• BMB Reports
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• v.51 no.11
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• pp.596-601
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• 2018

Colon cancer is one of the most lethal and common malignancies worldwide. STK899704, a novel synthetic agent, has been reported to exhibit anticancer effects towards numerous cancer cells. However, the effect of STK899704 on the biological properties of colon cancer, including cancer cell migration and cancer stem cells (CSCs), remains unknown. Here, we examined the inhibitory effect of STK899704 on cell migration and CSC stemness. In the wound healing assay, STK899704 significantly inhibited the motility of colon cancer cells. Furthermore, STK899704 downregulated the mRNA expression levels of the cell migration mediator focal adhesion kinase (FAK). STK899704 also suppressed mitogen-activated protein kinase kinase and extracellular signal-regulated kinase, which are downstream signaling molecules of FAK. Additionally, STK899704 inhibited stemness gene expression and sphere formation in colon cancer stem cells. These results suggest that STK899704 can be used to treat human colon cancer.

• Journal of Aerospace System Engineering
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• v.4 no.4
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• pp.37-43
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• 2010

Need for agile satellites increases for performing various mission due to increase of satellite image applications and users. This paper performs attitude maneuver analysis by using Satellite Tool Kit(STK) made by AGI. In order to automate the STK analysis process, a MATLAB program is developed to generate STK input data and to process STK output data. Five attitude maneuver modes are analyzed and attitude angle variation and required torques are calculated.

• Molecules and Cells
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• v.42 no.11
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• pp.804-809
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• 2019

Oncogenic gain-of-function mutations are clinical biomarkers for most targeted therapies, as well as represent direct targets for drug treatment. Although loss-of-function mutations involving the tumor suppressor gene, STK11 (LKB1) are important in lung cancer progression, STK11 is not the direct target for anticancer agents. We attempted to identify cancer transcriptome signatures associated with STK11 loss-of-function mutations. Several new sensitive and specific gene expression markers (ENO3, TTC39C, LGALS3, and MAML2) were identified using two orthogonal measures, i.e., fold change and odds ratio analyses of transcriptome data from cell lines and tissue samples. Among the markers identified, the ENO3 gene over-expression was found to be the direct consequence of STK11 loss-of-function. Furthermore, the knockdown of ENO3 expression exhibited selective anticancer effect in STK11 mutant cells compared with STK11 wild type (or recovered) cells. These findings suggest that ENO3-based targeted therapy might be promising for patients with lung cancer harboring STK11 mutations.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.15
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• pp.6021-6024
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• 2014

Background: The STK15 gene located on chromosome 20q13.2 encodes a centrosome-associated kinase critical for regulated chromosome segregation and cytokinesis. Recent studies have demonstrated STK15 to be significantly associated with many tumors, with aberrant expression obseved in many human malignancies. The purpose of this study was to investigate expression of STK15 in esophageal squamous cell carcinomas (ESCCs) in a Mongolian population. Methods: Two non-synonymous single nucleotide polymorphisms in the coding region of STK15, rs2273535 (Phe31Ile) and rs1047972 (Val57Ile) were assessed in 380 ESCC patients and 380 healthy controls. We also detected STK15 mRNA expression in 39 esophageal squamous cell carcinomas and corresponding adjacent tissues by real time PCR. Results: rs2273535 showed a significant association with ESCC in our Mongolian population (rs227353, P allele = 0.0447, OR (95%CI) = 1.259 (1.005~1.578)). Real time PCR analysis of ESCC tissues showed that expression of STK15 mRNA in cancer tissues was higher than in normal tissues (p = 0.013). Conclusions: Our study showed that functional SNPs in the STK15 gene are associated with ESCC in a Mongolian population and up-regulation of STK15 mRNAoccurs in ESCC tumors compared adjacent normal tissues. STK15 may thus have an important role in the prognosis of ESCC and be a potential therapeutic target.

• Journal of the Korean Institute of Telematics and Electronics S
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• v.36S no.8
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• pp.81-87
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• 1999

In general, feature detection and tracking algorithms is classified by EBGM using Garbor-jet, NNC-R and STK algorithm using pixel eigenvalue. In those algorithms, EBGM and NCC-R detect features with feature model, but STK algorithm has a characteristics of an automatic feature selection. In this paper, to solve the initial problem of NR tracking in STK algorithm, we detected features using STK algorithm in modelled feature region and tracked features with NR method. In tracking, to improve the tracking accuracy for features by NR method, we proposed BMA-NR method. We evaluated that BMA-NR method was superior to NBMA-NR in that feature tracking accuracy, since BMA-NR method was able to solve the local minimum problem due to search window size of NR.

