• Tuberculosis and Respiratory Diseases
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• 제78권3호
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• pp.239-245
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• 2015

Background: Chronic obstructive pulmonary disease is characterized by emphysema, chronic bronchitis, and small airway remodeling. The alveolar destruction associated with emphysema cannot be repaired by current clinical practices. Stem cell therapy has been successfully used in animal models of cigarette smoke- and elastase-induced emphysema. However, the optimal dose of mesenchymal stem cells (MSCs) for the most effective therapy has not yet been determined. It is vital to determine the optimal dose of MSCs for clinical application in emphysema cases. Methods: In the present study, we evaluated the therapeutic effects of various doses of MSCs on elastase-induced emphysema in mice. When 3 different doses of MSCs were intravenously injected into mice treated with elastase, only $5{\times}10^4$ MSCs showed a significant effect on the emphysematous mouse lung. We also identified action mechanisms of MSCs based on apoptosis, lung regeneration, and protease/antiprotease imbalance. Results: The MSCs were not related with caspase-3/7 dependent apoptosis. But activity of matrix metalloproteinase 9 increased by emphysematous lung was decreased by intravenously injected MSCs. Vascular endothelial growth factor were also increased in lung from MSC injected mice, as compared to un-injected mice. Conclusion: This is the first study on the optimal dose of MSCs as a therapeutic candidate. This data may provide important basic data for determining dosage in clinical application of MSCs in emphysema patients.

• 한국화재소방학회논문지
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• 제24권5호
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• pp.79-86
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• 2010

본 연구는 국내 고층건물 특별피난계단의 부속실에 설치되는 급기가압 제연시스템의 방연 풍속 기류 가화재 발생 시 피난을 위하여 출입문이 개방되었을 경우 거실 방향으로 정상적으로 형성되지 않고 부속실 내부로 역류되는 현상을 개선하기위해 실 모형실험을 통해 출입구 상부로 역류하지 않는 조건을 개발하였다. 부속실 바닥 면적이 $2m^2$와 $4m^2$인 두개의 실물 모형을 제작하여 실험을 실시한 결과, 방연풍속의 기류 특성은 바닥 면적이 $2m^2$인 경우 심하게 출입문 상부로 기류가 역류되었다. 다만, 급기댐퍼의 설치위치가 출입문 맞은편의 경우 날개각도가 45도 상향인 경우는 출입문 상부로는 역 기류 현상은 없었지만 하부로는 일부 역류 되었다. 부속실 면적이 $4m^2$ 인 경우는 출입문에서 거실방향으로 정상적인 기류 분포를 보였다. 부속실 바닥 면적이 작게 설계될 경우에는 성능위주 설계가 될 수 있도록 하여야 한다.

• 보건행정학회지
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• 제24권4호
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• pp.342-348
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• 2014

Background: Due to lack of regular and systematic evaluation tool, Korea's tobacco control policy has not been examined its overall process of implementation including efficiency and adequacy of the policies. This study developed policy monitoring and evaluation model to assess policy implementation and effectiveness of tobacco control in Korea. Methods: Based on World Health Organization operational manual for assessment, MPOWER (monitor tobacco use and prevention policies, protect from tobacco smoke, offer help to quit tobacco use, warn about the dangers of tobacco, enforce bans on tobacco advertising promotion and sponsorship, and raise taxes on tobacco) related policies were reviewed by rating policy efforts, programme management, people (human resources and their development), provision of organization, provision of fund and partnerships (range, 0 to 5). Results: As a result of the experts' assessment, overall Korean tobacco control policies scored 2.61 points, which is poor. In relation to each 'MPOWER' policies, 'W' scored the highest points (2.93), followed by 'O' (2.91), 'M' (2.87), 'P' (2.86), and 'E' (2.23). 'R' scored the lowest points of 1.87, meaning government efforts in tobacco price policy is insufficient. Conclusion: This study concludes that Korean tobacco control policy should strengthen tax and price measures, while programme infrastructure, people, and funds for policy enforcement should be secured. Furthermore, rather than focusing on one specific measure, a balanced approach reflecting various aspects of tobacco controls should be considered in order to decrease smoking rates and prevent smoking initiation.

