• 한국터널지하공간학회 논문집
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• 제22권1호
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• pp.107-120
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• 2020

공용중인 시설물의 성능기반 평가에서 보유 성능은 성능별 평가지표를 유목화 한 후 각 성능에 대한 평가지표의 중요도를 고려하여 가중평균하여 평가한다. 본 연구에서는 NATM 터널의 성능기반 평가기법을 제시하기 위해 이전 연구에서 도출된 평가지표의 지표별 특성과 유사성 등을 분석하여 최종 평가지표를 도출하였다. 평가지표별로 상대적 중요도를 산출하여 평가지표의 가중치를 도출하였다. 정량적인 평가모형을 개발하기 위하여 지표별 성능등급 평가기준을 관련 문헌 및 선행연구 분석을 통해 도출하고, 도로 및 철도 터널의 유지관리 시 적용할 수 있는 성능평가표를 제시하였다. 제시된 성능평가 모형의 유의미함을 제시된 평가표를 실제 공용중인 터널에서 정밀안전진단을 통하여 측정된 조사자료에 적용하여 각 평가지표와 최종 평가결과와의 상관분석을 실시함으로써 검증하였다. 본 연구에서 제시된 공용중인 터널의 성능평가를 위한 평가지표, 가중치, 그리고 용도별 평가모형은 추후 터널의 성능중심 유지관리 체계에 적용되어 유지관리 전략 수립 시 활용될 수 있을 것으로 판단된다.

• 대한안전경영과학회:학술대회논문집
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• 대한안전경영과학회 2008년도 추계학술대회
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• pp.681-692
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• 2008

• 한국안전학회지
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• 제18권1호
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• pp.64-70
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• 2003

For the unconfined vapor cloud explosion(UVCE) accident by the continuous release of gas-liquid flow of various saturated liquids in a vessel at ground level, overpressures were estimated by TNT equivalency model with two estimation methods, such as UVCE I model based on a constant release time and UVCEII model based on a real travel time of vapor by dispersion and analyzed with various release conditions. As a simulation result the simple, easy, and correct method of evaluation of consequences of the UVCE accident was proposed by using consequences of UVCE I model and correlation equations for differences of overpressures between UVCE models, so that this evaluation method could be used easily in the small and medium size enterprises without using the dispersion model.

• 대한안전경영과학회:학술대회논문집
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• 대한안전경영과학회 2002년도 춘계학술대회
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• pp.91-97
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• 2002

In this thesis presents line balancing problems of two-sided and mixed model assembly line widely used in practical fields using genetic algorithm for reducing throughput time, cost of tools and fixtures and improving flexibility of assembly lines. Two-sided and mixed model assembly line is a special type of production line where variety of product similar in product characteristics are assembled in both sides. This thesis proposes the genetic algorithm adequate to each step in tow-sided and mixed model assembly line with suitable presentation, individual, evaluation function, selection and genetic parameter. To confirm proposed genetic algorithm, we apply to increase the number of tasks in case study. And for evaluation the performance of proposed genetic algorithm, we compare to existing algorithm of one-sided and mixed model assembly line. The results show that the algorithm is outstanding in the problems with a larger number of stations or larger number of tasks.

• 대한안전경영과학회지
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• 제4권2호
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• pp.83-101
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• 2002

In this thesis presents line balancing problems of two-sided and mixed model assembly line widely used in practical fields using genetic algorithm for reducing throughput time, cost of tools and fixtures and improving flexibility of assembly lines. Two-sided and mixed model assembly line is a special type of production line where variety of product similar in product characteristics are assembled in both sides. This thesis proposes the genetic algorithm adequate to each step in tow-sided and mixed model assembly line with suitable presentation, individual, evaluation function, selection and genetic parameter. To confirm proposed genetic algorithm, we apply to increase the number of tasks in case study. And for evaluation the performance of proposed genetic algorithm, we compare to existing algorithm of one-sided and mixed model assembly line. The results show that the algorithm is outstanding in the problems with a larger number of stations or larger number of tasks.

• 한국화재소방학회:학술대회논문집
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• 한국화재소방학회 1997년도 International Symposium on Fire Science and Technology
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• pp.384-391
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• 1997

The hazard assessment in which the potential hazard factors In the buildings are investigated and the scale of the hazard is analyzed should be performed first in order to prevent personal and material damages due to building fire. In this study, the building fire hazard are assessed using 822-item checklist, for the qualitative evaluation of which the main factors are classified into 10 items, yielding 100 scale points with some weighting. It is shown that present model is applicable for the assessment of all general buildings through the examination of the suitability of assessment model by actual assessment of existing building. Also, the checklist is prepared in itemized questionnaire form for easy assessment of building fire hazard. Therefore, the present model will be helpful for those working in fire prevention, who are suffering from the lack of manifest evaluation model for the fire prevention assessment so far in Korea.

