• Journal of Acupuncture Research
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• 제29권1호
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• pp.37-45
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• 2012

목적 : 최근 NF-${\kappa}B$와 STAT3의 활성억제와 관련된 항암제 연구가 주목받고 있으며, 본 연구는 사독(蛇毒)이 세포자멸사 관련 단백질의 발현 조절을 통하여 세포자멸사를 유도하고, NF-${\kappa}B$와 STAT3의 활성억제를 유도하여 난소암 PA-1 세포의 성장을 억제하는지를 확인하고, 해당 기전을 살펴보고자 하였다. 방법 : 사독을 처리한 후 난소암 PA-1 세포의 세포자멸사의 관찰에는 DAPI, TUNEL staining assay를 시행하였고, 세포자멸사 조절단백질 및 NF-${\kappa}B$, STAT3의 활성 변동 관찰에는 western blot analysis를 시행하였다. 결과 : 1. 사독을 처리한 후 난소암 PA-1 세포에서 세포자멸사가 유도되어 암세포성장이 억제되었다. 2. 사독을 처리한 후 세포자멸사 관련 단백질 중 세포자멸사 촉진 단백질인 cleaved caspase-3, Bax의 발현은 증가되었고, 세포자멸사 억제 단백질인 Bcl-2의 발현은 감소되었다. 3. 사독을 처리한 후 난소암 PA-1 세포의 NF-${\kappa}B$와 STAT3 발현은 감소되었고, 각각의 길항제인 salicylic acid와 stattic 처리 후 NF-${\kappa}B$와 STAT3 발현은 더욱 감소되었다. 결론 : 사독은 난소암 세포의 세포자멸사 유발과, NF-${\kappa}B$와 STAT3의 활성억제를 통해 치료 효율이 높고, 내성이 적은 난소암 치료제의 개발에 도움이 될 것으로 기대된다.

• 한국어류학회지
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• 제23권1호
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• pp.46-60
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• 2011

본 연구는 2005년부터 2009년까지 우리나라 주변해역에서 서식하는 바다뱀과 6속 10종의 형태형질을 조사하여 분류학적 재검토를 실시하였다. 계수에서는 척추골수가 바다뱀이 201~209개로 가장 많았으며, 둥근물뱀(178~183개), 돛물뱀(179~182개), 돌기바다뱀(153~164개), 날붕장어(152~158개), 갯물뱀(155~156개), 까치물뱀(150~154개), 자물뱀(137~148개), 갈물뱀(135-138개) 제주바다뱀(124~134개) 순으로 나타났다. 계측에서는 두장에 대한 주둥이길이(바다뱀속 27.2~31.2 vs. 날붕장어속 18.0~27.7 vs. 까치물뱀속 12.3~21.5 vs. 돛물뱀속 16.5~20.8 vs. 갯물뱀속 11.4~11.9 vs. 자물뱀속 9.1~9.4)에서 잘 구분되었다. 한국 주변해역 바다뱀과 6속 10종의 종 검색표를 처음으로 제안하였다.

• Parasites, Hosts and Diseases
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• 제49권4호
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• pp.445-448
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• 2011

A survey was performed to find out the intermediate hosts of Gnathostoma nipponicum in Jeju-do (Province), the Republic of Korea. In August 2009 and 2010, a total of 82 tadpoles, 23 black-spotted pond frogs (Rana nigromaculata), 7 tiger keelback snakes (Rhabdophis tigrinus tigrinus), 6 red-tongue viper snakes (Agkistrodon ussuriensis), and 2 cat snakes (Elaphe dione) were collected in Jeju-do and examined by the pepsin-HCl digestion method. Total 5 gnathostome larvae were detected in 3 (50%) of 6 A. ussuriensis, 70 larvae in 3 of 7 (42.9%) R. tigrinus tigrinus, and 2 larvae in 2 of 82 (8.7%) frogs. No gnathostome larvae were detected in tadpoles and cat snakes. The larvae detected were a single species, and $2.17{\times}0.22mm$ in average size. They had characteristic head bulbs, muscular esophagus, and 4 cervical sacs. Three rows of hooklets were arranged in the head bulbs, and the number of hooklets in each row was 29, 33, and 36 posteriorly. All these characters were consistent with the advanced third-stage larvae of G. nipponicum. It has been first confirmed in Jeju-do that R. nigromaculata, A. ussuriensis, and R. tigrinus tigrinus play a role for intermediate and/or paratenic hosts for G. nipponicum.

