• Toxicological Research
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• v.31 no.4
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• pp.371-392
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• 2015

TS-DP2 is a recombinant human granulocyte colony stimulating factor (rhG-CSF) manufactured by TS Corporation. We conducted a four-week study of TS-DP2 (test article) in repeated intravenous doses in male and female Sprague-Dawley (SD) rats. Lenograstim was used as a reference article and was administered intravenously at a dose of $1000{\mu}g/kg/day$. Rats received TS-DP2 intravenously at doses of 250, 500, and $1000{\mu}g/kg/day$ once daily for 4 weeks, and evaluated following a 2-week recovery period. Edema in the hind limbs and loss of mean body weight and body weight gain were observed in both the highest dose group of TS-DP2 and the lenograstim group in male rats. Fibro-osseous lesions were observed in the lenograstim group in both sexes, and at all groups of TS-DP2 in males, and at doses of TS-DP2 $500{\mu}g/kg/day$ and higher in females. The lesion was considered a toxicological change. Therefore, bone is the primary toxicological target of TS-DP2. The lowest observed adverse effect level (LOAEL) in males was $250{\mu}g/kg/day$, and no observed adverse effect level (NOAEL) in females was $250{\mu}g/kg/day$ in this study. In the toxicokinetic study, the serum concentrations of G-CSF were maintained until 8 hr after administration. The systemic exposures ($AUC_{0-24h}$ and $C_0$) were not markedly different between male and female rats, between the administration periods, or between TS-DP2 and lenograstim. In conclusion, TS-DP2 shows toxicological similarity to lenograstim over 4-weeks of repeated doses in rats.

• KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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• v.23 no.3
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• pp.151-162
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• 2017

The purpose of this study was to investigate the quality change of fresh-cut tumeric (Curcuma Longa Linne) according to packaging method during storage time. The fresh-cut tumeric were packaged in three different methods : degassing valve packaging (DVP), $CO_2$ gas absorber packaging (CAP) and micro-perforated packaging (MPP). After the samples were packaged, they were stored for 15 days at 4 and $23^{\circ}C$ respectively. The following parameters were observed to indicate the quality changes of the samples: weight loss, CIE $L^*a^*b^*$ colour difference, variation of gas composition inside the package, curcumin contents and changes in hardness of fresh-cut tumeric. DVP did not effectively release $CO_2$ gas to the outside. MPP was suitable to release $CO_2$ gas. However, MPP showed very fast browning and erosion, because a large amount of oxygen was introduced through the perforated hole on the film. CAP was most effective packaging method to inhibit browning, to prevent expansion of the packaging by $CO_2$ gas and to minimize weight loss of fresh-cut tumeric.

• The Journal of the Korea Contents Association
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• v.10 no.4
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• pp.282-291
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• 2010

This study is carried out in order to suggest the effective method to enhance the resettlement of natives for re-maintenance promotion district of Asansi. This study is carried out through current status survey, native survey, and examining related laws, and the result of study is as follows. First, as a result of examining the intention of resettlement for the residents and merchants who live in the project district, 84% of residents and 80% of merchants wish to resettle. Second, in order to enhance the rate of resettlement, driving project to satisfy the demands of residents and merchants is needed. For this, house supplying policy and complex design technique for corresponding this tendency is needed because they prefer to live a single houses or housing attached to shopping street of 100 million won valued below as well as apartments,. And new types of business which can activate the function of the old city are needed, but making commercial space where current merchants can constantly do business activities is demanded. Third, the expansion of urban regeneration concept which have economics, society, culture, welfare and community as well as physical environment improvement are emphasized is needed. Fourth, the role of government for urban regeneration should be strengthened, and institutional improvement should be supported. Government needs to constantly support including financial supporting in order for the regeneration of regional city, and especially should scout for the policies which community can be maintained and should support first. For this, utilizing public lands inside project district into leading project, government should utilize into "constructing rental houses for natives", inducing the leading key facilities. Fifth, various plan techniques for the resettlement of natives of other advanced countries should be examined and be achieved.

