• Journal of Microbiology and Biotechnology
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• v.30 no.11
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• pp.1626-1639
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• 2020

In Caenorhabditis elegans, SHN-1 is the homologue of SHANK, a scaffolding protein. In this study, we determined the molecular basis for SHN-1/SHANK in the regulation of innate immune response to fungal infection. Mutation of shn-1 increased the susceptibility to Candida albicans infection and suppressed the innate immune response. After C. albicans infection for 6, 12, or 24 h, both transcriptional expression of shn-1 and SHN-1::GFP expression were increased, implying that the activated SHN-1 may mediate a protection mechanism for C. elegans against the adverse effects from fungal infection. SHN-1 acted in both the neurons and the intestine to regulate the innate immune response to fungal infection. In the neurons, GLR-1, an AMPA ionotropic glutamate receptor, was identified as the downstream target in the regulation of innate immune response to fungal infection. GLR-1 further positively affected the function of SER-7-mediated serotonin signaling and antagonized the function of DAT-1-mediated dopamine signaling in the regulation of innate immune response to fungal infection. Our study suggests the novel function of SHN-1/SHANK in the regulation of innate immune response to fungal infection. Moreover, our results also denote the crucial role of neurotransmitter signals in mediating the function of SHN-1/SHANK in regulating innate immune response to fungal infection.

• Journal of Korean Society of Steel Construction
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• v.24 no.1
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• pp.129-136
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• 2012

This study seeks to evaluate the welding characteristics of SHN400 steel, which is suitable for the steel material used in building structures in KS. For this purpose, the Y-groove weld crack test and hardness, tensile, bending, cross tensile, and charpy V notch tests at the welding point were conducted with specimens taken from the highest, the thickest and the commonly used H-beams for girder or beam members. Each test was conducted under the KS test conditions. All tests results satisfied the requirements of KS and the welding requirements for the proper inelastic behavior of structure, indicating that SHN400 can be used for the building structure as a structural material.

• Acta Via Serica
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• v.4 no.1
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• pp.87-109
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• 2019

In the Iranian epic $K{\bar{u}}shn{\bar{a}}ma$, there is a rather interesting story that recounts how the inhabitants of $B.s{\bar{i}}l\bar{a}$ cross-breed their domesticated horses with a magical horse living in the sea in order to obtain fine-bred ones. What is even more interesting is that similar accounts are also seen in many of other classical Perso-Arabic works and Chinese sources. The regions that such events took place in mainly spread over Central Asia and western China while in $K{\bar{u}}shn{\bar{a}}ma$, the story happens in $B.s{\bar{i}}l\bar{a}$, a legendary kingdom with its historical prototype being Silla. By sorting out certain records of how ancient people sought fine horses by cross-breeding domesticated horses with wild horses that inhabited mountains and waters within Chinese sources and classical Muslim works, and comparing these accounts with similar plot lines as depicted in $K{\bar{u}}shn{\bar{a}}ma$, this paper attempts to elucidate that the story in $K{\bar{u}}shn{\bar{a}}ma$ is a result of flourishing land and maritime exchanges between East Asia and West Asia during ancient and medieval times, rather than a purely literary fiction. It was not only influenced by the horse culture that thrived over the Eurasian Steppe, but the story is also coincidentally in accordance with the fact that the nomadic zone which lies within the central Eurasian continent extends as far as the Korean Peninsula in northeast Asia.

• Asian-Australasian Journal of Animal Sciences
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• v.1 no.1
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• pp.43-46
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• 1988

Based on our previous results that among 4 strains of mice SHN and GR/A showed the highest mammary growth potentials in females and males, respectively. Effects of crossbreeding on normal and neoplastic mammary growth were studied in $(SHN\;{\times}\;GR/A)F_1$ virgin female mice. $F_1$ mice were higher than the parental strains in the end-bud formation and the ductal growth of mammary glands at 60 days of age and at tumorous age, respectively. While there was little difference between $F_1$ and both parental strains in the onset age of the first mammary tumors, mammary tumorigenic potential was apparently higher in the former than in the latters. This would be the first report that demonstrated directly the contribution of mammary growth potential of males to that of female offspring.

