• Bulletin of the Korean Chemical Society
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• v.33 no.5
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• pp.1707-1714
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• 2012

Grb2 is an adapter protein involved in the signal transduction and cell communication. The Grb2 is responsible for initiation of kinase signaling by Ras activation which leads to the modification in transcription. Ligand based pharmacophore approach was applied to built the suitable pharmacophore model for Grb2. The best pharmacophore model was selected based on the statistical values and then validated by Fischer's randomization method and test set. Hypo1 was selected as a best pharmacophore model based on its statistical values like high cost difference (182.22), lowest RMSD (1.273), and total cost (80.68). It contains four chemical features, one hydrogen bond acceptor (HBA), two hydrophobic (HY), and one ring aromatic (RA). Fischer's randomization results also shows that Hypo1 have a 95% significant level. The correlation coefficient of test set was 0.97 which was close to the training set value (0.94). Thus Hypo1 was used for virtual screening to find the potent inhibitors from various chemical databases. The screened compounds were filtered by Lipinski's rule of five, ADMET and subjected to molecular docking studies. Totally, 11 compounds were selected as a best potent leads from docking studies based on the consensus scoring function and critical interactions with the amino acids in Grb2 active site.

• Journal of Chest Surgery
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• v.33 no.6
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• pp.469-475
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• 2000

Background: Thoracic aortomyoplasty is one of the surgical treatment for heart failure and has advantages over artificial heart or intraaortic balloon pumps. It uses autogenous skeletal muscles and solves problems such as energy source. However its use in clinical settings has been limited. This preliminary study was designed to develop surgical technique and to determine the effect of acute descending thoracic aortomyoplsty. Material and Method: Thirteen adult Mongrel dogs were used. The left latissimus dorsi muscle was wrapped around the descending aorta under general anesthesis. Swan-Ganz and microtipped Millar catheter were used for the hemodynamics and endocaridial viability ratio. Data were collected with myostimulator on and off in normal hearts and the ischemic hearts. Result: In normal hearts, the mean aortic diastolic pressure increased from 72$\pm$15mmHg at baseline to 78$\pm$13mmHg with stimulator on. Coronary perfusion pressure increased from 61$\pm$11mmHg to 65$\pm$9mmHg. Diastolic time increased from 0.288$\pm$0.003 msec to 0.290$\pm$0.003msec. Systolic time decreased from 0.164$\pm$0.002msec to 0.160$\pm$0.002 msec. Endocardial viability ratio increased from 1.21$\pm$0.22 to 1.40$\pm$0.18. In ischemic hearts, mean aortic diastolic pressure incrased from 56$\pm$21mmHg at baseline to 61$\pm$15mmHg with stimulator on. Coronary perfusion pressure increased from 48$\pm$17mmHg to 52$\pm$15mmHg. Diastolic time increased from 0.290$\pm$0.003 msec to 0.313$\pm$0.004msec. Systolic time decreased from 0.180$\pm$0.002 msec to 0.177$\pm$0.003 msec. Endovascular viability ratio increased from 0.9$\pm$0.31 to 1.1$\pm$0.31. The limited number of cases ruled out the statistic significance. Conclusion: Descending thoracic aortomyoplasty is a simple operation designed to use patient's own skeletal muscles. It trends to increase diastolic augmentation and coronary perfusion pressure. Modification of surgical technique and stimulator protocol would maximize the effect to assist the heart.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.29 no.4
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• pp.180-188
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• 2017

Recently, as the strength of winds and waves increases due to the climate change, abnormal waves such as swells have been also increased, which results in the increase of downtime events of loading/unloading in a harbour. To reduce the downtime events, breakwaters were constructed in a harbour to improve the tranquility. However, it is also important and useful for efficient port operation by predicting accurately and also quickly the downtime events when the harbour operation is in a limiting condition. In this study, numerical simulations were carried out to calculate the wave conditions based on the forecasted wind data in offshore area/outside harbour and also the long-term observation was carried out to obtain the wave data in a harbour. A forecasting method was designed using an auto-regressive (AR) and artificial neural networks (ANN) models in order to establish the relationship between the wave conditions calculated by wave model (SWAN) in offshore area and observed ones in a harbour. To evaluate the applicability of the proposed method, this method was applied to predict wave heights in a harbour and to forecast the downtime events in Pohang New Harbour with highly complex topography were compared. From the verification study, it was observed that the ANN model was more accurate than the AR model.