• Journal of Fashion Business
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• v.5 no.3
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• pp.19-34
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• 2001

The purpose of this study was to investigate the differences of the general characteristics of subjects, the utilizing realities and the degree of satisfaction in the shopping mall and purchasing intention between group I that specializes in fashion design and group II that doesn't specialize in it. The results are summarized as the following six aspects. First, as a result of the general characteristics of subjects and the utilizing realities, the most different variables were the visiting frequency and the goods purchasing frequency. The result indicated that group II took more interests than group I. Second, as a result of the degree of satisfaction according to the factors of the general characteristics of subjects and the utilizing realities in the shopping mall, both group I and group II showed high degree of satisfaction in factor 1 (variety of event) whereas both groups showed relatively low degree of satisfaction in factor 3 (variety of goods). Third, as a result of the degree of satisfaction according to the general characteristics of subjects and the utilizing realities, group I showed significant differences in the degree of satisfaction according to a monthly allowance of pocket money and goods purchasing frequency and group II showed significant differences in the degree of satisfaction according to grade, the utilizing reason, goods purchasing frequency. Fourth, as a result of purchasing intention of fashion goods according to the general characteristics of subjects and the utilizing realities, group I showed the higher purchasing intention of fashion goods in group that the terms of payment was on-line payment than group that they was credit card. On the other hand, group II showed a significant difference in grade, which showed that group that was above third grade had the higher purchasing intention of fashion goods than group that was under third grade. Fifth, as a result of purchasing intention of fashion goods according to the degree of satisfaction, group I showed significant differences in factor 1 and factor 3 among the degree of satisfaction. In other words, group that had high degree of satisfaction in factor 1 showed the higher purchasing intention of fashion goods than other groups and group that had medium degree of satisfaction in factor 3 showed the higher purchasing intention of fashion goods than other groups. In group II, on the other hands, group that had high total degree of satisfaction showed the higher purchasing intention of fashion goods than other groups. Sixth, as a result of relative influencing power of independent variable with respect to purchasing intention of fashion goods in group I, the higher degree of satisfaction in factor 1 and the lower degree of satisfaction in factor 3 showed, the higher purchasing intention of fashion goods showed. As a result of relative influencing power of independent variable in group II, however, the higher grade and the higher degree of satisfaction in factor 1 showed, the higher purchasing intention of fashion goods showed.

• Cartoon and Animation Studies
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• s.41
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• pp.153-168
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• 2015

In Kyung-GI DO, An-sung, Each local autonomous entity developed the character design to inform the public relations and revitalize local economy and culture. consequently, These have got benefits with marketing local speciality related to their an-sung character; we call it name is arum, pung-mul, duck-bugi who korea traditional face characters. On the contrary, Most of old characters which have been fallen off their formative qualities became a reason that unfit (4D,3D) special film at local doom movie theater. This thesis aims to study on the character of 'namsadang' group what have been produced in ansung-si, that the show up to people about an-sung 4D Contents what local actually character and to make it more competitive through 3D,4D spacial character project developing process. It is need for new various characters, that (3D,4D-VFX) -Graphics of new an-sung'namsadang' group. that will be total different and new development. total VFX; 4-Dimantion visual graphics released in next an-sung local festival, Business prospects are bright and receiving benefits are increasing. As seen in the case of the character of in 2015, it can be a measure to earn benefits as a higher value-added business if it is managed in the local autonomous entities. In this thesis, I propose what the of character in the local special graphics; VFX style characters design. also I was show up to '4D contents character;' ; 'namsadang' group; creative processing including planing. It is possible to be ranged from special 4D series animation, a feature-length special effct cartoon film, character products, and even local doom Theme parks show up film. which are all expected high profits. These profits will be returned back to the an-sung local autonomous entity, who can use them to develop new contents, one of foundations in local economy. As a result, it is helpful to make local traits and effective tourist attractions.

• Korean Journal of Veterinary Service
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• v.34 no.4
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• pp.341-352
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• 2011

Colibacillosis in pigs remain a major swine industry bruden worldwide. Although some progress has been made in treating collibacillosis in pigs by using biosecurity and antimicrobials, it still remain a considerable problem. The use of host-specific bateriophages as a biocontrol is one possible alternative. The purpose of this study was to evaluate the effect of bacteriophage against enterotoxigenic Escherichia coli (ETEC) K88 infection in piglets. Twenty-eight piglets were randomly divided into four groups and each group was allocated with 7 pigs. Group B, C and D were inoculated with 5 ml of ETEC K88 ($1{\times}10^8$ CFU/ml) per head of piglet via oral. Group C and D were fed with bacteriophages (Group C, $1.0{\times}10^6$ PFU/g; Group D, $1.0{\times}10^8$ PFU/g; CJ CheilJedang Corp., Korea) orally as treatment. In piglets administrated bacteriophages and challenged with ETEC K88 (Group C and D), Clinical signs and the growth performance were improved and antibody titers were maintained low level compared with piglets challenged with ETEC K88 (Group B, P<0.05). Group B were shown high pH in the alimentary tracts compared with other piglets (P<0.05). In quantitative analysis by real-time PCR, the results of Group C and D were lower than those Group B in faecal and intestinal samples (P<0.05). Severe villus atrophy and crypt hyperplasia were observed in Group B consequently V/C ratio increased, compared with other piglets. These results indicate that feeding with bacteriophage has effect to prevent ETEC K88 infection in piglets and suggest that use of bacteriophage can be considered a valid antibiotic alternative.

