• The Korean journal of internal medicine
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• 제39권4호
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• pp.603-611
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• 2024

Background/Aims: There is limited knowledge regarding the management of duodenal subepithelial lesions (SELs) owing to a lack of understanding of their natural course. This study aimed to assess the natural course of asymptomatic duodenal SELs and provide management recommendations. Methods: Patients diagnosed with duodenal SELs and followed up for a minimum of 6 months were retrospectively investigated. Results: Among the 443,533 patients who underwent esophagogastroduodenoscopy between 2008 and 2020, duodenal SELs were identified in 0.39% (1,713 patients). Among them, 396 duodenal SELs were monitored for a median period of 72.5 months (interquartile range, 37.7-111.3 mo). Of them, 16 SELs (4.0%) showed substantial changes in size or morphology at a median follow-up of 35.1 months (interquartile range, 21.7-51.4 mo). Of these SELs with substantial changes, tissues of two SELs were acquired using endoscopic ultrasound-guided fine needle aspiration biopsy: one was a lipoma and the other was non-diagnostic. Three SELs were surgically or endoscopically removed; two were diagnosed as gastrointestinal stromal tumors, and one was a lipoma. An initial size of 20 mm or larger was associated with substantial changes during follow-up (p = 0.016). Conclusions: While the majority of duodenal SELs may not exhibit substantial interval changes, regular follow-up with endoscopy may be necessary for cases with an initial size of 20 mm or larger, considering a possibility of malignancy.

• Clinical Endoscopy
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• 제56권6호
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• pp.744-753
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• 2023

Background/Aims: This study aimed to evaluate the prevalence and natural progression of subepithelial lesions (SELs) in the upper gastrointestinal (UGI) tract. Methods: The medical records of patients with UGI SELs who underwent endoscopic screening at eight university hospitals between January and December 2010 were retrospectively investigated. The follow-up evaluations were performed until December 2016. Results: UGI SELs were found in 1,044 of the 65,233 participants screened (endoscopic prevalence, 1.60%; the total number of lesions, 1,062; mean age, 55.1±11.2 years; men, 53.6%). The median follow-up period was 48 (range, 8-74) months. SELs were most frequently found in the stomach (63.8%) and had a mean size of 9.9±6.1 mm. Endoscopic ultrasonography (EUS) was performed in 293 patients (28.1%). The most common lesions were leiomyomas, followed by gastrointestinal stromal tumors (GISTs), and ectopic pancreas. The proportions of SELs with malignant potential according to size were 3% (<1 cm), 22% (1-2 cm), 27% (2-3 cm), and 38% (≥3 cm). In gastric SELs larger than 1 cm, resections were performed in 20 patients because of an increase in size, of which 12 were found to be GISTs. Conclusions: The prevalence of UGI SELs was 1.60%. Further, 23% of gastric SELs ≥1 cm were precancerous lesions, most followed by EUS and clinical decisions without initial pathological confirmation.

• Clinical Endoscopy
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• 제55권5호
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• pp.615-625
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• 2022

Background/Aims: Mucosal incision-assisted biopsy (MIAB) for tissue acquisition (TA) from subepithelial lesions (SELs) is emerging as an alternative to endoscopic ultrasound (EUS)-guided TA. Only a limited number of studies compared the diagnostic utility of MIAB and EUS for upper gastrointestinal (GI) SELs; therefore, we conducted this systematic review and meta-analysis. Methods: A comprehensive literature search from January 2020 to January 2022 was performed to compare the diagnostic accuracy and safety of MIAB and EUS-guided TA for upper GI SELs. Results: Seven studies were included in this meta-analysis. The pooled technical success rate (risk ratio [RR], 0.96; 95% confidence interval [CI], 0.89-1.04) and procedural time (mean difference=-4.53 seconds; 95% CI, -22.38 to 13.31] were comparable between both the groups. The overall chance of obtaining a positive diagnostic yield was lower with EUS than with MIAB for all lesions (RR, 0.83; 95% CI, 0.71-0.98) but comparable when using a fine-needle biopsy needle (RR, 0.93; 95% CI, 0.83-1.04). The positive diagnostic yield of MIAB was higher for lesions <20 mm (RR, 0.75; 95% CI, 0.63-0.89). Six studies reported no adverse events. Conclusions: MIAB can be considered an effective alternative to EUS-guided TA for upper GI SELs without an increased risk of adverse events.

