• 수산경영론집
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• 제46권3호
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• pp.51-61
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• 2015

The purpose of this study is to find food safety approach in the Eco-label Chain of Custody(CoC) which is only focused to traceability. Because, consumers want to be assured the certified seafood comes from sustainable fishery as well as hygienic. In order to this approach, we used Analytic Hierarchy Process(AHP) method as belows. We first understood the CoC criteria for using pair-wise comparison and analyzed and selected each Eco-label certifications and standards. Second, we carried out a survey to the targeted standard Marine Stewardship Council(MSC) CoC auditors all over the world and analyzed the priorities of food safety approach to 4 principles and 12 criteria belong the MSC CoC Standard. As the results, we found out that 'Management System' has the highest priority in the principles and 'Documentation' and 'Keeping Record' are the most important criteria for this approach. In addition, 'Training' and 'Identification' are also higher priority of criteria. So, we suggested food safety approach method for improvement of these criteria in conclusion based on discussion with specialist in this field.

• 한국균학회소식:학술대회논문집
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• 한국균학회 2016년도 춘계학술대회 및 임시총회
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• pp.17-17
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• 2016

Calcineurin governs stress survival, sexual differentiation, and virulence of the human fungal pathogen Cryptococcus neoformans. Herein, we identified and characterized calcineurin substrates in C. neoformans by employing phosphoproteomic $TiO_2$ enrichment and quantitative mass spectrometry. The identified targets include the zinc finger transcription factor Crz1 and proteins whose functions are linked to P-bodies/stress granules (PBs/SGs) and mRNA translation and decay, such as Pbp1 and Puf4. We show that Crz1 is a bona fide calcineurin substrate, and localization and transcriptional activity of Crz1 are controlled by calcineurin. Several of the calcineurin targets localized to PBs/SGs, including Puf4 and Pbp1, and are required for survival at high temperature and for virulence. Genetic epistasis analysis revealed that Crz1 and the novel targets Lhp1, Puf4, and Pbp1 function in a branched calcineurin pathway that orchestrates stress survival and virulence. These findings propose that calcineurin controls thermal stress and virulence at the transcriptional level via Crz1 and post-transcriptionally by regulating target factors involved in mRNA metabolism.

• 대한기계학회논문집B
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• 제30권5호
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• pp.438-445
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• 2006

We performed the simulation of the unsteady three dimensional flow over a square cylinder in a wind tunnel in moderate Reynolds number range, $100{\sim}2500$ by using LBM. SGS model was applied for the turbulent flow. Frist of all we compared LBM(Lattice Boltzmann Method) solution of Poiseuille flow applied Farout and bounce back boundary conditions with the analytical and FOAM solutions to verify the applicability of the boundary conditions. For LBM simulation the calculation domain was formed by structured grids and prescribed uniform velocity and density inlet and Farout boundary conditions were imposed on the in-out boundaries. Bounceback and wind tunnel boundary conditions were applied to the cylinder walls and the boundaries of calculation domain respectively. The maximum Strouhal number of the vortex shedding is 0.2025 at Re = 750. and the number maintains the constant value of 0.18 when Re>1000. We also predicted that the critical reynolds number of the turbulent flow is in the range of $250{\sim}500$.

• 한국추진공학회지
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• 제4권4호
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• pp.59-69
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• 2000

2차인 압축성/비압축성 Navier-Stokes 방정식은 이용하여 DCA 압푹기 익렬의 수치 해석을 수행하고 실험치와 비교 검토하였다. SIMPLE 알고리즘을 적용한 비압축성 코드는 대류항의 이산화에 하이브리드 도식을 진동해를 방지하기 위해 집중격자 기법을 사용하였다. 압축성 코드는 예조건화 기법 을 적용하였으며 공간 이산화출 위해 풍상 차분법을, 시간 적분을 위해서는 LU-SGS 기법을 사용하였다. 또한 난류 점성 유동장을 해석하기 위해 Baldwin-Lomax, standard $\kappa$ -$\varepsilon$, $\kappa$ -$\varepsilon$ Lam. Bremhorst, standard $\kappa$-$\omega$, $\kappa$ -$\omega$ SST 모델 등의 난류 모델을 적용하여 각 모델들의 특성을 살펴보았다.

• Journal of Microbiology and Biotechnology
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• 제33권5호
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• pp.582-590
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• 2023

Stress granules (SGs) are cytoplasmic aggregates of RNA-protein complexes that form in response to various cellular stresses and are known to restrict viral access to host translational machinery. However, the underlying molecular mechanisms of SGs during viral infections require further exploration. In this study, we evaluated the effect of SG formation on cellular responses to coxsackievirus B3 (CVB3) infection. Sodium arsenite (AS)-mediated SG formation suppressed cell death induced by tumor necrosis factor-alpha (TNF-a)/cycloheximide (CHX) treatment in HeLa cells, during which G3BP1, an essential SG component, contributed to the modulation of apoptosis pathways. SG formation in response to AS treatment blocked CVB3-mediated cell death, possibly via the reduction of mitochondrial reactive oxygen species. Furthermore, we examined whether AS treatment would affect small extracellular vesicle (sEV) formation and secretion during CVB3 infection and modulate human monocytic cell (THP-1) response. CVB3-enriched sEVs isolated from HeLa cells were able to infect and replicate THP-1 cells without causing cytotoxicity. Interestingly, sEVs from AS-treated HeLa cells inhibited CVB3 replication in THP-1 cells. These findings suggest that SG formation during CVB3 infection modulates cellular response by inhibiting the release of CVB3-enriched sEVs.

