• Asian Pacific Journal of Cancer Prevention
• /
• 제15권11호
• /
• pp.4567-4570
• /
• 2014

Background: This systemic analysis was conducted to evaluate the efficacy and safety of pemetrexed based chemotherapy in treating patients with metastatic breast cancer as first or second line chemotherapy. Methods: Clinical studies evaluating the efficacy and safety of pemetrexed based regimens on response and safety for patients with breast cancer were identified using a predefined search strategy. Pooled response rate (RR) of treatment were calculated. Results: In first line pemetrexed based regimens, 10 clinical studies which including 513 patients with advanced breast cancer were considered eligible for inclusion. For second line pemetrexed based chemotherapy, 5 clinical studies which including 281 patients with advanced breast cancer were considered eligible. Systemic analysis suggested that, in all patients, pooled RR was 32.6% (167/513) in pemetrexed based first line regimens, and 13.9 % (39/281) in pemetrexed based second line regimens. Major adverse effects were neutropenia, leukopenia, fatigue, and anemia in pemetrexed based first line treatment; and lymphopenia, neutropenia, leukopenia, as well as anemia in second line chemotherapy. One treatment related death occurred with pemetrexed based second line treatment. Conclusion: This systemic analysis suggests that pemetrexed based first line regimens are associated with a reasonable response rate and acceptable toxicity, however with low response rate for treating patients with metastatic breast cancer when is used in the second line.

• 한국안전학회지
• /
• 제30권4호
• /
• pp.46-50
• /
• 2015

This paper describes the measurement and analysis of ground impedance according to arrangement of auxiliary probe around ground grid using the fall-of-potential method and the testing techniques to minimize the measuring errors are proposed. The fall-of-potential method involves passing a current between a ground electrode and a current probe, and then measuring the voltage between a ground electrode and a potential probe. To minimize interelectrode influences due to mutual resistances, the current probe is a generally placed at a substantial distance from the ground electrode under test. In order to analyze the effects of ground impedance due to the arrangement of auxiliary probe and frequency, ground impedances were measured in case that the arrangements of auxiliary probe were straight line, perpendicular line, and horizontal line. The distance of current probe was located from 10[m] to 200[m] and the measuring frequency was ranged from 55[Hz] to 513[Hz]. As a consequence, the ground impedance increases with increasing the distance from the ground electrode to the point to be tested, but the ground impedance decreases with increasing the frequency.

• 한국항행학회논문지
• /
• 제18권4호
• /
• pp.319-324
• /
• 2014

LOSA(line operation safety audit)는 정상적인 운항 상태에서 운항 승무원이 발생할 수 있는 사고를 수집하기 위한 선제적 데이터 수집 방식으로 비행 중 발생하는 TEM(threat error management)과 CRM(crew resource management) 등을 수집하는 안전관리프로그램이다. 기존의 LOSA 기록 방식은 워크시트(worksheet) 에 관찰자가 직접 작성하여 자료를 보관하고 관리를 수행하였으나, 자료 보관의 어려움과 비밀 보장이 어려운 문제점이 있다. 기존의 LOSA 수집방식 대신 웹(web) 형태로 한국형 LOSA(K-LOSA)를 구현과 TEM 분류 코드를 변경하므로 효과적인 자료 관리 및 비밀 보장성을 확보하였다. 본 논문에서는 LOSA에 대하여 살펴보고 K-LOSA 프로그램의 구성을 소개한다.

• Nuclear Engineering and Technology
• /
• 제53권8호
• /
• pp.2477-2487
• /
• 2021

To improve safety analysis technology for a nuclear reactor containment considering an interaction between a reactor coolant system (RCS) and containment, this study aims at an experimental investigation on the integrated simulation of the RCS and containment, with an integral effect test facility, ATLAS-CUBE. For a realistic simulation of a pressure and temperature (P/T) transient, the containment simulation vessel was designed to preserve a volumetric scale equivalently to the RCS volume scale of ATLAS. Three test cases for a steam line break (SLB) transient were conducted with variation of the initial condition of the passive heat sink or the steam flow direction. The test results indicated a stratified behavior of the steam-gas mixture in the containment following a high-temperature steam injection in prior to the spray injection. The test case with a reduced heat transfer on the passive heat sink showed a faster increase of the P/T inside the containment. The effect of the steam flow direction was also investigated with respect to a multi-dimensional distribution of the local heat transfer on the passive heat sink. The integral effect test data obtained in this study will contribute to validating the evaluation methodology for mass and energy (M/E) and P/T transient of the containment.