• 약학회지
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• 제58권4호
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• pp.255-261
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• 2014

Poly-pharmacy has been on the rise because of aging of population and chronic disease. Most of drug metabolism happens in the liver by CYP isozymes and the metabolism by CYP450 enzymes. The Cytochrome P450 (CYP) is a superfamily of enzymes that catalyzes the oxidations of many endogenous and exogenous compounds. Primary human Hepatocytes (HH) are considered as the gold standard model for In vitro drug interaction studies. However, there are several limitations (cost, limited life span) for using HH cells. HepaRG cells are being used as a possible alternative. HepaRG cells were cultured in William E medium containing the positive control inducers (1A2: 10, 25, 50 ${\mu}M$ omeprazole, 2C9 and 2C19: 10 ${\mu}M$ rifampin, 3A4: 10, 25, 50 ${\mu}M$ rifampin) at $37^{\circ}C$, 5 % $CO_2$ in a humidified atmosphere. This study was to evaluate the induction of CYP isozymes (1A2, 2C9, 2C19 and 3A4) using LC-MS/MS. We evaluated the potential induction ability of Bosentan, as a drug of pulmonary artery hypertension, in HepaRG cells. For reference, dose of the Bosentan is determined to the basis of the $C_{max}$ (835 mg/ml) value. The enzyme activity demonstrated that CYP2C9 and 3A4 were induced up to 20 times by Bosentan. Like as In vivo, the enzyme activity of CYP2C9 and CYP3A4 is significantly induced in a dose-dependent by Bosentan.

• 한국안전학회지
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• 제35권6호
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• pp.54-60
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• 2020

Recently, the issue of construction safety is growing. In the construction industry, accidents have continued to increase since 2000. In particular, the number of accident deaths at small and medium-sized construction sites accounts for 72.11% of the total number of accident deaths in the construction industry. For construction safety, prior safety evaluation systems such as Design for safety and safety management plan preparation are in place. However, at construction sites, these systems are recognized as formal legal documents, and their effectiveness is greatly reduced. Therefore, in this study, a linkage model that links design safety review information and safety management plan information was presented so that the safety management plan can be efficiently established. In addition, the effectiveness of the proposed process was verified as an example of actual work. The linkage model will contribute to improving the safety management environment at the site by increasing the productivity of safety management work by enabling easy sharing of risk factor information in the construction stage safety management work. The results of this study will be used as basic information for the development of the integrated safety management system.

• Geomechanics and Engineering
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• 제30권3호
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• pp.313-324
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• 2022

With the development of the economy, people's utilization of underground space are also improved, and a large number of cities have begun to build subways to relieve traffic pressure. The choice of subway station construction method is crucial. If an inappropriate construction method is selected, it will not only waste costs but also cause excessive deformation that may also threaten construction safety. In this paper, a subway station construction scheme selects model based on the AHP-fuzzy comprehensive evaluation. The rationality of the model is verified using numerical simulation and monitoring measurement data. Firstly, considering the economy and safety, a comprehensive evaluation system is established by selecting several indicators. Then, the analytic hierarchy process is used to determine the weight of the evaluation index, and the dimensionless membership in the fuzzy comprehensive evaluation method is used to evaluate the advantages and disadvantages of the construction method. Finally, the method is applied to Liaoyang east road station of Qingdao metro Line 2, and the results are verified by numerical simulation and monitoring measurement data. The results show that the model is scientific, practical and applicable.

• 한국정보통신학회논문지
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• 제10권8호
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• pp.1435-1442
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• 2006

안전성에 대한 이상적인 평가방법은 운영체제내의 모든 가능한 연산을 대상으로 실행 결과의 안정성 여부를 검사하는 것이다. 하지만 이는 현실적으로 불가능하다. 그러나 정형기법을 사용할 경우 운영체제 동작논리상의 안전성 보장 여부를 이론적으로 증명할 수 있다. 따라서 본 논문에서는 보안커널의 안정성 검증방법에 대하여 논하고, 정형검증의 대표적인 도구들에 대하여 비교분석을 수행하였다. 그리고 보안커널에 기반한 다중레벨 접근통제모델인 수정된 BLP(Bell & LaPadula) 모델을 검증하기에 적합한 PVS(Prototype Verification System) 검증도구를 선정하였다. 마지막으로 PVS 검증도구를 활용하여 정형명세를 작성하고, 작성된 정형명세의 검증을 통하여 수정된 BLP 모델이 안전한 보안모델이라는 것을 검증하였다.