• Journal of The Korean Society of Grassland and Forage Science
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• v.31 no.1
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• pp.25-32
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• 2011

Oats are an important crop for forage production with good palatability of livestock. Compared with other winter cereals crops for forage, oats may be widely sowing, autumn (October), spring (early of March) and summer (late of August). The objectives of this study were to compare the effects of sowing dates and varieties on the growth, forage yield and feed quality. Oat were sown in 14 October and 10 March, and harvested 20 days after heading in middle region of Korea. Varieties used were the 3 winter oat cultivars with cold tolerant and 3 cultivars for summer sowing. Heading was delayed about 12 days in spring sowing than in autumn sowing and the difference among varieties was 8 days. The rate of spike and leaf above aerial parts reduced and the rate of culm increased in spring sowing than in autumn. The variety 'Donghan' was higher the rate of spike and lower the rate of culm than that of other varieties. In spring sowing than in autumn, acid detergent fiber (ADF) content was higher, and neutral detergent fiber (NDF) and digestible dry matter (DDM) content was lower. In DDM content surveyed on 20 days after heading, 'Donghan' was higher in autumn sowing and 'Samhan' in spring sowing than that of other varieties. The oat variety 'Samhan', 'Donghan' and 'Chohan' were higher fresh yield in autumn than in spring, but similar dry matter yield. The variety 'Swan', 'Darkhorse' and 'Hispeed' were higher fresh and dry matter yield in spring than in autumn. The variety 'Donghan' can supplement high quality forage production in middle region at October and March because of the high-tillering and rate of spike per aerial part.

• Journal of the Korean Society of Marine Environment & Safety
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• v.21 no.5
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• pp.599-607
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• 2015

The purpose of this study is to reproduce long-term wave fields in coastal waters of Korea based on wave hind-casting modelling and discuss its applications. To validate wind data(NCEP, ECMWF, JMA-MSM), comparison of wind data was done with wave buoy data. JMA-MSM predicted wind data with high accuracy. But due to relatively longer period of ECMWF wind data as compared to that of JMA-MSM, wind data set of ECMWF(2001~2014) was used to perform wave hind-casting modelling. Results from numerical modelling were verified with the observed data of wave buoys installed by Korea Meteorological Administration(KMA) and Korea Hydrographic and Oceanographic Agency(KHOA) on offshore waters. The results agree well with observations at buoy stations, especially during the event periods such as a typhoon. Consequently, the wave data reproduced by wave hind-casting modelling was used to obtain missing data in wave observation buoys. The obtained missing data indicated underestimation of maximum wave height during the event period at some points of buoys. Reasons for such underestimation may be due to larger time interval and resolution of the input wind data, water depth and grid size etc. The methodology used in present study can be used to analyze coastal erosion data in conjunction with a wave characteristic of the event period in coastal areas. Additionally, the method can be used in the coastal disaster vulnerability assessment to generate wave points of interest.

• Journal of the Korean earth science society
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• v.23 no.5
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• pp.416-423
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• 2002

The concentrations of dimethylsulfide (DMS) and carbon disulfide (CS$_2$) were measured concurrently with relevant environmental parameters at Kosan, Cheju during Apr 2001. Results of our analysis indicate that the combined temporal variations of both DMS and CS$_2$ record three distinctible patterns that are separable from each other. For instance, DMS behaved very similarly to CS$_2$ during the 1st (5${\sim}$18 Apr) and 3rd period (23${\sim}$26 Apr). The pronouncingly high concentration of CS$_2$ was maintained during the first period, but DMS values peaked mostly during the third period. It was furthermore striking to find that changes in DMS levels occurred in an opposite direction relative to CS$_2$ during the 2nd period. Although most of these variabilities appear to be associated with the interaction of source/sink processes and the air parcel movement, certain aspects of their behavior are found to be highly complicated enough to account for.

• The Korean Journal of Pharmacology
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• v.31 no.2
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• pp.251-259
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• 1995

Pharmacokinetics and pharmacodynamics of metoprolol, a selective beta-l blocker, were examined for 360 minutes after intravenous bolus administration of metoprolol to 6 dogs. Plasma concentration and excreted amount in the urine metoprolol were measured by liquid chromatography with fluorescence detection. PR interval and heart rate were measured by ECG monitoring. Blood pressure was monitored through intraarterial catheter in femoral artery and cardiac output by thermodilution method using Swan-Ganz catheter. To analyze the effect site concentration-response relationship, plasma concentration and pharmacological effects were simultaneously fitted to a two pharmacokinetic compartment linked to pharmacodynamic model with NONLIN program. Results are as follows. 1) The plasma concentration of metoprolol after intrvenous injection decreased biexponentially. The terminal half-life estimated was $1.33{\pm}0.40$ hours and the volume of distribution at steady state (Vdss) and the total body clearance were $1.04{\pm}0.4\;L/kg,\;6.55{\pm}2.21\;L/hr$, respectively. The central compartment volume of distribution and peripheral compartment volume of distribution were $0.35{\pm}0.14L/kg\;and\;0.69{\pm}0.34L/kg$. The renal clearance and intercompartment clearance were $0.53{\pm}0.25\;L/min\;and\;0.35{\pm}0.19\;L/min$. 2) Simulated biophase concentration-response curve shows hyperbolic relationship and the estimated concentration-effect relationship was best explained by Emax model when the prolongation of PR interval and the reduction of the heart rate were used as pharmacodynamic parameters. Emax and EC50 were estimated to be $26.3{\pm}4.7\;msec\;and\;88.8{\pm}82.3\;g/ml$ for PR interval, and $48.7{\pm}18.8\;beats/min\;and\;113.5{\pm}78.7\;ng/ml$ for heart rate, respectively. 3) The changes of cardiac output-effect site concentration relationship was best fitted by a linear model and the slope of the relationship was $0.005{\pm}0.003$. Diastolic blood pressure-effect site concentration relationship was also explained by the linear model and the slope of the relationship was $0.038{\pm}0.034$.

