even though there was no definite association between work and those diseases in subgroup analysis according to work duration. This result should be interpreted cautiously, because the majority of the cohort was young and the number of cases was small.

• Journal of Food Hygiene and Safety
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• v.34 no.3
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• pp.242-250
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• 2019

An analytical method was developed for the determination of fenquinotrione, a triketone herbicide, in agricultural products. Fenquinotrione was metabolized to KIH-3653-M-2 in plants. Analyte extraction was conducted using 2% formic acid in acetonitrile and cleaned up using a hydrophillic-lipophillic balance (HLB) cartridge. The limits of detection (LOD) and quantification (LOQ) were 0.004 and 0.01 mg/kg, respectively. Matrix-matched calibration curves were linear over the calibration ranges ($0.001{\sim}0.1{\mu}g/mL$) into a blank extract with $r^2>0.99$. The recovery results for fenquinotrione and KIH-3653-M-2 ranged between 81.1 to 116.2% and 78.0 to 110.0% at different concentration levels (LOQ, $10{\times}LOQ$, $50{\times}LOQ$) with relative standard deviation (RSD) less than 4.6%. All values were corresponded with the criteria ranges requested in both the Codex (CAC/GL 40-1993, 2003) and MFDS guidelines (2016). Therefore, the proposed method can be used as an official analytical method for determination of fenquinotrione in the Republic of Korea.

• Journal of Korean Academy of Nursing Administration
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• v.22 no.2
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• pp.199-208
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• 2016

Purpose: The purpose of this study was to investigate the influence of patient safety culture and perceived teamwork on the safety control of nurses. Methods: This study was conducted as a descriptive cross-sectional survey with 141 nurses who worked in a tertiary hospital with over 1,000 beds in S city, Gyeonggi province. Data were collected using structured questionnaires from July 20, to July, 31, 2015. Results: The average work period for nurses participating in the research was 8.84 years. The perceived teamwork and patient safety culture were positively correlated with safety control. The regression model with patient safety culture, perceived teamwork and clinical career against safety control was statistically significant (F=10.16, p<.001). This model also explained 37.1% of safety control (Adj. $R^2=.37$). Especially, communication (${\beta}=.27$, p=.023) of patient safety culture, clinical career (${\beta}=.26$, p<.001), mutual support (${\beta}=.24$, p=.042), and team leadership (${\beta}=.24$, p=.018) in perceived teamwork were identified as factors influencing safety control. Conclusion: The findings of this study imply that a broad approach including teamwork and patient safety culture should be considered to improve the safety control for nurses.

• Journal of Fisheries and Marine Sciences Education
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• v.28 no.2
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• pp.515-524
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• 2016

The purpose of this study was to identify how safety awareness and self-efficacy affect the safety practice with elementary school students. The participants were 369 elementary school students(4~6th grade) in Changwon city. Data were collected using self-report questionnaires and analyzed with the SPSSWIN 22.0 program. Analysis methods were t-test, one way ANOVA, Scheffe test, Pearsons correlation coefficient and multiple linear regression. As a results, safety awareness was an average 2.97 point which was moderate levels and self-efficacy was on over intermediate level of an average 3.73 point. Safety practice was an 3.00 point. Safety practice had statistically significant difference according to grade, number of family, mother's education, character and school life attitude. Safety awareness(r=.41, p<.001) and self-efficacy(r=.39, p<.001) was significant correlation with safety practice. Fire safety(${\beta}=.22$, t=3.56) and self-efficacy(${\beta}=.27$, t=5.32) were significantly influenced safety practice and explaining 24.0% of the variance. From the results of this study, I proposed the education programs to increase safety practice in elementary school students that emphasizes self-efficacy and safety awareness.

