• Asian-Australasian Journal of Animal Sciences
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• v.11 no.4
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• pp.337-343
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• 1998

In a feeding trial, Jamunapari male kids (18) of about 4 months age were equally divided into two groups of nine animals each. Goats in the experimental group were fed sun-dried pelleted Leucaena leucocephala leaves and those in the control group were offered a conventional diet without Leucaena leaves as per Kearl (1982) recommendations for a period of 6 months. Daily dry matter intake DMI/100 kg BW was $3.13{\pm}0.04kg$ in the Leucaena group and $3.30{\pm}0.05kg$ in the control. There were significant (p < 0.01) differences in the apparent digestibilities of DM, OM, CP, EE, CF and NFE being lower in the Leucaena group. Contents of digestible crude protein (DCP) and total digestible nutrients (TDN) were 11.40 and 52.20%, respectively, in the Leucaena group and 14.04 and 66.10%, respectively in the control. The nitrogen in the Leucaena group was not well utilized as compared to the control, though kids were in positive nitrogen balance in both the groups. The average daily weight gain of kids on pelleted Leucaena was $29.95{\pm}2.60g$ as against $42.09{\pm}3.24g$ observed in the control. The mean DMI/kg LW gain was significantly (p < 0.01) higher in the Leucaena group ($14.70{\pm}0.78kg$) as compared to the control ($11.55{\pm}0.46kg$). The Hb, BUN, SGOT and SGPT concentrations were statistically similar in both the groups. Histopathological examination of thyroid gland of goats sacrificed at the end of experiment did not reveal any signs of colloidal goitre associated with mimosine toxicity. No significant pathological alterations were observed in vital organs irrespective of dietary treatment. Sundried, pelleted Leucaena foliage appears to be a promising potential feed for growing goats without any significant deleterious effect.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.5
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• pp.1919-1924
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• 2015

Polymorphisms in the region of the interleukin IL-28 gene on chromosome 19 have been related with clearance of hepatitis C virus (HCV), a major human pathogen responsible for chronic hepatitis, cirrhosis and hepatocellular carcinoma. About 3% of the world's population is infected with HCV. The long-term response to therapy is influenced by many host and viral factors, and recent evidence has indicated that some host genetic polymorphisms related to IL-28 are the most powerful predictors of virological response in patients with HCV. This study assessed frequency of the IL-28 polymorphism (rs8099917) in 50 patients (39 men and 11 women) with chronic hepatitis C using ZNA probe real time PCR new method. All patients were tested for genotype of HCV and the HCV viral load. In parallel, the levels of SGOT, SGPT and ALK enzymes were assessed. Treatment using Peg-interferon alpha with ribavirin was conducted for patients and subsequently samples were collected to detect any change in viral load or liver enzyme rates. The overall frequency of the TT allele is 74%, TG allele 20% and GG allele 6% and the percent of patients who had T allele was 84%. Clear reduction in viral load and liver enzymes was reported in patients with the T allele. Especially for genotype 1 which is relatively resistant to treatment, these alleles may have a role in this decline. In conclusion, we showed that IL-28 polymorphism rs8099917 strongly predicts virological response in HCV infection and that real-time PCR with Zip nucleic acid probes is a sensitive, specific and rapid detection method for detection of SNPs which will be essential for monitoring patients undergoing antiviral therapy.

• Korean Journal of Health Education and Promotion
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• v.18 no.2
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• pp.115-128
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• 2001

This study was carried out to offer the basic data for more qualitative lives of the adulthood with obesity through their health maintenance and control. So, the researcher reviewed and analyzed the health problems of the subjects according to sex, age, and positive rate on the screening tests. The subjects were 91 obese persons in K university hospital in Seoul from December 1, 2000 to January 31, 2001. A Questionnaire developed by researcher to obtain subject's general characteristics, main symptoms, medical examination, diagnosed disease was used as the tool for the study. The results of this study are as follows: 1. For the distribution of diagnosis in subjects, liver disease was most frequent and hypertension was second. 2 The most common complaints were indigestion in the digestive system, throat pain in the respiratory system, dyspnea in cardiovascular system, thirsty in endocrine system, frequent urine in the urinary system, vertigo in the hematologic system. 3. The main symptoms according to sex were for females, a statistically significant higher rate of complaints in the digestive system, musculoskeletal system as compared to males. 4. The main symptoms according to age were that in the fourth decade there were higher rate of complaints in the musculoskeletal system. 5. In screening tests according to sex, males showed a higher positive rate for Alk-Phosphatase and females, in FBS, urine-micro, VDRL. 6. In screening tests according to age, higher positive rates of BP, Chest X-ray, mammography, ESR, CRP were seen in the fourth decades. 7. Obesity was positively related to cardiovascular system, endocrine system, urinary system, musculoskeletal system, mental and nervous system in main symptoms. 8. Obesity was positively related to BP, Sonography, FBS, SGOT, SGPT in screening tests.

