• Title/Summary/Keyword: Safety level

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Assessment of Immune Quality and Pathogen Contamination of Colostrums Collected from Colostrum Banks in Korea (초유은행에서 수거한 초유의 병원체 오염과 면역수준의 평가)

  • Kim, Won-Il;Park, Sang-Yul;Kim, Sang-Jin;Cho, Yong-Il;Hur, Tai-Young;Kim, Nam-Soo
    • Journal of Veterinary Clinics
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    • v.30 no.4
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    • pp.223-229
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    • 2013
  • Because colostrum is considered to be the sole source of passively acquired maternal antibodies for calves, newborn calves must consume colostrum to gain disease resistance during their early years of life. Storage of surplus colostrum from dairy cows right after calving and feeding newborn calves in deficiency of colostrum to assure adequate uptake of IgG for protection of the calf has been a common practice in the bovine production. In the current study, 35 colostrums were randomly collected from 3 colostrum banks located in different regions of Korea and monitored for general bacterial contamination and major bovine pathogens. Immunoglobulin concentrations and BVDV-specific antibodies were also determined to evaluate the immune quality of the colostrums. Moderate to severe bacterial contamination (up to 72,000,000 CFU/ml) was observed in most of the colostrums collected from colostrum banks. General immune quality of the colostrums was under the satisfactory level since most of the colostrums contained less than 50 g/L of IgG, which is the minimum concentration for good quality colostrums. Therefore, colostrum for colostrum bank should be collected at the first 2-3 post-partum milkings according to proper harvesting and handling procedures to guarantee the safety and quality of colostrum. In addition, it was recommended that colostrum should be heat-treated before frozen and stored in the bank because pasteurization at $63^{\circ}C$ for 30 min was very effective reducing the risk of disease transmission without causing significant degradation of immunoglobulins.

A Study on the Effects of the Electro-Acupuncture(EA) Stimulation after Global Ischemia(GI) on Changes in Bax and Caspase-3 Expression among Forebrain Apoptosis (뇌허혈 유발 후 전침자극이 전뇌세포사 중 Bax와 Caspase-3 발현 변화에 미치는 영향 연구)

  • Choi, Jung-Hyun;Min, Kyoung-Ok;Kim, Soon-Hee;Kim, Dong-Il;Lee, Sang-Bin;An, Ho-Jung;Kim, Ji-Sung;Choi, Wan-Suk;Kim, Bo-Kyoung;Song, Chi-Won
    • Journal of Oriental Neuropsychiatry
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    • v.21 no.1
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    • pp.59-69
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    • 2010
  • Objectives: The study aims to look into how the application of EA(Electro-acupuncture) in the initial step of ischemic brain injury affects the changes in Bax and Caspase-3 expression among forebrain apoptosis. Methods: It caused GI by using common carotid artery occlusion and conducted the test by dividing into the no applied EA group after 6 hours and 12 hours, the LI 4 EA group that applied EA to LI4, and GV 20 EA group that was applied to GV 20. After that, the following results were obtained by comparing Bax and Caspase-3 expression, which were apoptosis-related factors, with its application time through immunohistochemical staining after extracting brain of each group. Results: According to each group's Bax expression by the application time, the order of expression increase after 6 hours is shown to be the no applied EA group, LI 4 group, and GV 20 group. The stimulation after 12 hours was most lowly expressed in the GV 20 group, and the no applied EA group and LI 4 group showed similar level. Conclusions: EA stimulation in the initial step after ischemia seems to affect positively Bax and Caspase-3 expression that are index of forebrain apoptosis.

Risk Factors of Work-related Low Back Pain in Manufacturing Workers (제조업 근로자들의 작업과 연관된 요통의 위험요인에 관한 연구)