• Asian-Australasian Journal of Animal Sciences
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• v.1 no.3
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• pp.139-142
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• 1988

Effects of anthranilic acid on normal mammary gland growth were examined in SHN/Mei female virgin mice. Anthranilic acid was given to the experimental groups as drinking water at the concentrations of 0.01, 0.02 or 0.04% for 21 days beginning 2-3 months of age. The control group received tap water only. RNA content and RNA/DNA ratio in mammary glands were significantly higher in mice given 0.04% anthranilic acid than in the control, while not mammary DNA content. The results indicate that chronic ingestion of anthranilic acid can induce an enhancement of proliferation and differentiation of mammary cells.

• Journal of The Korean Astronomical Society
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• v.7 no.1
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• pp.19-23
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• 1974

The interpolation formula Chao-ch'a-shn devised for the Chinese calendar, Shou-shih-li, has been shown as the one of the 3rd order polynomial. Its 3 coefficients have been determined from the table of the Sun in Shou-shih-li. Its applications to the moon and planets are also briefly mentioned.

• International conference on construction engineering and project management
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• 2017.10a
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• pp.8-13
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• 2017

Nuclear power plant (NPP) constructions are large scale projects that are executed for several years, and schedule control utilizing various schedules is a critically important factor. Recently Korea independently developed the Advanced Power Reactor (APR) 1400 and is building nuclear facilities applying this new reactor type. The construction of Shin-Kori NPP (SKN) Unit 3, which adopted the APR1400, was completed and commercial operation has begun, while, SKN 4, Shin-Hanul NPP (SHN) Units 1&2, and SKN 5&6 are currently under construction. Prior to the development of the APR1400, Korea built 24 reactors and accumulated the schedule data of various reactor types which provided the foundation for schedule reduction to be possible. However, as there is no schedule development and review system established based on the standard schedule data (standard activities, durations, etc.) by reactor type, the process for developing the schedule for new builds is low in efficiency consuming much time and manpower. Also all construction data has been accumulated based on schedule activities. But because the connectivity of activities between projects is low, it is difficult to utilize such accumulated data (causes for schedule delay, causes for design changes, etc.) in new build projects. Due to such reasons, issues continue to arise in the process of developing standard schedule activities and a standard schedule for nuclear power plant construction. In order to develop a standard schedule for NPP construction, i) the development of an NPP standard schedule activity list, ii) development of the connection logic of NPP standard schedule activities, iii) development of NPP standard schedule activity resources and duration, and iv) integration of schedule data need to be performed. In this paper, an analysis was made on the coherence of schedule activity descriptions of existing NPPs by applying the probabilistic methodology on activities with low connectivity due to the utilization of the numbering system of four APR1400 reactors (SHN 1&2 and SKN 3&4).This study also describes the method for developing a standard schedule activity list and connectivity measures by extracting same and/or similar schedule activities.

• The Journal of Engineering Geology
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• v.8 no.3
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• pp.261-273
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• 1998

Multiple well log analysis technique consisting of geophysical well log and geological core log has been made to analysis the discontinuities of a test borehole-PABH1 located in Pungam sedimentary basin, Sosok, Hongchon-gun, Kangwon Province. Well log methods consist of normal resistivity log, focussed log, single point resistance log, SP log, gamma log, natural gamma log as well as acoustic televiewer log and borehole television log. Core scanning technique was used as an aid for geological core log. The analysis was made by comparing firstly the televiewer and core discontinuities, and then the results from conventional geophysical log analysis were compared to those from core log and acoustic televiewer log. Fractures deduced from the acoustic televiewer log coincide well with discontinuities shown on the core and conventional geophysical logs. Particularly close coincidence could be observed between fractures derived from acoustic televiewer and conventional geophysical log analysis. It has been noted that the geophysical logs such as, caliper, resistivity, density and high resolution gamma gamma curves are effective in delineating the fractures. For example the ratio between density and resistivity (BRD/SHN) provides also an alternative indicator for discerning the fracture condition in the study area.