• Journal of the Korean GEO-environmental Society
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• v.14 no.5
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• pp.33-39
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• 2013

A drilling exploration in deep sea is being processed to develop new energy resource in the world. In 2007, the presence of the gas hydrate had been confirmed during the UBGH1 (Ulleung Basin Gas Hydrate Expedition 1) in the Ulleung Basin. Geotechnical properties of the deep marine sediment are important factors for assessing the safety of gas production facility and productivity from the hydrate bearing sediment. In this study, comprehensive laboratory tests are conducted to investigate the geotechnical engineering characteristics of the deep marine sediments recovered from the hydrate occurrence regions during the UBGH2 (Ulleung Basin Gas Hydrate Expedition 2) in the Ulleung Basin, East Sea, Korea. The index properties of the specimens including the specific gravity, atterberg limits, specific surface, and particle size distribution are measured, and these are compared to the results reported by previous studies. A zero-lateral strain cell, which houses bender elements, is used to determine stress-dependant characteristics and shear wave velocities with the vertical effective stresses. Furthermore, the hydraulic conductivity is calculated based on the consolidation test results.

• Genomics & Informatics
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• v.16 no.3
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• pp.52-58
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• 2018

In this report, we present a case study of how pharmacogenomics and pharmacometabolomics can be useful to characterize safety and pharmacokinetic profiles in early phase new drug development clinical trials. During conducting a first-in-human trial for a new molecular entity, we were able to determine the mechanism of dichotomized variability in plasma drug concentrations, which appeared closely related to adverse drug reactions (ADRs) through integrated omics analysis. The pharmacogenomics screening was performed from whole blood samples using the Affymetrix DMET (Drug-Metabolizing Enzymes and Transporters) Plus microarray, and confirmation of genetic variants was performed using real-time polymerase chain reaction. Metabolomics profiling was performed from plasma samples using liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. A GSTM1 null polymorphism was identified in pharmacogenomics test and the drug concentrations was higher in GSTM1 null subjects than GSTM1 functional subjects. The apparent drug clearance was 13-fold lower in GSTM1 null subjects than GSTM1 functional subjects (p < 0.001). By metabolomics analysis, we identified that the study drug was metabolized by cysteinylglycine conjugation in GSTM functional subjects but those not in GSTM1 null subjects. The incidence rate and the severity of ADRs were higher in the GSTM1 null subjects than the GSTM1 functional subjects. Through the integrated omics analysis, we could understand the mechanism of inter-individual variability in drug exposure and in adverse response. In conclusion, integrated multi-omics analysis can be useful for elucidating the various characteristics of new drug candidates in early phase clinical trials.

• Korean Journal of Occupational Health Nursing
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• v.4
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• pp.48-57
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• 1995

The purpose of this study was to assess the performance of the role and function of some industrial nurses and to characterize the factors affecting the performance of their activities. Thus the results could be used to suggest the direction in the performance of industrials nurses' activities effectively. During a period from January 10 to March 31, 1994, the data were collected from 87 industrial nurses, who were working as health managers in the plants, in Ulsan city and the vicinity in Kyungnam province, using a structured questionnaire. The results were as follows : 1. The general characteristics of industrial nurses in this study were 82.8% being 30 years old or less, 60.9%, being not married, and 93.1% having eduction levels above junior college. 2. With respect to general work conditions, 94.3% were working in a separate room provided for health care division, 40.2% working under the safety and health department, and 98.9% working as common-level staffs. And 60.9% were working less than 44 hours a week, 70.1% had work experiences less than 5 years, and 50.6% had annual incomes ranging 10 to 14 million wons. 3. As work conditions related to health care activities, 49.4% performed the activities not related to health care as always or occasionally, and 87.4% answered that occupational physicians were appointed in their plant and among them, however, only 6.9% worked on full-time basis and 52.8% perform little activities as occupational physicians. For a decision related to health care activity, 69.0% discussed the problems with the supervisors, and 19.5% made decisions by themselves. 4. As for attitude and perception to their activities as health managers, 66.7% moderately recognized the importance of health manager in the workplace, with 63.2% being satisfied their wages and treatment from the company, 57.5% being satisfied with their job positions and 51.7% having positive attitudes as being health managers. 5. The degree of performance at least in one of health related activities were very high in activities such as general medical care(100%), general health examination(98.0%) and specific health examination(100%), and relatively high in health education(72%), new employee health examination(60.9%), document handling(79.3%) and activity for work environment(70.1%). However, the performance rate was very low in preparing protective equipment (20.8%). 6. The levels of activities related to health care were significantly high when making decisions by themselves, when occupational physicians not being full-time, and when satisfying their job positions, and, on the other hand, significantly decreased as work hours increased. 7. In addition to some kinds of periodic education asked by all of the nurses, 89.7% wanted a specialized licensing system for industrial nurse, and 97.4% wanted to apply for the license test. As a conclusion, it is suggested that industrial nurses should be given more authority and placed in more self-controlled system to perform health care and other activities more efficiently, and the role and function of the occupational physician should be clearly distinguished from that of the industrial nurse as a health manager to avoid an unnecessary overlapping.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.38 no.1
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• pp.69-83
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• 2020

