• 한국산업보건학회지
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• 제20권2호
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• pp.131-138
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• 2010

This technical report was developed to suggest the guideline to assess the safe use and handling metalworking fluids (MWFs) in machining operation. The basis of this method developed in this study was based on self assessment procedure recommended by Organization Resources Counselors (ORC) of the United States (US). In addition, various MWF management elements obtained from the review on various articles, reports and author's experience regarding MWF were newly added to the evaluation guideline. A total of four areas were finally selected in order to control exposure to MWF used in machining operations. They are all related to the presence and efficiency of the control measures, exposure assessment, management on tank and sump, and safe treatment of chips and metal fines generated during machining operations. Each area is consisted of several related elements. Several evaluation areas and elements used in this study could be revised, replaced, added and deleted according to the process environment, evaluation objectives and evaluator's (manager) criteria etc. This evaluation guide manual could be used for safe management of MWF in metalworking operation. In addition, industrial hygienists can use this evaluation method for auditing and evaluating the management status on MWF.

• 한국약용작물학회지
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• 제16권6호
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• pp.390-396
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• 2008

The aim of this work is to assess the safety of fungicide tolclofos-methyl, difenoconazole and azoxystrobin in ginseng sprayed by safe use guideline. When tolclofos-methyl was sprayed on ginseng by safe use guideline, the residue amounts (MRL) of it in ginseng was 0.13 mg/kg which is below than 0.3 mg/kg, maximum residue limit established by Korea Food & Drug Administration (KFDA). The residue amounts of ginseng parts, head part was 0.37 mg/kg and main body part was 0.13 mg/kg. In case of difenoconazole, the residue amounts in ginseng was 0.81 mg/kg. which was exceed the MRL, 0.2 mg/kg. By the analyze results of ginseng part, the residues of head and main body part were 3.01 and 0.40 mg/kg, respectively. In experiment of vinyl mulching, the residue amount of difenoconazole in ginseng was 0.05 mg/kg. The residue amounts of azoxystrobin in ginseng sprayed by safe use guideline was 0.14 mg/kg. This residue was not exceed the MRL 0.5 mg/kg. The residue amounts by ginseng parts was 0.51 mg/kg for head part and 0.28 mg/kg for main body part. In case of vinyl mulching, the residue amount of azoxystrobin was 0.02 mg/kg.

• 한방비만학회지
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• 제7권1호
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• pp.23-29
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• 2007

Background : Mahuang (Ephedra sinica) has been used widely to treat respiratory disease in traditional medicine for over thousands years. Mahuang preparations contain approximately $0.75{\sim}1%$ ephedrine alkaloids. Recently in North America, the Eephedra alkaloids has aroused a controversy due to its adverse effects in those using whole extracts as "dietary supplements" for weight loss or athletic performance enhancement. Objective : To discuss the need for clinical practice guidelines on the use of Mahuang. Results and Conclusion : It is widely assumed that Mahuang is one of the useful medicines and is safe for human body. Most of scientific literatures support that the safety of Mahuang prescription in common dosage. However, it has been claimed that there were some warnings and apprehensions about the harmfulness of Mahuang as dietary supplements. This article does not negate the fact that it is necessary to pay more attention for use of Mahuang in clinical situations. We assert that the establishment of clinical practice guideline on the use of Mahuang, which is based on scientific materials and consensus, is required in traditional medicine.

• 화약ㆍ발파
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• 제32권1호
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• pp.23-30
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• 2014

국내 화약류에 대한 전반적인 관리와 발파작업에 대한 규정은 총포 도검 화약류등 단속법에 의하여 관리되고 있으나, 세부적인 취급과 사용법에 대한 지침은 산업안전보건법 제27조에 의거하여 발파작업 표준 안전작업지침을 마련하여 발파작업에서의 재해예방을 위한 화약류의 취급, 운반, 저장, 사용 및 관리와 작업상의 안전에 관하여 사업자에게 지도 권고하고 있다. 본 연구에서는 고용노동부에서 고시한 발파작업 표준 안전작업지침에 대하여 검토하였고, 국내화약시장에 도입된 신제품과 최신발파기술이 지침의 개정 시 반영될 수 있도록 화약류에 대한 용어의 정의와 추가로 포함해야 하는 에멀젼계 폭약과 벌크형태의 폭약, 그리고 최근 국내 발파현장에서 사용이 증가하고 있는 전자뇌관에 대하여 수록을 제안하였다. 또한, 작업지침에 대해서는 비전기식 뇌관과 전자뇌관의 대표적인 취급 방법을 예시를 들어 제안하여 지침안 개정 시 보완된 발파작업 표준 안전작업지침을 마련하도록 제안하였다.

• 대한의용생체공학회:의공학회지
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• 제31권2호
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• pp.129-133
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• 2010

Intense pulsed light(IPL) is a photo-therapeutic medical device using xenon lamps with optical characteristics of incoherence, defocusing, and polychromatic. IPL has been recognized as a representative medical therapeutic device with growth of domestic skin care market. However, there is no standard regulation manual and guideline to evaluate the safety and performance of IPL. International Electrotechnical Commission(IEC) is being statued "Technical Report IEC TR 60825-16" which is a guidelines for the safe use of intense light source equipment on humans and animals. In this study, a standard Korea Food & Drug Administration (KFDA) regulation for the safety and performance of IPL was suggested by developing minimal evaluation methods for optical parameters of IPL such as output energy density, pulse mode, spot size, wavelength and uniformity of output light. We expect that this study may be a step to statue a standard regulation manual and guideline for IPLs used in domestic.

