• 제목/요약/키워드: SM-101

검색결과 35건 처리시간 0.024초

In vitro and in vivo Activities of SM-101, a Micture of Metampicillin and Sulbactam

  • Choi, Keum-Hwa;Kim, Sook-Kyung;Baek, Moon-Chang;Kim, Byong-Kak;Lee, Dong-Young;Choi, Eung-Chil
    • Archives of Pharmacal Research
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    • 제18권6호
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    • pp.423-426
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    • 1995
  • SM-101 is a mixture of metampicillin and sulbactam(2:1). The antibacterial activities of SM-101 were compared with those of metampicillin, piperacillin and Augmentin. It showed powerful antibacterial activities against major strains. Except P. anruginosa and S. marcescens, the in vitro antibacterial activity of SM-101 was higher than those of metampicillin, piperacillin and Augmentin against Staphylococcus spp., Streptococcus spp., Moganella morganii, E. Coil, and Proteus spp. The $ED_{50}$ values of SM-101 were two-fold or greater than those of metampicillin, piperacillin and Augmentin against $\beta-lactamase$ producing strains, p. mirabilis GN79 and M. morganiii MB4-11. The in vivo efficacy of SM-101 was more active than metampicillin and pipeeracillin and similar to Augmentin against S. aureus Smith, E coli MB4-01 and K. pneumoniae MB4-02.

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복합항생제 SM-101(설박탐.메탐피실린)의 생식독성연구: 랫트 수태능력시험 (Reproductive Toxicity Study of SM-101(sulbactam.metampicillin): Fertility Study in Rats)

  • 정문구;송시환;노정구
    • Biomolecules & Therapeutics
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    • 제4권1호
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    • pp.51-58
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    • 1996
  • A new composite antibiotic, SM-101(sulbactam.metampicillin), was at dose levels of 0, 250, 500 and 1000 mg/kg/day administered intravenously to Sprague-Dawley male rats from predating to mating period and to females from premating to early gestation period. Effects of test agent on general findings and reproductive performance of parent animals and embryonic development were examined. In male parents, two deaths occurred at 1000 mg/kg. The increase in kidney weight of the 1000 mg/kg group were also observed. The decrease in body weight and food consumption were found at 500 and 1000 mg/kg. The decrease in spleen weight were seen at 250, 500 and 1000 mg/kg. In female parents, three deaths were found at 1000 mg/kg. Mating performance and fertility of parent animals were not adversely affected by all doses tested. F1 fetuses showed no changes related to treatment of SM-101. The results show that the no effect dose level(NOEL) for general toxicity of parent animals is under 250 mg/kg/day and NOELS for reproductive capability and fatal development are over 1000 mg/kg/day.

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복합항생제 SM-101(설박탐.메탐피실린)의 생식독성연구: 랫트 최기형시험 (Reproductive Toxicity Study of SM-101(sulbactam.metampicillin): Teratogenicity Study in Rats)

  • 정문구;김종춘;한상섭
    • Biomolecules & Therapeutics
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    • 제4권1호
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    • pp.59-67
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    • 1996
  • A new composite antibiotic, SM-101(sulbactam·metampicillin), was at dose levels of 0, 375, 750 and 1500 mg/kg/day administered intravenously to pregnant Sprague-Dawley rats during the organogenetic period. Two-third of dams per group were subjected to caesarean section on day 20 of pregnancy and the remaining 10 dams per group were allowed to deliver. Effects of test substance on dams, embryonal development of F1 fetuses, as well as growth, behaviour and mating performance of F1 offspring were examined. In dams, two deaths occurred at 375 and 1500 mg/kg, respectively. The decrease in the weight of adrenal glands of the 1500 mg/kg group was observed. The prolongation of pregnancy period was found at 1500 mg/kg. F1 fetuses showed no changes related to the treatment of SM-101. In F1 offspring, the increase in spleen weight was seen at all doses treated. No treatment-related abnormalities were observed in each treated group in terms of development, behaviour and reproductive performance. In F2 fetuses, no drug-induced abnormalities occurred at all doses. The results show that the no-effect dose levels (NOELS) for dams and Fl offspring are under 375 mg/kg/day and NOELs for F1/F2 fetuses are over 1500 mg/kg/day.