• Biomedical Science Letters
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• v.13 no.2
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• pp.83-89
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• 2007

Effects of alkaline reduced water (ARW) on the scavenging of reactive oxygen species (ROS) and diabetes were recently reported. However, no studies have yet been investigated on general drinking effects. In this study, we examined 100 patients hospitalized for senile disease treatment and recuperation. All examines received the ARW for 2 months. WBC level was decreased from $6.34\pm1.9(\times10^9/L)$ to $5.66\pm1.7(\times10^9/L)$. SGPT level was decreased from 27.47$\pm$14 Ut to 23.95$\pm$8.8 U/L. Cholesterol level was increased from 167.9$\pm$32 mg/dl to 176.21$\pm$42 mg/dl within normal range. However, the levels of potassium, adiponectin, SGOT and blood pressure showed no significant difference. The levels of growth hormone and homocysteine and mini-mental state examination also showed no significant difference. We suppose that the slight blood parameter trends indicate an improved physical condition induced by the ARW. Furthermore, we could found no harmful effect of the ARW in this study.

• Journal of Oral Medicine and Pain
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• v.21 no.1
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• pp.141-152
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• 1996

Oral Lichen Planus(OLP) is a idiopathic chronic inflammatory disease with more difficult to clear and higher recurrent rate than cutaneous lesions. But, there has been no estabilished theories about the proper treatment for OLP. The purpose of this study is to examine the clinical feature, relationship with systemic disease and dental treatment of OLP patients of Korea and to gain helpful information about clinical characteristics and treatment of OLP. The subjects chosen for the study were 54 patients who had visited Department of Oral Diagnosis & Oral Medicine at Yonsei University Dental Hospital Dental Hospital and diagnosed as OLP. Previous clinical records has been reviewed and questionnaires, oral examination, laboratory examination were done and recorded. The following results were obtained : 1. Of the 54 patients, 21 were men and 33 were women with an average age of 47.8 years. 2. The most common intraoral site was bilateral buccal mucosa, followed by unilateral buccal mucosa, gingiva, vesibule, lip mucosa, glossal mucosa, palatal mucosa and mouth floor. 3. The mixed, erosive and reticular form of OLP was most frequent(83.3%) clinical form. 4. OLP patients with liver disease were 5, and drug medication patients were 7. But, we could not find its evidence of association with OLP. 5. Associated events on onset of symptom were stress, denture wearing, dental treatemtn, and common cold. 6. Associated symptoms were dry mouth, tingling, sore throat, and altered taste perception. 30.8% of patients had no specific associated symptoms. 7. Aggravating factors of symptom were peppery food, hot food, fatigue, toothpaste, salty food, sour food, tension, and conversation. Reducing factors were cold food, sleeping. 69.2% of patients had no specific reducing factors. 8. There were no significant differences between normal papulation and OLP patients in CBC, SGOT< SGPT, Serum iron, Total iron binding capacity. 66.7% of subjects were positive response to fungus study for Candida Albicans. The incidence of stress and dental treatment on onset of symptom appeared high in OLP patients. Especially, high incidence of positive response to fungus study for Candida albicans, prescription of anti-fungal agents and dental treatment considerations may be helpful to treatment of OLP.

• Korean Journal of Environmental Biology
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• v.22 no.4
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• pp.543-549
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• 2004

Ixeris dentata is a typical oriental herb. It is a widely distributed perennial in Korea, Japan and China, which belongs to the Compositae Family. The whole plant of I. dentata has been used for the treatment of pneumonia, contusion, tumor and hepatitis. It has also been used for the treatment of allergic diseases as a folk therapy in Korea. I. dentata is known to have aliphatics, triterpenoids and sesquiterpene glycosides in its composition. The present study was designed to explore the protective effects of water- and ethanol- extracts from I. dentata on irradiated rodents. For oral administration (twice per day), the extractive powder of I. dentata and the positive control (ascorbic acid) were dissolved at a concentration of 0.5 and 250mg $ml^{-1}$ in saline, respectively. Thirty days after irradiation, the ratio of the weight of the testis to the body weight was lower than 50% in the radiation groups than the control group. The ALP concentrations in the group treated with the water-extracts of the leaf were $79.68\pm{1.39%}$ (p<0.05) of those of the radiation control. Both of the SGOT and SGPT in the group treated with the ethanol-extract of the root were $72.68\pm{0.95}\;and\;77.87\pm{5.74}$ (p<0.05) of those of the radiation control, respectively. The levels of DNA damage induced by gamma radiation decreased in the experimental group to which the extracts of I. dentata were administered before irradiation. In conclusion, these results indicate that the extracts of I. dentata have an excellent ability to reduce the radicals and they have a protective effect on DNA breakage caused by radiation.

