• Toxicological Research
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• v.20 no.2
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• pp.159-166
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• 2004

Safety pharmacological properties of CJ-11555, an anti-cirrhotic agent, were investigated in experimental animals and in vitro test system. CJ-11555 had no effects on normal body temperature in rats, motor coordination, chemoshock induced by pentetrazol, electric shock induced by electric shocker and writhing syndromes in mice at dose levels of 100, 300 and 1,000 mg/kg. CJ-11555 inhibited intestinal activity and prolonged hexobarbital-induced sleeping time in mice at the dose level of 1,000 mg/kg. CJ-11555 affected on general activity and behaviour tests in SD rats, such as lacrimation, ptosis, piloerection, decreased body tone, abnormal dispersion within the cage, diarrhoea, red colored faeces, slight hypothermia and decreased grooming, at the dose level of 1,000 mg/kg in rats. CJ-11555 was effected on cardiovascular and respiratory system in anesthetized beagle dogs, such as tachycardia, increase of mean blood pressure and decrease of PR interval, decrease of respiratory rate and minute volume, at dose levels of 10 and 30 mg/kg. However, these effects were also observed in vehicle treated anesthetized beagle dogs. In in vitro experiments, CJ-11555 inhibited agonists (histamine, acetyl-choline or $BaCl_2$) induced contraction of isolated guinea-pig at the concentration of 30$\times$$10^6$ M. CJ-11555 was weekly inhibited hERG channel current at concentrations of 10 and 30$\times$$10^6$ M, and $IC_{50}$ was estimated to be higher than 30${\times}$$10^6$M. Based on these results, it was concluded that CJ-11555 affected on cardiovascular and respiratory system, general activity and behaviour and hexobarbital-induced sleeping time at the dose level of 1,000 mg/kg and contraction of the smooth muscle and hERG channel current at the concentration of 30$\times$$10^6$ M.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.13 no.2
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• pp.57-67
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• 2014

In the last decade, various situations were simulated through virtual environment due to rapid improvement of computer capability and technology. Transportation engineering also has adopted the virtual environment facility in order to identify drivers behaviour under various circumstances. This study aims to evaluate driver reactions to the introduction of new ITS interventions at railway crossings (RLX) in driving simulator. Three ITS safety devices were used to figure out how drivers reacted to them. In addition, a survey was conducted to find participants' work load and acceptance of the technology. The ultimate purpose of this paper is to evaluate ITS safety devices in various aspects. Each participant made 3 runs (2 baselines, 1 ITS randomly) for approximately 20 minutes each. The participants answered that current railway crossings did not look safe prior to experiment. They responded that the use of ITS technologies were easy and the technologies were more effective on passive railway crossings.

• Journal of the Korean Society of Marine Environment & Safety
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• v.12 no.1 s.24
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• pp.39-45
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• 2006

Based on the previous studies on alcohol effects on human behaviour and performance in transportation system such as air-plane and car driving, the alcohol exposure before and on watch of a ship has a great influence on subsequent behaviour. In this paper, to examine the drinking status of officers on board multiple choice questionnaires are circularized under instruction and surveyed for 118 officers. According to the results of the questionnaire survey on alcohol dependency (Alcoholism) that was invented by WHO, over 27 % of those surveyed represented alcohol abuse symptoms. In addition to that, the existing state and awareness for on-board-drinking was summarized to make a scenario of drink-operation with a ship handling simulator to investigate the effect of alcohol (0.08 g% blood alcohol concentrations) on ship operational performance. A main effect for alcohol was found indicating that ship operational performance was comparatively impaired by this alcohol relative to performance in the non-alcohol condition The results of this research can be applied to minimize marine accidents as basic data.

• Nuclear Engineering and Technology
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• v.55 no.3
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• pp.884-894
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• 2023

Design and safety assessment of fuel pins for application in innovative Generation IV fast reactors calls for a dedicated nuclear fuel modelling and for the extension of the fuel performance code capabilities to the envisaged materials and irradiation conditions. In the INSPYRE Project, comprehensive and physics-based models for the thermal-mechanical properties of U-Pu mixed-oxide (MOX) fuels and for fission gas behaviour were developed and implemented in the European fuel performance codes GERMINAL, MACROS and TRANSURANUS. As a follow-up to the assessment of the reference code versions ("pre-INSPYRE", NET 53 (2021) 3367-3378), this work presents the integral validation and benchmark of the code versions extended in INSPYRE ("post-INSPYRE") against two pins from the SUPERFACT-1 fast reactor irradiation experiment. The post-INSPYRE simulation results are compared to the available integral and local data from post-irradiation examinations, and benchmarked on the evolution during irradiation of quantities of engineering interest (e.g., fuel central temperature, fission gas release). The comparison with the pre-INSPYRE results is reported to evaluate the impact of the novel models on the predicted pin performance. The outcome represents a step forward towards the description of fuel behaviour in fast reactor irradiation conditions, and allows the identification of the main remaining gaps.

