• 터널과지하공간
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• 제8권2호
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• pp.118-129
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• 1998

A three dimensional boundary element method-BEAP3D was applied to the stability analysis of the mine openings not only to improve the stability during mining operations but also to serve the evaluation of the mine openings for further utilization. Stability analysis on the stability of the room-and-pillar stopes underneath of the old mine openings and the openings to be created by the newly proposed sublevel stoping method at the Nowhado Pyrophyllite Mine, showed that rock mass around the old and new stopes would be stable. Six stopes of a sublevel stoping designed for the Choongmu Limestone Quarry would be stable, too. A sublevel stoping method consisting of six stopes was similarly suggested for the Keumpyung Quartzite Mine. The stability can be guaranteed through out six stopes. Since mining starts from the bottom 1st sublevel to the uppermost sublevel, the safety of the stopes will improve together with the mining process. It would highly be recommended to investigate in-situ rock properties and the rock stresses for future studies. Even though the rock around the uppermost part and bottom of all the stopes have a very high factor of safety, spot reinforcements such as rock bolting would be recommended to mitigate the intermediate and minor principal stresses acting in a tensile mode.

• 대한안전경영과학회지
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• 제5권1호
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• pp.83-92
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• 2003

Scheduling plays an important role in shop floor planning. A scheduling shows the planned time when processing of a specific job will start on each machine that the job requires. It also indicates when the job will be completed on every process. Thus, it is a timetable for both jobs and machines. There is only one server available and arriving work require services from this server. Job are processed by the machine one at a time. The most common objective is to sequence jobs on the severs so as to minimize the penalty for being late, commonly called tardiness penalty. Based on other objectives, many criteria may serve as s basis for developing job schedules. The process also comprises all strategic planning, capital investments, management decisions, and tasks necessary to create a new product. manufacturing processes must be created so that the product can be produced in the product facility. Purchasing new equipment and training workers may be required if new technology is to be used. Tools, fixtures, and the sequence of steps in the manufacturing processes must all be developed to allow rapid, high-quality, cost effective production. Also, it may be needed to be rearrange the production facility to adapt to the new manufacturing processes. Therefore, this study tries to proposed that Scheduling by customer needs group for minimizing the problem and reducing inventory, product development time, cycle time, and order lead time.

• 한국컴퓨터정보학회논문지
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• 제18권10호
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• pp.193-198
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• 2013

본 논문에서는 다양한 앱의 종류 중에서 유통 기한과 관련 있는 앱을 조사하고 이를 화장품 관리에 적용하는 방안을 제시하고자 한다. 이를 위해 화장품의 안전성과 안정성을 향상시키는 안드로이드 기반 앱을 설계 구현하도록 한다. 화장품은 종류가 워낙 많기 때문에 이를 잘 알고 쓰기가 무척 어려울 뿐만 아니라 각 화장품마다 구입 시기 및 개봉 시기가 각각 다르기 때문에 이를 효율적으로 관리해 주는 앱이 필요하다. 본 연구는 화장품의 유통 기한을 관리해 주는 앱을 설계 구현하므로써, 화장품의 안전한 사용을 도와주며, 화장품 업체와의 연계를 통해서 좋은 화장품의 정보를 제공 받는 것을 목표로 하고 있다.

• 한국산학기술학회논문지
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• 제12권2호
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• pp.841-846
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• 2011

현재 우리나라 도로의 서비스 수준은 차량의 평균 통행속도를 기준으로 평가되어지고 있다. 이는 도로의 혼잡도만을 기준으로 적용한 것으로 교통안전 측면이 고려되지 않은 것이 현실이다. 합리적인 도로 설계와 운영을 위한 평가 지표라면 도로 이용자에게 영향을 미치는 제반 인자들을 보다 포괄적으로 포함할 수 있어야 한다. 본 논문에서는 교통안전과 소통측면을 총괄할 수 있는 변수로 사용자비용 개념을 적용하여 도로 평가방법을 개발하고자 한다. 또한, 본 논문에서는 이러한 도로 평가 방법을 기존의 일회성 개발 방법이 아닌 UML 기반의 사용자 중심 분석 방법을 이용하여 설계한다.

• Genomics & Informatics
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• 제21권4호
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• pp.45.1-45.11
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• 2023

Nonalcoholic fatty liver disease (NAFLD) is a common type of chronic liver disease, with severity levels ranging from nonalcoholic fatty liver to nonalcoholic steatohepatitis (NASH). The extent of liver fibrosis indicates the severity of NASH and the risk of liver cancer. However, the mechanism underlying NASH development, which is important for early screening and intervention, remains unclear. Weighted gene co-expression network analysis (WGCNA) is a useful method for identifying hub genes and screening specific targets for diseases. In this study, we utilized an mRNA dataset of the liver tissues of patients with NASH and conducted WGCNA for various stages of liver fibrosis. Subsequently, we employed two additional mRNA datasets for validation purposes. Gene set enrichment analysis (GSEA) was conducted to analyze gene function enrichment. Through WGCNA and subsequent analyses, complemented by validation using two additional datasets, we identified five genes (BICC1, C7, EFEMP1, LUM, and STMN2) as hub genes. GSEA analysis indicated that gene sets associated with liver metabolism and cholesterol homeostasis were uniformly downregulated. BICC1, C7, EFEMP1, LUM, and STMN2 were identified as hub genes of NASH, and were all related to liver metabolism, NAFLD, NASH, and related diseases. These hub genes might serve as potential targets for the early screening and treatment of NASH.