  • Kim, D.H.;Shin, H.R.;Chun, J.H.;Kim, Y.W.;Kim, J.H.;Lee, C.U.
    • Journal of Preventive Medicine and Public Health
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    • v.26 no.1 s.41
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    • pp.20-36
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    • 1993
  • Work-related low back pain is one of the major factors that cause the loss of working power especially in actively working age, therefore controlling the work-related low back pain is one of the major issues in the field of industrial safety and health. This study was performed for detecting the risk factors and proposing the efficient control program of the work-related low back pain. The subjects were male workers employed at the manufacturing industry in Pusan with longer than 6 months' working duration. The data was collected by self-reported questionnaire and interview from May 1 to October 31,1992. The contents of questionnaire were as follows:. the experience of low back pain within the recent one month, general characteristics(age, marital status, education level, religion, regular exercise), physical characteristics(height, weight), employment status(working duration, daily working hours, rest during work, satis(action fur the job), type of work and working environments(posture, forward bending, lifting and movement, satisfaction for table and chair). The result was analyzed for 608 entire respondents by case-control comparative method. The number of cases was 152 with a history of work-related low back pain, so the relative frequency of self-reported work-related low back pain was 25.0%, and the number of controls was 344 without any history of low back pain. As a result, two characteristics of the employment status(working duration, satisfaction fur the job) and all characteristics of type of work and working environments showed a statistical significance between the case and control groups(p<0.01). The Oddb ratios of these variables for Work-related low back pain were calculated. They were 7.88 for the satisfaction fur chair, 7.86 for lifting and movement,3.31 for satisfaction for table, and 2.22 fur bending forward(p<0.01). And for the multivariate logistic regression analysis confirmed that unsatisfaction for table was independent risk factor for Work-related low back pain. In summary, though this study was based upon the self-reported questionnaire and the subjective complaints, the satisfaction for chair, lifting and movement, satisfaction for table, and bending forward concerned with the type of work and working environments were considered as the main factors causing the work-related low back pain, and the work-related low back pain may be preventable by the ergonomic control of these factors.

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10% Pentastarch Versus 5% Albumin Solution for Volume Expansion Following Cariopulmonary Bypass in Patients Undergoing Open Heart Surgery (개심수술후 혈량 증가를 위한 10% Pentastarch와 5% Albumin 용액의 비교연구)

  • 장병철
    • Journal of Chest Surgery
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    • v.27 no.3
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    • pp.177-186
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    • 1994
  • Pentastarch is a hydroxyethyl starch similar to hetastarch, but lower average molecular weight and fewer hydroxyethyl groups which result in enhanced enzymatic hydrolysis and faster renal elimination.This report was performed to compare the clinical efficacy and safety of 10 % pentastarch[Pentaspan , group I] for plasma volume expansion after open heart surgery with that of 5% albumin[Plasmanate, group II]. There were no statistically significant differences between the group I [n=18] and group II [n:19] in the preoperative parameters [age, sex, body weight] and operative parameters[bypass time, aorta cross clamping time]. During the first 24 hours after arrival of the patient in the surgical intensive care unit, colloid solution [500--1000 ml] was infused to maintain left atrial pressure of more than 8 mmHg, or cardiac index of 2.0 L/min/M2 of more. In results, there were 3 complications of hypotension immediately after infusion of 5 % albumin solution and 2 among the 3 patients were excluded for the study. However there was no complication after infusion of 10 % pentastarch solution. Hemodynamic responses to infusion was similar for both groups, although in group I a greater increase in both left atrial pressure[mean 1.8 versus 0.7 mmHg, p< 0.05] and right atrial pressure [mean 2.2 versus 1.7 mmHg, p < 0.05] was observed during infusion of the first 500 ml. There were no significant differences in any of the measured respiratory parameters[PaO2, intrapulmonary shunt, and effective lung compliance]. Homodilution with colloid significantly reduced hemoglobin [mean 1.2 versus 0.8 gm/dl], and serum protein and albumin level[total protein;4.8$\pm$ 0.5 versus 5.2 $\pm$0.5 gm/dl, p < 0.05: albumin: 3.2 $\pm$0.4 versus 3.6 $\pm$0.6 gm/dl, p < 0.05] by 6:00 AM on 1 day postoperatively, however there were no significant differences on 7 day postoperatively. The mean serum colloid osmotic pressure and osmolarity was similar in both group.There were no abnormal findings of liver function and kidney function in all the patients. There were no significant between-group differences in bleeding time, platelets, prothrombin time, activated partial thromboplastin time and amount of chest tube output measured on 1st and 7th postoperative day. These findings demonstrated that 10% pentastarch is more effective and safe for plasma volume expension than 5 % albumin solution with no adverse effects on coagulation. Also 10 % pentastarch is less expensive than 5 % albumin and it would appeare to be a reasonable first choice for plasma volume expansion.

