• 한국공작기계학회:학술대회논문집
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• 한국공작기계학회 2004년도 춘계학술대회 논문집
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• pp.293-297
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• 2004

This paper is described manufacturing to jewelry by using rapid prototype. At that time, the SLC file is useful for solved generating errors to part build file. Then. we have reduced the time of manufacturing complicated three-dimensional form. Generally, it is used the STL file for rapid prototype that it is necessary to considerable time when complicated firm as jewelry generated pan build file. But the SLC file is solved to problem because it consists of configuration of a section. Neter the less, Generating Part build file hate had a lot of problem when the SLC file is used.

• 대한임상검사과학회지
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• 제55권4호
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• pp.291-297
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• 2023

위염과 위궤양은 위 점막에 염증이 생기고 상처가 생기는 것을 말한다. 과거 연구는 주로 환경적 요인이 위 질환의 주요 요인이라는 관점에서 이루어졌으나, 최근 유전자 연구의 발전으로 유전적 요인의 중요성이 강조되고 있다. SLC25A26은 활성산 소종의 축적과 관련이 있는 유전자이다. 산화 스트레스는 염증반응을 촉진하여 활성 산소를 증가시키고 세포 손상을 유발하기 때문에 이는 위 질환의 발생과 관련이 있을 것이라 추정된다. 본 연구에서는 SLC25A26과 위 질환과의 연관성을 분석하였다. 국내 위 질환 환자 1,369명과 건강한 대조군 7,471명을 대상으로 SLC25A26 내 다형성을 분석하였다. 그 결과 11개의 단일 염기 다형성(single nucleotide polymorphism, SNP) (genotype)과 13개의 SNP (imputation)가 통계적인 유의성(P<0.05)을 가지고 높은 위 질환과의 상대 위험도를 보였다. 그 중 SLC25A26의 rs13874가 위 질환과 높은 연관성을 보였다. 유전자형 기반 mRNA 발현 분석에 따르면 SLC25A26이 minor allele를 가지면 mRNA 발현이 증가하고 이는 산화 스트레스를 증가시킬 가능성이 있다. 결론적으로 SLC25A26 다형성은 위질환과 관련이 있어 우리나라 인구에서 위 질환 관리의 새로운 지침에 대한 근거를 제공할 수 있을 것이다.

• 한국측량학회:학술대회논문집
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• 한국측량학회 2006년도 춘계학술발표회 논문집
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• pp.229-234
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• 2006

On May 31, 2003. Landsat 7 experienced an anomaly causing the Scan Line Corrector(SLC) to stop functioning normally. The SLC-off causes individual scan lines to alternately overlap and then leave large gaps at the edge of the Image. A many scientists with ongoing experience using ETM+ data evaluated the scientific usability and validity of Landsat 7 products containing the SLC anomaly The best reference scene for gap-filling is the other SLC-on Landsat scene that provide same resolution, few changes, and similar data acquisition. But receiving of Landsat imagery is not stable in Korea. So SPOT image can be another alternative solution because it is a steady-state multispectral satellite image as Landsat image. In this study, we filled the SLC-off gap s of 2, 3, 4 bands using SPOT image by a local regression technique, and assigned the optimum spectral value to gaps of 1, 5, 7 bands based on a spectral adjacency. Through this process, we could restore Landsat SLC-off image and evaluated the accuracy of the results.

• Reproductive and Developmental Biology
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• 제33권4호
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• pp.211-216
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• 2009

A cell frequently utilizes glucose as a fuel of energy and a major substrate of lipid and protein syntheses. A regulation of glucose movement into and out of the cells is precisely controlled by cooperative works of passive and sodium-dependent active processes. At least 13 glucose cotransporter (Slc2a, GLUT) isoforms involve in passive movement of glucose in cells. The efferent ductules (EDs) play in a number of important functions for maintenance of male fertility. In the present study, using real-time PCR analysis, we determined gene expression of five Slc2a isoforms in the EDs. In addition, we compared expression levels of these Slc2a isoforms according to postnatal development ages, 1 week, 2 weeks, 1 month, and 3 months. Results from the current study showed that expression of Slc2a1, Slc2a3, and Slc2a5 mRNAs reached the highest levels at 1 month of age, followed by a transient decrease at 3 months of age. In addition, the level of Slc2a4 mRNA reminded at steady until 1 month of age and was significantly reduced at 3 months of age, whereas the highest level of Slc2a 8 mRNA was detected at 2 weeks of age. Data from the present study indicate a differential expression of various Slc2a isoforms in the ED according to postnatal ages. Thus, it is believed that glucose movement through the epithelial cells in the ED would be regulated by the coordinated manner among Slc2a isoforms expressed at a given age.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2004년도 추계학술대회 논문집
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• pp.114-118
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• 2004