• Parasites, Hosts and Diseases
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• 제45권3호
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• pp.191-198
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• 2007

A total of 205 larval gnathostomes were collected from 18 (22.5%) of 80 red banded odd-tooth snakes, Dinodon rufozonatum rufozonatum, which had been smuggled from China and confiscated at Customs in Susan, Republic of Korea. In order to identify the species, some of the larvae were observed by a light microscope and a scanning electron microscope (SEM). The larvae were $2.18{\times}0.29mm$ in average size, and had a pair of lips at the anterior end, a muscular esophagus, 2 pairs of cervical sacs, and brownish intestines. The head bulb was characteristically equipped with 4 rows of hooklets; the average number of hooklets in each respective row was 38.6, 40.5, 41.5, and 43.7. In SEM views, the mouth evidenced a pair of lateral lips of equal size in a half-moon shape. Each lip featured a couple of labial papillae and a small amphid located between the 2 papillae. The hooklets on the head bulb had single-pointed, posteriorly-curved tips. The cuticular spines were larger and more densely distributed on the anterior part of the body, and decreased gradually in size and number toward the posterior body. On the basis of these morphological characteristics, the larvae were identified as the third stage larvae of Gnathostoma hispidum.

• Parasites, Hosts and Diseases
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• 제56권4호
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• pp.359-364
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• 2018

The taxonomy of Spirometra species has been controversial despite the medical and veterinary importance. Currently, only a few Spirometra species are considered valid species in the genus Spirometra. In the present study, the distribution of Spirometra species obtained from animals in Korea were identified by molecular analysis of the mitochondrial cytochrome c oxidase I (cox1) gene. A total of 28 Spirometra species specimens were analyzed. These were all collected between 1973 and 2008 in the Republic of Korea. Mitochondrial cox1 sequences were examined for a total of 28 specimens comprising 14 S. decipiens and 14 S. ranarum. The difference in partial cox1 sequences (316 bp) between S. erinaceieuropaei (KJ599680) and S. ranarum (this study) was 9.3%, while that between S. decipiens (KJ599679) and S. ranarum (this study) was 2.2%. Genetic analyses identified 2 Spirometra species in animals such as cat, leopard cat, dog, duck and snake in Korea as S. decipiens and S. ranarum. S. decipiens and S. ranarum were present in Gyeongnam Province (P), Jeonnam P, Gangwon P, Chungbuk P, and Seoul. S. decipiens was found in tadpoles, snakes, ducks, cats, leopard cats and dogs, while S. ranarum was found in cats and dogs. The ratio of S. decipiens:S. ranarum calculated from the molecular data was 14:14 (or 1:1). These results indicate that S. decipiens and S. ranarum are sympatrically distributed in Korea.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제14권8호
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• pp.3295-3311
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• 2020

With the wide application of hyperspectral images, it becomes more and more important to compress hyperspectral images. Conventional recursive least squares (CRLS) algorithm has great potentiality in lossless compression for hyperspectral images. The prediction accuracy of CRLS is closely related to the correlations between the reference bands and the current band, and the similarity between pixels in prediction context. According to this characteristic, we present an improved CRLS with adaptive band selection and adaptive predictor selection (CRLS-ABS-APS). Firstly, a spectral vector correlation coefficient-based k-means clustering algorithm is employed to generate clustering map. Afterwards, an adaptive band selection strategy based on inter-spectral correlation coefficient is adopted to select the reference bands for each band. Then, an adaptive predictor selection strategy based on clustering map is adopted to select the optimal CRLS predictor for each pixel. In addition, a double snake scan mode is used to further improve the similarity of prediction context, and a recursive average estimation method is used to accelerate the local average calculation. Finally, the prediction residuals are entropy encoded by arithmetic encoder. Experiments on the Airborne Visible Infrared Imaging Spectrometer (AVIRIS) 2006 data set show that the CRLS-ABS-APS achieves average bit rates of 3.28 bpp, 5.55 bpp and 2.39 bpp on the three subsets, respectively. The results indicate that the CRLS-ABS-APS effectively improves the compression effect with lower computation complexity, and outperforms to the current state-of-the-art methods.