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복합항생제 SM-101(설박탐-메탐피실린)의 생식독성연구: 랫트 주산기 및 수유기시험 (Reproductive Toxicity of SM-101(sulbactam.metampicillin): Peri- and Postnatal Study in Rats)

  • 정문구;김종춘;노정구
    • Biomolecules & Therapeutics
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    • 제4권4호
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    • pp.339-348
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    • 1996
  • A new composite antibiotic, SM-101 (sulbactam·metampicillin), was at dose levels of 0, 250, 500 and 1000 mg/kg/day administered intravenously to pregnant and subsequently delivered Sprague-Dawley rats from day 17 of gestation to day 21 of lactation. Effects of test agent on dams and growth, behaviour and mating performance of Fl offspring were examined. In dams, one death occurred at 1000 mg/kg. The increase in kidney weight of the 250, 500 and 1000 mg/kg group was found. In F1 offspring, both delayed incisors eruption and decreased body weight were observed in females of the 1000 mg/kg group. The increase in the weights of liver and kidney was found in males of the 1000 mg/kg group. No treatment-related abnormalities were observed in each treated group in terms of behaviour and reproductive performance. In F1/F2 fetuses, no drug-induced abnormalities occurred at all doses tested. The results show that the no effect dose level (NOEL) of SM-101 is under 250 mg/kg/day for dams and 500 mg/kg/day for F1 offspring, and over 1000 mg/kg/day for F1/F2 fetuses.

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한국산 고감염 Agrobacterium spp의 분리 및 연초의 형질전환에 이용 (Isolation of Hypervirulent Agrobacterium spp from Korea and Application for Transformation of Tobacco)

  • 양덕춘;정재훈;이정명
    • 식물조직배양학회지
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    • 제25권3호
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    • pp.207-217
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    • 1998
  • 한국에서 자생한 자연산 tumor 조직과 근권토양으로부터 형질전환율이 높은 hypervirulent Agrobacterium spp를 분리하기 위해서 Salix, Diospyros, Populus 및 Malus에서 형성된 tumor 조직과 근권토양을 채취하괴 Schroth 선택배지와 New and Kerr 배지를 이용하여 78 균주의 colony를 특성에 따라 분리하였다. 이중에서 48 균주가 당근 disc에서 tumor를 형성하였으며 tumor를 형성한 균주중 형성시기가 빠르며 크기가 커 hypervirulent 균주로 생각되는 A. tumefaciens SP101을 biotype 1, 그리고 A. tumefaciens SM042를 biotype 2로 동정하였다. 토양중에서 선발한 A. tumefaciens SM042와 disarmed A. tumefaciens PC2760에 kanamycin 저항성 유전자를 함유하고 있는 binary vector pGA643을 도입하여 conjugant인 A. tumefaciens SM643과 A. tumefaciens PC643을 kanamycin과 tetracycline이 함유된 최소배지에서 획득하였다. 연초의 형질전환을 위해서 conjugant Agrobacterium과 연초조직을 동시배양 후 2,4-D와 kanamycin이 함유된 선발배지에 치상하여 형질전환을 유도한 결과 A. tumefaciens SM643이 A. tumefaciens PC643보다 더 많은 캘러스가 형성되었다. 그러나 A. tumefaciens PC643을 사용한 형질전환 캘러스는 대부분 friable한 캘러스로 유도되었으며 정상적으로 식물체로 생장하였으나 A. tumefaciens SM643을 사용한 캘러스는 매우 딱딱하며 둥그런 형태의 캘러스와 friable한 캘러스가 혼재한 상태로 생장하였으며, 이중에서 friable한 캘러스는 정상적인 shoot가 형성되었으나 딱딱한 캘러스로 유도된 형질전환체는 식물체로 형성되지 않고 반구형 미색의 전형적인 tumor 캘러스로 생장하였다. 한편 형질전환시 캘러스를 유도하지 않고 직접 shoot를 형성시킨 결과 disarmed Ti-plasmid를 사용하지 않고 wild-type Ti-plasmid를 사용해도 정상적인 형질전환체를 획득할 수 있었다.

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박막자석이 연자성박막에 미치는 바이어스 효과 (The effect of Thin Film magnet on soft magnetic thin film)

  • 김영학;신광호
    • 한국전기전자재료학회:학술대회논문집
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    • 한국전기전자재료학회 2003년도 춘계학술대회 논문집 초전도 자성체 연구회
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    • pp.101-104
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    • 2003
  • The maximum coercive force of SmCo thin film was obtained at the Sm=28.2% and dc bias field was generated to CoZrNb, soft magnetic thin film, deposited on the SmCo thin film. DC field point having the maximum permeability for CoZrNb was shifted to higher dc field. DC field strength increased as the length of easy direction of magnetization decreased and 60Oe was measured for $3mm{\times}0.5mm$ sample.