• 한국환경보건학회지
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• 제38권6호
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• pp.472-481
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• 2012

Objectives: This study aims to investigate the AD (allergic diseases: asthma, allergic rhinitis and atopic dermatitis) prevalence among elementary schoolchildren in an industrial city, Ulsan, and identify major environmental risk factors associated with AD prevalence. Methods: Data on the physician-diagnosed prevalence over the past 12 months and potential risk factors of AD were collected through a questionnaire from a 2009-2010 survey of 4,067 schoolchildren living in different urban environments. The logistic regression analysis was performed to assess differences in AD prevalence among the areas and to determine which environmental factors impacted AD. Results: Our survey results showed that the AD prevalence rate ranged between 26.2% and 35.9%. Children living in polluted areas (near industrial and central urban areas) had about a 10% higher prevalence of AD than did those living in coastal or suburban residences. The Chi-Square test demonstrated that this local difference was statistically significant before and after adjustment of major confounders such as parental AD history and parental education. The results of the logistic regression analysis showed a statistically significant association between several environmental factors (ventilation in winter, odor conditions and exposure to traffic smoke, and outdoor $PM_{10}/O_3$ pollution) and the prevalence of AD found by multivariate model after adjusting confounders. Conclusion: These results suggest that local differences in AD prevalence are significantly associated with outdoor environmental factors. Although there are likely to be other risk factors for AD, living in a polluted area and exposure to high levels of air pollutants can contribute to an increased risk of childhood AD.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.1023-1029
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• 2014

Background: The purpose of our study was to elucidate the joint effects of combined smoking and alcohol intake on esophageal cancer mortality in Japanese men through a large cohort study with a 20-year follow-up period. Materials and Methods: The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study) was established in the late 1980s, including 46,395 men and 64,190 women aged 40 years and older and younger than 80. Follow-up of these participants was conducted until 2009. We used the Cox proportional hazards model to analyze data for 42,408 people excluding female participants, 411 people with histories of malignant neoplasms, and 3,576 with unclear smoking and drinking data. Results: The joint effects of age at start of smoking and amount of alcohol consumed per day were compared with non-smokers and non-drinkers or those consuming less than one unit of alcohol per day. The mortality risk was 9.33 (95% confidence interval, 2.55-34.2) for those who started smoking between ages 10 and 19 years and drinking at least three units of alcohol per day. Regarding the joint effects of cumulative amount of smoking and alcohol intake, the risk was high when both smoking and alcohol intake were above a certain level. Conclusions: In this Japanese cohort study, increased cancer mortality risks were observed, especially for people who both started smoking early and drank alcohol. Quitting smoking or not starting to smoke at any age and reducing alcohol consumption are important for preventing esophageal cancer in Japan.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.625-630
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• 2013

Background: Hardcore smoking is represented by a subset of daily smokers with high nicotine dependence, inability to quit and unwillingness to quit. Estimating the related burden could help us in identifying a high risk population prone to tobacco induced diseases and improve cessation planning for them. This study assessed the prevalence and associated factors of hardcore smoking in three South-East Asian countries and discussed its implication for smoking cessation intervention in this region. Materials and Methods: Global Adult Tobacco Survey (GATS) data of India, Bangladesh and Thailand were analyzed to quantify the hardcore smoking prevalence in the region. On the basis of review, an operational definition of hardcore smoking was adopted that includes (1) current daily smoker, (2) no quit attempt in the past 12 months of survey or last quit attempt of less than 24 hours duration, (3) no intention to quit in next 12 months or not interested in quitting, (4) time to first smoke within 30 minutes of waking up, and (5) knowledge of smoking hazards. Logistic regression analysis was carried out using hardcore smoking status as response variable and gender, type of residence, occupation, education, wealth index and age-group as possible predictors. Results: There were 31.3 million hardcore smokers in the three Asian countries. The adult prevalence of hardcore smoking in these countries ranges between 3.1% in India to 6% in Thailand. These hardcore smokers constitute 18.3-29.7% of daily smokers. The logistic regression model indicated that age, gender, occupation and wealth index are the major predictors of hardcore smoking with varied influence across countries. Conclusions: Presence of a higher number of hardcore smoking populations in Asia is a major public health challenge for tobacco control and cancer prevention. There is need of intensive cessation interventions with due consideration of contextual predictors.

• 한국화재소방학회논문지
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• 제32권4호
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• pp.7-16
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• 2018

본 연구에서는 CFAST를 이용하여 구획실 가스연료 화재실험에 대한 디자인 화재곡선(Design fire curves, DF)의 예측성능을 평가하였다. 평가된 디자인 화재곡선은 이전의 연구에서 제안된 2-stage DF, Ingason이 제안한 Quadratic DF와 Exponential DF이며, 예측성능 평가를 위해 각 디자인 화재곡선을 CFAST의 입력조건으로 하여 시뮬레이션을 수행하였다. 시뮬레이션결과와 실험결과의 비교를 통해 구획실 내부의 공간평균온도와 $O_2$, $CO_2$ 농도에 대해 전반적으로 2-stage DF > Quadratic DF > Exponential DF 순으로 실험결과를 합리적으로 예측하는 것을 확인하였다. CFAST 시뮬레이션 결과를 통해서도 실험에서 보이는 구획실 내 개구부측과 내측에서의 온도와 $O_2$ 및 $CO_2$ 농도 차이를 예측할 수 없음을 명확히 확인하였다. 또한 CFAST는 구획실 가스연료 화재의 CO 농도와 하층부의 공간평균온도에 대한 예측에 한계가 있음을 확인하였다.

