• Title/Summary/Keyword: SGOT

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A Study on the Positivity of HBsAg in Urban, Rural and Coastal Area (일부(一部) 도시(都市), 농촌(農村), 해안지역(海岸地域) 주민(住民)의 B형간염(型肝炎) 표면항원(表面抗原) 양성률(陽性率)에 관(關)한 비교연구(比較硏究))

  • Sohn, Seok-Joon
    • Journal of Preventive Medicine and Public Health
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    • v.19 no.1 s.19
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    • pp.45-55
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    • 1986
  • It is well known that Korea is one of the endemic area for type B viral hepatitis. A screening test for HBsAg by RPHA method was performed to evaluate the prevalence of HBsAg among urban, rural and coastal area population during the period between Jan. 1985 and Aug. 1985. The results obtained are as follows; 1) The HBsAg was detected in 242 among 2,849 with positive rate of 8.49%. The positive rate by sex showed higher rate in males(9.07%) than females(6.79%) for HBsAg. But these differences by sen were not statistically significant. 2) By living area, the positivity of HBsAg was 8.67% in urban, 7.43% in rural and 8.37% in coastal area. But the differences were not statistically significant. 3) The positivity differences of HBsAg were significantly observed between male(9.26%) and female(6.44%) in urban area. But there was not in rural and coastal area. 4) The positivity was the highest in 4th decade in urban area. But 6th decade in rural and 4th and 5th decade in coastal area. Generally the positivity of HBsAg was more prevalent in young age and decreasing by the age increasing in the male. But in the female it was most common in 6th decade. 5) Elevated SGOT(>40 Unit) was significantly higher in HBsAg positive group(13.6%) than in HBsAg negative group(3.4%).

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Hematological and Serum Chemical Values in Pere David′s Deer and Wapiti (사불상 및 와피티 사슴의 혈액 및 혈청화학치)

  • Shin Nam-Sik;Kwon Soo-Wahn;Han Duk-Hwan;Lee Heung-Shik
    • Journal of Veterinary Clinics
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    • v.11 no.1
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    • pp.471-478
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    • 1994
  • The hematologic values and serum chemistry were examined healthy male 12 Pere David's Deer and 8 Wapiti at the Farmland Zoological Garden. In wapiti, the blood values collected from horn and jugular vein were compared. The results were as follows: 1. There were not any significant differences in hematologic values and serum chemistry of blood col. looted from horn and jugular vein in wapiti. 2. In Pere David's Deer, Mean$\pm$SD Values of White Blood Cell(WBC) count were 4673.50$\pm$1893.42/${mu}ell$, of Neutrophils 65.42$\pm$12.7%, of Lymphocytes 31.50$\pm$8.68%, of Monocytes 0.25$\pm$0.43%, of Eosinophils 0.17$\pm$0.37%. of Basophils, of Red Blood Cell(RBC) 9.93$\pm$1.38$\times$10/${mu}ell$, of PCV 54.25$\pm$6.25%, of Hb 16.89$\pm$2.43g/㎗, of Tot protein 7.63$\pm$0.6g/㎗, of Cholesterol 87.25$\pm$10.76mg/㎗, of Glucose 109.36$\pm$43.7mg/㎗, of SGOT 85.17$\pm$33IU/$\ell$, of SGPT 102.92$\pm$31.49IU/$\ell$, of BUN 21.00$\pm$5.18mg/㎗, of Creatinine 2.1$\pm$0.43mg/㎗, of ALKP 156$\pm$32.72IU/$\ell$, of Ca 11.28$\pm$1.04mg/㎗, of Na 127.92$\pm$10.04mmo1/$\ell$, of NH3 102.83$\pm$42.25mmo1/$\ell$, of Cl 105.91$\pm$3.45mmo1/$\ell$, respectively. 3. In wapiti, Mean$\pm$SD Values of White Blood Cell(WBC) count were 3450.00$\pm$1040.73/${mu}ell$, of Neutrophils 53.88$\pm$7.42%, of Lymphocytes 36.00$\pm$5.72%, of Monocytes 1.13$\pm$1.05%, of Eosinophils 1.38$\pm$1.93%, of Basophils 7.63$\pm$4.15%, of Red Blood Cell 10.09$\pm$1.3$\times$10/${mu}ell$, of PCV 46.88$\pm$3.33%, of H 15.09$\pm$1.48g/㎗, of Total protein 7.15$\pm$0.73g/㎗, of Cholesterol 78.63$\pm$12.27mg/㎗, of Glucose 75.63$\pm$33.22mg/㎗ , of SGOT 79.25$\pm$18.43IU/$\ell$, of SGPT 36.50$\pm$19.20IU/$\ell$, of BUN 29.63$\pm$4.15mg/㎗, of Creatinine 1.35$\pm$0.21mg/㎗ , of ALKP 283.50$\pm$88.13IU/$\ell$, of Ca 9.78$\pm$0.43mg/㎗ , of Na 120.00$\pm$10.02mmol/$\ell$, of NH3 261.50$\pm$ 103.46mmol/$\ell$, of Cl 92.00$\pm$9.19mmol/$\ell$, respectively.