• Research in Community and Public Health Nursing
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• v.13 no.2
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• pp.260-271
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• 2002

Objectives: The purpose of this study was to identify basic health needs of adult clients to develop a community nursing center model in Seoul. Methods: Data were collected using a questionnaire survey from 894 adults registered at a public health center who were health management members, and visiting 4 community nursing centers, University of Wisconsin, Milwaukee during the period from July 1999 to January 2000. The data were analyzed using frequency, percentile, t-test, and ANOVA. Results: 1) The University of Wisconsin- Milwaukee School of Nursing has a long tradition of developing 4 community nursing centers with innovative health care programs. CNCs integrate the ability to implement and test effective intervention strategies with education, research, and practices of nursing students and faculty. They were designed to enhance the health status and quality of life for urban communities through the development of productive, outcome focused, collaborative partnerships among UWM-Nursing faculties and staff, other health and human service providers, consumers, and policy makers. It links the financial resources between UWM and 9 voluntary agencies and 12 public funding organizations including federal. state, and local governments. 2) Of the total health management members, 37.4% were reported to have at least one type of chronic disease such as hypertension, diabetes, and arthritis. Ten percent of them reported having obesity, and 44.2% reported lack of exercise. The health status of the subjects was within normal range in laboratory tests. However, female subjects showed more significant differences in obesity and cholesterol levels than male subjects. The subjects, who were in their 50s, showed more significant differences in obesity, SGOT, SGPT, and cholesterol levels than the subjects in other age groups. Conclusion: A community nursing center needs to be developed, that has a link between the nursing college and the public health center, with partnerships and a multidisciplinary approach. Based on the study results, exercise programs for middle aged adults are considered necessary. In particular, specific exercise programs for pre-menopausal women needs to be implemented in the future to prevent them from developing osteoporosis.

• Journal of Yeungnam Medical Science
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• v.3 no.1
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• pp.209-213
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• 1986

To study the therapeutic effect of ribavirin, a broad spectrum antiviral agent, for chronic hepatitis B in pediatric patients, 24 patients who were diagnosed as chronic hepatitis B (elevated SGOT and SGPT and positive HBsAg and HBeAg for more than 6 months) at the pediatric department of Yeungnam University Hospital from Mar. 1, 1985 to Sep. 30, 1986 were randomly divided into two groups. Ribavirin was administered to 11 patients in dose of 15mg/kg/day and 13 patients were control group and both groups were followed for 12 months. Serum HBsAg and HBeAg were measured with RIA(Ausria-1I and Abbott-HBe, respectively) and compared in PIN ratio (counts per minute of patient's sample/counts per minute of normal serum). There were no statistically significant reductions in PIN ratios of HBsAg and HBeAg in both groups between prior to the therapy and 12 months follow-up period. It seems that ribavirin does not have the therapeutic effect on chronic hepatis B in children. Also, there were no noticeable side effects from ribavirin therapy.

• The Journal of Dong Guk Oriental Medicine
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• v.2 no.2
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• pp.1-15
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• 1993

The purpose of this study is to observe the effect of Woogyuyem on serum reaction and hepatic tissue in Cyclosporin A treated rats. In this study, the experimental rats divided two group(Control group and Sample group). Under the same condition, both control group and sample group were injected to abdomen with Cyclosporin A for 7days. And then, control group were administered water, sample group were administered Woogy-uyeum for 300days. The change of transaminase and bile acid and SOD activity in blood serum, hepatic tissue were measured at 3rd, 7th, 15th, 30th day. The obtained results are summarised as follows : 1. In the change of SGOT contents, as compared with control group, sample group was significantly decreased at 7th and 15th day. 2. In the. change of SGPT contents, as compared with control group, sample group was significantly decreased at 15th day. 3. In the change of serum bile acid contents, as compared with control group, sample group was significantly decreased at 7th and 15th day. 4. In the change of serum SOD activity, as compared with control group, sample group was significantly increased at 15th and 30th day. 5. In the change of hepatic tissue, as compared with control group, the vacuolation of hepatocytes in the sample group was reduced, the liver plates were reconstructed, and the epitheriai cell wasn't destructed.

• Journal of Korean Biological Nursing Science
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• v.16 no.2
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• pp.133-140
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• 2014

Purpose: The purpose of this study was to investigate the comparison of blood biochemical parameters, physical activity, stress, and sleep management between obese and non-obese subjects according to the body mass index (BMI). Methods: Data were collected from February 1 to May 31 in 2012. This research involved 403 subjects who visited an obesity clinic in Korea. They were divided into 4 groups: normal weight 100 ($18.5{\leq}BMI$ < $23.0kg/m^2$), overweight 100 ($23.0{\leq}BMI$ < $25.0kg/m^2$), obese 100 ($25.0{\leq}BMI$ < $30.0kg/m^2$), and severely obese 103 ($BMI{\geq}30.0kg/m^2$). Data were analyzed using SPSS version 19.0. Results: There were significant differences on the SGPT (F=22.98, p<.001), SGOT (F=12.91, p<.001), creatinine (F=4.82, p=.003), triglyceride (F=20.17, p<.001), and total cholesterol (F=6.55, p<.001) among the subjects according to the BMI. There was no significant association between frequency of physical activity according to the BMI. There was significant association regarding the management of sleep (F=5.13, p=.002), but no significant association regarding the management of stress. Overall, there were significant association regarding the management of stress and sleep (F=3.79, p=.011) among the groups. Conclusion: The result of this study suggests that it is possible to use the information as basic data for educational and nursing intervention programs based on the BMI.