• 대한한방부인과학회지
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• 제27권1호
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• pp.152-166
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• 2014

Purpose: The purpose of this study is to compare with the result of experimental study about antithrombotic effect by reviewing recent oriental medicine journals that have been published since 2001' in Korea. Methods: Articles on antithrombotic effect that have been published from 2001' to 2013' in oriental medicine journals registered National Research Foundation of Korea were searched. After that, 12 articles using same 'thrombosis condition model' were selected and reviewed. Results: The results were as follows. 1. If there is no limit drug concentrations, platelet aggregation induced by adenosine diphosphate (ADP) in hyulbuchukeo-tanggamibang (HBCT) was the largest aggregation inhibitory effect and platelet aggregation induced by epinephrine in Saegeum-san (SGS), Jogan-tanggagambang (JGTG), hyulbuchukeo-tanggamibang (HBCT) had a large inhibitory effect on aggregation. 2. At the lowest concentration, Mokdan-san (MDS) of the inhibition of platelet aggregation induced by ADP and Hyunhosaik-san (HHS) of the inhibition of platelet aggregation induced by epinephrine were effective. 3. Pulmonary embolism induced by collagen and epinephrine in Neungasojeok-tang (NSJT) has the highest antithrombotic effect. 4. Pathological conditions of extravasated blood by dextran, Jogan-tanggagambang (JGTG) has the highest inhibitory effect on decrease in platelet numbers. Compared to the rest of the experimental drug, Saegeum-san (SGS), Heanggyonghonghwa-tang (HGTHHT), Wusl-san (WSS), Mokdan-san (MDS) showed significant inhibitory effect on the prothrombin time (PT) increases. Honghwadanggui-san (HDS), Saegeum-san (SGS) showed significant inhibitory effect on increase in activated partial thromboplastin time (APTT) and Jogan-tanggagambang (JGTG), Heanggyonghonghwa-tang (HGTHHT) showed significant inhibitory effect on decrease in fibrinogen. Conclusions: This result will provide useful information for the prescriptions of antithrombotic medicine in the field of Oriental medicine. We will have to carry out further studies that will compare each herb used in the diseases caused by extravasated blood.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2006년도 추계 학술대회논문집
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• pp.18-21
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• 2006

This paper investigates LES of turbulent combustion flow based on 2-scalar flamelet approach, where a G-equation and a conserved scalar equation simulate a propagation of premixed flame and a diffusion combustion process, respectively. The turbulent SGS modeling on these flamelet combustion approach is also researched. These LES models are applied to an industrial flows in a full scale gasturbine combustor with premixed and non-premixed flames. The numerical results predict the characteristics of experiment temperature profiles. Unsteady features of complex flames in combustor are also visualized.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 1999년도 제13회 학술강연논문집
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• pp.18-18
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• 1999

IRR형태의 액체 램제트 추진기관의 공기 흡입구 유동과 내부 연소 유동을 파악하기 위한 수치적 해석을 수행하였다. 해석은 다원 혼합기체에 대한 압축성 Navier-Stoke 방정식과 공기/Kerosene에 대한 화학 반응을 고려하였으며, 결합된 형태의 k-$\omega$/k-$\varepsilon$ 2 방정식 난류모델을 이용하였다. 기본 유동 해법으로는 고차의 시간 및 공간 정확도를 가지는 근사 Riemann 해법과 LU-SGS 방법을 이용하였다.

• 콘크리트학회논문집
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• 제26권4호
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• pp.457-463
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• 2014

이 연구는 화학혼화제 인수검사 기준으로 활용할 수 있는 고형분량 변동이 콘크리트 품질에 미치는 영향에 대해 살펴보는데 그 목적을 두었다. 현재 한국도로공사의 잠정기준으로 운용 중인 ASTM C 494 기반의 고형분량 변동범위 ${\pm}12%$는 혼화제의 종류 및 고형분량의 특성을 반영하지 못해 혼화제 종류에 따라 상이하게 나타났다. 고형분량 변동에 따른 콘크리트의 품질 변동을 평가한 결과 리그닌은 감수율이 낮은 관계로 고형분량의 변동범위가 큰 반면 나프탈렌계 및 폴리칼본산계 고성능감수제는 높은 감수율로 인하여 인수검사 기준으로 활용 중인 고형분량의 차이에 대한 허용범위 재조정이 요구되었다.

• 전기학회논문지
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• 제62권7호
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• pp.918-924
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• 2013

In a conventional power system, the frequency is recovered to the nominal value by the inertial, primary, and secondary responses of the synchronous generators (SGs) after a large disturbance such as a generator tripping. For a power system with high wind penetration, the system inertia is significantly reduced due to the maximum power point tracking control based operation of the variable speed wind generators (WGs). This paper proposes a virtual inertial control for a wind power plant (WPP) based on the maximum rate of change of frequency to release more kinetic energy stored in the WGs. The performance of the proposed algorithm is investigated in a model system, which consists of a doubly fed induction generator-based WPP and SGs using an EMTP-RV simulator. The results indicate that the proposed algorithm can improve the frequency nadir after a generator tripping. In addition, the algorithm can lead the instant of a frequency rebound and help frequency recovery after the frequency rebound.