• The KIPS Transactions:PartD
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• v.16D no.4
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• pp.583-594
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• 2009

Most of the SOA solutions applicable to businesses and organizations are taking a top-down methodology. It starts with an analysis of an organization's requirements, followed by definition of business models and identification of candidate services and ends with finding or developing required services. Challenges in adopting SOA while abandoning legacy systems involve time and cost required during the process. Many businesses and organizations want to gradually migrate into SOA while making the most of the existing system. In this paper, we propose A Method for Migration of Legacy System into Web Service(M-LSWS); it allows legacy system to be migrated into web service accessible by SOA and be used as data repositories. M-LSWS defines procedures for migration into reusable web services through analysis of business processes and identification of candidate services based on design specification and code of legacy system. M-LSWS aims to migrate of legacy system into web service appropriate for SOA. The proposed method consists of four steps: analysis of legacy system, elicitation of reusable service and its specification, service wrapping and service registration. Each step has its own process and guideline. The eligibility of the proposed method will be tested by applying the method to book management system.

• Korean Journal of Ichthyology
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• v.33 no.3
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• pp.167-176
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• 2021

This study was carried out to clarify the egg, larvae and juveniles development of Abbottina springeri. For the experiments, the matured adults were collected at the Seowon-cheon, Dangjin-si, Chungcheongnam-do, in Korea. The amount of spawning of female A. springeri was about 1,225~2,100 (1,662±437, n=10). The fertilized eggs were circular in shape and 1.05~1.13 (1.08±0.02, n=30) mm in diameter. The hatching time was required 72 hours to 80 hours after fertilization under water temperature of 22℃. The newly hatched larvae were 2.10~2.23 (2.16±0.04, n=10) mm in total length and had egg yolk in the abdomen but the mouth was not opened. At 5 days after hatching, the preflexion larvae were 3.19~3.30 (3.24±0.03, n=10) mm in total length and the most of yolk-sac was absorbed. At the 15 days after hatching, the flexion larvae were 4.97~5.30 (5.13±0.12, n=10) mm in total length and the tip of the caudal fin was began to bend upward. At the 25 days after hatching, the postflexion larvae were 8.97~9.60 (9.44±0.16, n=10) mm in total length and the tip of the caudal fin was bent at 45°. At the 35 days after hatching, the juvenile were 12.0~13.5 (12.7±0.53, n=10) mm in total length and all fin-rays (iii7 dorsal fin, iii6 anal fin, i7 ventral fins) were reached a constant number of each part.

• Journal of the Korea Society of Computer and Information
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• v.29 no.3
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• pp.67-74
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• 2024

In this paper, we present a study aimed at analyzing how different rainfall measurement methods affect the performance of reservoir water level predictions. This work is particularly timely given the increasing emphasis on climate change and the sustainable management of water resources. To this end, we have employed rainfall data from ASOS, AWS, and Thiessen Network-based measures provided by the KMA Weather Data Service to train our neural network models for reservoir yield predictions. Our analysis, which encompasses 34 reservoirs in Jeollabuk-do Province, examines how each method contributes to enhancing prediction accuracy. The results reveal that models using rainfall data based on the Thiessen Network's area rainfall ratio yield the highest accuracy. This can be attributed to the method's accounting for precise distances between observation stations, offering a more accurate reflection of the actual rainfall across different regions. These findings underscore the importance of precise regional rainfall data in predicting reservoir yields. Additionally, the paper underscores the significance of meticulous rainfall measurement and data analysis, and discusses the prediction model's potential applications in agriculture, urban planning, and flood management.

• Journal of Advanced Navigation Technology
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• v.14 no.3
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• pp.426-431
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• 2010

68% of the manufacturing costs of solar cell wafer can be attributed to the slurry. The recycling of slurries is mandatory for reducing the costs of manufacturing wafering production, and the disposal of industrial waste, as well as for cutting down pollution levels. Slurries are currently being recycled using the centrifuge(decanter) method. However, this method is less than optimal as it does not completely remove the fine particles, leading to low quality. Also, be cause of the incomplete separation from the oil, it causes the impurities in the dried slurries. This study aims to develope a new recycling technology that overcomes the flaws of the centrifuge by utilizing chemicals. It will provide a total solution to the crucial process of recycling slurries in the making of solar cell wafer, by increasing the efficiency and renewable rate.