• Archives of Plastic Surgery
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• 제44권5호
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• pp.378-383
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• 2017

Background This study aimed to assess the effects of the topical application of tamoxifen on wound healing of burned skin in Wistar rats by evaluating 3 healing characteristics: fibrotic tissue thickness (FTT), scar surface area (SSA), and angiogenesis in the healed scar tissue. Methods Eighteen male Wistar rats were used in this study. A third-degree burn wound was made on the shaved animals' back, measuring $2{\times}2{\times}2cm$. In the first group, a 2% tamoxifen ointment was applied to the wound twice daily for 8 weeks. The second group received a placebo ointment during the same period. The third group did not receive any treatment and served as the control group. Results The median (interquartile range=[Q1, Q3]) FTT was 1.35 (1.15, 1.62) mm, 1.00 (0.95, 1.02) mm, and 1.25 (0.8, 1.5) mm in the control, tamoxifen, and placebo groups, respectively (P=0.069). However, the FTT in the tamoxifen group was less than in the placebo and control groups. The median angiogenesis was 3.5 (3.00, 6.25), 8.00 (6.75, 9.25), and 7.00 (5.50, 8.25) vessels per high-power field for the control, tamoxifen, and placebo groups, respectively (P=0.067). However, the median angiogenesis was higher in the tamoxifen group than in the control group. No significant difference was observed in the mean SSA between the tamoxifen group and the control group (P=0.990). Conclusions Local application of tamoxifen increased angiogenesis and decreased the FTT, with no change in the SSA in burned skin areas. These effects are expected to expedite the wound healing process, reducing contracture and preventing hypertrophic scar and keloid formation.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.1967-1971
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• 2016

Background: In tumor cells, aberrant differentiation programs have been described. Several neuronal proteins have been found associated with morphological neuronal-glial changes in breast cancer (BCa). These neuronal proteins have been related to mechanisms that are involved in carcinogenesis; however, this regulation is not well understood. Microtubule-associated protein-tau (MAP-Tau) has been describing in BCa but not its variants. This finding could partly explain the neuronal-glial morphology of BCa cells. Our aim was to determine mRNA expression of MAP-tau variants 2, 4 and 6 in breast cancer cell lines. Materials and Methods: Cultured cell lines MCF-10A, MDA-MB-231, SKBR3 and T47D were observed under phase-contrast microscopy for neural morphology and analyzed for gene expression of MAP-Tau transcript variants 2, 4 and 6 by real-time PCR. Results: Regarding morphology like neural/glial cells, T47D line shown more cells with these features than MDA-MB-231 and SKBR. In another hand, we found much greater mRNA expression of MAP-Tau transcript variants 2, and to a lesser extent 4 and 6, in T47D cells than the other lines. In conclusion, regulation of MAP-Tau could bring about changes in cytoskeleton, cell morphology and motility; these findings cast further light on neuronal transdifferentiation in BCa.

• 한국대기환경학회지
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• 제33권2호
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• pp.97-107
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• 2017

Columnar aerosol properties retrieved from solar radiation were investigated at the Yongin (YGN) SKYNET site over seven years from October 2008 to October 2015. Hourly averages were calculated when the data were available, and back trajectories were calculated to examine the effects of regional transport. Data recovery rate was low at 6.6%, primarily because solar radiation was measured only under daytime clear-sky conditions. Mean values of the fine-mode volume fraction (FMVF) as well as its seasonal variation were similar to those of $PM_{2.5}/PM_{10}$ although the coarse-mode fraction of column aerosols tended to be slightly larger. The values of single scattering albedo (SSA) and FMVF were lower in spring due to the effects of mineral dust, and higher in summer due to secondarily-formed inorganic ions. Back trajectories were grouped into five clusters according to the directions of transport paths. Aerosol loading was highest for Cluster 2 from the northwest, but SSA and FMVF were not particularly high or low because aerosols were composed of various materials with different properties. Aerosol loading was lowest for Cluster 5 from the Pacific Ocean passing through the south end of Japan, whose SSA and FMVF were highest as secondarily-formed inorganic ions were mixed.

