• Biomolecules & Therapeutics
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• v.24 no.6
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• pp.623-629
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• 2016

(1S,2S,3E,7E,11E)-3,7,11,15-cembratetraen-17,2-olide (LS-1), a marine cembrenolide diterpene, has anticancer activity against colon cancer cells such as HT-29, SNU-C5/5-FU (fluorouracil-resistant SNU-C5) and SNU-C5. However, the action mechanism of LS-1 on SNU-C5 human colon cancer cells has not been fully elucidated. In this study, we investigated whether the anticancer effect of LS-1could result from apoptosis via the modulation of $Wnt/{\beta}$-catenin and the TGF-${\beta}$ pathways. When treated with the LS-1, we could observe the apoptotic characteristics such as apoptotic bodies and the increase of sub-G1 hypodiploid cell population, increase of Bax level, decrease of Bcl-2 expression, cleavage of procaspase-3 and cleavage of poly (ADP-ribose) polymerase in SNU-C5 cells. Furthermore, the apoptosis induction of SNU-C5 cells upon LS-1 treatment was also accompanied by the down-regulation of $Wnt/{\beta}$-catenin signaling pathway via the decrease of GSK-$3{\beta}$ phosphorylation followed by the decrease of ${\beta}$-catenin level. In addition, the LS-1 induced the activation of TGF-${\beta}$ signaling pathway with the decrease of carcinoembryonic antigen which leads to decrease of c-Myc, an oncoprotein. These data suggest that the LS-1 could induce the apoptosis via the down-regulation of $Wnt/{\beta}$-catenin pathway and the activation of TGF-${\beta}$ pathway in SNU-C5 human colon cancer cells. The results support that the LS-1 might have potential for the treatment of human colon cancer.

• Korean Journal of Ecology and Environment
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• v.34 no.3 s.95
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• pp.206-214
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• 2001

Water quality and Pollution state of Lake Chungcho were evaluated during three years from 1998 to 2000. We surveyed physicochemical parameters, and TSI (trophic state index) was calculated using TP, Chl. a, and SD (secchi disc transparency) data of growing season average. Water samples were collected bimonthly except freezing season. During the study period, total annual precipitation in 1998, 1999 and 2000 year was 1,797,1,722 and 1,345 mm, respectively. Salinity and conductivity were high($29.3{\pm}5.5\;ppt$, and $45,105{\pm}7,585\;{\mu}S/cm$) then other lagoons in the Eastern Coast of Korea. Chemocline was formed by salinity at $0.5{\sim}1.5\;m$ water depth. As a result of this, DO concentration of hypolimnion was below $3.0\;mgO_2/L$. Especially, when intense chemocline was formed, temperature of hypolimnion was higher than epilimnion. Secchi disc transparency, chlorophyll a, and COD were $1.8{\pm}0.3\;m$, $15.7{\pm}20.7\;mg/m^3$, and $3.1{\pm}0.8\;mgO_2/L$, respectively. Most of TN/TP ratios below 20, but concentration of TN and TP was high. Values of TSI ranged between 59 and 77, indicating a eutrophic condition in this system.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.39 no.1
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• pp.97-107
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• 2002

In this paper, we propose the realization of on-line handwritten Chinese character recognition for mobile personal digital assistants (PDA). We focus on the development of an algorithm having a high recognition performance under the restriction that PDA requires small memory storage and less computational complexity in comparison with PC. Therefore, we use index matching method having computational advantage for fast recognition and we suggest a unit reconstruction method to minimize the memory size to store the character models and to accomodate the various changes in stroke order and stroke number of each person in handwriting Chinese characters. We set up standard model consisting of 1800 characters using a set of pre-defined units. Input data are measured by similarity among candidate characters selected on the basis of stroke numbers and region features after preprocessing and feature extracting. We consider 1800 Chinese characters adopted in the middle and high school in Korea. We take character sets of five person, written in printed style, irrespective of stroke ordering and stroke numbers. As experimental results, we obtained an average recognition time of 0.16 second per character and the successful recognition rate of 94.3% with MIPS R4000 CPU in PDA.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.47 no.1
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• pp.35-43
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• 2010

1D PCA utilized in the face appearance-based face recognition methods such as eigenface-based face recognition method may lead to less face representative power and more computational cost due to the resulting 1D face appearance data vector of high dimensionality. To resolve such problems of 1D PCA, 2D PCA-based face recognition methods had been developed. However, the face representation model obtained by direct application of 2D PCA to a face image set includes both face common features and face distinctive identity features. Face common features not only prevent face recognizability but also cause more computational cost. In this paper, we first develope a model of a face distinctive identity feature subspace separated from the effects of face common features in the face feature space obtained by application of 2D PCA analysis. Then, a novel robust face recognition based on the face distinctive identity feature subspace model is proposed. The proposed face recognition method based on the face distinctive identity feature subspace shows better performance than the conventional PCA-based methods (1D PCA-based one and 2D PCA-based one) with respect to recognition rate and processing time since it depends only on the face distinctive identity features. This is verified through various experiments using Yale A and IMM face database consisting of face images with various face poses under various illumination conditions.