Signboards are standardized according to national legislation for the safety of pedestrians and disaster prevention in urban areas. Signboards should be installed according to the standard. However, it is not easy to manage the signboards systematically due to the number of signboards that have been installed for a long time and frequently changing stores. In this study, we proposed a methodology for distinguishing signboards that deviated from the standard. To this end, the signboard was photographed using a stereo camera, and then the three-dimensional coordinates of the signboard were determined from the signboard image to calculate the signboard's horizontal and vertical dimensions to determine the signboard's specifications. In order to determine the interior and relative orientation parameters of the stereo camera, an outdoor three-dimensional building was used as the test field. Then, the image coordinates of four vertices of the signboard were extracted from the signboard image taken from about 15m ~ 22m distance using deep learning. After determining the signboard's three-dimensional coordinates by using the interior and relative orientation parameters of the stereo camera and the image coordinates of the four vertices of the signboard, the horizontal and vertical sizes of the signboard were calculated, resulting in an error of about 2.7cm on average. The specifications for the ten flat-type signboards showed that all of the horizontal sizes were compliant with the specifications, but the vertical sizes exceeded about 36.5cm on average. Through this, it was found that maintenance of flat-type signboards is needed overall.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.36 no.4
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• pp.281-288
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• 2010

In this study, we investigated anti-oxidative effects of Duchesnea indica extracts by using Oxygen Radical Absorbance Capacity (ORAC). The extracts were prepared with 0 %, 30 %, 50 %, 70 % and 100 % aqueous ethanol respectively. The 30 % EtOH D. indica extract showed higher ORAC activity than the other extracts. Therefore, we performed in vitro studies on cytotoxicity of NIH-3T3 cells and MMP-8 collagenase inhibition using by the 30 % EtOH extract. The 30 % EtOH extract showed no cytotoxicity and significant inhibition on MMP-8 collagenase. And we performed clinical studies for the anti-wrinkle effect of the Di-Wrinkle Free Cream. The cream formula was prepared with 2 % arbutin and 1 % D. indica extract. Twenty one healthy women volunteers, ages of 35 and 50, applied the cream on their faces twice a day for 8 weeks. The skin was evaluated with PRIMOS (phaseshift rapid in vivo measuring of human skin) system and analyzed by the student's paired t-test. The wrinkles on the eye region were reduced by 13 % based on the PRIMOS system after 8 weeks. In the safety study of the Di-Wrinkle Free Cream, no symptoms were observed such as erythema, edema, scaling, itching, stinging, burning, tightness and prickling by visual observation and medical examination of volunteers for 8 weeks. Moreover, there was no noticeable skin disorder during experience period. These results suggested that D. indica extracts could be applied as cosmeceuticals effective for anti-wrinkle.

• Journal of dental hygiene science
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• v.8 no.4
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• pp.255-260
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• 2008

The purposes of this study were to examine the effect of 35% hydrogen peroxide (HP) bleaching agent on the changes in physical and chemical characteristics of tooth. The bleached teeth showed an apparent color changes. The whiteness increased linearly within the tested period as the period of bleaching increased. The microhardness between bleached groups after bleaching showed any statistically significant difference according to the paried t-test. The bleached enamel surface showed any apparent morphological changes compared to the enamel which was stored in distilled water only. The difference of the total mineral contents for the distilled water and hydrogen peroxide did not show statistical significance. These results demonstrated that bleaching using 35% hydrogen peroxide were adversely affects application time of experimental group and may confirm the safety of using these agents for a short time in dentist-monitored bleaching.

• KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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• v.24 no.1
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• pp.1-11
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• 2018

In this study, pro-oxidant($d2w^{(R)}$) and rPP/ZnO nanocomposite flexible films for food packaging were prepared, and their mechanical and antimicrobial properties were investigated. As a result, the carbonyl index and hydroxyl index increased with exposured time to heat and UV rays. Surface analysis showed that the addition of zinc oxide improved the dispersibility and compatibility of the polymer, so that the surface of the composite film was smooth and the zinc oxide particles were smaller than the compared film. And it kept the physical properties by heat and UV ray blocking effect, and it worked to reduce decomposition. In the antimicrobial activity test, the microbial reduction rate was 3 logs or more at the use concentration of zinc oxide. The tensile strength was increased and the elongation was decreased. Oxidative degradability of multi-layered film in UV exposured for 72 hours, the molecular weight of the film decreased by 75.6%, 1,294 g/mol Mn and 5,920 g/mol Mw. In the safety analysis of food packaging materials, we obtained that are in standard of polypropylene, a food contact material of domestic law.

• Nuclear Engineering and Technology
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• v.27 no.3
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• pp.393-402
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• 1995

The structural analysis of the reactor coolant system mainly consist of too fields. The one is the static analysis considering the impact of pressure and temperature built up during normal operation. The other is the dynamic analysis to estimate the impact of postulated events such as the seismic loads or postulated branch line pipe breaks event. Since the most important goal of the RCS structural analysis is to prove the safety of the RCS during normal operation or postulated events, a widely proven theory having enough conservatism is adopted. The load occurring on the RCS during normal operation is considered as the basic design loading condition throughout whole plant life time. The most typical characteristic of the RCS during normal operation is the thermal expansion of the RCS caused by reactor coolant with high temperature and pressure. Therefore, the exact estimation on the thermal movement of the RCS is needed to get more clear understanding on the thermal movement behavior of the RCS. In this study, the general structural analysis concept and modeling method to evaluate the thermal movement of the RCS under the normal plant operation condition are presented. To discuss the validation of the suggested analysis, analysis results are compared with the measured data which ore referred from the standardized 1000 MWe PWR plant under construction.

• Fire Science and Engineering
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• v.33 no.4
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• pp.140-151
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• 2019

It is to assess the indoor air quality of the chemical hazardous materials exposed to the fire after firefighters returned to the fire scene. The research subject randomly selected four fire stations located in Seoul, Korea. Two fire stations were set up as control groups after the return of the firefighting activities at the actual fire scene, and two other fire stations were set up as control groups to measure the air quality of the room at normal levels regardless of the action. We conducted 24-hour monitoring for all fire accidents that occurred in Seoul Metropolitan using fire safety map computer system. Also, indoor air quality was measured immediately after homecoming if the experiment group was to be dispatched due to an accident of intermediate or larger scale. 11 hazardous substance items such as fine dust, formaldehyde, volatile organic compounds, PAH, VCM, acidity, asbestos, CO₂, NO₂, O₃ were measured according to the process test method. Three of 11 types of harmful substances exceeded domestic and foreign standards, and one of them was found to be close to foreign standards. In particular, total volatile organic compounds, carbon dioxide and sulfuric acids were 2.5 times, 2.2 times and 1.1 times higher than the standard. Also, for formaldehyde and sulfuric acid, it was measured higher in the control group than in the case group. This findings could be used in policies to improve indoor air quality in the fire station of the Seoul Metropolitan Government.

• Fire Science and Engineering
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• v.33 no.4
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• pp.16-27
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• 2019

A burning test was conducted on the smoke and combustion gases generated from cypress wood treated with sodium silicate, 3-aminopropyltrimethoxysilane sol, 3-(2-aminoethylamino)propylmethyldimethoxysilane sol, and 3-(2-aminoethylamino) propyltrimethoxysilane sol. The silicone compound sol was applied to each of the cypress wood specimens three times with a brush. The smoke and combustion generation gas were analyzed using a cone calorimeter (ISO 5660-1) and the smoke was also evaluated by applying new smoke risk assessment method. The smoke performance index (SPI) of the cypress treated with silicone compound increased 1.66 to 8.42 times and the smoke growth index (SGI) was 11.8 to 88.2%, respectively. The smoke intensity (SI) is expected to be 1.0~50.5% lower than that of the base specimens, resulting in lower smoke and fire hazards. The third maximum carbon monoxide (CO_peak) concentration of the specimens treated with silicone compounds was 22.5~33.3% lower than that of the base specimens. On the other hand, it produced potentially fatal toxicity that was 1.48~1.72 times higher than the US Occupational Safety and Health Administration (OSHA) acceptance standard (PEL). Cypress wood itself produced a high carbon monoxide concentration, but the silicon compound played a role in reducing this level.