• Clinical Endoscopy
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• 제57권1호
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• pp.89-95
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• 2024

Background/Aims: In stereomicroscopic sample isolation processing, the cutoff value (≥4 mm) of stereomicroscopically visible white cores indicates high diagnostic sensitivity. We aimed to evaluate endoscopic ultrasound-guided tissue acquisition (EUS-TA) using a simplified stereomicroscopic on-site evaluation of upper gastrointestinal subepithelial lesions (SELs). Methods: In this multicenter prospective trial, we performed EUS-TA using a 22-gauge Franseen needle in 34 participants with SELs derived from the upper gastrointestinal muscularis propria, requiring pathological diagnosis. The presence of stereomicroscopically visible white core (SVWC) in each specimen was assessed using stereomicroscopic on-site evaluation. The primary outcome was EUS-TA's diagnostic sensitivity with stereomicroscopic on-site evaluation based on the SVWC cutoff value (≥4 mm) for malignant upper gastrointestinal SELs. Results: The total number of punctures was 68; 61 specimens (89.7%) contained stereomicroscopically visible white cores ≥4 mm in size. The final diagnoses were gastrointestinal stromal tumor, leiomyoma, and schwannoma in 76.5%, 14.7%, and 8.8% of the cases, respectively. The sensitivity of EUS-TA with stereomicroscopic on-site evaluation based on the SVWC cutoff value for malignant SELs was 100%. The per-lesion accuracy of histological diagnosis reached the highest level (100%) at the second puncture. Conclusions: Stereomicroscopic on-site evaluation showed high diagnostic sensitivity and could be a new method for diagnosing upper gastrointestinal SELs using EUS-TA.

• 한국빅데이터학회지
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• 제5권1호
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• pp.11-27
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• 2020

본 논문에서는 교육종단연구 데이터를 효과적으로 저장·처리·분석하기 위한 데이터 플랫폼을 개발하고, 이를 서울교육종단연구(SELS)에 적용하여 유용성을 확인한다. 플랫폼은 데이터 전처리부와 데이터 분석부로 구성된다. 데이터 전처리부에서는 1) 마스킹 2) 요인화 3) 정규화·이산화 4) 데이터 유도 5) 데이터 웨어하우징 과정을 통해 교육종단연구 데이터 웨어하우스를 생성하게 된다. 데이터 분석부는 OLAP과 데이터 마이닝(DM)으로 구성된다. 먼저, OLAP에서는 측정값 선정, 스키마 설계를 거쳐 OLAP을 수행하게 된다. 이후 DM에서는 변수 선택, 연구모형 선택, 데이터 수정, 인수튜닝, 모형학습, 모형평가 및 해석단계를 거친다. 본 플랫폼에서 전처리 과정을 거쳐 생성된 데이터 웨어하우스는 다양한 연구자들에 의해 공유될 수 있고, 지속적인 연구결과 데이터 셋의 축적이 가능하므로 후속 연구자들은 추가적인 분석을 수월하게 수행할 수 있게 된다. 또한, 정책입안자들도 SELS 데이터 웨어하우스에 직접 접근하여 다차원 분석을 통해 온라인으로 분석할 수 있어 과학적인 의사결정이 가능하게 된다. 본 연구에서는 개발된 플랫폼의 유용성을 입증하기 위해 SELS 데이터를 플랫폼 상에서 구축하고 수학 학업성취도를 측정값으로 선정하여 OLAP 및 DM을 수행하였으며, 측정값에 영향을 주는 다양한 요인을 데이터 마이닝 기법을 사용하여 분석하였다. 이를 통해 데이터 기반 교육정책 시사점을 빠르고 효과적으로 도출할 수 있었다.

• 한국수학교육학회지시리즈A:수학교육
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• 제57권2호
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• pp.75-92
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• 2018

Based on Perceptions about Mathematics Teachers (PMT) perceived by high school students, measured by 2189 students from Seoul Educational Longitudinal Study 2014 (SELS 2014), latent profile analysis (LPA) identified five distinct types of student groups (positive, partial positive, middle, negative, extreme negative). These student of positive, middle, and negative groups are positive, moderate and negative perceptions about math teachers. Partial positive group generally had a positive perception about mathematics teachers, extremely negative group was very negative about mathematics teachers. Both of these groups had peculiarly inconsistent trends and several anomalies. The Multinomial logistic regression analyses also indicated that individual factors (gender, major, self-concept, resilience, self-assessment, career maturity), school factors (friendship, relationship with school teachers) and parental factors (academic-relationship, emotional-relationship) were significant predictors of PMT profile groups. The Analysis of variance also indicated that mathematics class (attitude, satisfaction and atmosphere), Mathematics achievement were significant predictors of PMT profile groups. The profiling of perceptions about mathematics teachers resulted in enhanced understanding of the complex range of processes students employed. During mathematics class, implementation of smooth interactions and communications between students and teachers added in the teaching and learning of mathematics.

