• 제목/요약/키워드: SZ effect

검색결과 30건 처리시간 0.024초

지실 추출물의 전사인자 SREBP-1 활성에 의한 지질 생성 촉진 (Ponciri Fructus Extract Induces Lipogenesis through Transcription Factor SREBP-1 Activation)

  • 김대성;전병국;문연자;이강태;이건국;우원홍
    • 약학회지
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    • 제56권4호
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    • pp.268-273
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    • 2012
  • This study was to explore the lipogenic effect by ethanol extract of ponciri fructus (EPF) and possible molecular mechanisms in sebocyte. When SZ95 sebocyte cell line were treated with the EPF, lipid droplets were accumulated in the majority of cells. EPF increased expression of sterol regulatory element-binding protein-1 (SREBP-1) and fatty acid synthase (FAS) in the SZ95 cells. EPF augmented expression of PPAR-${\beta}$ and PPAR-${\gamma}$ but not that of PPAR-${\alpha}$. These results suggest that EPF induces lipogenesis in SZ95 cells through SREBP-1, PPAR-${\beta}$ and PPAR-${\gamma}$ activations.

The effect of resin cements and primer on retentive force of zirconia copings bonded to zirconia abutments with insufficient retention

  • Kim, Seung-Mi;Yoon, Ji-Young;Lee, Myung-Hyun;Oh, Nam-Sik
    • The Journal of Advanced Prosthodontics
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    • 제5권2호
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    • pp.198-203
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    • 2013
  • PURPOSE. The purpose of this study was to investigate the effect of resin cements and primer on the retentive force of zirconia copings bonded to zirconia abutments with insufficient retention. MATERIALS AND METHODS. Zirconia blocks (Lava, 3M ESPE, St. Paul, MN, USA) were obtained and forty sets of zirconia abutments and copings were fabricated using CAD/CAM technology. They were grouped into 4 categories as follows, depending on the types of resin cements used, and whether the primer is applied or not:Panavia F2.0 (P), Panavia F2.0 using Primer (PRIME Plus, Bisco Inc, Schaumburg, IL, USA) (PZ), Superbond C&B (S), and Superbond C&B using Primer (SZ). For each of the groups, the cementation was conducted. The specimens were kept in sterilized water ($37^{\circ}C$) for 24 hours. Retentive forces were tested and measured, and a statistical analysis was carried out. The nature of failure was recorded. RESULTS. The means and standard deviations of retentive force in Newton for each group were $265.15{\pm}35.04$ N (P), $318.21{\pm}22.24$ N (PZ), $445.13{\pm}78.54$ N (S) and $508.21{\pm}79.48$ N (SZ). Superbond C&B groups (S & SZ) showed significantly higher retentive force than Panavia F2.0 groups (P & PZ). In Panavia F2.0 groups, the use of primer was found to contribute to the increase of retentive force. On the other hand, in Superbond C&B groups, the use of primer did not influence the retention forces. Adhesive failure was observed in all groups. CONCLUSION. This study suggests that cementation of the zirconia abutments and zirconia copings with Superbond C&B have a higher retentive force than Panavia F2.0. When using Panavia F2.0, the use of primer increases the retentive force.

라벤더 에탄올 추출물의 피지생성 억제효과 (Inhibitory Effects of the Ethanol Extract of Lavandula vera on Sebum Synthesis)

  • 박시준;김호민;한규수;성금수;신미란;문연자;우원홍
    • 한국전통의학지
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    • 제15권1호
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    • pp.77-82
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    • 2006
  • Lavandula vera is indispensable member of the herb family, used for perfumes and potpourri. Androgens have profound effects on the physiology of the sebaceous gland. Sebum is secreted due to the effect of androgen, which starts to be secreted at puberty. Using the human sebocyte cell line SZ95. the author investigated the inhibitory effect of Lavandula vera on the lipid production. Light microscopic finding were examined numerous cytoplasmic lipid droplets SZ95 cells by Oil red staining and lipid droplets were increased markedly by testosterone. On the other hand, combined treatment with Lavandula vera and testosterone resulted in a lower lipid droplets than with testosterone alone in a dose-dependent manner. These findings indicate that Lavandula vera acts antagonistically to testosterone and inhibits the lipid synthesis of SZ95 cells at the cellular level.

