• The Korean Journal of Pain
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• 제14권2호
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• pp.266-270
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• 2001

An 85-year old female patient visited our pain clinic because of pin pricking pain and allodynia on the left forehead area for 2 days. Vesicular eruptions were seen along the left supraorbital nerve distribution. She experienced similar pain and eruptions on the contralateral forehead, the supraorbital counter area, 8 years previous. She had been taking antihypertensive medications for 15 years. She also had suffered from diabetes mellitus. She received a total hysterectomy and anterior posterior colporrhapy due to procidentia uteri and severe cystocele and rectocele. She had been treated intermittently for back pain due to advanced osteoarthritis and spondylosis. She was treated with famciclovir and triamcinolone acetonide with daily stellate ganglion block and supraorbital nerve block. Nortriptyline (a tricyclic antidepressant) and midazolam was prescribed to relieve pain and difficulty in sleeping. After 3 days, all treatment was ended because it was impossible to assess the severity of pain due to the senile psychosis of the patient. She eventually expired after 2 months. We report this case because it is rare for herpes zoster to recur, and particularly on the contralateral counter area.

• 전력전자학회논문지
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• 제9권1호
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• pp.58-64
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• 2004

본 논문에서는 직류를 전원으로 하는 지하철에서 직류모선의 잉여전력을 교류모선으로 회생할 수 있는 직류전력 회생시스템의 고조파를 저감시키는 새로운 제어기법을 제안하였다. 직류전력 회생시스템에 수정 a도통(MAC : Modified a-Conduction)방식을 적용하면 출력전압에 12k$\pm$1차의 고조파가 존재한다. 이에 반해 본 논문에서 제안하는 SHE(Selected Harmonic Elimination)에 기반을 둔 방식을 적용하면 11차 고조파와 13차 고조파가 추가로 제거된다. 또한 회생시스템의 출력단에 23차 교류필터를 설치하면 잔존하는 고조파중 최저차 고조파인 23차 고조파도 제거할 수 있다. 본 논문에서 제안한 SHE방식을 적용한 고조파 저감기법을 검증하기 위하여 축소모델을 대상으로 하여 시뮬레이션을 행하였다. 그 결과, 출력전압의 THD가 기존의 MAC방식보다 더 낮으며 제어범위에서의 THD가 0.53∼0.68(%) 범위임을 확인하였다.

• 대한한방부인과학회지
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• 제18권4호
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• pp.242-252
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• 2005

Purpose : Dysfunctional uterine bleeding is an abnormal uterine bleeding without an organic disease. A hormone therapy or anti-depressant medicine is chosen to treat dysfunctional uterine bleeding. However sometimes it didn't work. Hysterectomy is recommended to stop bleeding but a lot of women are afraid of it. The purpose of this study is to show the possibility of oriental medical treatment for dysfunctional uterine bleeding in this case report. Methods : The 30-year-old female patient who had suffering from uterine bleeding was treated with hormone therapy and anti-depressant medicine. However she was bleeding again. She had no organic disease in some medical examination, finally she was recommended a hysterectomy. But she didn't want the operation. In addition, she started acute abdominal pain. She wanted a oriental medical treatment and we treated her from the May 14th 2005 to the June 4th 2005 in admission. We used Yikweseungyangtang(益胃升陽湯), Ojuksan(五積散), Kwibitang hap Gyoesamultang(歸婢湯合膠艾四物湯) for herb-medication. In acupuncture therapy,　ST36(Chok-Samni 足三里) SP1(Eunbek, 隱白) SP6(Samumgyo, 三陰交) SP10(Hyulhae, 血海) Liv1(Daedon, 大敦) Liv3(Taechung, 太衝) LI4(Hapgok, 合谷) was selected. In moxa therapy CV4(Kwanwon, 關元), CV6(Kihae, 氣海), CVl2(Chung-wan, 中脘) was used.　Results : After oriental medical treatment for 22 days, she stopped uterine bleeding　and recovered her health．　Conclusion ：　Oriental medical treatment is expected to have an effect on　dysfuctional uterine bleeding with abdominal pain.

