• Information Systems Review
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• v.21 no.3
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• pp.49-61
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• 2019

As the number of security incidents and damages increase steadily, interest in the security of society is growing, and the amount of academic interest and research is steadily increasing. However, despite these concerns and the quantitative increase in research, the terms 'security' and 'safety' have been mixed and studies have been conducted without the conceptual definition of various security terms being clearly defined. As a result, various forms of security concepts based on ICT environments have been misused. Therefore, we tried to derive the consensus of experts among the various security terms which are mixed in this study, and to summarize the concepts based on the analysis of domestic and foreign documents based on the concept of the terms. Through this research, we intend to contribute to the establishment of the academic identity of security by preventing related mistakes caused by the mixed use of terminology.

• IMMUNE NETWORK
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• v.20 no.4
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• pp.31.1-31.14
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• 2020

The effectiveness of current influenza vaccines is considered suboptimal, and 1 way to improve the vaccines is using adjuvants. However, the current pool of adjuvants used in influenza vaccination is limited due to safety concerns. Aloe vera, or aloe, has been shown to have immunomodulatory functions and to be safe for oral intake. In this study, we explored the potential of orally administered processed Aloe vera gel (PAG) as an adjuvant for influenza vaccines in C57BL/6 mice. We first evaluated its adjuvanticity with a split-type pandemic H1N1 (pH1N1) Ag by subjecting the mice to lethal homologous influenza challenge. Oral PAG administration with the pH1N1 Ag increased survival rates in mice to levels similar to those of alum and MF59, which are currently used as adjuvants in influenza vaccine formulations. Similarly, oral PAG administration improved the survival of mice immunized with a commercial trivalent influenza vaccine against lethal homologous and heterologous virus challenge. PAG also increased hemagglutination inhibition and virus neutralization Ab titers against homologous and heterologous influenza strains following immunization with the split-type pH1N1 Ag or the commercial trivalent vaccine. Therefore, this study demonstrates that PAG may potentially be used as an adjuvant for influenza vaccines.

• Journal of Advanced Navigation Technology
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• v.28 no.2
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• pp.201-209
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• 2024

This study investigates the operational facets of low-density urban air mobility (UAM) from an airline's perspective amid burgeoning concerns about urban congestion in megacities. UAM, employing electric vertical takeoff and landing (eVTOL) technology, emerges as a potential remedy to the challenges of traffic gridlock and environmental degradation. As the UAM market progresses from initial stages to maturity, tailored traffic control systems become paramount. Focused on the context of low-density environments during UAM's inception, this research scrutinizes operational frameworks, essential infrastructure, and likely scenarios. It aims to bolster the safety and efficiency of UAM operations by delving into the specifics of traffic control concepts designed for these unique settings. The study seeks to significantly contribute to optimizing UAM's initial phases, providing insights into crucial operational dynamics for a smoother integration of urban air mobility into contemporary urban landscapes.

• Journal of Dental Anesthesia and Pain Medicine
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• v.24 no.1
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• pp.67-73
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• 2024

Background: Nitrous oxide has been an integral part of surgical anesthesia for many years in the developed world and is still used in developing countries such as India. The other main concerns in low-resource countries are the lack of an advanced anesthesia gas-scavenging system and modular surgical theatres. As a greenhouse gas that has been present in the atmosphere for more than 100 years and damages the ozone layer, nitrous oxide is three times worse than sevoflurane. Here, we conducted an observational study to quantify the annual nitrous oxide consumption and its environmental impact in terms of carbon dioxide equivalence in one of busiest tertiary health care and research centers in Northern India. Methods: Data related to nitrous oxide expenditure' from the operation theatre and manifold complex of our tertiary care hospital and research center from 2018 to 2021 were collected monthly and analyzed. The outcomes were extracted from our observational study, which was approved by our institutional ethics board (INT/IEC/2017/1372 Dated 25.11.2017) and registered prospectively under the Central Registry (CTRI/2018/07/014745 Dated 05.07.2018). Results: The annual nitrous oxide consumption in our tertiary care hospital was 22,081.00, 22,904.00, 17,456.00, and 18,392.00 m³ (cubic meters) in 2018, 2019, 2020, and 2021, respectively. This indicates that the environmental impact of nitrous oxide (in terms of CO₂ equivalents) from our hospital in 2018, 2019, 2020, and 2021 was 13,016.64, 13,287.82, 10,289.94, and 10,841.24 tons, respectively. Conclusion: This huge amount of nitrous oxide splurge is no longer a matter of laughter, and serious efforts should be made at every central and peripheral health center level to reduce it.

