• The Journal of Korea Robotics Society
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• v.17 no.1
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• pp.40-47
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• 2022

A reward function suitable for a task is required to manipulate objects through reinforcement learning. However, it is difficult to design the reward function if the ample information of the objects cannot be obtained. In this study, a demonstration-based object manipulation algorithm called stochastic exploration guided by demonstration (SEGD) is proposed to solve the design problem of the reward function. SEGD is a reinforcement learning algorithm in which a sparse reward explorer (SRE) and an interpolated policy using demonstration (IPD) are added to soft actor-critic (SAC). SRE ensures the training of the critic of SAC by collecting prior data and IPD limits the exploration space by making SEGD's action similar to the expert's action. Through these two algorithms, the SEGD can learn only with the sparse reward of the task without designing the reward function. In order to verify the SEGD, experiments were conducted for three tasks. SEGD showed its effectiveness by showing success rates of more than 96.5% in these experiments.

• Advances in aircraft and spacecraft science
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• v.10 no.5
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• pp.457-471
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• 2023

The paper evaluates the aerodynamic coefficients on a blunt-nose re-entry capsule with a conical cross-section followed by a cone-flare body. A computer code is developed to solve three-dimensional compressible inviscid equationsfor flow over a Space Recovery Experiment (SRE) configuration at different flare-cone half-angle at Mach 6 and angle of attack up to 5°, at 1° interval. The surface pressure variation is numerically integrated to obtain the aerodynamic forces and pitching moment. The numerical analysis reveals the influence of flare-cone geometry on the flow characteristics and aerodynamic coefficients. The numerical results agree with wind tunnel results. Increase of cone-flare angle from 25° to 35° results in increase of normal force slope, axial forebody drag, base drag and location of centre of pressure by 62.5%, 56.2% and 33.13%, respectively, from the basic configuration ofthe SRE of 25°.

• Journal of the Korean Applied Science and Technology
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• v.37 no.5
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• pp.1239-1247
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• 2020

Sedum kamtschaticum Fisch., a native plant of Korea, has been used in Korean traditional medicine in the form of water extract for its capacity to improve blood circulation and for its antioxidant and anti-inflammatory effects. Since previous research suggests that S. kamtschaticum Fisch. has excellent antioxidant and mushroom tyrosinase inhibition activities, in this study, the root and stem parts of S. kamtschaticum Fisch. are extracted in 70% ethanol (SKS, SKR), fractionated with and in order of n-hexane (SSH), ethyl acetate (SSE, SRE), chloroform (SSC, SRC) and water (SSW, SRW) according to the polarity of each solvent, and tested for its applicability as a cosmetic material. According to the total polyphenol, flavonoid contents and DPPH radical scavenging activity of each fraction, the contents and scavenging activity of the root extractions (SKR) were higher than those of the stem extractions (SKS), ethyl acetate fractions (SSE, SRE) being the most effective. In addition, ethyl acetate fractions had the highest tyrosinase inhibition activity and melanin synthesis inhibition activity used on B16F10 melanoma cells, at the concentration of 10 ㎍/mL. HPLC analysis detected a variety of polyphenols including gallic acid and quercetin. This study suggests the potential role of S. kamtschaticum Fisch. as a natural cosmeceutical material.

• Proceedings of the Korean Nutrition Society Conference
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• 2003.10a
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• pp.139-139
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• 2003

• Molecules and Cells
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• v.26 no.5
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• pp.462-467
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• 2008

TPA is known to cooperate with an activated Ras oncogene in the transformation of rodent fibroblasts, but the biochemical mechanisms responsible for this effect have not been established. In the present study we used c-fos promoter-luciferase constructs as reporters, in transient transfection assays, in NIH3T3 cells to assess the mechanism of this cooperation. We found a marked synergistic interaction between TPA and a transfected v-Ha-ras oncogene in the activation of c-fos promoter and SRE. SRE has binding sites for TCF and SRF. A dominant-negative Ras (ras-N17) inhibited the TPA-Ras synergy by blocking the PKC-MAPK-TCF pathway. Dominant-negative RhoA and Rac1 (but not Cdc42Hs) inhibited the TPA-Ras synergy by blocking the Ras-Rho-SRF signaling pathway. Constitutively active $PKC{\alpha}$ and $PKC{\varepsilon}$ showed synergy with v-Ras. These results suggest that the activation of two distinct pathways such as Ras-Raf-ERK-TCF pathway and Rho-SRF pathway are responsible for the induction of c-fos by TPA and Ras in mitogenic signaling pathways.