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Study on Fatty Liver Duagnosed by Abdominal Ultrasonography and Clinical Laboratory Findings (초음파로 진단된 지방간과 임상검사수치의 관련성에 관한 비교 연구)

  • Yang, Jeong-Hwa
    • Journal of radiological science and technology
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    • v.29 no.1
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    • pp.7-11
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    • 2006
  • This study obtained the following conclusions by making a comparative study on fatty liver diagnosed by abdominal ultrasonography and clinical laboratory findings. I surveyed the value of abdominal ultrasound in 400 patients without clinical symptoms at C Health Clinic Center, Seoul. 1. Compare with blood pressure was high(systolic/diastolic) in 7.5%/4.5% on persons who were diagnosed fatty liver. 2. At the time of the diagnosis, Total cholesterol level was increased in fatty liver patients, HDL-cholesterol level was high in fatty liver patients. And Trigryceride level was increased in fatty liver persons, LDL-cholesterol was high in fatty liver persons. 3. SGOT level was increased in 5.5% on patients who were diagnosed fatty liver, 0% on persons who were normal and SGPT level was high in 29.5% on people who were diagnosed fatty liver, 0% on patients who were diagnosed normal.

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A Clinical and Serologic Study of 21 Cases of Tsutsugamushi Disease Confirmed by Serologic test (혈청학적으로 확진된 쯔쯔가무시(Tsutsugamushi)병 21예에 대한 임상적 고찰)

  • Park, Jong-Seon;Kweon, Young-Su;Lee, Kwan-Ho;Hyun, Myung-Su;Chung, Moon-Kwan;Lee, Hyun-Woo
    • Journal of Yeungnam Medical Science
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    • v.7 no.1
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    • pp.151-163
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    • 1990
  • Tsutsugamushi disease is an acute febrile disease caused by Rickettsia tsutsugamushi, and which has been reported with increasing frequency through the nation since 1986. We experienced 21 cases of Tsutsugamushi disease diagnosed with serologic test occuring in Taegu city and Kyungpook province during October-November, 1989. The results of survey are as follow. 1) Of 21 cases, 12(57%) were males and 9(43%) were females, and the peak incidence was the 4th decade. 2) The outbreak was in October to November and the peak incidence was in October. 3) The most frequent symptoms were fever and chill(100%), myalgia(95%), headache(90%). Eschar and rash were observed in 18 patients(86%) and the eschar was detected in all over the body, especially thorax(33%) and lower extremity(22%). 4) Laboratory features were SGOT elevation(83%), SGPT elevation(61%), LDH elevation(67%). leukocytosis (38%). 5) Indirect immunofluorescent antibody test was done m 18 patients and the antibody titer was above 1 : 320 in all patients. 6) The chloramphenicol, tetracycline or doxycycline regimens were very effective and mean duration of defervescence from iniation of therapy was 1.3 days. 7) The complication such as meningitis or shock, was not seen.