• Animal Bioscience
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• v.37 no.4_spc
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• pp.775-785
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• 2024

Pork production is a significant agricultural enterprise in the United States and Canada. The United States is the third-largest global producer of pork and Canada ranks seventh in pork production. The North American Free Trade Agreement and its successor, the U.S.-Mexico-Canada Agreement, have facilitated trade and integration between the two countries. The majority of production systems are modern and intensive, characterized by large vertically integrated farms using advanced technologies. Both nations benefit from their status as major producers of feed grains, with the United States leading in corn and soybeans, while Canada excels in canola and barley production. The regulatory frameworks for food safety, animal welfare, and environmental stewardship differ slightly, with the FDA and USDA overseeing these aspects in the United States, and Health Canada and the Canada Food Inspection Agency in Canada. The United States and Canada also have well-established distribution networks for pork products, relying on both domestic and international markets. Export markets play a crucial role, with the United States being a major importer of Canadian pigs, and both countries exploring opportunities in Asia. Despite a rise in global demand, domestic pork consumption trends differ, with per capita consumption remaining stable in the USA and declining in Canada. Changing consumer preferences, including a demand for ethically raised and locally sourced pork, may influence production practices. Future trends in pig production include a focus on consumer concerns, sustainability, disease prevention, reduction of antimicrobial use, and advancements in technology. The industry is adapting to challenges such as disease outbreaks and changing regulations, with a strong emphasis on animal welfare. Labor and workforce considerations, along with advancements in technology and automation, are expected to shape the efficiency of pork production in the future.

• The Korean Journal of Pain
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• v.37 no.2
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• pp.119-131
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• 2024

There are growing concerns regarding the safety of long-term treatment with opioids of patients with chronic non-cancer pain. In 2017, the Korean Pain Society (KPS) developed guidelines for opioid prescriptions for chronic non-cancer pain to guide physicians to prescribe opioids effectively and safely. Since then, investigations have provided updated data regarding opioid therapy for chronic non-cancer pain and have focused on initial dosing schedules, reassessment follow-ups, recommended dosage thresholds considering the risk-benefit ratio, dose-reducing schedules for tapering and discontinuation, adverse effects, and inadvertent problems resulting from inappropriate application of the previous guidelines. Herein, we have updated the previous KPS guidelines based on a comprehensive literature review and consensus development following discussions among experts affiliated with the Committee on Hospice and Palliative Care in the KPS. These guidelines may assist physicians in prescribing opioids for chronic non-cancer pain in adult outpatient settings, but should not to be regarded as an inflexible standard. Clinical judgements by the attending physician and patient-centered decisions should always be prioritized.

• The Korea Journal of Herbology
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• v.39 no.4
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• pp.1-9
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• 2024

Objective : In this study, the anti-obesity effect of Fragaria orientalis (FO) on high-fat diet-induced obese mice was investigated. Drug treatment methods are widely used as obesity treatment methods, but research using various natural products is being conducted due to safety concerns. This study aims to evaluate the anti-obesity effect of FO extract, a natural product derived from Mongolia. Methods : C57BL/6 mice were used and divided into three groups, normal diet group, high-fat diet group, and high-fat diet with FO oral treatment group at a dose of 300 mg/kg. Extract was orally provided everyday for 6 weeks. Body Weight and food intake were measured every 2 days and blood lipid profiles and liver function in the sacrificed mice were evaluated. In addition, protein expression in hepatic tissue and histomorphological changes in liver and adipose tissue were observed. Results : Body weight, adipose tissue weight and FER were significantly lower in a high-fat diet with FO treatment than fed only high-fat diet. There was a significant difference between the high-fat diet and the FO-treated high-fat diet mice. As a result of analyzing lipid metabolism-related genes in hepatic tissue, all of p-AMPK, p-ACC, PPAR-α, CPT-1, and UCP-1 showed significant increases, and PPAR-γ also decreased significantly compared to the high-fat diet group. Conclusion : Overall, these results indicate that FO is effectual in improving obesity, suggesting that it can be used as a possible material for anti-obesity agents or functional supplements for weight control.