• International Journal of Computer Science & Network Security
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• v.24 no.5
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• pp.40-52
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• 2024

Cyber-Physical Systems (CPS) are introduced as complex, interconnected systems that combine physical components with computational elements and networking capabilities. They bridge the gap between the physical world and the digital world, enabling the monitoring and control of physical processes through embedded computing systems and networked communication. These systems introduce several security challenges. These challenges, if not addressed, can lead to vulnerabilities that may result in substantial losses. Therefore, it is crucial to thoroughly examine and address the security concerns associated with CPS to guarantee the safe and reliable operation of these systems. To handle these security concerns, different existing security requirements methods are considered but they were unable to produce required results because they were originally developed for software systems not for CPS and they are obsolete methods for CPS. In this paper, a Security Requirements Engineering Methodology for CPS (CPS-SREM) is proposed. A comparison of state-of-the-art methods (UMLSec, CLASP, SQUARE, SREP) and the proposed method is done and it has demonstrated that the proposed method performs better than existing SRE methods and enabling experts to uncover a broader spectrum of security requirements specific to CPS. Conclusion: The proposed method is also validated using a case study of the healthcare system and the results are promising. The proposed model will provide substantial advantages to both practitioners and researcher, assisting them in identifying the security requirements for CPS in Industry 4.0.

• Membrane Journal
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• v.27 no.3
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• pp.240-247
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• 2017

In this study, the heterogeneous ion exchange membranes prepared by the combination of the carbon electrode and mixed the cation and anion exchange polymers and polyvinylidene fluoride as the basic polymer together were made to recognize the efficiency of the salt removal for the application of the membrane capacitive deionization process. The mixing weight ratio of the solvent, basic polymer and ion exchange resin was 7 : 2 : 1 and this mixed solution was directly cast on the electrode. As for the operating conditions of the adsorption voltage and time, feed flow rate, desorption voltage and time of the feed solution NaCl 100 mg/L, the salt removal efficiencies (SRE) were measured. Apart from this NaCl, the $CaCl_2$ and $MgSO_4$ solutions were investigated in terms of SRE as well. Typically, SRE for NaCl 100 mg/L solution under the conditions of adsorption voltage/time, 1.5 V/3 min, desorption voltage/time -0.1 V/3 min, was shown 98%. And for the $CaCl_2$ and $MgSO_4$ solutions, the SREs of 70 and 59% were measured under the conditions of adsorption voltage/time, 1.2 V/3 min, desorption voltage/time -0.5 V/5 min, respectively.

• Journal of Life Science
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• v.20 no.2
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• pp.202-207
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• 2010

Ras genes are responsible for up to 30% of human tumor mutations and are composed of three isoforms: H-Ras, K-Ras and N-Ras. The post-translational modification of the CAAX motif of the Ras protein is essential in Ras actions. In the present study, we studied the effects of novel farnesyl transferase inhibitors (FTIs), YH3938 and YH3945, on the actions of oncogenic mutants of H-Ras, K-Ras and N-Ras. YH3938 and YH3945 completely reverted the proliferation and morphology of oncogenic H-Ras-transformed Rat2 cells, but not of oncogenic K-Ras-transformed Rat2 cells. Oncogenic N-Ras-transformed Rat2 cells were slightly affected. Activation of SRE promoters by oncogenic H-Ras and N-Ras, but not by K-Ras, were inhibited by treatment with YH3938 and YH3945. Using bandshift analysis, YH3938 suppressed the processing of oncogenic H-Ras and N-Ras, but not that of oncogenic K-Ras protein. YH3945 only inhibited the processing of H-Ras. From these results, we conclude that YH3938 and YH3945 specifically inhibit actions of oncogenic H-Ras through inhibition of its farnesylation, that YH3938 also inhibits N-Ras activity in a dose-dependent manner, and that these drugs have no effect on oncogenic K-Ras activity.

• BMB Reports
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• v.43 no.1
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• pp.17-22
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• 2010

In this study, a novel member of BTB-kelch proteins, named KBTBD7, was cloned from a human embryonic heart cDNA library. The cDNA of KBTBD7 is 3,008 bp long and encodes a protein product of 684 amino acids (77.2 kD). This protein is highly conserved in evolution across different species. Western blot analysis indicates that a 77 kD protein specific for KBTBD7 is wildly expressed in all embryonic tissues examined. In COS-7 cells, KBTBD7 proteins are localized to the cytoplasm. KBTBD7 is a transcription activator when fused to GAL4 DNA-binding domain. Deletion analysis indicates that the BTB domain and kelch repeat motif are main regions for transcriptional activation. Overexpression of KBTBD7 in MCF-7 cells activates the transcriptional activities of activator protein-1 (AP-1) and serum response element (SRE), which can be relieved by siRNA. These results suggest that KBTBD7 proteins may act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.

• International Journal of Reliability and Applications
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• v.9 no.1
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• pp.79-93
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• 2008

The aim of this work is to generalize reliability equivalence techniques to apply them to a system consists of two independent and non-identical components connected in series(parallel) system, that have constant failure rates. We shall improve the system by using one component only. We start by establishing two different types of reliability equivalence factors, the survival reliability equivalence (SRE) and mean reliability equivalence (MRE) factors. Our second studies, introducing some applications for our studies in airports and our life. Also, we introduced some numerical results.