• Nuclear Engineering and Technology
• /
• 제36권5호
• /
• pp.388-402
• /
• 2004

A phenomena identification and ranking table(PIRT) was developed for a main steam line break (MSLB) event for the Advanced Power Reactor-1400 (APR-1400). The selectee event was a double-ended steam line break at full power, with the reactor coolant pump running. The developmental panel selected the fuel performance as the primary safety criterion during the ranking process. The plant design data, the results of the APR-1400 safety analysis, and the results of an additional best-estimate analysis by the MARS computer code were used in the development of the PIRT. The period of the transient was composed of three phases: pre-trip, rapid cool-down, and safety injection. Based on the relative importance to the primary evaluation criterion, the ranking of each system, component, and phenomenon/process was performed for each time phase. Finally, the knowledge-level for each important process for certain components was ranked in terms of existing knowledge. The PIRT can be used as a guide for planning cost-effective experimental programs and for code development efforts, especially for the quantification of those processes and/or phenomena that are highly important, but not well understood.

• International Journal of Railway
• /
• 제3권2호
• /
• pp.68-72
• /
• 2010

Railway vehicles equipped with semi-active suspension system can improve the ride quality of car bodies. Semi-active suspension system is usually applied onto high speed train, and therefore higher running safety requirement is desirable. The influence of semi-active suspension system on safety of vehicles running on straight line and curve line is studied, and the influences of sky hook damping coefficient and system time-delay on operational safety of cars fitted with semiactive suspension system is analyzed. The results show that in vehicles equipped with semi-active suspension system, while the vibration of car body is decreased, the running safety of cars is not affected to any significant degree. As a result, the ride quality is much improved with negligible deterioration of the running safety of cars.

• 한국안전학회지
• /
• 제11권2호
• /
• pp.128-135
• /
• 1996

The aim of this study is that HPMA(Hazard Potentials in My Areas) System is to present for establishment of the voluntary safety management on industrial region. HPMA System Itself means that manager, supuryisor and worker on process-line find out the hazardous and/or unsafe potentials from their work places and make the plan of improvement by means of mutual communication with top manager and the department of safety staff, eventually put in the practice. In case that it takes the longer time to improve hazard potentials and is impossible improvement by existing technique, appropriate check-list will be used by the worker himself on the identified production line. Form this system, therefore, it makes them to get more and more sensitivity to the hazards. In this study, we present the voluntary safety management system which is controlable systematically and in the final analysis the direction of safety management by computerization of HPMA System which is activated in their work places.

• International Journal of Railway
• /
• 제2권4호
• /
• pp.147-151
• /
• 2009

Railway vehicles equipped with semi-active suspension system can improve the ride quality of car bodies. Semi-active suspension system is usually applied onto high speed train, and therefore higher running safety requirement is proposed. The influence of semi-active suspension system on safety of vehicles running on straight line and curve line is studied, and the influences of sky hook damping coefficient and system time-delay on operation safety of cars fitted with semiactive suspension system is analyzed. The results show that the vehicles equipped with semi-active suspension system, not only the vibration of car body is decreased, it can also give little influence on running safety of cars, as a result, it will not endanger the running safety of cars.

• 한국환경농학회:학술대회논문집
• /
• 한국환경농학회 2009년도 정기총회 및 국제심포지엄
• /
• pp.119-126
• /
• 2009

In recent years, research at the Environmental Microbial and Food Safety Laboratory (EMFSL), Agricultural Research Service (ARS) has focused on the development of novel image-based sensing technologies to address agro-food safety concerns, and transformation of these novel technologies into practical instrumentation for industrial implementations. The line-scan-based hyperspectral imaging techniques have often served as a research tool to develop rapid multispectral methods based on only a few spectral bands for rapid online applications. We developed a newer line-scan hyperspectral imaging platform for high-speed inspection on high-throughput processing lines, capable of simultaneous multiple inspection algorithms for different agro-food safety problems such as poultry carcass inspection for wholesomeness and apple inspection for fecal contamination and defect detection. In addition, portable imaging devices were developed for in situ identification of contamination sites and for use by agrofood producer and processor operations for cleaning and sanitation inspection of food processing surfaces. The aim of this presentation is to illustrate recent advances in the above agro.food safety sensing technologies.

• 한국해양공학회지
• /
• 제26권4호
• /
• pp.77-85
• /
• 2012

A study was performed on the design of a mooring line to maintain the position of a floating WEC (wave energy conversion) system. The procedure to design a mooring line is set up and the safety of the designed mooring system is evaluated using commercial software, Orcaflex. The characteristics curve for one line is analyzed to determine the properties and pretension of a mooring line. While considering the ocean environmental condition and importance of a floating WEC system, a multi-line layout is determined. A 4-point mooring system with 4 lines shows the instability in the yaw motion of the floating WEC system under a designed ocean environmental condition. The redesigned 4-point mooring system with 8 lines is found to be safe on the condition of a harsh ocean environment. The floating WEC system with the redesigned mooring system also shows stable motion in surge and pitch under operating conditions. From a parametric study on the mooring line length, the extreme value of the mooring line tension is found to be very sensitive to the pretension and length of mooring line. The results of this study can contribute to the establishment of a design procedure for mooring lines.