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공초점 레이저주사현미경을 이용한 산부식 시간에 따른 법랑질 표면 양상에 관한 연구 (EFFECT OF ETCHING TIME ON ENAMEL SURFACE ROUGHNESS: CONFOCAL LASER SCANNING MICROSCOPIC STUDY)

  • 감동훈;김정욱;장기택;이상훈;김종철;한세현
    • 대한소아치과학회지
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    • 제30권1호
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    • pp.41-46
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    • 2003
  • 공초점 레이저주사현미경(confocal laser scanning microscopy)을 이용하여 산부식시간에 따른 법랑질표면의 변화양상을 관찰하고, 접착에 필요한 표면의 양상을 얻을 수 있으면서도 법랑질의 소실을 최소화할 수 있는 산부식시간을 측정하고자, 60개의 발치된 건전대구치를 협면이 노출되도록 아크릴봉에 자가중합레진을 이용하여 매몰한 뒤, 220, 500, 800, 1000, 2000, 4000번 SiC 연마지를 이용하여 순차적으로 연마하였다. 연마된 시편을 임의로 10개씩 6개의 군으로 나누고, 37% 인산으로 10초, 20초, 30초, 40초, 50초, 60초간 산부식하고 충분한 물로 세척한 후 air syringe로 건조시킨 후, 공초점 레이저주사현미경으로 표면영상을 얻은 후 조도분석을 시행하고, 5개의 계측치(Sa, Sq, Sz, Sdr, Ra)를 통계분석한 결과, 모두 30초 산부식의 경우가 가장 높은 조도를 나타내었다. 특히 Sz의 경우 10초의 경우가 통계적으로 유의하게 낮은 값을 보였으며, 30초의 경우 통계적으로 유의하게 높은 값을 보였다(p<0.05).

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Fabrication of $(La, Sr)MO_3$ (M=Mn or Co)/YSZ Nanocomposite Thin Film Electrodes for the Exhaust Gas Purification by a Chemically-Modified Sol-Gel Process

  • Hwang, H.J.;Moon, J.W.;Awano, M.;Maeda, K.
    • 한국분말재료학회지
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    • 제8권3호
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    • pp.201-206
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    • 2001
  • $>LaMnO_3$$(La, Sr)MO_3$, and $(La, Sr)MO_3/YSZ$ gel films were deposited by spin-coating technique on scandium-doped zirconia (YSZ) substrate using the precursor solution prepared from $La(O-i-C_3H_7)_3$, $Co(CH_3COO)_2$or $Mn(O-i-C_3H_7)_2$,2-methoxyethanol, and polyethylene glycol. By heat-treating the gel films, the electrochemical cells, $(La, Sr)MnO_3{\mid}ScSZ{\mid}Pt$ were fabricated. The effect of polyethylene glycol on the microstructure evolution of $$LaCoO_3and $LaMnO_3$thin films was investigated, and NOx decomposition characteristics of the electrochemical cells were investigated at $500^{\circ}C$ to $600^{\circ}C$. By applying a direct current to the $(La, Sr)MnO_3{\mid}ScSZ{\mid}Pt$ electrochemical cell, good NOx conversion rate could be obtained relatively at low current value even if excess oxygen is included in the reaction gas mixture.

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백굴채(白屈菜) 추출물의 피지생성 억제효과 (Inhibitory Effect of Extract of Chelidonii Harba on Sebum Synthesis)

  • 최두호;박시준;김호민;노성택;유일수;문연자;임규상;우원홍
    • 동의생리병리학회지
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    • 제20권6호
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    • pp.1561-1566
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    • 2006
  • Sebum is secreted due to the effect of androgen, which start to be secreted at puberty. Androgens have profound effects on the physiology of the sebaceous gland, Using the human sebocyte cell line SZ95, we investigated the inhibitory effect of Chelidonii Harba (CH) on the subum production. Our results showed that numerous cytoplasmic lipid droplets were examined by Oil red staining and lipid droplets were increased markedly by testosterone. Cell viability was dose-dependently decreased by CH as compared with untreated cells, while total lipid content and cholesterol slightly were increased by CH. Testosterone significantly stimulated the synthesis of total lipid and the synthesis of specific sebaceous lipids such as cholesterol and triglyceride. Combined treatment with CH and testosterone resulted in a lower lipid synthesis than with testosterone alone. Especially cholesteol content was reduced by combined treatment with CH and testosterone. These results indicate that CH inhibits the testosterone-induced lipid synthesis in SZ95 cells and acts antagonistically to androgen at the cellular level.

