• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.3 no.2
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• pp.194-203
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• 1993

Quality Control programs for industrial hygiene laboratory have successfully been operated since the 1st round was initiated in April 1992. Three rounds have been completed. Overall analytical performance of participants was improved through a subsquent round. The first round had a large variation among analytical results of all participants, 26.34%~504.22% of coefficient of variation. But the variation of analytical performance in the 2nd and 3rd rounds decreased to 40.42%~52.55% and 10.74%~20.98%, respectively. The difference of analytical performance among participants was decreased by operation of subsquent round. By distribution of Running Performance Index (RPI), over 50% of participants belongs to Category 3 in the first round. The average percentage of participants assigned to Category 3 in the 2nd and 3rd round was decreased to 37.2%. A definite analytical performance improvement of participants seems to be obtained. "A" and "B" group have more participants assigned to Category 3 than those of "C" group through the distribution of RPI by group divided to similar participant. By the distribution of RPI all participants, the percent of participant being over 200 RPI in the 1st round was 43%~52%, but decreased to 9%~29% and 9%~27%, in the 2nd and 3rd round, respectively. These results mentioned above indicate that the analytical performance of all participants have been improved by subsquent Quality Control Program although newcomers joined and a few participants droped out. But, there are some participants with poor analytical performance. Industrial Health Research Institute (IHRI) will offer service such as education, communication and visitation to them, and improve quality of their analytical performance in the future.

• Korean Journal of Clinical Pharmacy
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• v.30 no.3
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• pp.196-205
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• 2020

Background: The indication of denosumab for osteoporosis was expanded from second-line to first-line therapy in 2019. The aim of this study was to evaluate the efficacy of denosumab as both first- and second-line therapy in postmenopausal women with osteoporosis and osteopenia with risk factors by using the Fracture Risk Assessment Tool (FRAX). Methods: We conducted a medication use evaluation of denosumab in 98 patients who had been treated three or more times for osteoporosis or osteopenia at Chungnam National University Hospital from July 1^st, 2017 to January 31^st, 2020. Risk factors were identified using quantitative N-gram analyses of FRAX estimations. Patient information, including menopause status and results of bone mineral density tests (T-score), was obtained from electronic medical records. Results: Age, body mass index (BMI), prior medication use, and T-score were identified as risk factors and were included as variables in the evaluation of denosumab use. Since no significant differences were detected between groups, denosumab is likely effective regardless of age or BMI. In addition, no significant difference was detected in T-scores following denosumab treatment, between groups who took bisphosphonates and selective estrogen receptor modulators (SERMs) with denosumab as first-line therapy for postmenopausal osteoporosis. Denosumab may, therefore, be effective as second-line therapy. Conclusion: Efficacy of denosumab was evaluated in postmenopausal women with osteoporosis. Denosumab may be used as first- and second-line therapy regardless of age, BMI, and prior use of bisphosphonates and SERMs.

• Korea Journal of Hospital Management
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• v.15 no.3
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• pp.143-169
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• 2010

This is a case study of Seoul St. Mary's Hospital applying a real-time enterprise (RTE) strategy to improve customer satisfaction and operational efficiency with the main process of medical institutions. The hospital is applying an RTE strategy to get real-time information on occurrences at each contact point of the main process of the medical institution from reservation to discharge through dashboard and to resolve issues through rapid decision-making. The RTE strategy of the hospital has some summaries: First, the hospital has linked a hospital management strategy to the RTE strategy to build a patient-centered treatment process. Second, the hospital has operated a control tower for change management and implementation monitoring in the process of implementing the RTE strategy. Third, the hospital has built systematic RTE-based environment as an application program in which the nU System is linked to Business Processor Renovation (BPR) promoted from 2006 on. Fourth, the hospital is applying a strategy to improve efficiency in operating the hospital by increasing customer satisfaction, removing inefficiency and variability, and managing medical resources efficiently through the RTE strategy. Fifth, it has established an information-sharing system through authority management for each user in terms of RTE information. Sixth, it has supplemented limitations of short-term information of the RTE strategy by linking the key performance index to the cost information system in order to improve performance of the RTE strategy. Seventh, it has improved customer satisfaction and achieved higher performance in improving operational efficiency, as compared with rival hospitals, through the RTE strategy.