• ALGAE
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• 제37권4호
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• pp.331-347
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• 2022

Atopic dermatitis (AD) is one of major skin inflammatory diseases characterized by excessive Th2-mediated immune responses. Recent evidence provides that interlukin-13 (IL-13) plays the role of a key Th2 cytokine that drives the inflammation underlining AD. Due to adverse effects of commercially available synthetic drugs, the need for treatments based on natural products is gaining much attention. Sargassum horneri is an edible brown algae known for beneficial bioactivities including anti-inflammation. We investigated if polyphenol-rich S. horneri extracts (SHE) could suppress AD-like skin lesions in NC/Nga mice and if that involved inhibition of the infiltration of Th2-mediated cytokine IL-13. We observed markedly increased infiltration of IL-13 positive cells in AD-like skin lesions of mice but SHE treatments decreased it. Also, the dermal expression of IL-13 was sufficient to cause inflammatory responses in mice skin resembling human AD. SHE suppressed the dermal infiltration of inflammatory cells where IL-13 plays a crucial role in skin tissues and in the recruitment of inflammatory cells. Furthermore, it was confirmed that SHE reduced T cell, dendritic cell, and macrophage populations in spleen. Moreover, SHE decreased the collagen deposition in skin and ear dermis resulting in reduced fibrosis that occurs in AD due to excessive collagen. Taken together, our results reveal that SHE suppressed the infiltration of inflammatory cells into skin dermis by decreasing the infiltration of IL-13 positive cells. Therefore, SHE could be taken as a useful therapeutic agent to alleviate AD.

• 대한한방내과학회지
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• 제44권6호
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• pp.1279-1293
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• 2023

A 67-year-old female patient diagnosed with acute transverse myelitis visited our hospital in February 2023. Consultation papers indicated that she was diagnosed with acute transverse myelitis and that she complained of quadriparesis and numbness in both hands and feet. However, her spine magnetic resonance imaging (MRI) did not clearly indicate that she suffered from acute transverse myelitis. She was then sent to a high-level hospital and diagnosed with Guillain-Barre Syndrome through electromyography, cerebrospinal fluid test, and spine MRI. On March 2023, she visited our hospital again, still complaining about weakness in both hands and inability to walk. She was treated with Korean medicine, including acupuncture, electroacupuncture, pharmacopuncture, and herbal medicine such as Yanggyeoksanhwatang and Sipimijihwang-tanggami. After three months, she was discharged on cane walking. The manual muscle test (MMT) grade of her upper limbs increased from 3-/3-/3-/3- (shoulder/elbow/wrist/fingers) to 4/4/4/3+, and the MMT grade of her lower limbs increased from 2/2/2/2 (pelvis/knee/ankle/feet) to 4/4/4-/4-. Her numbness in both feet disappeared, and her numbness in both hands decreased from a numeric rating scale of 7 to 2. No adverse events were reported during treatment. This case implies the therapeutic potential of Korean medicine for Guillain-Barre Syndrome, especially for those who had delayed diagnosis and missed the opportunity to get plasma exchange.

• 동의생리병리학회지
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• 제18권6호
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• pp.1643-1651
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• 2004

This experimental study was designed to investigate the effects of SIEGESBECKIAE HERBA extract (SHE) on the change of cerebral hemodynamics 〔regional cerebral blood flow (rCBF) and mean arterial blood pressure(MABP)〕 in normal condition and cerebral ischemic rats, and to determine the mechanism of action of SHE. This study was designed to investigate whether or not SHE inhibit lactate dehydrogenase (LDH) activity in neuronal cells and cytokines production in serum of cerebral ischemic rats. The results were as follows SHE increased rCBF significantly in a dose-dependent manner, but MABP was not changed by SHE in normal rats. The SHE-induced increase in rCBF was significantly inhibited by pretreatment with indomethacin (IDN), an inhibitor of cyclooxygenase but was increased by methylene blue (MTB), an inhibitor of guanylate cyclase. SHE inhibited lactate dehydrogenase (LDH) activity significantly in neuronal cells. rCBF was increased significantly and stably by SHE(10㎎/㎏, i.p.) during the period of cerebral reperfusion, which contrasted with the findings of rapid and marked increase in control group in ischemic rats. In serum by drawing from femoral arterial blood after middle cerebral arterial occlusion(MCAO) for 1hr and reperfusion for 1hr, the sample group was decreased IL-1β production significantly compared to that of the control group. In serum by drawing from femoral arterial blood after MCAO 1hr and reperfusion 1hr, sample group decreased TNF-α production significantly compared to that of the control grolilp. In serum by drawing from femoral arterial blood after reperfusion 1hr, sample group increased TGF-β production significantly compared to that of the control group. In serum by drawing from femoral arterial blood after MCAO for 1hr and reperfusion for 1hr, IL-10 production of the sample group was similar to that of control group. These results suggested that SHE had inhibitive effect on the brain damage by inhibited LDH activity, IL-1β and TNF-α production, but accelerated TGF-β production.