• The Journal of Internal Korean Medicine
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• v.21 no.1
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• pp.169-180
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• 2000

Objectives : To satisfy the demand of good treatment of constipation Methods : we investigated the literatures of Oriental Medicine about Constipation. Results: 1. There are three categories of etimological factors of constipation, that is, endogenous, exogenous and non-exo-endogenous factor. The endogenous factor is caused by seven emotions, called depression of Ki and stagnation of Ki. The exogenous factor is six excessive atmospheric influences, for example, wind, cold, dampness, heat and dryness. And the non-exo-endogenous factors are overfatigue, improper diet, stagnated blood and deficiency of Ki and blood that comes from old age, long disease and after delivery. 2. Classification: According to cause of disease it is classified by constipation due to cold, heat, wind, dryness, retention of undigested and phlegm. According to Internal Organs there are constipation due to deficiency syndrome of the stomach, excess syndrome of the stomach, deficiency syndrome of kidney and splenic constipation. And Differentiation of syndromes according to Ki and blood, there are constipation of deficiency type and excess type. There are constipation due to stagnation and deficiency of Ki, deficiency of blood and stagnated blood. 3. Principles and Methods of treatment 1) Herbal Medicine (1) Excess type [1] Constipation due to heat : Seunggitang(承氣湯) and Majainwhan(麻子仁丸) [2] Constipation due to stagnation of Ki : Samatang(四磨湯) and Yukmatang(六磨湯) (2) Deficiency type [1] Constipation due to deficiency of Ki : Whanggitang(黃?湯) [2] Constipation due to deficiency of blood: Yunjangwhan(潤腸丸) [3] Constipation due to cold : Jechunjun(濟川煎) and Banyuwhan(半硫丸) 2) Enema therapy: It is a method to induce defecation by honey or pig's bile juice for weak people. 3) Acupuncture and Moxibustion: Acupoints used to treat constipation are BL25, ST25 and TE6. Moxibustion at CV8, CV6 is good for constipation due to cold. (4) Diet therapy: It is very important that we eat meals regularly and defecate on the same time even if you don't. And we have to eat food like fruits, vegetables and beans. (5) finger pressure: Finger pressing around these points like ST25, SP25, BL25, BL31, BL32, BL33 and BL34 is good for it. (6) Kigong therapy: Abdominal breathing (7) Old man' s constipation: Hip bath or diet therapy is commended. Laxation with lubricant like Supungyunjangwhan(搜風潤腸丸) is used. (8) Women' s constipation: After delivery, we have to administer tonifying prescription Sipjundaebotang(十全大補湯) and enema can be used. Conclusion : We have to examine the cause of disease and bowl movement carefully. After comprehensive analysis of the data gained by the four methods of diagnosis, we diagnose and treat patients on the base of overall of symptoms and signs.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.42 no.2 s.302
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• pp.101-112
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• 2005

As we perceive the world as 3-dimensional through our two eyes, we can extract 3-dimensional information from stereo images obtained from two or more cameras. Since stereo images have a large amount of data, with recent advances in digital video coding technology, efficient compression algorithms have been developed for stereo images. In order to compress stereo images and to obtain 3-D information such as depth, we find disparity vectors by using disparity estimation algorithm generally utilizing pixel differences between stereo pairs. However, it is not unusual to have stereo images having different intensity values for several reasons, such as incorrect control of the iris of each camera, disagreement of the foci of two cameras, orientation, position, and different characteristics of CCD (charge-coupled device) cameras, and so on. The intensity differences of stereo pairs often cause undesirable problems such as incorrect disparity vectors and consequent low coding efficiency. By compensating intensity differences between left and right images, we can obtain higher coding efficiency and hopefully reduce the perceptual burden of brain to combine different information incoming from two eyes. We propose several methods of intensity compensation such as local intensity compensation, global intensity compensation, and hierarchical intensity compensation as very simple and efficient preprocessing tool. Experimental results show that the proposed algerian provides significant improvement in coding efficiency.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.42 no.2 s.302
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• pp.27-36
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• 2005