금속(金屬) Bracket의 화학적(化學的) 재생처리(再生處理) 방법(方法)에 관(關)한 연구(硏究) (A STUDY ON THE CHEMICAL RECYCLING METHOD OF METAL BRACKET)

  • 방상용;이동주
    • 대한치과교정학회지
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    • 제20권1호
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    • pp.103-110
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    • 1990
  • Metal brackets were recycled by variable methods for economic reason. Such recycling methods had a great effect on bracket slot width and bonding strength. Therefore, the recycling methods that don't change the properties of original bracket were suggested. In this study, debonded brackets were recycled with 30 kinds of solvents and bracket surfaces were examined by S.E.M. (Super IIIA, ISI International Scientific Instruments, Japan) and Stero Microscope (Sz-Tr, Olympus Tokyo, Japan) methods. The following results were obtained. 1. Thermosetting resin adhesives (eq. $Monolok^{(R)}$, $Concise^{(R)}$) were swelled most in sulfuric acid (assays 95%) and slightly in alcohol groups. 2. The solvent was exchanged every 24 hours during the brackets were recycled with sulfuric acid (assays 95%). As the passage of time, the adhesives were removed more clearly, and after 72 hours adhesives were nearly detached from bracket base. 3. Chemical recycled metal bracket surface showed no irregular structure by S.E.M. method.

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Weak Lensing Analysis of the Two High-z Massive Clusters, SPT-CL J0205-5829 and MOO1014+0038, with HST Observations

  • Kim, Seojin F.;Jee, Myungkook J.
    • 천문학회보
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    • 제42권2호
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    • pp.41.3-42
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    • 2017
  • The mass function of massive high-z clusters is extremely sensitive to the cosmological parameters. However, it is challenging to estimate their accurate masses. The "See Change" HST programme offers a rare opportunity to measure them using weak gravitational lensing. In this talk, we study SPT-CL J0205-5829 (z=1.322) and MOO1014+0038 (z=1.24) discovered in the SPT-SZ survey and MaDCoW Survey, respectively. We perform weak lensing analysis with the Advanced Camera for Surveys (ACS) and Wide Field Camera 3 (WFC3) images by carefully taking into account the instrumental effect. We successfully detect weak lensing signals which produce cluster masses consistent with those from non-lensing methods based on hydrostatic equilibrium.

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FSW를 이용한 AZ31B Mg합금의 접합성 평가 (Evaluation of Joint Properties of Friction Stir Welded AZ31B Mg Alloy)

  • 노중석;김흥주;장웅성;방국수
    • Journal of Welding and Joining
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    • 제22권3호
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    • pp.56-61
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    • 2004
  • Friction stir weldability of AZ31B Mg alloy was studied using microstructural observation and mechanical tests. Defect free joints was obtained under the condition of 2000rpm-100mm/min. In TMAZ, a lot of twin deformation were observed due to the mechanical effect of the FSW tool and thus relatively high hardness was obtained. In SZ, the twin deformation was disappeared by recovery and the hardness decreased because the. grain structure was coarsened by dynamic recrystallization and grain growth. The Al-Mn precipitates were observed throughout the joint regions. On the other hand, $$\beta$-Mg_{17}Al_{12}$ intermetallic compounds were not observed in either of the zone. The joint efficiency was about 80% and the impact value of the joint was almost equal to that of base metal.

A6061-T6/AZ31 이종금속 마찰교반접합부의 기계적 특성에 미치는 툴 삽입 위치의 영향 (Effects of Tool Plunge Position on Mechanical Properties of Friction-stir-weleded Region in A6061-T6/AZ31 Dissimilar Metals)

  • 이광진;김상혁
    • Journal of Welding and Joining
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    • 제30권5호
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    • pp.22-26
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    • 2012
  • Butt-joints of A6061-T6 and AZ31 plates were successfully manufactured by using a friction stir welding method. Off-set free joints and off-set joints were fabricated to investigate the effect of the tool plunge position on the mechanical properties of the joints. Hardness test, tensile test and charpy impact test was performed to evaluate the mechanical properties of the joints. Off-set condition resulted in increase of mechanical properties of the joints. The variation of the hardness distribution in the SZ was also stabilized in the off-set condition. Tensile strength of the off-set joint was about 85% against to that of the AZ31 base metal. Impact absorption energy by Charpy-Impact-Test of the off-set joint also increased by almost 2 times against to that of the AZ31 base metal.