• Korean Journal of Biological Psychiatry
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• v.27 no.2
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• pp.94-100
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• 2020

Objectives Amyloid β positron emission tomography (Aβ PET) is widely used as a diagnostic tool in patients who have symptoms of cognitive impairment, however, this diagnostic examination is too expensive. Thus, predicting the positivity of Aβ PET before patients undergo the examination is essential. We aimed to analyze clinical predictors of patients who underwent Aβ PET retrospectively, and to develop a predicting model of Aβ PET positivity. Methods 468 patients who underwent Aβ PET with cognitive impairment were recruited and their clinical indicators were analyzed retrospectively. We specified the primary outcome as Aβ PET positivity, and included variables such as age, sex, body mass index, diastolic blood pressure, systolic blood pressure, education, dementia family history, Mini Mental Status Examination (MMSE), Clinical Dementia Rating (CDR), Clinical Dementia Rating-Sum of Box (CDR-SB), hypertension (HTN), diabetes mellitus (DM) and presence of apolipoprotein E (ApoE) E4 as potential predictors. We developed three final models of amyloid positivity prediction for total subjects, mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia using a multivariate stepwise logistic regression analysis. Receiver operating characteristic (ROC) curve analysis was performed and the area under curve (AUC) value was calculated for the ROC curve. Results Aβ PET negative patients were 49.6% (n = 232), and Aβ PET positive patients were 50.4% (n = 236). In the final model of all subjects, older age, female sex, presence of ApoE E4 and lower MMSE are associated with Aβ PET positivity. The AUC value was 0.296. In the final model of MCI subjects (n = 244), older age and presence of ApoE E4 are associated with Aβ PET positivity. The AUC value was 0.725. In the final model of AD subjects (n = 173), lower MMSE scores, the presence of ApoE E4 and history of HTN are associated with Aβ PET positivity. The AUC value was 0.681. Conclusions The cerebral amyloid positivity model, which was based on commonly available clinical indicators, can be useful for prediction of amyloid PET positivity in MCI or AD patients.

• KIISE Transactions on Computing Practices
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• v.22 no.7
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• pp.315-319
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• 2016

Recurrent neural network based language models (RNN LM) have shown improved results in language model researches. The RNN LMs are limited to post processing sessions, such as the N-best rescoring step of the wFST based speech recognition. However, it has considerable vocabulary problems that require large computing powers for the LM training. In this paper, we try to find the 1st pass N-gram model using word embedding, which is the simplified deep neural network. The class based language model (LM) can be a way to approach to this issue. We have built class based vocabulary through word embedding, by combining the class LM with word N-gram LM to evaluate the performance of LMs. In addition, we propose that part-of-speech (POS) tagging based LM shows an improvement of perplexity in all types of the LM tests.

• Journal of Korean Society of Environmental Engineers
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• v.35 no.8
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• pp.586-591
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• 2013

This experiment was performed to enhance $CH_4$ purity of landfill gas by applying gas separator membrane for purified nitrogen gas production. 1:6 area ratios of $1^{st}$ to $2^{nd}$ membrane module was suitable for $CH_4$ recovery. After separation membrane system was installed, 249 tries were performed. Average permeability for $CH_4$ was 28.4% and for $CO_2$ was 94.3%. This can explain nitrogen gas separator membrane can be applied to collect $CH_4$ from LFG. However, nitrogen permeability only reached up to 16.5%. Therefore, the final purified landfill gas concentration was rounded up to 69.7% for $CH_4$, 4.3% for $CO_2$ and 26.0% for $N_2$. For the high degree of $CH_4$ purity, $N_2$ should be kept at least under 2.0% by controlling air inflow to landfill.

• Korean journal of applied entomology
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• v.43 no.1
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• pp.21-26
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• 2004

These studies were carried out to investigate the oviposition and host feeding characteristics of Neochrysocharis formosa Westwood, an endoparasitoid of Liriomyza trifolii. N. formosa female oviposited inside the abdomen at the rear end of the host larva. Number of eggs and host feeding per day of N. formosa tended to increase as temperatures go up. The ratio of oviposition and host feeding of N. formosa were 0.5, 0.9, 1.0 and 1.0 at 15, 20, 25, and 30$^{\circ}C$, respectively. In 25$^{\circ}C$, number of eggs and host feeding were 176.0 and 188.7, respectively, and aduly female longevity was 11.8 days. N. formosa female preferred to the 3rd rather than 1st and 2nd larva for oviposition and host feeding.

• Journal of Acupuncture Research
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• v.18 no.5
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• pp.155-163
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• 2001

It has known that acupuncture exerts various effects, such as analgesia, promotion of homeostasis, improvements in brain circulation, and rectification of internal disorders in Oriental medicine. Of particular, acupuncture at the Zusanli acupoint (ST36) has been widely used to relieve symptoms of diabetes mellitus. The effect of acupuncture at Zusanli on neuronal nitric oxide synthase (nNOS)-positive neurons in streptozotocin (STZ)-induced diabetic rats was investigated via immunohistochemistry. Decreased nNOS-positive neurons was detected in cerebrocortex of STZ-induced diabetic rats. Needling on the Zusanli in diabetic rats resulted in increase of nNOS-positive neurons in cerebrocortex, The present study indicate that acupuncture may affect nNOS-positive neurons in cerebrocortex of STZ-induced diabetic rats.