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Prevalence of the Increased Liver Enzymes in Obese Children (소아 비만이 간기능에 주는 영향)

  • Park, Seon-Mi;An, Sang-Yong;Kim, Hyeon-Mi;Hwang, Ok-Bun;Park, Dae-Jeong;Kim, Hyeon-Ju;Gang, Sun-Ju;O, Yun-Jeong;Kim, Sun-Gi
    • Journal of Korea Association of Health Promotion
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    • v.4 no.1
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    • pp.95-103
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    • 2006
  • Purpose: With remarkable increase in the prevalence of childhood obesity, nonalcoholic fatty liver disease increased, The aim of this study is to evaluate the prevalence of the increase liver enzymes, lipid levels and fasting blood glucose level in normal and obese children. Methods: A total of 2206 elementary students were grouped according to obesity index; normal group and obesity group(mild, moderate, severe). Aspartate aminotransferase(AST, SGOT) and alanine aminotrausferase(ALT, SGPT) were measured with tota1 cholesterol, triglyceride and fasting blood glucose. Results: Compared with the 2.7% of ALT > 50 IU/L in normal group, obese groups showed significantly higher prevalence; 6.7% in mild obesity group, 11.8% in moderate group and 15.0% in severe group. The prevalence of hypertriglyceremia was 12,4% in normal weight group, which is significantly lower than obesity group(mild obesity group 24.8%, moderate and severe 32.1% each). Conclusion: The prevalence of nonalcoholic fatty liver increased along with severity of obesity. Of Nutritional assessment, intervention, and preferably prevention are necessary for health promotion elementary students.

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The Effect of Codium fragile (Chlorophyta) Extract on Hepatic Dysfunction and Hyperlipidemia in Rats

  • Park, Kap-Joo;Hwang, Eun-Kyoung;Park, Chan-Sun;Cho, Myung-Hwan;Lee, Jae-Seok
    • Korean Journal of Environmental Biology
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    • v.28 no.2
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    • pp.79-85
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    • 2010
  • To examine the effect of Codium fragile on blood cholesterol and lipid metabolism, hyperlipidemia was induced in experimental animal rats through the administration of a hypercholesterolemic diet. Codium fragile powder was then administered to the rats for 5 weeks, after which, blood biochemical changes such as blood cholesterol, Aspartate Aminotransferase (AST: serum SGOT) and Alanine Aminotransferase (ALT: serum SGPT) enzyme activity, etc. were determined. And histological changes in liver cells were examined using an electron microscope. Codium fragile treatment resulted in a significant reduction of the levels of total cholesterol, blood triglyceride and low-density cholesterol (LDL. Chol) compared to the control rats. In contrast the expression levels of high-density cholesterol (HDL. chol.) were increased. The AST value of the Codium fragile administration group was significantly reduced and the blood ALT value of the Codium fragile group showed a significant decrease in comparison to the negative control group. In summary, this study demonstrated the beneficial possibilities of Codium fragile in improving the abnormality of lipid metabolism caused by liver cell damage and hyperlipidemia.

Median Sternotomy for Bilateral Resection or Plication of Bullae (정중 흉골절개술을 이용한 동시적 양측 폐기포 절개술)

  • 박희철
    • Journal of Chest Surgery
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    • v.24 no.2
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    • pp.182-189
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    • 1991
  • Fourteen patients underwent surgical resection of bullae between February, 1987 and June, 1990 via median sternotomy. Twelve patients had spontaneous pneumothorax with previous history of pneumothorax on the contralateral side or visible bullae on chest X-ray films. Two patients had bullous emphysema. The duration of operation and admission, frequency and amount of analgesic administered for pain control, pulmonary function test [FEV1, FVC, MVV] and the amount of bleedings were compared with six cases of staged unilateral thoracotomy. The results were as follows: 1. All patients were male. 2. Mean follow up period was 13.5 month and no recurrence of pneumothorax are noted after the operation. 3. Median sternotomy showed shortened admission days than thoracotomy. [12.4$\pm$2.7, 15.6$\pm$3.1 days] 4. Significantly shortened anesthetic time in median sternotomy than thoracotomy [121$\pm$21, 184$\pm$33 minutes] 5. Median sternotomy required less injection of analgesics than thoracotomy. [6.5$\pm$2.7, 13.5$\pm$3.1 ampules] 6. Bleeding amount and PFT showed no differences. 7. Complications were prolonged air leakage for more than 7 days [2 patients], transient elevation of SGOT and SGPT[2 patients], and wound infection[1 patient]

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새로운 Quinolone 항균제(Q-35)의 제 1 상 임상 연구