• 한국환경보건학회지
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• 제35권5호
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• pp.426-432
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• 2009

Asbestos is a commercial term of natural occurring silicated minerals and forms long, thin fibers. Chrysotile, the serpentine asbestos, accounts for most use in commercial use. Asbestos is well known health hazard material and it is proved that inhalation of asbestos fibers leads to increased risk of developing several diseases such as lung cancer, mesothelioma, asbestosis. In these days, people most at risk for exposure are maintenance and construction workers and general citizens who are working on and close to the work area at which asbestos containing material is disturbing. Non asbestiform, though its chemical composition is same with regulated asbestos, is known to be less hazardous than asbestiform. Exposure guideline, 0.01 f/ml, is not safe level in terms of health risk. It is reasonable to take preventable action when asbestos is suspicious. In Korea, it is necessary to clarify the concept between hazard and risk, to differentiate asbestiform from non asbestiform, to make regulations for compensation for asbestos related patients, to manage future exposure for general citizens.

• 대한불안의학회지
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• 제1권1호
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• pp.37-42
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• 2005

Benzodiazepines are widely used for a variety of conditions in psychiatric field. In this article, the author reviewed the indications, the effects on anxiety and sleep disorders, the side effects, the drug-drug interactions, and the tapering strategies. Benzodiazepines were relatively safe and useful for the treatment of anxiety and sleep disorders. However, used clinically, benzodiazepines can induce many adverse effects (e. g. over-sedation, cognitive impairments, paradoxical effects, dependence and withdrawal symptoms, and so on). Currently available informations about their effects on the developing fetus is controversial. For this reason, pregnant women and nursing mother should be cautioned against the use of benzodiazepines. Drug-drug interactions have to be considered in combination treatments. For the tapering issues, gradual tapering was important to prevent the withdrawal symptoms. Especially, the tapering schedules have to be individualized for the each long-term benzodiapzepine users.

• 터널과지하공간
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• 제18권6호
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• pp.418-426
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• 2008

인도네시아 파시르탄광에서 적용되고 있는 전형적인 발파방법은 지표면을 유일한 자유면으로 하는 일자유면 노천발파 공법이다. 일반적으로 일자유면 발파방법은 자유면이 하나뿐이므로 구속이 커서 큰 지반진동을 일으키게 된다. 큰 지반진동은 다시 채광장의 경계를 이루는 사면의 안정성에 나쁜 영향을 미칠 수 있다. 이런 측면에서 발파로 인한 지반진동으로부터 파시르탄광의 채광장 사면과 폐석장의 안전을 확보할 수 있는 발파지침을 마련하기로 하였다 먼저, 파시르탄광에서 발파로 발생될 수 있는 지반진동 수준을 예측할 수 있는 예측식을 유도하였다. 다음으로, 채광장 사면과 폐석장의 폐석더미를 관리하기 위한 지반진동 허용수준을 PPV 측정치로 각각 120mm/s 및 60mm/s로 설정하였다. 도출된 예측식과 설정된 허용수준으로부터 현장에서 사용할 수 있는 안전발파를 위한 환산거리 조건식을 설정하였다. 설정된 환산거리 조건식은 채광장 사면과 폐석더미에 대해 각각 $D_s{geq}5$ 및 $D_s{geq}10$이다. 또한, 환산거리 조건식을 만족시킬 수 있도록 천공장 $3.3{sim}8.8m$에 대하여 몇 가지 표준발파패턴을 제안하였다.

• 약학회지
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• 제57권3호
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• pp.173-186
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• 2013

To ensure the safe use of pharmaceuticals in the market, US, EU and Japan reached a consensus to adopt ICH harmonised tripartite guideline "E2E Pharmacovigilance Planning" in 2004. Subsequently these regions established and implemented new pharmaceutical safety management systems for patients based on ICH E2E guideline and Risk Evaluation and Mitigation Strategy (REMS) in US or Risk Management Plan (RMP) in EU and Japan. In this study we investigated these new foreign systems and suggested a way to improve Korea's regulatory system for pharmaceutical safety management under Korea Pharmaceutical Law in the view of international harmonization.

• Journal of Acupuncture Research
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• 제38권3호
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• pp.233-235
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• 2021

Although warts are a common skin condition/disease that recurs in childhood, treatment completion is difficult owing to the pain associated with conventional therapies. In this case, Korean herbal medicine, Guijakjihwang-Tang, and indirect moxibustion was used to treat a recalcitrant cutaneous wart without pain and recurrence. A 7-year-old boy presented with recurrent cutaneous warts on his right hand and received cryotherapy 3 times in the previous year. The wart recurred during the course of cryotherapy treatment, and the patient did not want to suffer any more pain from the previous treatment. Therefore, parents sought an efficient and painless therapy. The patient was treated for 2 months using Guijakjihwang-Tang combined with indirect moxibustion. The prominent lesion separated in the 2^nd month of treatment and completely recovered without adverse events in the 3^rd month. There was no recurrence over 12 months of follow-up. This report provides meaningful insights into the use of Korean medicine as a safe, painless and efficient treatment for warts in pediatric patients.