• 인문언어
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• 제6권
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• pp.213-240
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• 2004

This paper argues that Koguryo historically belonged to Korea based on the linguistic homogeneity among Koguryo, Sinra, and Paekche. The language of Koguryo shows the following four distinct properties from Chinese. First, Koguryo, Sinra, and Kara share a dual structure of national birth myths, and the directional vocabulary found in the countries also shows the evidence that the Korean people moved from North to South. Chinese, on the other hand, has no indication of these facts. Second, the place names in Koguryo shared the same properties with those of the countries in the Korean Peninsula at the same period, but were different from those of China. It is also noticeable that the national name of Korea, adopted from the national name of Koruryo, was announced to the world and that Korea has been acknowledged as our national name since then. The legitimate lineage of Koguryo > Parhay > Hu-Koguryo > Korea proves that Koguryo belonged to Korea historically, Third, the names of kings were very similar among the Three Kingdoms, but distinct from those of China. The names of kings were created on the basis of the sun as well as nature and human functions or activities like nuri (world), Piryu (originated from the name of a river), onjo (all over world), Chumong Hwar-bo (a person who is good at shooting), Paem-bo (a baby crawling like a snake), K\ulcornerchir-bo, Isa-bo, etc. This is a common characteristic among the Three Kingdoms, but clearly different from China. Fourth, the governmental names were very similar among the Three Kingdoms, but distinct from Chinese ones. These linguistic properties shared among the Koguryo, Packche, and Sinra are never accidental, but provide reliable evidence that the countries were founded by the Korean people. Koguryo, therefore, belonged to Korea historically.

• 전자공학회논문지
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• 제53권9호
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• pp.99-109
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• 2016

본 논문에서는 미소혈관내 백혈구 운동을 검출하기 위한 시공간 영상을 생성하는 방법을 제안한다. 백혈구는 혈관벽의 윤곽선을 따라 움직인다는 구속조건을 사용하여 백혈구 운동을 검출하고 시공간 영상을 생성한다. 우선, 생체내의 운동에 의해 발생한 평행운동을 템플레이트 정합법으로 제거한다. 다음으로, 시간 분산 영상을 이진화하기 위한 자동 문턱값 선정법에 기초하여 혈관 영역을 검출하고 그 다음, 혈관벽 윤곽선을 B-스플라인 함수로 나타낸다. 최종적으로, 검출된 혈관벽 윤곽선을 초기곡선으로하여 가장 정확한 위치의 혈장층을 스네이크에 의한 공간축으로 결정하고 시공간 영상을 생성한다. 실험 결과, 제안방법은 세개 영상 계열의 각 단계별 비교를 통해 시공간 영상을 양호하게 생성함을 보여준다.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2007년도 춘계학술대회 논문집
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• pp.1097-1106
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• 2007

Rail provides running tract for train and broadly and widely conveys the weight of the train exerted from the train wheels that the rail directly supports onto the cross tie and roadbed, and supports the cross-sectional pressure exerted by centrifugal force at curvatures. That is, stationary rail provides surface on which dynamic train runs and guarantees cross-sectional resistance to enable the vertical snake motion of the train wheels as well as to maintain lateral force at curvatures. Rail provides running surface on which train wheels can run smoothly, and secures vertical and lateral force. However, it undergoes continuous destructive reactions (wearing and damages) and abrasion of the cladding by the train wheels. It is obvious that wearing will result when two metal parts act against each other. However, occurrence of abnormal wearing such as rapid wearing of the rail side due to complex generation of various mechanisms at the contact surface between the rail and train wheel flange. It is not easy to simply examine the causes of occurrence of abnormal wearing of rail and train wheel flange. Although countless number of academicians and specialists are conducting researches on abnormal wearing of rail and vertical wearing of train wheels, I believe it is too early to argue on pros and cons due to insufficiency of officially verified information on the issue. This review will be focusing on the examples of repairs that reduced the generation of abnormal wearing of rail by reviewing and improving characteristics of wearing and slack, speed of the train and cant as well as status of lubricator by choosing the compound curves present in the section between the $Anguk{\sim}Jongno3-ga$ Stations of the Route No. 3 among the compound curve tracks of the Seoul Metro Routes No. 3 & 4 at which abnormal wearing is generated continuously.

• Journal of Chest Surgery
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• 제39권6호
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• pp.502-504
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• 2006

스파르가눔증의 주요 발생 원인은 뱀이나 개구리의 생식이다. 스파르가눔증의 흔한 임상 증상은 복벽, 흉벽, 대퇴부, 음낭 등에 나타나는 이동성 피하 결절이며, 가장 확실한 진단 및 치료는 외과적으로 충체를 적출하는 것이다. 저자들은 70세 남자 환자의 흉막에 발생한 스파르가눔증을 치험하였기에 문헌 고찰과 함께 보고하는 바이다.