• The Journal of the Convergence on Culture Technology
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• v.10 no.4
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• pp.311-321
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• 2024

This study comprehensively analyzed the perceptions of Chinese consumers who have and have not purchased Samsung smartphones, based on data from the social media platform Weibo. Various big data analysis techniques were used, including text mining, frequency analysis, centrality analysis, semantic network analysis, and CONCOR analysis. The results indicate that positive perceptions of Samsung smartphones include aspects such as design aesthetics, camera functionality, AI features, screen quality, specifications, and performance, and their status as a premium brand. On the other hand, negative perceptions include issues with pricing, a yellow tint in photos, slow charging speeds, and safety concerns. These findings will provide a crucial basis for making significant improvements in Samsung's market strategy in China.

• Korean Journal of Microbiology
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• v.43 no.3
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• pp.151-158
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• 2007

The possibility of inadvertent introduction of therapeutic gene expressing viral vectors has raised safety concerns about germ-line infection. Particularly, for indications such as prostate cancer and ovarian cancer, the proximity of the point of viral administration to organs of the reproductive system raises concerns regarding inadvertent germ-line transmission of genes carried by the virus vector. To evaluate the safety of in vivo adenovirus mediated gene transfer, we explored the biodistribution, persistance and potential germ-line transmission of p53-expressing adenovirus (Ad-CMV-p53). Both male and female Balb/c mice were injected with $1{\times}10^9$ PFU of Ad-CMV-p53. The PCR analysis showed that there were detectable vector sequences in liver, kidney, spleen, seminal vesicle, epididymis, prostate, ovary, and uterus. The RT-PCR analysis for detecting inserted gene, p53 showed that Ad-CMV-p53 viral RNA were present in spleen, prostate and ovary. Direct injected male and female mice of adenovirus vector into testis and ovary were mated and their of offspring were evaluated for germ-line transmission of the adenoviral vector. The PCR and RT-PCR analysis showed no evidence of germline transmission, although vector sequences were detected in DNA extracted from gonadal tissues. Real-time PCR result confirmed a significant decrease of adenovirus in gonad tissues 1 week after injection. We have also analysed the cell specific localization of viral DNA in gonad tissues by using in-situ PCR. Positive signals were detected in interstitial tissue but not in seminiferous tubule in sperm. In the case of ovary, adenovirus signal were localized to the stromal tissue, but no follicular signals were observed. Together, these data provide strong evidence that the risk of the Inadvertent germ-line transmission of vector sequences following intraperitoneal or direct injection into genito-urinary system of adenovirus is extremely low.

• Journal of the Korean GEO-environmental Society
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• v.8 no.2
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• pp.11-18
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• 2007

Slope failure triggered by rainfall produces severe effects on the serviceability and stability of railway, Therefore, slope stability problem is one of the major concerns on the operation of railway. In this study, the rainfall conditions triggering slopes failure adjacent to railroads are investigated and the numerical analysis approach in consideration of infiltration and limit equilibrium method based upon multiple slip surfaces are proposed. The rainfall conditions triggering slope failure are as follow: cumulative rainfall is in the range of 150~500 mm, and duration is from 3 to 24 hours. Base upon the rainfall conditions, infiltration analysis and limit equilibrium method for infinite slope condition are carried out. The depth of infinite slope is assumed as 2 m and the multiple slip surfaces modeled with 16.7 cm interval from the bottom slip surface located at the 2 m depth. The assumed bottom slip surface is the location at which factor of safety is converging. The proposed approach shows more reasonable results than the results from the general codes assuming water table at slope surface. In addition, three dimensional plot of cumulative rainfall, rainfall duration, and factor of safety shows that slope stability analysis in consideration of rainfalll must account for cumulative rainfall (rainfall duration).