  • 임동석;이경훈;장인진;신상구;이명묵;김의종;김진규;권준수
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1994.04a
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    • pp.189-189
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    • 1994
  • Q-35의 일회 및 반복투여 연구결과, 자타학 증상은 단지반복투여 피험자에서 중등도의 두통(1예)과 설사(3예)가 관찰되었으나 이들 설사증례는 장내 세균총 검사상 복감염에 의한 것이 아니었다. Q-35 투여 후 Q-EEG 및 평행기능의 장애 등은 관찰되지 않았으며 임상화학 검사상 반복투여 3예에서 SGOT, SGPT의 경미한 상승을 보였으나 이러한 변화는 정상 범위내에서의 변화이었다. Q-35의 반복투여에 따라 투약 3일에서 8일에 걸처 장내세균총은 일부 호기성 및 혐기성 세균총의 감소를 보였으나 투약종료 10일 후에는 투약전 상태로 회복되었다. Q-35는 투여량의 약 70 % 가 24시간 뇨중으로 배설되었으며 일회 및 반복투여의 결과 용량의존적인 동태양상은 관찰할 수 없었다. 50 mg에서 400 mg까지 일회 투여시 5.6-7.1 시간의 혈장반감기를 보였으며, 반복투여 시험에서는 평균 5.6 $\pm$ 0.7 시간의 반감기를 보였다. Q-35는 타액내로 신속히 이행되었으며 타액내 AUC는 혈장 AUC의 약 75 %에 해당하였고, 식사에 의해 약간의 흡수속도지연(Cmax 0.4 시간지연)과 공복시에 비해 82 %의 상대적 생체이용율을 보였다.

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Study of Effects of Harpagophyti Radix on Edema and Blood of Rats with Arthritis (관절염 백선의 부종과 혈액에 미치는 천수근의 효능연구)

  • Lee Joung Hun;Kim Youn-Sub
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.18 no.2
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    • pp.446-450
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    • 2004
  • Objectives: In order to study the effects of Harpagophyti Radix in rats with arthritis induced by Freund's complete adjuvant. Methods : In this study, rats with arthritis induced by Freund's complete adjuvant were divided into four groups; Normal, Control, Sample A(Harpagophyti Radix 6mg/200g) and Sample B(Harpagophyti Radix 12mg/200g). After 1 week, separated searches were made on the change of edema rate, the count of WBC, the quantity of total protein, total bilirubin, GOT and GPT in the serum. Results: In the right plantar edema, both of Sample groups showed a decrease in comparison with Control group. In the count of WBC, the quantity of serum total protein and SGOT, Sample B showed a decrease with statistical significance in comparison with Control group. In the quantity of serum total bilirubin and SGPT, both of Sample groups did not show any harmful change in in comparison with Control group. Conclusion : Reviewing these experimental results, it appeared that Harpagophyti Radix showed the therapeutic effect of anti-inflammatation on adjuvant arthritis.

Studies on the Toxicity of Dietary Ethionine and Methionine to Pancreas and Liver (취장 및 간장에 미치는 식이성(食餌性) Ethionine 과 Methionine 의 독성에 관한 연구)

  • Kim, Jae-Joun
    • The Korean Journal of Pharmacology
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    • v.7 no.1
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    • pp.37-52
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    • 1971
  • It has been demonstrated repeatedly that the administration of ethionine, a methionine analogue, will produce destruction of pancreatic tissue and liver cells. Destruction of acinar cells of pancreas by the administration of excess methionine similar to that seen after feeding diets supplemented with ethionine was also reported, but the liver was not involved by this amino acid. In an attempt to reproduce the results of these investigators the tissue damages were found to be slight and seen only irregulary in rats receiving ethionine on a complete diet and the result of tissue damages by excess methionine were also controversial. The present studies describe the toxicity of dietary supplemented ethionine and methionine to liver and pancreas in rats fed a low protein diet. Hundred five albino rats weighing around 120 gm were divided into three groups as follows; 1) Control group: A low protein diet containing 8% casein was fed throughout the experimental period. 2) Methionine group: A low protein diet (7% casein) supplemented with 1% methionine was used. 3) Ethionine group: A similar diet as methionine group except the supplementation of 1% ethionine instead of methionine was used. Five animals per wee from each group were killed for 6 weeks. The liver and pancreas were fixed in 10% formalin and histologic sections were prepared and stained with hematoxylin eosin. Serum amylase was expressed as much of glucose liberated from a starch substrate. The glucose was determined by the method of Nelson (1944). Serum glutamic pyruvic transaminase (SGPT) and glutamic oxaloacetic transaminase (SGOT) were determined by the technique described in Sigma Bulletin.

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