• Journal of Satellite, Information and Communications
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• v.4 no.2
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• pp.12-19
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• 2009

In the modern UAV systems, the role of radar payload has been increasing with its unique performance of day-and-night operation and see-through capability over hidden obstacles. Contrary to the satellite reconnaissance, UAV is expected to provide high resolution target detection and recognition capability while frequent flight missions would deliver enhanced SAR image and local information over the target area. STK(Satellite Tool Kit) is a professional space-analysis software widely used in all phases of a space system's life cycle. The simulation of STK is efficient and accurate relatively. In this paper, the author attempt to model the UAV operation and measure the expected SAR image quality. STK(Satellite Tool Kit) is employed to analyze UAV operation and produce SAR raw data. A SAR simulator is developed to produce high resolution SAR image for various ground targets.

• Korean Journal of Materials Research
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• v.29 no.1
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• pp.30-36
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• 2019

We evaluate the properties of friction welded STK400 steel tube in terms of the relationship between microstructures and mechanical properties. Friction welding is conducted at a rotation speed of 1,600 rpm and upset time of 3-7 sec for different thicknesses of STK 400 tubes. To analyse the grain boundary characteristic distributions(GBCDs) in the welded zone, electron backscattering diffraction(EBSD) method is introduced. The results show that a decrease in welding time (3 sec.) creates a notable increase grain refinement so that the average grain size decreases from $15.1{\mu}m$ in the base material to $4.5{\mu}m$ in the welded zone. These refined grains achieve significantly enhanced microhardness and a slightly higher yield and higher tensile strengths than those of the base material. In particular, all the tensile tested specimens experience a fracture aspect at the base material zone but not at the welded zone, which means a soundly welded state for all conditions.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.24 no.3
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• pp.299-309
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• 2013

A comprehensive SAR(Synthetic Aperture Radar) simulation is considered to be a complicated task since a full knowledge of the signal propagation characteristics, antenna pattern, system internal errors and interference noises should be taken into account. In high resolution target application modes, the time varying nature of target RCS(Radar Cross Section) strongly affects the generated SAR images. In this paper, in-depth SAR simulations are performed and analyzed incorporating the STK tools and MATLAB software. STK provides realistic orbit parameters while its radar module helps to extract accurate radiometric parameters of ground targets. SAR raw data corresponding to a given target is generated and processed using MATLAB simulator. The performance is measured by PSLR(Peak Sidelobe Ratio) and ISLR(Integrated Sidelobe Ratio) for a point target, which can be used as reference parameters for accurate radiometric calibration. Finally, high resolution target simulations are performed by adopting time varying target RCS characteristics.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.37 no.9
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• pp.923-930
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• 2009

In this paper, we introduce a satellite conceptual design software which can be used for outlining a new satellite as well as for educational purpose. This software consists of three commercial tools: MATLAB, STK(Satellite Tool Kit), and Excel. The management of the design software is done by MATLAB which provides basic calculations, GUI(Graphical User Interface), Excel data base management, and STK control. STK, an orbital simulation software developed by AGI, takes a part of obtaining accurate orbital information of a satellite. Excel, a product of Microsoft, is used for the data base of previous satellites and for the saving place of temporary and final results of the software. The conceptual design of a satellite is to roughly estimate power system and mass. In the power system design, the sizes of solar array and battery are determined. Based on the database of existing satellites, we can estimate the subsystems's mass fraction of a target satellite. Design examples for Kompsat 1 and 2 are suggested for verification of the developed software.

• Journal of the Korean Geosynthetics Society
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• v.15 no.4
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• pp.71-78
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• 2016

In this study, execution costs of the foundation system are compared with PHC and steel pile in the same soil layers and load condition. Steel piles installed on the thin weathered rock are reduced as 12.5% in comparison with the number of PHC piles. Steel piles installed on the soft rock through weathered rock with 1.7m of thickness reduce the number of piles as 35.7% (STK 400) and 46.4% (STK 490), respectively, in comparison with PHC piles installed on the weathered rock. Also, they reduce the number of piles as 26.5% (STK 400) and 38.8% (STK 490), respectively, in comparison with steel piles (STK 400) installed on the weathered rock. When the thickness of footings is constant, steel piles installed on the soft rock may reduce the area of footings up to 12.2% (STK 400) and 45.4% (STK 490), respectively, in comparison with PHC piles installed on the weathered rock. Total cost of foundation system installed on the soft rock with steel piles (STK 400) increases as 12%, whereas in case of replaced with steel piles (STK 490), it reduces as 16% in comparison with PHC piles installed on the weathered rock. This is because the cost reduction due to the number of piles and footing area is more effective despite high cost of steel piles (STK 490). When the thickness of weathered rock is less than 5m, installing steel piles (STK 490) on the soft rock through it is more economic in comparison with installing PHC piles on the weathered rock.