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Survey of calcium, fat and lactose contents in processed milks (가공유의 칼슘, 지방, 유당 함량 및 표시기준에 대한 고찰)

  • Jeon, Hae-Chang;Lee, Kyung-Hye;Han, Hye-Jin;Yun, Min;Kim, Doo-Hwan;Lee, Ju-Hyung;Shin, Bang-Woo
    • Korean Journal of Veterinary Service
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    • v.36 no.3
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    • pp.217-222
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    • 2013
  • In this study, we compared nutrient content emphasized on labelling of processed milks with that of whole milks and evaluated how well they conform to labelling standard. A total of 98 samples (33 whole milks, 28 calcium fortified milks, 30 low-fat milks and 7 lactose hydrolyzed milks) were collected in hypermarkets in Seoul from August 28 to August 30 in 2012. Calcium, fat and lactose contents were tested in the samples. Calcium contents ranged 102.2~113.0 mg/100 mL in whole milks and 120.1~337.8 mg/100 mL in calcium fortified milks. The level of calcium contents in fortified milks ranged very broad. Accordingly, the standard of calcium contents on fortified milks will be required. Fat contents ranged 3.1~3.9 g/100 mL in whole milks and 0.1~1.9 g/100 mL in low-fat milks. The average of fats content in low-fat milks was nearly one third than whole milks. Lactose contents was ranged 4.6~5.1 g/100 mL in whole milks and not detected in lactose hydrolyzed milks. All of processed milks were suitable to processing standard and labelling standard. But nutrition claims often used on processed milk such as "High" or "Low" were not adequate to indicate the exact nutrient content, which is a cause of the confusion for milk product labelling to consumers. We need a lot of research about nutrient labelling that can deliver appropriate and understandable information to customers.

Evaluation of the Stress Corrosion Cracking Behavior of Inconel G00 Alloy by Acoustic Emission (음향 방출에 의한 인코넬 600 합금의 응력 부식 균열 거동 평가)

  • Sung, Key-Yong;Kim, In-Sup;Yoon, Young-Ku
    • Journal of the Korean Society for Nondestructive Testing
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    • v.16 no.3
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    • pp.174-183
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    • 1996
  • Acoustic emission(AE) response during stress corrosion cracking(SCC) of Inconel 600 alloy has been monitored to study the AE detectability of crack generation and growth by comparing the crack behavior with AE parameters processed, and to evaluate the applicability as a nondestructive evaluation(AE) by measuring the minimum crack size detectable with AE. Variously heat-treated specimens were tensioned by constant extension rate test(CERT) in various extension rate to give rise to the different SCC behavior of specimens. The AE amplitude level generated from intergranular stress-corrosion cracking(IGSCC) is higher than those from ductile fracture and mechanical deformation, which means the AE amplitude can be a significant parameter for distinguishing the An source. AE can also provide the effective means to identify the transition from the small crack initiation and formation of dominant cracks to the dominant crack growth. Minimum crack size detectable with AE is supposed to be approximately 200 to $400{\mu}m$ in length and below $100{\mu}m$ in depth. The test results show that AE technique has a capability for detecting the early stage of IGSCC growth and the potential for practical application as a NDE.

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Prediction of Occupant Load Density using People Counting System in Discount Stores (무인계수시스템을 이용한 대형할인점의 재실자밀도 예측)

  • Seo, Dong-Goo;Hwang, Eun-Kyoung
    • Fire Science and Engineering
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    • v.31 no.6
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    • pp.53-59
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    • 2017
  • The purpose of this study is to verify the suitability of the current standards by predicting the density of the occupant load density for discount stores. An internal data survey as well as an actual survey using a People Counting System (PCS) were employed to ascertain the number of occupants and 95% confidence interval of nationwide discount stores. According to the results of the actual survey, the time and days on which the maximum number of occupants were reached was from 16:00 to 18:00 and Christmas Eve and the weekend before New Year's Day, respectively. From the results of the maximum number of occupants, a regression equation was derived from the relationship between the internal data and the amount of sales, and this equation was verified in a previous study. Thus, the internal data of 50 discount stores were analyzed using this process. As a result, the 95% confidence interval was determined to be $2.7{\sim}2.9m^2/pers.$ and the error level was not large compared to the domestic and foreign standards. Therefore, this study proposes that a conservative estimate of the standard occupant load density for discount stores is $2.7m^2/pers.$

Genotyping, Phage Typing, and Antimicrobial Resistance of Salmonella Typhimurium Isolated from Pigs, Cattle, and Humans