• Asia-Pacific Journal of Business
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• v.3 no.2
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• pp.1-7
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• 2012

The purpose of this case study is to discuss the issues and challenges pertaining to industrial safety. The case study begins with the shocking incident of the brutal killing of top-executive of the company by agitated workers. Inspite of having conducive environment for business, Italian subsidiary Robusto Muro Ltd had to confront industrial Relations issues at an incredible and unprecedented level. Management perspective, workers viewpoint, competitors approach and diplomatic comments by political bigwigs have also been incorporated so that the students may have 3-dimensional understanding of the scenario. The case of such genre will facilitate the students to comprehend and discuss the employee-employer relationship and industrial safety, in particular and industrial relations and IR machinery, in general.

• Journal of the Korea Safety Management & Science
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• v.4 no.4
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• pp.97-108
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• 2002

This study deals with the application of knowledge-based engineering and a methodology for the assessment & measurement of reliability, availability, maintainability, and safety of industrial systems using fault-tree representation. A fuzzy methodology for fault-tree evaluation seems to be an alternative solution to overcome the drawbacks of the conventional approach. To improve the quality of results, the membership functions must be approximated based on heuristic considerations. Conventionally, it is not always easy to obtain a system reliability for components with different individual failure probability density functions(p.d.f.), We utilize fuzzy set theory to solve the adequacy of the conventional probability in accounting and processing of built-in uncertainties in the probabilistic data. The purpose of this study is to propose the framework of knowledge-based engineering through integrating the various sources of knowledge involved in a FTA.

• 한국방재학회:학술대회논문집
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• 2008.02a
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• pp.13-18
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• 2008

The 2005 west off Fukuoka earthquake with Mjma 7.0 occurred in the vicinity of Fukuoka city with 1.4 million populations, which had been regarded as rather seismically inactive in Japan. The strong motion records by K-net indicated PGV of 64 cm/s in Fukuoka city and some condominium buildings sustained extensive non-structural damages. In this study, we conducted a questionnaire survey for residents of 8 condominium buildings located in the downtown area of Fukuoka city after the earthquake. The results indicate that damaged nonstructural walls and distorted doors disrupted evacuation route for many occupants, and furniture and content damage on upper floors became severer resulting in higher rates of human casualty. Earthquake preparedness for indoor safety was raised after the earthquake, though further safety measures can be advised. In the phase of post-earthquake emergency and restoration period, residents' management organizations play important roles, so that neighborhood activities to promote communication networks are important in urban environment with aging population.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.4 no.1
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• pp.7-24
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• 1996

A methodology has been developed for predicting aircraft reliability incorporating both C.C.F.s(Common-Cause Failures), and phased missions. Failure behaviour of an aircraft, or it's systems are predicted. Both independent failures, and C.C.F.s, are modelled by the Markov process, and simulated using Monte Carlo sampling with the robust variance reduction method. Prediction of safety and reliability is made through discrete-event simulation of aircraft operations. A case study is described for investigating the safety and reliability of the propulsion system of two-, three- and four-engined aircraft. This is particularly important for the design of ETOPS(Extended Range of Two-Engined Aircraft Operations) and results are presented for the cases with, and without the effect of C.C.F.s.

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
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• 1997.11a
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• pp.275-281
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• 1997

The destruction by accident is affected by the blast of explosion. However, there are few of research on the external effect of vented gas explosions. Therefore it is necessary to study the effect of vented explosion. This study aims to find the characteristics of gas explosion, and the effect of vented gas explosion. Using an explosion chamber, we obtained a LPG explosion characteristics according to the vent size and concentration. The result of experiment showed that the explosion pressure effect to external space was much stronger than inner space during the course of a gas explosion. And the external pressure become higher in explosion pressure as the vent diameter become smaller.

• Journal of the Korean Institute of Gas
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• v.19 no.5
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• pp.1-6
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• 2015

In this paper, the strength safety of a fuse cock main body has been analyzed by the finite element method. The stress and displacement behaviour characteristics have been investigated for thickness variations at the region of (T) between a ball valve and a fuse cock safety connector. The FEM analyzed results recommend that the optimized thickness at the region of (T) is from 1.55mm to 1.6mm for the supplied gas pressure of 1.5~3.5MPa. This is considered for the optimized strength safety and light weight of a fuse cock main body.