• Journal of Plant Biotechnology
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• 제50권
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• pp.215-224
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• 2023

Disinfecting water containing pathogenic microbes is crucial to the food safety of fresh green agricultural products. The UV-activated peracetic acid (UV/PAA) treatment process is an efficient advanced oxidation process (AOP) and a versatile approach to disinfecting waterborne pathogens. However, its effects on plant growth remain largely unknown. This study found that low-dose UV/PAA treatment induced moderate oxidative stress but enhanced the innate immunity of Arabidopsis against Pseudomonas syringae pv. (Pst) DC3000. When applied as water sources, 5- and 10-ppm UV/PAA treatments slightly reduced biomass and root elongation in Arabidopsis seedlings grown under hydroponic conditions. Meanwhile, treatments of the same doses enhanced defense against Pst DC3000 infection in leaves. Accumulation of hydrogen peroxide and callose increased in UV/PAA-treated Arabidopsis samples, and during the post-infection period, UV/PAA-treated seedlings maintained vegetative growth, whereas untreated seedlings showed severe growth retardation. Regarding molecular aspects, priming-related defense marker genes were rapidly and markedly upregulated in UV/PAA-treated Arabidopsis samples. Conclusively, UV/PAA treatment is an efficient AOP for disinfecting water and protecting plants against secondary pathogenic attacks.

• 직업교육연구
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• 제35권4호
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• pp.89-107
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• 2016

본 연구는 서울지역 중 고등학생의 자기주도학습능력과 진로성숙도 간 종단관계를 살펴보기 위해 서울교육종단연구 데이터를 활용하여 자기회귀교차지연 모형검증을 실시하였다. 분석 결과를 종합하면 다음과 같다. 첫째, 자기주도학습능력 변인의 경우, 1차년도에서 6차년도에 이르는 시간경로에 따라 통계적으로 유의미한 정적 영향을 미치는 것으로 나타났다. 둘째, 진로성숙도 변인 역시 1차년도에서 6차년도에 이르는 시간경로에 따라 통계적으로 유의미한 정적 영향을 미치는 것으로 나타났다. 셋째, 자기주도학습능력이 진로성숙도에 미치는 영향은 시간 흐름에 따라 통계적으로 유의미한 정적 영향관계를 보인 반면, 진로성숙도가 자기주도학습능력에 미치는 영향은 통계적으로 유의미한 결과를 보이지 않았다. 연구 결과를 바탕으로 중학교에서의 자기주도학습 강화 프로그램 정착, 입시제도가 아닌 진로발달단계를 고려한 진로지도 및 진로교육, 중 고등학교에의 진로진학상담교사 추가 배치 등을 제안하였다.

• Journal of Microbiology and Biotechnology
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• 제31권12호
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• pp.1709-1715
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• 2021

Outbreaks of food poisoning due to the consumption of norovirus-contaminated shellfish continue to occur. Male-specific (F+) coliphage has been suggested as an indicator of viral species due to the association with animal and human wastes. Here, we compared two methods, the double agar overlay and the quantitative real-time PCR (RT-PCR)-based method, for evaluating the applicability of F+ coliphage-based detection technique in microbial contamination tracking of shellfish samples. The RT-PCR-based method showed 1.6-39 times higher coliphage PFU values from spiked shellfish samples, in relation to the double agar overlay method. These differences indicated that the RT-PCR-based technique can detect both intact viruses and non-particle-protected viral DNA/RNA, suggesting that the RT-PCR based method could be a more efficient tool for tracking microbial contamination in shellfish. However, the virome information on F+ coliphage-contaminated oyster samples revealed that the high specificity of the RT-PCR- based method has a limitation in microbial contamination tracking due to the genomic diversity of F+ coliphages. Further research on the development of appropriate primer sets for microbial contamination tracking is therefore necessary. This study provides preliminary insight that should be examined in the search for suitable microbial contamination tracking methods to control the sanitation of shellfish and related seawater.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2004년도 전력전자학술대회 논문집(2)
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• pp.822-825
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• 2004

This paper describes the improvement of performance of power supply for ship's emergency lighting system(SELS). Proposed system is composed of power factor correction (PFC) circuit, emergency power supply system (EPSS), half bridge(HB) inverter, fluorescent lamp(FL) starting circuit and microprocessor control system. Experimental works using proposed system confirm that speedy and stable power to be supplied when main power source cut-off, compared with conventional relay type, and control power factor up to $97.5[\%]$ and input power up to $35.0[\%]$ by adjusting of pulse frequency of the HB inverter.