• Medical Lasers
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• v.10 no.2
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• pp.90-95
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• 2021

Background and Objectives Surgery for harvesting costal cartilage is often required for revision septorhinoplasty due to a lack of septal cartilage in patients with a severely contracted nose, and postoperative scarring on the anterolateral rib cage commonly requires additional treatment. This study aimed to evaluate the therapeutic efficacy and safety of combined polydeoxyribonucleotide (PDRN) and microlens array (MLA)-type nanosecond-domain neodymium (Nd):yttrium-aluminum-garnet (YAG) laser treatment for postoperative scars after costal cartilage harvest surgery. Materials and Methods Nine Korean patients with scars after costal cartilage harvest surgery treated with PDRN injections and MLA-type Nd:YAG laser treatments were retrospectively reviewed. Results Most of the scar lesions exhibited clinical improvement at 2 weeks after PDRN and MLA-type nanosecond-domain laser treatments, and the lesions further improved after adding more treatment sessions. The median Vancouver Scar Scale (VSS) score decreased from 6 (interquartile range [IQR]: 6-7) before combined intralesional PDRN injection and MLA-type, nanosecond-domain Nd:YAG laser treatments to 3 (IQR: 2-4) thereafter. Patient satisfaction after the combination treatments was rated as satisfactory. None of our patients reported major adverse events. Conclusion This case series study demonstrated that combined PDRN and MLA-type, nanosecond-domain Nd:YAG laser treatments are effective and safe for treating scars from costal cartilage harvest surgery.

• Proceedings of the Korean Nuclear Society Conference
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• 1996.05b
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• pp.429-434
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• 1996

K-REM［1］, which is under development as a realistic evaluation model of large break LOCA, is applied to the analysis of cold leg guillotine break of Ulchin 3&4. Fuel parameters on which statistical analysis of their effects on the peak cladding temperature (PCT) are made and system parameters on which the concept of limiting value approach (LVA) are applied, are determined from the single parameter sensitivity study. 3 parameters of fuel gap conductance, fuel thermal conductivity and power peaking factor are selected as fuel related ones and 4 parameters of axial power shape, reactor power, decay heat and the gas pressure of safety injection tank (SIT) are selected as plant system related ones. Response surface of PCT is generated from the plant calculation results and on which Monte Carlo sampling is made to get plant application uncertainty which is statistically combined with code uncertainty to produce the 95th percentile PCT. From the break spectrum analysis, blowdown PCT of 1350.23 K and reflood PCT of 1195.56 K are obtained for break discharge coefficients of 0.8 and 0.5, respectively.

• Journal of Microbiology and Biotechnology
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• v.33 no.1
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• pp.43-50
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• 2023

Fungal keratitis is a refractory kind of keratopathy. We attempted to investigate the antiinflammatory role of thymol on Aspergillus fumigatus (A. fumigatus) keratitis. Wound healing and fluorescein staining of the cornea were applied to verify thymol's safety. Mice models of A. fumigatus keratitis underwent subconjunctival injection of thymol. The anti-inflammatory roles of thymol were verified by hematoxylin-eosin (HE) staining, slit lamp observation, quantitative real-time polymerase chain reaction (qRT-PCR), and Western blotting. In contrast with the DMSO group, more transparent corneas and less inflammatory cells infiltration were detected in mice treated with 50 ㎍/ml thymol. Thymol downregulated the synthesis of TLR4, MyD88, NF-kB, IL-1β, NLRP3, caspase 1, caspase 8, GSDMD, RIPK3 and MLKL. In summary, we proved that thymol played a protective part in A. fumigatus keratitis by cutting down inflammatory cells aggregation, downregulating the TLR4/ MyD88/ NF-kB/ IL-1β signal expression and reducing necroptosis and pyroptosis.

• Nuclear Engineering and Technology
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• v.54 no.11
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• pp.4373-4391
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• 2022

Marine reactor systems experience platform movement, and therefore, the system thermal-hydraulic analysis code needs to reflect the motion effect on the fluid to evaluate reactor safety. A moving reactor model for MARS-KS was developed to simulate the hydrodynamic phenomena in the reactor under motion conditions; however, its applicability does not cover the MULTID component used in multidimensional flow analyses. In this study, a moving reactor model is implemented for the MULTID component to address the importance of multidimensional flow effects under dynamic motion. The concept of the volume connection is generalized to facilitate the handling of the junction of MULTID. Further, the accuracy in calculating the pressure head between volumes is enhanced to precisely evaluate the additional body force. Finally, the Coriolis force is modeled in the momentum equations in an acceleration form. The improvements are verified with conceptual problems; the modified model shows good agreement with the analytical solutions and the computational fluid dynamic (CFD) simulation results. Moreover, a simplified gravity-driven injection is simulated, and the model is validated against a ship flooding experiment. Throughout the verifications and validations, the model showed that the modification was well implemented to determine the capability of multidimensional flow analysis under ocean conditions.