• Journal of Information Technology and Architecture
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• v.9 no.2
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• pp.167-176
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• 2012

In Korean military measuring systems interoperability is based on LISI (Level of Information System Interoperability) model at the requirement generation and acquisition process. However, LISI model cannot be used for interoperability measurement of system of systems (SoS) because LISI model is focused on interoperability measurement of a given system or system pair. Also, LISI model cannot provide quantitative information for interoperability decision because of qualitative rather than quantitative approach. This paper proposes a quantitative interoperability measurement methodology of SoS. At the proposed methodology, mission threads and supporting systems are identified using architecture approach, and Interoperability of SoS is measured with systems multiplicity and resemblance coefficient. Finally, a case study is presented to show the usefulness of the methodology.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.49 no.5
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• pp.635-641
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• 2016

The feeding habits of juvenile and young Seriola quinqueradiata, which were collected by a hand net and set net in coastal waters of the South Sea during the period from June to August 2014 and 2015, were analyzed. The size range of juveniles was 4.9-10.9 cm FL, and that of young S. quinqueradiata was 11.0-20.4 cm FL. Important prey items in the diets of juveniles were euphausiacea and copepoda, dominated by the Euphausia sp., Paracalanus sp. and Calanus sinicus while the diets of the young consisted mainly of pisces, dominated by Engraulis japonicus, Trachurus japonicus. Stomach content compositions differed significantly among body size levels in both the juveniles and young (ANOSIM, P<0.05). With increasing size, the mN/ST constantly decreased while the mW/ST constantly increased (one-way ANOVA). Graphical analysis of the diet composition showed that juvenile S. quinqueradiata are generalized feeders, young is a specialized feeders characterized by strong individual feeding specialization.

• The Journal of Korean Academy of Prosthodontics
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• v.36 no.2
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• pp.293-301
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• 1998

The purpose of this study was to investigate the effects of load on root that was applied to edentulous area in three simulated situation, in each case the guiding planes of abutment were right vertical, 95 degrees, or 100 degrees to residual ridge. The 2-dimensional finite element method was used and the finite element model was prepared as fellows. Right mandibular 1st and 2nd molar was lost and the 2nd premolar with distal rest was used as primary abutment which had three different degrees of guiding plane. Then 150N of compressive force was applied to central fossae of the 1st and 2nd molars and von Mises stress and displacement was measured. The results were as follows; 1. Irrespective of slopes of guiding planes, the stress was concentrated on mesial side of root apex and distal side of coronal portion of root, in particular on junction with distal alveolar bone. As slopes of guiding planes were increased. stress on root and compact bone surrounding abutment was increased but no considerable effect was seen on compact bone of residual ridge. 2. Distal side of coronal portion of root limited by periodontal ligament was displaced distally and mesial side of apical portion was mesially. With slope of guiding plane increasing, the pattern of displacement was similar with one another but the quantity was increased. 3. Both abutment & alveolar bone were displaced downward and root of abutment, especially distal side of coronal portion, was displaced severely. As the guiding plane was tiffed more mesially over $90^{\circ}$, the degree of displacement was also increased.

• Journal of Korean Clinical Nursing Research
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• v.18 no.2
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• pp.205-214
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• 2012

Purpose: The purposes of this study were to develop the constipation assessment tool for identifying their bowel movement patterns, and to provide basic information for the assessment and intervention protocol on constipation for patients with terminal cancers. Methods: The study followed the steps: the first step was to build a conceptual framework based on literature review; the second step was to develop a tentative instrument by analyzing the conceptual framework and existing instruments; the third step was to test content validity and reliability; and the final step was to apply the tool to patients with terminal cancers (N=112). Results: The constipation assessment tool was consisted of total nine items; under the categories of subjective and objective data for diagnosis had 4 items, and under the initial assessment category which includes stool type, physical examination, and abdomen X-ray had 5 items. Conclusion: The constipation assessment tool developed in this study is very easy to use and useful in nursing practice, especially in hospice and palliative care setting. Particularly this tool has items on patient assessment which would be considered as an evidence for choosing nursing interventions. Based on the constipation assessment tool, the development and application of intervention protocol on constipation for patients with terminal cancers is warranted in future research.