• Journal of the Korean Society of Safety
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• v.27 no.2
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• pp.127-133
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• 2012

This paper shows survey result on safety management status of laboratories in Korea. In Korea, many studies and reports on laboratory safety have been published since the ministry of education, science and technology (MEST) enforced the Act on Establishing a Safe Environment of Laboratories (Lab Safety Act) in 2006. The MEST has surveyed status of safety management in institutions subject to Lab Safety Act in 2008 and 2010. According to the survey result, safety management status of universities and colleges has been improved on several factors such as establishment of safety manual and implementation of safety inspection; while the number of safety managers of universities and colleges have increased. However, the difficulties in performing duties of safety managers has increased because the number of exclusive safety managers has decreased. This paper identifies the similarities and differences between Occupational Safety and Health Act and Lab Safety Act on assignment and duties of safety managers; therefore, this paper suggests a standard to determine the number of safety managers and decide whether or not their duties should be exclusive. Besides current standard that is based on the number of researchers, the number of individual laboratories should be considered. The new method would be helpful to determine the number of exclusive safety managers because the amount of safety managers' duties generally do not depend on only the number of people who may be exposed to any risk but also the number of facilities that may be cause of any accident.

• Journal of Radiation Protection and Research
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• v.42 no.2
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• pp.98-105
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• 2017

Background: By examining the safety issues involved in on-site training sessions conducted at specialized vocational high schools, and by analyzing the effects of non-destructive testing (NDT) safety training, this study aims to contribute to ensuring the general safety of high school students. Materials and Methods: Students who expressed an interest in participation were surveyed regarding current NDT training practices, as well as NDT safety training. A total of 361 students from 4 schools participated in this study; 37.7% (136 students) were from the Seoul metropolitan area and 62.3% (225 students) were from other areas. Results and Discussion: Of the respondents, 2.2% (8 students) reported having engaged in NDT. As a result of safety training, statistically significant improvements were observed in most areas, except for individuals with previous NDT experience. The areas of improvement included safety awareness, acquisition of knowledge, subjective knowledge levels, objective knowledge levels, and adjustments to existing personal attitudes. Conclusion: Even at absolutely necessary observation-only training sessions, it is crucial that sufficient safety training and additional safety measures be adequately provided.

• International Journal of Advanced Culture Technology
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• v.11 no.2
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• pp.44-48
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• 2023

To enhance safety in dangerous situations, it is essential to provide practice-oriented safety education. However, direct experiences can be limited, and thus, metaverse-based safety education is emerging as an alternative. In this study, we analyzed the first official metaverse safety education program of the Korea Ministry of Education, mainly focusing on its title, objectives, content, and results using the Revised PRISMA framework. The program concentrates on "life safety" for "fire safety," "disaster safety" for "earthquake safety," and "first aid" for "abrasions, burns, fractures, cardiopulmonary resuscitation, and the use of AED." We classified the objectives of the entire program and its three sub-programs, and identified the knowledge, main practice tasks, and their results. The aim of this study is to promote an understanding of the main cases of national-led metaverse safety education and infer the practical safety education contents emphasized to Korean school-age students.

• Korean Journal of Health Education and Promotion
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• v.18 no.2
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• pp.45-63
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• 2001