• Nuclear Engineering and Technology
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• v.55 no.4
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• pp.1448-1459
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• 2023

A key element of the safety analysis is Loss of Coolant Analysis (LOCA) which must be performed using system thermal-hydraulic codes. These codes are extensively validated against separate effect and integral experiments. RELAP/SCDAPSIM is one such code that may be used to predict LBLOCA response in a CANDU reactor. The RD-14M experiment selected for the Best Estimate Plus Uncertainty study is a 44 mm (22.7%) inlet header break test with no Emergency Coolant Injection. This work has two objectives first is to simulate pipe break with RELAP and compare these results to those available from experiment and from comparable TRACE calculations. The second objective is to quantify uncertainty in the fuel element sheath (FES) temperature arising from model coefficient as well as input parameter uncertainties using Integrated Uncertainty Analysis package. RELAP calculated results are found to be in good agreement with those of TRACE and with those of experiments. The base case maximum FES temperature is 335.5 ℃ while that of 95% confidence 95^th percentile is 407.41 ℃ for the first order Wilk's formula. The experimental measurements fall within the predicted band and the trends and sensitivities are similar to those reported for the TRACE code.

• Nuclear Engineering and Technology
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• v.56 no.4
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• pp.1513-1525
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• 2024

An improved mitigation system for thermally-induced steam generator tube rupture accidents was introduced to prevent direct environmental release of fission products bypassing the containment in the OPR1000. This involves injecting bypassed steam into the containment, cooling, and decontaminating it using a water coolant tank. To evaluate its performance, a severe accident analysis was performed using the MELCOR 2.2 code for OPR1000. Simulation results show that the proposed system sufficiently prevented the release of radioactive nuclides (RNs) into the environment via containment injection. The pool scrubbing system effectively decontaminated the injected RN and consequently reduced the aerosol mass in the containment atmosphere. However, the decay heat of the collected RNs causes re-vaporization. To restrict the re-vaporization, an external water source was considered, where the decontamination performance was significantly improved, and the RNs were effectively isolated. However, due to the continuous evaporation of the feed water caused by decay heat, a substantial amount of steam is released into the containment. Despite the slight pressurization inside the containment by the injected and evaporated steam, the steam decreased the hydrogen mole fraction, thereby reducing the possibility of ignition.

• Nuclear Engineering and Technology
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• v.56 no.6
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• pp.2079-2091
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• 2024

In this paper, a model is developed for calculating pH in the presence of organic impurities due to dissolution of paint and/or continuous injection of organic impurities in the sump. The model is implemented in the AnCheBi code for the analysis of chemical behaviors of the iodine in the containment when the pH changes during a severe accident. Validation of the model is performed with P10T2 and P11T1 experiments carried out by AECL in Canada under the BIP project. Importance analyses of the pH calculation model in the AnCheBi code are then performed with the aforementioned experimental data via Latin hypercube sampling on the reaction coefficients, sensitivity analyses of AnCheBi, and calculation of the correlation coefficients between the reaction coefficients and figure of merits (the pH and the concentrations of the various iodine species). From the importance analyses, we provide the sensitivity of the pH calculation model to the change of pH and the concentrations of the various iodine species and the reaction coefficients related with the dominant phenomena underlying the change of pH and the concentrations of the species.

• Oncology Letters
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• v.17 no.3
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• pp.2576-2582
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• 2019