• 한국화재소방학회논문지
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• 제23권5호
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• pp.110-116
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• 2009

본 연구는 Double Skin System의 화재 전파 위험성을 전산유체역학모델인 FDS를 이용하여 평가하였다. 화재모델링을 구현하기 위해 오피스 용도의 단위 구획공간을 화재지역으로 선정하였으며, 화재시나리오는 외창으로의 연소확대 위험 분석을 위하여 일반적으로 많이 설치되는 시스템조건들을 Case로 선정하여 분석하였다. 본 연구의 목적은 일반적으로 많이 사용되는 Double Skin System의 설치 간격에 따른 건물상층부로의 화재확대 위험성을 평가하고, 이에 따른 방화대책 등을 수립하는데 있다. 해석 결과, 더블스킨 중간층 간격이 넓을수록 상부층으로 연소확대 영향이 작은 것을 확인할 수 있었으며, 중간층 간격이 1m 미만인 경우는 발화층 상부 2개층으로 연소확대가 예상되므로 층간연소 확대 방지 시스템이 요구됨을 알 수 있다.

• 보건교육건강증진학회지
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• 제26권2호
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• pp.1-13
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• 2009

Objectives: This study identified how personal characteristics, family environment, governmental policy for the prevention and cessation of smoking might influence on adolescent smoking. Methods: This study used data from the 2006 Korea Youth Risk Behavior Web-based Survey of 71,404 middle school and high school students, giving a response rate of 90.9%. We selected 61,508 adolescents subjects of the final analysis without missing data on independent variables and dependent variables which are used in this study. This study used $\chi^2$ tests and logistic regression models. Variables were added to the regression model in three groups using a hierarchical approach.Results: Adolescents were significantly more likely to become current smokers if they were boys, were in a higher grade, and had lower academic achievement. Adolescents experiencing stress and depression were associated with increased risk of current smoking. Adolescents with single parents or students of non-living with parents comparing with students of living with parents showed the high possibility of smoking. Lower father's education was associated with increased likelihood of current smoking. Adolescents who were exposed to smoking at home were more likely to smoke. Adolescents without contacting with the antismoking media campaign was associated with increased likelihood of current smoking. Conclusion: Promoting antismoking media campaigns targeted at adolescent is required, and the smoking prevention education which are proper for subjects are required. Proper plans which could decrease the exposure of secondhand smoking should be established.

• 한국비블리아학회지
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• 제6권1호
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• pp.179-213
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• 1984

The history of recording and conserving for maintenance the human's memory from ancient times to modern's has brought about a lot of changing process of the recorded information media with developing in culture, and each society has made important recorded materials in his library as essentially the social apparatus. But most of them that were damaged by factors of the natural disaster, humidity, temperature, light, fungi and insects in the library, and were resulted in deterioration and losing the numerous materials. For removing the inevitable phases repeated, there are studying for counterplan of the fundamental environment factors about preservation, restoration and chemical research of materials in advanced countries, but I get a few researches about protecting the cultural properties. Therefore I research the survey of the actual conditions on 72 university libraries centering around them, and then I have researched the collection rate 81 percent, 58 university libraries. (local : 35, in seoul : 23) As the result of this research, I propose the model of the environment factors of conserving the library materials. 1) To apply the equipment of processing the radiant energy to the new construction and buildings. 2) To remove factors that occur fungi and insects by facilities being controlled relative humility, temperature, and to equip the ventilation arrangement in the library. 3) To shelve all acquired and bound materials after proceeding the vacuum fumigator. 4) Those who want to enter into the library stack were surely taken in sterilzing their hands and shoes, and must put on the gown. 5) To use the vacuum dusting thing (machine) for removing the dust without spreading out the floor of the library at any time. 6) To set up the gas automatic fire extinguisher worked by smoke sensor. 7) To assist the research into the preservation, natures and environment of recorded materials, and to supply financial funds for librarian. 8) To hold regularly the workshop be able to educate the methods of preservation materials by the constant system. (Library Association) 9) To add to responsibilities on certification of preservation materials for librarian. 10) To hold the constant committee system in each library. 11) To keep up with the ideal environment (humidity, temperature, light, ventilation, etc.) of preservation materials in the arrangement room, and to put on the gown.