This thesis proposed an effective encryption method for the DCT-based image/video contents and made it possible to operate in a high speed by implementing it as an optimized hardware. By considering the increase in the amount of the calculation in the image/video compression, reconstruction and encryption, an partial encryption was performed, in which only the important information (DC and DPCM coefficients) were selected as the data to be encrypted. As the result, the encryption cost decreased when all the original image was encrypted. As the encryption algorithm one of the multi-mode AES, DES, or SEED can be used. The proposed encryption method was implemented in software to be experimented with TM-5 for about 1,000 test images. From the result, it was verified that to induce the original image from the encrypted one is not possible. At that situation, the decrease in compression ratio was only $1.6\%$. The hardware encryption system implemented in Verilog-HDL was synthesized to find the gate-level circuit in the SynopsysTM design compiler with the Hynix $0.25{\mu}m$ CMOS Phantom-cell library. Timing simulation was performed by Verilog-XL from CadenceTM, which resulted in the stable operation in the frequency above 100MHz. Accordingly, the proposed encryption method and the implemented hardware are expected to be effectively used as a good solution for the end-to-end security which is considered as one of the important problems.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.45 no.2
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• pp.81-89
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• 2008

Wideband speech, characterized by a bandwidth of about 7 kHz (50-7000 Hz), provides a substantial quality improvement in terms of naturalness and intelligibility. Although higher data rates are required, it has extended its application to audio and video conferencing, high-quality multimedia communications in mobile links or packet-switched transmissions, and digital AM broadcasting. In this paper, we present a new bandwidth-scalable coder for wideband speech and audio signals. The proposed coder spits 8kHz signal bandwidth into two narrow bands, and different coding schemes are applied to each band. The lower-band signal is coded using the ITU-T G.729/G.729E coder, and the higher-band signal is compressed using a new algorithm based on the gammatone filter bank with an invertible auditory model. Due to the split-band architecture and completely independent coding schemes for each band, the output speech of the decoder can be selected to be a narrowband or wideband according to the channel condition. Subjective tests showed that, for wideband speech and audio signals, the proposed coder at 14.2/18 kbit/s produces superior quality to ITU-T 24 kbit/s G.722.1 with the shorter algorithmic delay.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.45 no.2
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• pp.21-28
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• 2008

This paper proposes a novel reduced-reference assessment method for video quality assessment, in which one-dimensional (1-D) histograms of motion vectors (MVs) are used as features of videos. The proposed method is more efficient than the conventional methods in view of computation time, because the proposed quality metric decodes MVs directly from video stream in the parsing process instead of reconstructing the distorted video at the receiver. Moreover, in view of data size, the propose method is efficient because a sender transmits 1-D histograms of MVs accumulated over whole input video sequences. Here, we use 1-D histograms of MVs accumulated over the whole video sequences, which is different from the conventional methods that assessed each image independently. For testing the similarity between histograms, we use histogram intersection and histogram difference methods. We compare the proposed method with the conventional methods for 52 video clips, which are coded under varying bit rate, image size, and frame rate. Experimental results show that the proposed method is more efficient than the conventional methods and that the proposed method is more similar to the mean opinion score (MOS) than conventional algorithms.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.3
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• pp.889-896
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• 2015

Matrix metalloproteinase-2 (MMP2) is an endopeptidase, mainly responsible for degradation of extracellular matrix components, which plays an important role in cancer disease. A single nucleotide polymorphism (SNP) at -1306 disrupts a Sp1-type promoter site. The results from the published studies on the association between MMP2 -1306 C>T polymorphism and cancer risk are contradictory and inconclusive. In the present study, a meta-analysis was therefore performed to evaluate the strength of any association between the MMP2 -1306 C>T polymorphism and risk of cancer. We searched all eligible studies published on association between MMP2 -1306 C>T polymorphism and cancer risk in PubMed (Medline), EMBASE and Google Scholar online web databases until December 2013. Genotype distribution data were collected to calculate the pooled odds ratios (ORs) and 95% confidence intervals (95%CIs) to examine the strength of the association. A total of 8,590 cancer cases and 9,601 controls were included from twenty nine eligible case control studies. Overall pooled analysis suggested significantly reduced risk associated with heterozygous genotype (CT vs CC: OR=0.758, 95%CI=0.637 to 0.902, p=0.002) and dominant model (TT+CT vs CC: OR=0.816, 95%CI=0.678 to 0.982, p=0.032) genetic models. However, allelic (T vs C: OR=0.882, 95%CI=0.738 to 1.055, p=0.169), homozygous (TT vs CC: OR=1.185, 95%CI=0.825 to 1.700, p=0.358) and recessive (TT vs CC+CT: OR=1.268, 95%CI=0.897 to 1.793, p=0.179) models did not show any risk. No evidence of publication bias was detected during the analysis. The results of present meta-analysis suggest that the MMP2 -1306 C>T polymorphism is significantly associated with reduced risk of cancer. However, further studies with consideration of different populations will be required to evaluate this relationship in more detail.