• 한국항공우주학회지
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• 제44권5호
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• pp.447-454
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• 2016

우주파편의 증가는 지구궤도 환경을 날이 갈수록 복잡하게 만들고 있고 우주상황인식(SSA)의 중요성은 날로 높아지고 있다. 우주상황인식의 필수적인 분야인 우주물체 감시 및 추적은 미국과 유럽을 비롯한 세계 각국에서 활발히 연구가 진행되고 있으며, 레이더는 우주물체 감시 및 추적에 중추적인 역할을 하는 센서이다. 한국은 현재 다목적실용위성 등 다수의 저궤도위성을 운영 중이지만, 위성과 우주물체간의 충돌 감시를 위한 전용레이더는 보유하고 있지 않다. 하지만 한국항공우주연구원 나로우주센터는 발사체 궤적을 추적하기 위한 레이더를 고흥과 제주에 각각 운영하고 있다. 본 논문에서는 나로호 발사체 추적레이더를 국제우주정거장 추적에 사용하기 위해 운용개념을 개발한 내용과 국제우주정거장을 추적한 내용을 기술한다. 또한 추적결과 획득한 레이더 데이터를 이용하여 국제우주정거장을 궤도결정한 내용을 기술하고 TLE와 비교하여 궤도결정의 유효성을 분석하였다.

• 한국물환경학회지
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• 제34권3호
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• pp.316-327
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• 2018

Liquid fertilizers made from livestock manure contain high concentrations of nitrogen and phosphorus and thus are used as a fertilizer. However, excessive use of liquid fertilizer causes eutrophication of agricultural land and nonpoint source pollution. In this study, as a means of lowering the nutrient concentrations, struvite ($MgNH_4PO_4{\cdot}6H_2O$) production from the liquid fertilizer was investigated. When liquid fertilizers produced in Gyeonggido were analyzed, its characteristics differed by region and season, but the phosphorus concentration was commonly lower than that of nitrogen. When $K_2HPO_4$ and $MgCl_2$ were added to the liquid fertilizers, the optimal pH for struvite formation was pH 9.5. For environmentally friendly sources of magnesium and phosphate, ferronickel slag (FNS) and sewage sludge ash (SSA) were suspended in deionized water and extracted by sulfuric acid with various mass ratios. The optimum conditions for extracting FNS and SSA were 4.0 M sulfuric acid and 0.35 mass ratio of sulfuric acid to sewage sludge ash, respectively. For forming struvite, 0.233 L of SSA leachate (SSAL) was added into 0.3 L of liquid fertilizer containing 2,586 mg/L of ammonia and 110 mg/L of phosphate, pH was then adjusted to pH 9.5 using 10 M of NaOH. Afterwards 0.333 L of FNS leachate (FNSL) was added to this mixed solution. After a reaction for 1 hr at room temperature, the remaining concentrations of magnesium, ammonium, and phosphate were less than 50 mg/L, 500 mg/L and 150 mg/L, respectively, and 30 g of precipitates were obtained, most of which were struvite.

• 한국세라믹학회지
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• 제46권2호
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• pp.200-210
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• 2009

It is necessary to minimize the mismatch of sintering shrinkage between dielectric ceramic and Ni inner electrode layers for the purpose of developing the ultra high-capacity multi layered ceramic condenser(MLCC). Thus, low temperature sintering of dielectric $BaTiO_3$ ceramic should be precedently investigated. In this work, the influence of the milling condition on sintering behavior and electrical properties of $BaTiO_3$ ceramics was investigated in the $BaTiO_3$(BT)-Mg-Dy-Mn-Ba system with borosilicate glass as a sintering agent. As milling time increased, specific surface area(SSA) of the powder increased linearly, while both sinterability and dielectric property were found to be drastically decreased with an increasing SSA. It was also revealed that the sinterability of the excessively milled $BaTiO_3$ ceramics could be recovered by increasing Ba content, rather than increasing glass addition. These results suggest that the sintering behavior of $BaTiO_3$ ceramics under the high SSA was more strongly dependent on the transient liquid phase caused by Ba addition, than the liquid phase from additional glass.