Gestational trophoblastic disease (GTD) is an unusual disease occurring in pregnancy that originates from abnormal trophoblastic cells and comprises a group of diseases with different properties of invasion, metastasis and recurrence. The GTD group includes hydatidiform moles and gestational trophoblastic neoplasms (GTNs), with GTNs being divided into invasive moles, choriocarcinoma, placental site trophoblastic tumors and epithelioid trophoblastic tumors. The present review focuses on current effective treatments for GTD, including conventional and novel promising direct enzyme prodrug therapies (DEPTs). Conventional therapies, such as chemotherapy and hysterectomy, are currently used in a clinical setting; however, the use of diverse DEPTs, including antibody-DEPT and gene-DEPT is also being attempted to cure GTNs. In addition, gene delivery tools using genetically engineered neural stem cells (NSCs) are presently being examined for the treatment of GTNs. The tumor-tropism of NSCs by chemoattractant factors is a unique characteristic of these cells and can serve as a vehicle to deliver anticancer agents. Previous studies have demonstrated that injection with NSC-expressing suicide genes into xenograft animal models has a significant inhibitory effect on tumor growth. Stem cells can be genetically engineered to express anticancer genes, which migrate to the metastatic sites and selectively target cancer cells, and are considered to effectively target metastatic GTNs. However, the safety issue of stem cell therapy, such as tumorigenesis, remains a challenge. Novel therapies comprising a combination of conventional and novel promising treatments are anticipated to be definitive treatments for metastasized and/or recurrent patients with GTNs.

• Journal of the Society of Disaster Information
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• v.11 no.4
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• pp.556-569
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• 2015

With about 75% of the population of Korea criticizing the government's disaster policy and a failure to respond to large-scale emergency like the Sewol ferry sinking means that there is a deep distrust in the government. In order to prevent dreadful disasters such as the Sewol ferry sinking, it is important to secure a prime time with respect to disaster safety. Improving crisis management skills and managerial role of police officers who are in close proximity to the people is necessary for the success of disaster management. With disaster management as one of the most essential missions of the police, as a part of a national crisis management, a step by step strengthening of the disaster safety management system of the police is necessary, as below. First, at the prevention phase, law enforcement officers were not injected into for profit large-scale assemblies or events, but in the future the involvement, injection should be based on the level of potential risk, rather than profitability. In the past and now, the priortiy was the priority was on traffic flow, traffic communication, however, the paradigm of traffic policy should be changed to a safety-centered policy. To prevent large-scale accidents, police investigators should root out improper routines and illegal construction subcontracting. The police (intelligence) should strengthen efforts to collect intelligence under the subject of "safety". Second, with respect to the preparatory phase, on a survey of police officers, the result showed that 72% of police officers responded that safety management was not related to the job descriptions of the police. This, along with other results, shows that the awareness of disaster safety must be adopted by, or rather changed in the police urgently. The training in disaster safety education should be strengthened. A network of experts (private, administrative, and police) in safety management should be established to take advantage of private resources with regard to crisis situtions. Third, with respect to the response phase, for rapid first responses to occur, a unified communication network should be established, and a real-time video information network should be adopted by the police and installed in the police situation room. Fourth, during the recovery phase, recovery teams should be injected, added and operated to minimize secondary damage.

• Tuberculosis and Respiratory Diseases
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• v.51 no.1
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• pp.25-34
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• 2001

Background : Inhaled glucocorticoids are the medical treatment of choice in asthma patients. Fluticasone propionate is one of the most effective inhaled corticosteroids and has been reported to have minimal effect on the hypothalamic-pituitary-adrenal axis at the recommended dose. However, reports of long-term trials characterizing their systemic safety with chronic use are rare. This study was designed to evaluate the long-term safety of inhaled fluticasone propionate to the hypothalamic-pituitary-adrenal axis. Method : This study was conducted on 21 patients to evaluate the adrenal response to rapid ACTH stimulation test after 6 months of treatment with fluticasone propionate from $200\;{\mu}g$ to $750\;{\mu}g$ daily. The serum cortisol levels was measured to assess its effect on the hypothalamic-pituitary-adrenal axis just prior to the injection, at 30 minutes and 60 minutes after an intramuscular injection of synthetic ACTH. Result : The mean dose of inhaled fluticasone propionate was $355\;{\mu}g$ per day(SD=$174\;{\mu}g$, range=$200\;{\mu}g$ to $750\;{\mu}g$). The mean serum cortisol levels of the patients was $11.0\;{\mu}g/d{\ell}$(SD=$6.4\;{\mu}g/d{\ell}$) prior to the injection, $20.0\;{\mu}g/d{\ell}$ (SD=$7.7\;{\mu}g/d{\ell}$) after 30 minutes, and $23.0\;{\mu}g/d{\ell}$(SD=$6.3\;{\mu}g/d{\ell}$) after 60 minutes. Sixteen patients of the 21 patients had a normal response(> $18\;{\mu}g/d{\ell}$), and 5 out of the 21 patients had serum cortisol levels below the normal range after the rapid ACTH stimulation test. Conclusion: Adrenal suppression occurred in 5 out of 21 patients with 6 months treatment with inhaled fluticasone propionate.