This paper is compared the build time of scanning path as to laminate height of the SLC and STL file. The STL file improve the surface roughness according to slicing height. But it have the fault spending long time to the creation of scanning path by being lower slicing height. So we proposed the SLC file to improve this fault. Therefore this paper showed to the build time of scanning path by the increase of peace using the jewellery model.

• 한국전자파학회논문지
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• 제26권5호
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• pp.514-520
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• 2015

부엽 잡음 재머 제거를 위한 SLC(Sidelobe Canceller, 부엽제거기)는 주 채널(합 채널) 빔 패턴에 의한 수신 신호 외에 보조 채널 빔 패턴에 의한 수신 신호를 요구한다. 적응형 SLC가 최상의 부엽 잡음 재머 제거 성능을 발휘하기 위해서는, 주 채널 빔 패턴의 부엽에 해당하는 고각/방위각 영역에서 각각의 보조 채널 빔 패턴의 우세한 이득(gain)을 보이는 영역이 서로들 겹치지 않게 되어야 한다. 그리고 주 채널 빔 패턴의 주엽에 해당하는 영역에서 보조 채널 빔 패턴들이 낮은 이득을 보여야 한다. 모노펄스 레이더에서 모노펄스 처리용 차 채널들의 빔 패턴들은 이러한 특성을 가지고 있다. 본 논문에서는 부엽 제거를 위한 보조 채널로서 모노펄스 처리용 차 채널을 이용하는 방법을 제안하고, 제안한 방법의 SLC 성능 분석 및 시뮬레이션 결과를 보였다. 모노펄스 레이더에서 모노펄스 처리용 차 채널의 빔으로 SLC를 구현하면 추가적인 채널 구성없이 기본적으로 사용되는 합, 차 채널들을 이용하여 SLC를 구성할 수 있다.

• 대한의생명과학회지
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• 제18권4호
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• pp.377-383
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• 2012

Recent genome-wide association studies (GWAS) have identified a number of common variants associated with blood pressure homeostasis and hypertension in population. In the previous study, single nucleotide polymorphisms (SNPs) in the SLC4A4 gene have been reported to be associated with hypertension in Han Chinese population. We aimed to confirm whether the genetic variation of SLC4A4 gene influence the susceptibility to blood pressure and hypertension in Korean population. We genotyped variants in or near SLC4A4 in a population-based cohort including 7,551 unrelated Korean from Ansan and Ansung. Here, we performed association analysis to elucidate the possible relations of genetic polymorphisms in SLC4A4 gene with blood pressure traits. By examining genotype data of a total of 7,551 subjects in the Korean Association REsource (KARE) study, we discovered the SLC4A4 gene polymorphisms are associated with blood pressure and hypertension. The common and highest significant polymorphism was rs6846301 (${\beta}$=0.839, additive P=0.032) with systolic blood pressure (SBP), rs6846301 (${\beta}$=0.588, additive P=0.027) with diastolic blood pressure (DBP), and rs6846301 (OR=1.23, CI: 1.09~1.40, additive $P=1.2{\times}10^{-3}$) with hypertension. Furthermore, the SNP rs6846301 was consistently associated with both blood pressure and hypertension. Consequently, we found statistically significant SNPs in SLC4A4 gene that are associated with both blood pressure and hypertension traits. In addition, these results suggest that the individuals with the minor alleles of the SNP in the SLC4A4 gene may be more susceptible to the development of hypertension in the Korean population.