• 멤브레인
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• 제28권5호
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• pp.332-339
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• 2018

막 결합형 축전식 탈염공정에서 이온교환막의 이온교환용량이 염 제거 효율에 미치는 영향을 알아보기 위해 poly(vinyl alcohol)(PVA) 수용성 고분자에 sulfosuccinic acid (SSA) 가교제를 첨가하고 poly(4-styrene sulfonic acid-co-maleic acid)(PSSA_MA)를 PVA 질량대비 10, 50, 90 wt%로 달리 첨가하여 제조하였다. PSSA_MA의 함량이 증가함에 따라 함수율과 이온교환용량이 증가하는 경향을 나타내었으며 막 결합형 축전식 탈염공정에서 염 제거 효율도 상승되었다. PSSA_MA 90 wt%, 100 mg/L NaCl의 공급액과 유속 15 mL/min에서 흡착 1.4 V/5분의 조건에서 가장 높은 65.5%의 염 제거 효율을 나타내었다.

• Journal of Electrical Engineering and Technology
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• 제9권2호
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• pp.514-522
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• 2014

A new type of high precision electromagnetic suspension (EMS) which can support heavy tray along long stroke rail is proposed in this paper. Compared with the conventional EMS, the suggested moving-core typed EMS has the levitation electromagnets (EMs) on the fixed rail. This scheme has high load capability caused by iron-core and enables simple tray structure. Also it does not have precision degradation caused by heat generation from EMs, which is a drawback of conventional EMS. With these merits, the proposed EMS can be an optimal contactless linear bearing in next generation flat panel display (FPD) manufacturing process if the ability of long stroke movement is proved. So a special Section Switching Algorithm (SSA) is derived from the resultant force and moment equations of the levitated tray which enables long stroke movement of the tray. In order to verify the feasibility of the suggested SSA, a simple test-setup of the EMS with 2 Section-changes is made up and servo-controlled in the simulation and experiment. The simulation shows the perfect changeover the EMs, and the experiment shows overall control performance of under ${\pm}40{\mu}m$ gap deviations. These results reveal that the newly suggested contactless linear bearing can simultaneously achieve high load capability and precision gap control as well as long stroke.

• 멤브레인
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• 제13권2호
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• pp.101-109
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• 2003

본 연구에서는 설폰기를 함유한 sulfosuccinic acid를 가교제로 사용하였다. 또한, 메탄을 투과도를 줄이기 위해 실리카를 졸-겔 방법을 사용하여 성장시킨 PVA/Silica 하이브리드막을 제조하여 수소 이온 전도도 및 메탄을 투과도에 관하여 연구하였다. 수소 이온 전도도 및 메탄을 투과도는 가교제 농도 및 친수성 $SO_3H$의 함량에 영향을 받았으며, 제조된 막의 수소 이온 전도도는 10^{-3}~10^{-2}$ S/cm 범위에 있었고, 메탄을 투과도는 $10^{-8}~10^{-7}\;cm^2/s$ 를 갖는다.

• Computers and Concrete
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• 제33권1호
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• pp.77-90
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• 2024

Waste foundry sand (WFS) is the waste product that cause environmental hazards. WFS can be used as a partial replacement of cement or fine aggregates in concrete. A database comprising 234 compressive strength tests of concrete fabricated with WFS is used. To construct the machine learning-based prediction models, the water-to-cement ratio, WFS replacement percentage, WFS-to-cement content ratio, and fineness modulus of WFS were considered as the model's inputs, and the compressive strength of concrete is set as the model's output. A base extreme gradient boosting (XGBoost) model together with two hybrid XGBoost models mixed with the tunicate swarm algorithm (TSA) and the salp swarm algorithm (SSA) were applied. The role of TSA and SSA is to identify the optimum values of XGBoost hyperparameters to obtain the higher performance. The results of these hybrid techniques were compared with the results of the base XGBoost model in order to investigate and justify the implementation of optimisation algorithms. The results showed that the hybrid XGBoost models are faster and more accurate compared to the base XGBoost technique. The XGBoost-SSA model shows superior performance compared to previously published works in the literature, offering a reduced system error rate. Although the WFS-to-cement ratio is significant, the WFS replacement percentage has a smaller influence on the compressive strength of concrete. To improve the compressive strength of concrete fabricated with WFS, the simultaneous consideration of the water-to-cement ratio and fineness modulus of WFS is recommended.