• 대한한방부인과학회지
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• 제30권2호
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• pp.144-152
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• 2017

Objectives: The aim of this case is to report the effects of oriental medicine on one patient with primary amenorrhea for endometrial preparation and implantation. Methods: A patient with primary amenorrhea had symptoms of sleep disorder, diarrhea, colpoxerosis. For preparing endometrium and implantation in oocyte donation after one previous failure, she was treated by twice a day herb medication for 75 days. And we observed the effects of treatments by improvement of symptoms and following up endometrial proliferation ultrasonography. After implantation, for maintaining pregnancy and live birth, she was also treated by twice a day herb medication for 45 days. Results: After treatments, Symptoms of sleep disorder, diarrhea, colpoxerosis were improved and the thickness of endometrium was prepared for implantation in oocyte donation. So she was pregnant and gave birth to a healthy baby 36 weeks later. Conclusions: This case shows that oriental medicine has its effective implementation for the implantational surroundings on patients with primary amenorrhea in oocyte donation programs.

• Human Ecology Research
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• 제55권3호
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• pp.303-319
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• 2017

This study explored the sandplay therapy case of a middle-aged woman having difficulty with interpersonal relationships and wanting to increase her self-identity. The goal of the therapy was to change her relationships with others by self-examination and becoming conscious of her negative animus and femininity in a free and protected space provided by sandplay therapy. Forty-five therapy sessions were held. The client exhibited her lonesomeness and fantasies by making sandtrays of a house she would like to live in, a park she would like to relax at and dreams she would like to fulfill in the initial phase of therapy (1~8, Who am I?). In the intermediate phase of therapy (9~33, Meeting myself), she displayed scenes of her negative self and breaking away from her negative self by making sandtrays of shadows, deaths, creations, a soaring scene and a disappearing alligator. In the final phase of therapy (34~45, Discovery of the real Self), she showed scenes of her meeting a positive self by making sandtrays of hope, coexistence, start, harmony and community. This study showed the effectiveness of sandplay therapy since the client' relationships with others were improved through her self-awareness by sandplay therapy in the free and protected space.

• 대한한의학회지
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• 제21권4호
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• pp.84-92
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• 2000

Objectives : The water extract of Sebsaeng-eum(SheShengYin) has been used for treatment of ischemic brain damage in oriental medicine, However, little is known about the mechanism by which the water extract of Sebsaeng-eum(SheShengYin) rescues brain cells from ischemic damages. Methods : To elucidate the protective mechanism on ischemic induced cytotoxicity, We investigated the regulation of LPS and PMA induced iNOS expression in $C_{6}$ glial cells. Results : LPS and PMA treatment for 48 h in $C_{6}$ glial cells markedly induced NO, but treatment of the cells with the water extract of Sebsaeng-eum(SheShengYin) decreased nitrite formation. In addition, LPS and PMA treatment for 48 h induced severe cell death in $C_{6}$ glial cells. However treatment of the cells with the water extract of Sebsaeng-eum(SheSheng Yin) did not induce significant changes compared to the control. LPS and PMA induced iNOS activation in $C_{6}$ glial cells caused chromosomal condensation and fragmentation of nuclei. Conclusions : Taken together, We suggest that the protective effects of the water extract of Sebsaeng-eum(SheShengYin) against ischemic brain damages may be mediated by regulation of iNOS during ischemic condition.

• Clinical and Experimental Pediatrics
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• 제57권12호
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• pp.538-541
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• 2014

Varicella is usually considered to be a benign disease in healthy children; however, serious complications can occur such as necrotizing fasciitis and toxic shock syndrome. We describe a 38-month-old girl with necrotizing fasciitis and streptococcal toxic shock syndrome following varicella. She was previously healthy and vaccinated against varicella at 12 months of age. She had been diagnosed with varicella three days prior to presenting at our facility; she developed fever, vomiting, and painful swelling on her left flank. Her skin lesions worsened, she became lethargic, and had episodes of hypotension and coagulopathy. Necrotizing fasciitis on the left abdominal wall, buttocks, and left thigh was diagnosed by magnetic resonance imaging, and group A Streptococcus was isolated from a tissue culture. She was diagnosed as necrotizing fasciitis and streptococcal toxic shock syndrome, and successfully treated with repeated surgical debridement and fasciotomy, in addition to intensive antibiotics. Our experience suggests that necrotizing fasciitis in patients with varicella should be considered to be a rare complication even with widespread vaccine use. Early diagnosis and intensive treatment are required to prevent a fatal outcome.