The objective of this study is to give basic materials for selection and improvement of contents of safety education, which is substantially helpful to elementary students, by analysis of contents of safety education in some subjects and assessment of the needs of elementary students for safety education. For this purpose, this study was analyzed the contents of safety education in five subjects for elementary school and conducted the survey of 883 students in some elementary schools in Seoul from April 7 to 22, 2000. The results were as follows; 1. As a result of analysis of the proportion of contents regarding safety-related education in some subjects, Physical Education occupied the highest proportion (14.09％), and that was followed by Practical Subject (9.55％) and Moral Education (9.34％). However, the proportions in Social Study and Natural Science were very low, 1.85％ and 1.31％ each. In total lines of these five subjects, the numbers of line regarding safety education was contained by 5.78％. 2. Analyzing the proportion of domains of safety education in five textbooks, the Meaning of Safety and Basic Principles occupied the highest portion (29.5％), and that was followed by the Home Safety (24.0％), the Safety in School (17.1％), and the Play and Leisure Safety (14.0％). The Coping with Accidents and First Aid, the Safety from Fire and Explosion, and the Traffic Safety occupied relatively low portion, 6.9％, 5.7％, and 2.8％ each. 3. As a result of analysis of the proportion of the safety education domain in each subject, the Meaning of Safety and Basic Principles occupied the highest portion (23.6％) in Moral Education, the Home Safety (12.7％) in Practical Subject, and the Play and Leisure Safety (10.9％) in Physical Education. 4. Most of the participants in this survey experienced the Home Accidents (71.1％). And also, they experienced the Play and Leisure Accidents (57.9％), the Accidents in School (49.7％), the Traffic Accidents (45.3％), and the Fire and Explosion Accidents (24.7％) in order. 5. In the average proportion of the needs of participants for safety education in each domain, the Coping with Accidents and First Aid has the highest point (4.05). And, that was followed by the Home safety (3.79), the Safety from Fire and Explosion (3.73), the Meaning of Safety and Basic Principles (3.65), the Play and Leisure Safety (3.50), the Safety in School (3.37), and the Traffic Safety (3.35). The average proportion of the needs for safety education of total domains was 3.66. 6. In the needs for safety education regarding the feature of participants, it showed higher scores in female students than male ones (p〈0.001), in lower grader than higher grader (p〈0.05), and in the students born to wealth than those born poor (p〈0.05). Also, the children who recognize the necessity of safety education showed higher scores of the needs for safety education (p〈0.001). And it also showed the same results of high score to the children whose parents did the safety education (p〈0.00l) and to the children and their parents who have the higher degree of practicing safety (p〈0.001), and these differences were statistically significant. 7. In the extent of preference for methods of safety education, it showed high score to the Field Learning, followed by the Audio- Visual Education, the Discussion, and the Instruction of teacher. In the extent of preference for subjects regarding the contents of safety education by each domain, it showed high score to the subject of Safety for 4 domains - the Meaning of Safety and Basic Principles, the Traffic Safety, the Safety from Fire and Explosion, and the Coping with Accidents and First Aid. And also, they preferred Moral Education for 2 domains - the Home safety and the Safety in School, and Physical Education for a domain of the Play and Leisure Safety. 8. While 27 of 36 detail items was contained the contents of safety education, the proportion of needs of participants for safety education showed more than average 3.00 score in 34 of 36 detail items. However, none of 9 detail items was included in five textbooks. Also, 2 detail items - the Coping with Disasters and the Safety from Poisoning - were included together 2 parts; One part had the higher ranked 7 items acquired by analysis of the needs, and the other had the higher ranked 7 items acquired by analysis of the contents. But, except those 2 items, none of items were matched with each part.

• YAKHAK HOEJI
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• v.58 no.4
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• pp.255-261
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• 2014

Poly-pharmacy has been on the rise because of aging of population and chronic disease. Most of drug metabolism happens in the liver by CYP isozymes and the metabolism by CYP450 enzymes. The Cytochrome P450 (CYP) is a superfamily of enzymes that catalyzes the oxidations of many endogenous and exogenous compounds. Primary human Hepatocytes (HH) are considered as the gold standard model for In vitro drug interaction studies. However, there are several limitations (cost, limited life span) for using HH cells. HepaRG cells are being used as a possible alternative. HepaRG cells were cultured in William E medium containing the positive control inducers (1A2: 10, 25, 50 ${\mu}M$ omeprazole, 2C9 and 2C19: 10 ${\mu}M$ rifampin, 3A4: 10, 25, 50 ${\mu}M$ rifampin) at $37^{\circ}C$, 5 % $CO_2$ in a humidified atmosphere. This study was to evaluate the induction of CYP isozymes (1A2, 2C9, 2C19 and 3A4) using LC-MS/MS. We evaluated the potential induction ability of Bosentan, as a drug of pulmonary artery hypertension, in HepaRG cells. For reference, dose of the Bosentan is determined to the basis of the $C_{max}$ (835 mg/ml) value. The enzyme activity demonstrated that CYP2C9 and 3A4 were induced up to 20 times by Bosentan. Like as In vivo, the enzyme activity of CYP2C9 and CYP3A4 is significantly induced in a dose-dependent by Bosentan.

• International Journal of Advanced Culture Technology
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• v.10 no.1
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• pp.138-143
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• 2022

The purpose of this study was to test the effects of video-based fire safety education among college students on the students' fire safety knowledge and disaster safety awareness and competency. Improvements were found in fire safety knowledge (t = -3.24, p = 0.001), social disaster awareness (t = -2.25, p = 0.025), basic disaster awareness (t = -2.44, p = 0.015), and disaster safety capacity (t = -2.04, p = 0.043). The contents of safety-education materials should be continuously developed. Those materials should be provided to many people, and future research should test the longer-term effects of those educational interventions.