• Journal of The Korean Society of Grassland and Forage Science
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• v.18 no.4
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• pp.323-328
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• 1998

A field experiment was carried out to determine the effects of chemical and mechanical treatment at mowing on the field drying rate and hay quality of autumn oat (Avena sativa L.). The chemical drying agent/mower conditioner ($K_2CO_3$ 2%, conditioning, $K_2CO_3$ 2% + conditioning and control) were treated at different harvest stages (late boot, heading and bloom stage) for hastening hay manufacture in the autumn of 1996. After field dry, square bales were made by hay baler, and the dry matter(DM) loss and visual estimation of oat hay were evaluated after storing two months. In general, the field drying rate of oat was slow, regardless of harvest stage. Mechanical and chemical + mechanical treatment were effective, but the effectiveness of chemical alone was very low. With mower conditioning, the duration of field dry was shortened by 2 days compared with control. The DM loss of hay was higher at boot stage(51.4%) than at heading stage (21.1%), and the DM loss was reduced by mechanical and chemical + mechanical combined treatment. The visual score (leafiness, green color, odor and softness) of hay after storing was high in mechanical and chemical + mechanical, but the score by chemical alone was very low. The nutritive value (ADF, NDF, digestibility, and relative feed value) of hay was also high with treatment of mechanical and chemical + mechanical, but the quality by chemical alone was similar compared with control. In conclusion, mower conditioning can enhance the field drying rate of autumn oat, but the drying efficiency of the chemical drying agent was very low. However, it is suggested that hay-making of oat in autumn is very hard though using mower conditioner.

• Journal of The Korean Society of Grassland and Forage Science
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• v.23 no.1
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• pp.49-58
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• 2003

This study was conducted to determine the effect of seeding times and mixture rates of oat and forage rape on the growth characteristics and forage yields during rest periods from March to June after the harvest of potatoes in potato cultivation fields located in the areas about 600m above the sea level in Jeju. The experiment was a split plot desist with seeding times(early, middle and late March) sown . at intervals of ten days from early March to late March as the nam plots and mixture rates as subplots, consisted of oat single(150kg/ha), forage rape single(15kg/ha), oat/rape mixtures 75 : 25% (112.5kg/ha of oat and 3.75kg/ha of rape), oat/rape mixtures 50 : 50％(75kg/ha of oat and 7.5kg/ha of rape) and oat/rape mixtures 25 : 75％(37.5kg/ha of oat and 11.3kg/ha of rape). The germination and establishment of eat and rape were not significantly different among seeding times and mixture rates. The plant heights were higher when seeded middle March compared to seeding times of early and late March. The growth stage of the oats seeded early March was dough stage, while that of oats seeded middle or late March was milk stage. The dry matter yields per ha were higher(p<0.05) when seeded middle March than those of seeding time of early and late March. The crude protein contents of rape single, mixtures and oat single treatments were 15.9, 12.4∼14.5 and 8.5％, respectively.

• Journal of The Korean Society of Grassland and Forage Science
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• v.38 no.1
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• pp.23-29
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• 2018

'Dakyeong' (Avena sativa L.), a winter oats for forage use, was developed by the breeding team at National Institute of Crop Science, RDA in 2016. It was derived from a cross between 'CI7505'(IT133304) and 'Swan'(IT197920). Subsequent generations followed by the cross were handled in bulk and pedigree selection programs at Iksan and Jeonju, respectively. After preliminary and advanced yield test for 2 years, 'SO2004009-B-B-10-8-3-9', designated as a line name of 'Gwiri91', were subsequently evaluated for earliness and forage yield during 3 years in four parts such as Jeju (upland), Yesan (upland), Iksan (upland), and Jeonju (paddy), from 2014 to 2016, and finally named as 'Dakyeong'. Cultivar 'Dakyong' has leaves of dark green color, thick diameter culm and long grain of brown color. Over 3 years, the heading date of 'Dakyeong' was about 5 days earlier than that of check cultivar 'Samhan' (April 30 and May 5, respectively), and their average forage dry matter yield harvested at milk-ripe stage was higher 12% ($15.7tone\;ha^{-1}$) than $14.0tone\;ha^{-1}$ of check cultivar. Cultivar 'Dakyeong' was lower than the check cultivar 'Samhan' in terms of the protein content (6.1% and 7.0%, respectively) and total digestible nutrients (62.1%, and 62.5%, respectively), while the TDN yield was more than the check ($7.79tone\;ha^{-1}$ and $7.64tone\;ha^{-1}$, respectively). Fall sowing cropping of 'Dakyeong' is recommended only in areas where average daily minimum mean temperatures in January are higher than $-6^{\circ}C$, and it should not be cultivated in mountain areas, where frost damage is likely to occur.