  • Ju, Min-Seok;Kang, Zheng-Wu;Jung, Ji-Hun;Cho, Seong-Beom;Kim, Sung-Hun;Lee, Young-Ju;Hong, Chong-Hae;Pak, Son-Il;Hahn, Tae-Wook
    • Food Science of Animal Resources
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    • v.31 no.1
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    • pp.47-53
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    • 2011
  • Salmonella enterica serovar Typhimurium (ST) is one of the most common serovars isolated from humans and animals. It has been suggested that ST infections in Koreans are largely due to the consumption of contaminated pork and beef. To investigate the genotypes, phage types, and antimicrobial resistance patterns for ST isolates of different origins, a total of 70 ST strains, including 19 isolates from humans, 44 isolates from pigs, and 6 isolates from cattle, were analyzed using pulsedfield gel electrophoresis (PFGE), phage typing, and antimicrobial susceptibility tests. Forty-three distinct PFGE patterns were generated from 70 ST isolates, which were grouped into 14 PFGE groups (from A to N) at the level of 75% similarity. The most prevalent group was the A (A1-A17 subtypes) group, encompassing 54.5% (38/70) of ST isolates. ST isolates from pigs and cattle mostly belong to groups A and L, whereas ST isolates from humans mostly belong to groups F and C. Antimicrobial susceptibility tests using 11 antimicrobial agents showed that resistance to tetracycline (TE) (81.4%) was highly prevalent, followed by streptomycin (S) (64.3%) and nalidixic acid (NA) (31.4%) resistance. A total of seventeen antimicrobial resistance patterns were observed. Only 8.6% of isolates, including a reference strain, were susceptible to all antimicrobial agents tested. The most prevalent resistance pattern was TE-S (37.1%), which was seen in 66.6% of bovine, 40.8% of swine and 21.1% of human isolates. Three ST isolates from humans (15.9%) showed resistance to 7-8 antimicrobials. The most predominant phage type (PT) was U302 (64.3%), followed by DT170 (10.0%). PFGE types did not coincide with antimicrobial resistance patterns and phage types; therefore, the combination of those types allowed for further differentiation between tested ST isolates.

An Evaluation on the Radiation Shielding of the Radwaste Drum Assay Facility (방사성폐기물드럼 핵종재고량 평가시설 구축에 따른 방사선차폐 영향평가)

  • Ji, Young-Yong;Kwak, Kyung-Kil;Hong, Dae-Seok;Shon, Jong-Sik
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.10 no.2
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    • pp.117-123
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    • 2012
  • In order to dispose of the LILW(low and intermediate level radioactive waste) stored at KAERI, the radwaste drum assay system will be introduced to evaluate the radioisotopes inventory of stored drums. At present, the construction project of the dedicated assay facility to operate it and carry out routine maintenance of that equipment has been conducting at the radwaste treatment facility. Since that facility will be constructed in front of a 1st radwaste storage facility as well as the radwaste drums to be assayed and the transmission source in the radwaste drum assay system are in that facility, they could act as the radioactive sources and then, would affect the dose rate at the inside and the outside of the facility. Therefore, the radiation shielding should be evaluated through the concrete wall near to the radioactive sources whether the wall thickness is sufficient against the regulations. In this study, the radiation safety for the concrete wall around the radiation controlled area in the radwaste drum assay facility was evaluated by the MCNP code. From the evaluation results, the thickness of those concrete walls which are under consideration of about 30 cm was enough to shield the radiation from the radioactive sources.

An Overview of Operations and Applications of HF Ocean Radar Networks in the Korean Coast (한국연안 고주파 해양레이더망 운영과 활용 개관)

  • Kim, Ho-Kyun;Kim, Jung-Hoon;Son, Young-Tae;Lee, Sang-Ho
    • Korean Journal of Remote Sensing
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    • v.34 no.2_2
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    • pp.351-375
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    • 2018
  • This paper aims to i) introduce the characteristics of HF ocean radar and the major results and information produced by the radar networks in the Korean coasts to the readers, ii) make an up-to-date inventory of the existing radar systems, and iii) share the information related to the radar operating skill and the ocean current data application. The number of ocean radars has been showing a significant growth over the past 20 years, currently deploying more than 44 radars in the Korean coasts. Most of radars are in operation at the present time for the purposes related to the marine safety, tidal current forecast and understanding of ocean current dynamics, mainly depending on the mission of each organization operating radar network. We hope this overview paper may help expand the applicability of the ocean radar to fisheries, leisure activity on the sea, ocean resource management, oil spill response, coastal environment restoration, search and rescue, and vessel detection etc., beyond the level of understanding of tidal and ocean current dynamics. Additionally we hope this paper contributes further to the surveillance activity on our ocean territory by founding a national ocean radar network frame and to the domestic development of ocean radar system including signal processing technology.