• 한국안전학회지
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• 제38권6호
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• pp.72-78
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• 2023

The purpose of this paper is to derive a quantified approach for Operator Manual Actions (OMAs) based on the existing fire Human Reliability Analysis (HRA) methodology developed by the Korea Atomic Energy Research Institute (KAERI). The existing fire HRA method was reviewed, and supplementary considerations for OMA quantification were established through a comparative analysis with NUREG-1852 criteria and the review of the existing literature. The OMA quantification approach involves a timeline that considers the occurrence of Multiple Spurious Operations (MSOs) during a Main Control Room Abandonment (MCRA) determination and movement towards the Remote Shutdown Panel (RSP) in the event of a Main Control Room (MCR) fire. The derived failure probability of an OMA from the approach proposed in this paper is expected to enhance the understanding of its reliability. Therefore, it allows moving beyond the deterministic classification of "reliable" or "unreliable" in NUREG-1852. Also, in the event of a nuclear power plant fire where multiple OMAs are required within a critical time range, it is anticipated that the OMA failure probability could serve as a criterion for prioritizing OMAs and determining their order of importance.

• Journal of Acupuncture Research
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• 제41권2호
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• pp.135-141
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• 2024

The use of ultrasound (US)-guided interventions has rapidly increased in Korean medicine (KM) to ensure the safety and accuracy of invasive procedures, such as pharmacopuncture and acupotomy. Although hands-on training is important for the acquisition of skills, it requires considerable time and cost. A detailed guide on the procedure and treatment regions is needed to ensure hygiene and safety during US-guided procedures in KM practice. In this study, we present the overall procedure, target structures, and treatment approaches of US-guided pharmacopuncture and acupotomy for nerve entrapment in the upper extremities of the cubital and radial tunnel, posterior interosseous nerve, carpal tunnel, and Guyon's canal syndrome. We believe that the findings of our study will serve as a foundation for future clinical research, practice, and education on US-guided KM procedures. Further research involving US-guided interventions should specify target structures in three-dimension to delineate the treatment areas.

• 약학회지
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• 제57권3호
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• pp.226-233
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• 2013

Although the dissolution test can serve as an effective tool for quality control and predictor of in vivo performance, there are a number of drugs with no established dissolution specification in Korean Pharmaceutical Codex (KPC). So, with each reference and test drugs, the dissolution test method and an analytical procedure by HPLC were developed and validated to establish dissolution specification for acebrophylline capsules and bromhexine hydrochloride tablets. The dissolution condition was determined based on the "Guidelines on Specifications of Dissolution tests for Oral dosage forms" of Ministry of Food and Drug Safety (MFDS). The analytical method of HPLC was validated in specificity, linearity, precision and accuracy. Final dissolution test was performed with commercially available samples of 3 lots to establish specification. In addition, no difference was observed by the inter-laboratory evaluation. Dissolution specifications and conditions will be used for revising the monograph of acebrophylline capsules and bromhexine hydrochloride tablets in next supplement of KPC.

• Toxicological Research
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• 제24권3호
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• pp.201-206
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• 2008

Exposure to formaldehyde(FA) is closely associated with adverse health effects such as irritation, inflammation, and squamous cell carcinomas of the nasal cavities. Owing to its rapid metabolism and elimination, exposure to FA does not always result in an increased concentration in blood or urine of animals and humans. Therefore, the development of biomarkers for FA exposure is necessary for risk assessment. In the present study, the effects of FA were investigated on the expression of genes involved in the MAPK pathway in vitro and results confirmed in rats exposed to FA by inhalation. Treatment of Hs 680.Tr human tracheal epithelial cells with FA induced gene expression for PDGFA, TNFSF11, SHC1, and HRAS. HRAS expression was also increased in tracheas of rats exposed to FA. In addition, FA exposure induced the expression of RASSF4, a member of the Rasassociation domain family of Ras effectors, in rat tracheas. In conclusion, data showed FA-inducible expression of genes involved in the MAPK pathway occurred and increased expression of HRAS and RASSF4 was noted in rat tracheas subchronically exposed to FA by inhalation. These genes may serve as molecular targets of FA toxicity facilitating the understanding of the toxic mechanism.

• 수산해양기술연구
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• 제56권2호
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• pp.138-146
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• 2020

Stow net fishery is one of the fishery with high fishing work accidents in southwestern sea of Korea. We conducted to serve as basic data for improving the healthy and safe working environment of fisher using risk assessment process (ISO45001) with fishermen's occupational accidents of the National Federation of Fisheries Cooperative (NFFC) from 2016 to 2018. The average occurrence rate of victim in this fishery was 9.04%, 16.7 times more than such rate in all industries. In addition, the average fatality rate was found to have a very serious level management to 31.06‱, 27.7 times more than such rate in all industries. The safety hazards of stow net fishery was more likely to occur by other general industrial groups, with more severe consequences after the accident. According to 4M analysis, 58.6% of all accidents were caused by human factors, 24.0% by environmental factors, 16.0% by mechanical factors, and 1.5% by managerial factors, respectively. The occurrence frequency by accident type was the highest in 187 cases (32.2%) for struck by object, 158 cases (27.2%) for slipping, and 94 cases (16.2%) for being in contact with machinery. Severity is the highest for others such as diseases etc., in the order of being struck by object, being in contact with machinery, falling from above slipping, collapsing, bumping, and burning. Being struck by object, being in contact with machinery, and slipping are high-risk groups, falling from above others, bumping, and burning are medium-risk groups based on the risk assessment using the occurrence frequency and severity of accident. The obtained results are expected to contribute to the safe operation environment subsidy for fishing crews on the stow net fishing vessel.