• Journal of Ginseng Research
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• 제47권6호
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• pp.784-794
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• 2023

Background: ginsenoside Rg5 is a rare ginsenoside with known hypoglycemic effects in diabetic mice. This study aimed to explore the effects of ginsenoside Rg5 on skin wound-healing in the Lepr^db/db mutant (db/db) mice (C57BL/KsJ background) model and the underlying mechanisms. Methods: Seven-week-old male C57BL/6J, SLC7A11-knockout (KO), the littermate wild-type (WT), and db/db mice were used for in vivo and ex vivo studies. Results: Ginsenoside Rg5 provided through oral gavage in db/db mice significantly alleviated the abundance of apoptotic cells in the wound areas and facilitated skin wound healing. 50 μM ginsenoside Rg5 treatment nearly doubled the efferocytotic capability of bone marrow-derived dendritic cells (BMDCs) from db/db mice. It also reduced NF-κB p65 and SLC7A11 expression in the wounded areas of db/db mice dose-dependently. Ginsenoside Rg5 physically interacted with SLC7A11 and suppressed the cystine uptake and glutamate secretion of BMDCs from db/db and SLC7A11-WT mice but not in BMDCs from SLC7A11-KO mice. In BMDCs and conventional type 1 dendritic cells (cDC1s), ginsenoside Rg5 reduced their glycose storage and enhanced anaerobic glycolysis. Glycogen phosphorylase inhibitor CP-91149 almost abolished the effect of ginsenoside Rg5 on promoting efferocytosis. Conclusion: ginsenoside Rg5 can suppress the expression of SLC7A11 and inhibit its activity via physical binding. These effects collectively alleviate the negative regulations of SLC7A11 on anaerobic glycolysis, which fuels the efferocytosis of dendritic cells. Therefore, ginsenoside Rg5 has a potential adjuvant therapeutic reagent to support patients with wound-healing problems, such as diabetic foot ulcers.

• 생물정신의학
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• 제16권2호
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• pp.121-126
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• 2009

Objectives : The serotonin transporter gene(SLC6A4) is one of the most widely studied candidate genes in autism spectrum disorder(ASD), but there have been conflicting results from studies into the association between SLC6A4 and ASD. The aim of this study was to evaluate the association between single nucleotide polymorphisms(SNPs) in the SLC6A4 gene and ASD in the Korean population. Methods : We selected 12 SNPs in SLC6A4 and observed the genotype of 151 Korean ASD trios. We tested the family-based association for each individual polymorphism and haplotype by using the standard TDT method in Haploview(http://www.broad.mit.edu/mpg/haploview/). Results : Through transmission-disequilibrium testing and haplotype analysis, we could not find any statistically significant transmitted allele or haplotype. In addition, a case-control association test with Korean HapMap data did not reveal any statistical significance. Conclusion : Although serotonin-related genes must be considered candidate genes for ASD, we suggest that common SNPs of SLC6A4 are not important markers for associations with Korean ASD.

• 한국항행학회논문지
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• 제20권4호
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• pp.321-328
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• 2016

일반적으로 MLC NAND 플래시 저장장치는 SLC NAND 플래시 기반의 장치에 비해 정보 신뢰성이 낮은 것으로 평가된다. MLC 플래시는 SLC 플래시 보다 약 1000배 이상의 RBER (raw bit error rate)을 갖는다고 평가되나 최근 Google 데이터 센터에서 수집된 결과로부터 수행된 연구를 통해 실제 RBER은 이보다 훨씬 낮은 것으로 확인되었다. 이런 연구 결과를 바탕으로 우리는 MLC 플래시의 여유 저장 공간과 SSD 내부에 존재하는 Firmware 층을 활용하여 하드웨어적 구조 복잡성의 증가 없이 정보 신뢰성을 향상시키는 방법인 IDDD (in drive data duplication) 방식을 고안하였고 실 측정결과와 계산을 통해 MLC 플래시의 정보 신뢰성이 SLC 플래시 대비 상당히 높아질 수 있음을 보였다. 우리가 연구한 총 48개 상황 중 44개의 상황에서 SLC 플래시의 RBER이 MLC 플래시보다 낮았음에도 불구하고 IDDD방식을 적용함으로써 48개의 모든 상황에서 MLC 플래시의 RBER이 SLC 플래시보다 낮으며, 43개의 상황에서 UBER (uncorrectable bit error rate) 또한 SLC 플래시 대비 낮음을 보였다.