• Analytical Science and Technology
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• v.13 no.1
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• pp.49-54
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• 2000

The 8-hydroxyquinoline derivative of silica gel has been prepared through the 5 step reaction. We carried out infrared as well as nuclear magnetic resonance spectrometric characterization of products taken from each step of reaction. IR study of bare silica gel showed free and hydrogen bonded hydroxyl. From the 1st step reaction, we observed IR bands for N-H and C-H as well as NMR peaks for three methylene carbons in APTS group. From the 2nd step, we observed IR bands for carbonyl, nitro and aromatic carbon group with NMR peaks for aliphatic, aromatic and carbonyl carbons. The reduction of $NO_2$ group to $NH_2$ group is confirmed by IR and NMR from 3rd step reaction. In the last step, the immobilization of 8-quinolinol is confirmed by disappearance of $N{\equiv}N$ IR peak observed in 4th step.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.31 no.1
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• pp.94-104
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• 2021

Objectives: A number of medical institutions have been conducting fit tests to perform seal checks on masks. This study aimed to compare the differences fit factor before and after domestic N95 mask-wearing training through a fit-test. Methods: A survey of 59 healthcare workers was conducted regarding whether they had undergone a fit test or received training on mask-wearing. Further, the fit of two types of domestic N95 masks was measured before and after the training using a QNFT(Quantitative Fit test). The average fit factors before and after training were compared using a paired t-test. Additionally the differences in the fit test pass rate were analyzed using a McNemar test. Results: A statistically significant difference was seen between the fit factors in the fit tests conducted before and after the training (p=0.0015), as well as in the fit of the two types of masks tested (p<0.01). Thus, an improvement in mask fitting was seen after the training, even with differently fitted masks. Conclusions: Upon using a QNFT, a significant increase in the fit factors for N95 masks was observed after training compared with masks that were fitted as usual. This highlights the importance of training in mask-wearing, with the conclusion that training healthcare providers will improve the fit of masks.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.36 no.2
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• pp.45-59
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• 2023

Objectives : The purpose of this study is to analyze the various methods of sound therapy(ST) applied to tinnitus patients and their effectiveness, and to suggest an effective method that can be applied in clinical settings. Methods : Studies published from January 2018 to March 2023 were searched on 5 databases(Pubmed, RISS, OASIS, KISS, KCI). All RCTs that applied sound therapy as a main treatment method were included. Results : 14 studies were included. In 13 studies, sound therapy was statistically significant in improving tinnitus. Basic sound therapy was used in 6 studies(42%), followed by tinnitus rehabilitation therapy(TRT)(n=5, 35%). White noise(n=11, 75%) and nature sound(n=4, 28%) were the most frequently used sound sources. In the case of intensity, mixing point were the most common with 6 studies(42%). The mobile application(n=4) was the most frequently used implement. The application time of sound therapy per day was more than 3 hours(n=7), and the total treatment period was more than 3 months(n=9). Conclusions : Our findings indicate that sound therapy could be considered as an intervention for tinnitus patients. For better use, we suggest a basic type of sound therapy or TRT using white noise or nature sound at the mixing point level provided as a mobile phone application. In addition, the treatment period is recommended to be more than 3 hours/day for 3 months.

• Journal of Chest Surgery
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• v.57 no.3
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• pp.291-299
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• 2024

Background: Postoperative pain management following minimally invasive repair of pectus excavatum (MIRPE) remains a critical concern due to severe post-procedural pain. Promising results have been reported for cryoanalgesia following MIRPE; however, its invasiveness, single-lung ventilation, and additional instrumentation requirements remain obstacles. Serratus anterior plane block (SAPB) is a regional block technique capable of covering the anterior chest wall at the T2-9 levels, which are affected by MIRPE. We hypothesized that SAPB would be a superior alternative pain control modality that reduces postoperative pain more effectively than conventional methods. Methods: We conducted a retrospective study of patients who underwent MIRPE between March 2022 and August 2023. The efficacy of pain control was compared between group N (conventional pain management, n=24) and group S (SAPB, n=26). Group N received intravenous patient-controlled analgesia (IV-PCA) and subcutaneous local anesthetic infusion. Group S received bilateral continuous SAPB with 0.3% ropivacaine after a bilateral bolus injection of 30 mL of 0.25% ropivacaine with baseline IV-PCA. Pain levels were evaluated using a Visual Analog Scale (VAS) at 1, 3, 6, 12, 24, 48, and 72 hours postoperatively and total intravenous rescue analgesic consumption by morphine milligram equivalents (MME). Results: Mean VAS scores were significantly lower in group S than in group N throughout the 72-hour postoperative period (p<0.01). Group S showed significantly lower MME at postoperative 72 hours (group N: 108.53, group S: 16.61; p<0.01). Conclusion: SAPB improved immediate postoperative pain control in both the resting and dynamic states and reduced opioid consumption compared to conventional management.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.1
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• pp.367-376
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• 2014

The purpose of this study was to investigate the effect of either endurance training only or endurance and weight training on muscle morphology and oxidative enzyme activities in human skeletal muscles. Fourteen healthy males were randomly divided into one of two experimental training groups, either swim exercise training (n=7, ST) or combined exercise training (swim and resistance exercise training; n=7, SWT). The change of muscle fiber type was not significantly different between ST and SWT following 6 weeks of exercise training. Mean cross sectional areas as well as the numbers of capillary of different types of muscle fiber were not also significantly different from baseline for both exercise training groups (p>.05) although the tendency of increase were more notable in SWT. All oxidative enzyme activities (i.e., ${\beta}$-hydroxyl acyl dehydrogenase, citrate synthase, and carnitine palmitoyl transferase) were marginally higher in SWT compared to ST even though statistical power did not reach the level of significance. Based on these results, it was concluded that performing of combined (swimming and weight) exercise training could be the better modality for improving muscle morphological changes and oxidative enzyme activities than performing of only single aerobic exercise intervention in young healthy human skeletal muscles.