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서로 다른 증착 온도에서 성장된 BaWO4:Sm3+ 형광체 박막의 구조, 광학, 표면 형상의 특성 (Structural, optical, and morphological properties of BaWO4:Sm3+ phosphor thin films grown at different deposition temperature)

  • 조신호
    • 한국표면공학회지
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    • 제55권2호
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    • pp.96-101
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    • 2022
  • The effects of the growth temperature on the structural, optical, and morphological properties of BaWO4:Sm3+ phosphor thin films were investigated. The BaWO4:Sm3+ thin films were grown on quartz substrates at several growth temperatures by radio-frequency magnetron sputtering. All the thin films crystallized in a tetragonal structure with a main BaWO4 (112) diffraction peak. The 830 nm-thick BaWO4:Sm3+ thin films grown at 300 ℃ exhibited numerous polygon-shaped particles. The excitation spectra of BaWO4:Sm3+ thin films consisted of a broad excitation band in the 200-270 nm with a maximum at 236 nm due to the O2--Sm3+ charge transfer and two small bands peaked at 402 and 463 nm, respectively. Under 236 nm excitation, the BaWO4:Sm3+ thin films showed an intense red emission peak at 641 nm due to the 4G5/26H9/2 transition of Sm3+, indicating that the Sm3+ ions occupied sites of non-inversion symmetry in the BaWO4 host lattice. The highest emission intensity was observed for the thin film grown at 300 ℃, with a 51.8% transmittance and 5.09 eV bandgap. The average optical transmittance in the wavelength range of 500-1100 nm was increased from 53.2% at 200 ℃ to 60.8% after growing at 400 ℃. These results suggest that 300 ℃ is the optimum temperature for growing redemitting BaWO4:Sm3+ thin films.

질소고정(窒素固定)의 유전공학(遺傳工學的) 연구(硏究) 및 농업(農業)에의 응용방안(應用方案) - 대두(大豆)에 효율적인 공생질소고정(共生窒素固定)을 할 수 있는 Rhizobium japonicum mutant의 선별 - (Genetic Engineering of Biological Nitrogen Fixation and its Application to Agronomy - Selection of Rhizobium japonicum Mutants having Greater Symbiotic Nitrogen Fixing Activity with Soybean -)

  • 조무제;양민석;윤한대;최진룡;최용락;강규영
    • 한국미생물·생명공학회지
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    • 제13권1호
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    • pp.79-85
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    • 1985
  • 대두 경남 장려품종인 장백, 광교, 강림 및 남천등의 근류로부터 Rhizobium japonicum을 분리하여 그 중 질소고정력이 R. japonicum 61A 76이나 3 I1110보다 강한 JB 101을 선별하였다. 선별된 JB 101을 N-methy1-N'-nitro-N-nitrosoguanidine 처리 및 UV조사에 많은 돌연변이체를 얻고 이들로 부터 경남 장려품종인 장백에 접종시근류 생성력 및 질소고정력등 JB 101에 비하여 훨씬 높을 뿐만아니라 SM 35에 비해서도 다소 높은 JB 65를 선별하여 이 균주의 근류생성력, 질소고정력, 고정된 암모니아가 질소고정에 미치는 영향, hydrogenase 활성등 공생관련 제 특성과 아울러 이 균주 단백질의 아미노산 조성, 2D-polyacrylamide gel을 이용한 전기영동등의 생화학적 특성도 아울러 조사하였다.

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Machining Center에서의 Drill가공시 절삭저항과 그 동적성분에 관한 연구 (제1보) -SM45C 중심으로- (A Study on Static and Dynamic Cutting Force in Drilling Process for Machining Center (1st report) -SM45C-)

  • 전언찬;제정신;이동의;남궁척
    • 한국정밀공학회지
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    • 제3권2호
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    • pp.91-101
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    • 1986
  • This paper deals with the effect of static and dynamic cuttig force and the behaviour of drill life in drilling process. The experiments are performed with cemented carbide drills and high speed steel drills of 10mm in diameter and in an annealed SM45C. The conclusions are as follows (1) Dynamic cutting force is varied with the dept of hole. (2) Dynamic cutting forces of torque and thrust are increase with the increase in feed and cutting speed. (3) Chipping influence the dynamic cutting force of thrust than torque, and in the case of thrust, the amplitude is 3-7 times large than ordinary cutting state. (4) Prediction of drill life can be obtained from more easily the amplitude of static cutting force than that of dynamic cutting force.

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