• Progress in Superconductivity
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• v.8 no.1
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• pp.46-53
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• 2006

Magnetocardiography(MCG) has been proposed as a novel and non-invasive diagnostic tool for the detection of cardiac electrical abnormality associated with myocardial ischemia. In our previous study, we have proposed a new classification method of MCG parameters, based on the different populations of the parameters between coronary artery disease(CAD) patients, symptomatic patients and healthy volunteers. We used four parameters, representing the directional changes of the electrical activity in the period of an R-ST-T interval. In patients with chest pain and without ST-segment elevation, who were selected consecutively from all patients admitted to the hospital in 2004, the patients with CAD could be classified with a higher sensitivity than conventional methods, showing that the proposed method can be useful for the diagnosis of CAD with MCG. In this study, we examined the validity of the algorithm with the prior probability distribution in diagnosis of new patients admitted to the hospital in 2005. In the results, presence of CAD could be found with sensitivity and specificity of 81.3% and 71.4%, respectively, in patients with chest pain and non-diagnostic ECG findings.

• Journal of Korean Society on Water Environment
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• v.30 no.4
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• pp.394-402
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• 2014

High-voltage dielectric discharges are an emerging technique in environmental pollutant degradation, which are characterized by the production of hydroxyl radicals as the primary degradation species. The initiation and propagation of the electrical discharges depends on several physical, chemical, and electrical parameters such as 1st and 2nd voltage of power, gas supply, conductivity and pH. These parameters also influence the physical and chemical characteristics of the discharges, including the production of reactive species such as OH, $H_2O_2$ and $O_3$. The experimental results showed that the optimum 1st voltage and oxygen flow rate for RNO (N-Dimethyl-4-nitrosoaniline, indicator of the generation of OH radical) degradation were 160 V (2nd voltage of is 15 kV) and 4 L/min, respectively. As the 2nd voltage (4 kV to 15 kV) was increase, RNO degradation was increased and, generated $H_2O_2$ and $O_3$ concentration were increased. The conductivity of the solution was not influencing the RNO degradation, $H_2O_2$ and $O_3$ generation. The pH effect on RNO degradation was not high. However, the lower pH and the conductivity, the higher $H_2O_2$ and $O_3$ generation were observed.

• Molecules and Cells
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• v.26 no.1
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• pp.74-80
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• 2008

Bisphenol A bis (2,3-dihydroxypropyl) ether ($BADGE.2H_2O$) is a component of commercial liquid epoxy resins commonly used in the food-packing industry and in dental sealants. There is evidence that it has significant estrogenic activity. Nur77 plays a crucial role in the regulation of certain genes involved in LH-mediated steroidogenesis in testicular Leydig cells. It was previously demonstrated that Bisphenol A (BPA) stimulates Nur77 gene induction and steroidogenesis. In this study, we investigated the effects of $BADGE.2H_2O$ on Nur77 gene expression and steroidogenesis. Northern blot analysis showed that it increased the expression of Nur77 mRNA and protein, and transient transfection assays demonstrated that it increased the promoter activity and transactivation of Nur77. It also increased the expression of certain steroidogenic genes, such as StAR and $3{\beta}$-HSD. Finally, over-expression of a dominant negative Nur77 cDNA via adenoviral infection reduced $BADGE.2H_2O$-mediated progesterone biosynthesis. These results indicate that $BADGE.2H_2O$ disrupts testicular steroidogenesis by increasing Nur77 gene expression.