• Asian Pacific Journal of Cancer Prevention
• /
• 제15권1호
• /
• pp.25-28
• /
• 2014

Background: This study analyzed whether socio-economic factors affect the cause specific survival of soft tissue sarcoma (STS). Methods: Surveillance, Epidemiology and End Results (SEER) soft tissue sarcoma (STS) data were used to identify potential socio-economic disparities in outcome. Time to cause specific death was computed with Kaplan-Meier analysis. Kolmogorov-Smirnov tests and Cox proportional hazard analysis were used for univariate and multivariate tests, respectively. The areas under the receiver operating curve were computed for predictors for comparison. Results: There were 42,016 patients diagnosed STS from 1973 to 2009. The mean follow up time (S.D.) was 66.6 (81.3) months. Stage, site, grade were significant predictors by univariate tests. Race and rural-urban residence were also important predictors of outcome. These five factors were all statistically significant with Cox analysis. Rural and African-American patients had a 3-4% disadvantage in cause specific survival. Conclusions: Socio-economic factors influence cause specific survival of soft tissue sarcoma. Ensuring access to cancer care may eliminate the outcome disparities.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권12호
• /
• pp.7133-7136
• /
• 2013

Background: We studied Surveillance, Epidemiology and End Results (SEER) breast cancer data of Georgia USA to analyze the impact of socio-economic factors on the disparity of breast cancer treatment outcome. Materials and Methods: This study explored socio-economic, staging and treatment factors that were available in the SEER database for breast cancer from Georgia registry diagnosed in 2004-2009. An area under the receiver operating characteristic curve (ROC) was computed for each predictor to measure its discriminatory power. The best biological predictors were selected to be analyzed with socio-economic factors. Survival analysis, Kolmogorov-Smirnov 2-sample tests and Cox proportional hazard modeling were used for univariate and multivariate analyses of time to breast cancer specific survival data. Results: There were 34,671 patients included in this study, 99.3% being females with breast cancer. This study identified race and education attainment of county of residence as predictors of poor outcome. On multivariate analysis, these socio-economic factors remained independently prognostic. Overall, race and education status of the place of residence predicted up to 10% decrease in cause specific survival at 5 years. Conclusions: Socio-economic factors are important determinants of breast cancer outcome and ensuring access to breast cancer treatment may eliminate disparities.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권9호
• /
• pp.5043-5047
• /
• 2013

Background: This is a part of a larger effort to characterize the effects on socio-economic factors (SEFs) on cancer outcome. Surveillance, Epidemiology and End Result (SEER) bone and joint sarcoma (BJS) data were used to identify potential disparities in cause specific survival (CSS). Materials and Methods: This study analyzed SEFs in conjunction with biologic and treatment factors. Absolute BJS specific risks were calculated and the areas under the receiver operating characteristic (ROC) curve were computed for predictors. Actuarial survival analysis was performed with Kaplan-Meier method. Kolmogorov-Smirnov's 2-sample test was used to for comparing two survival curves. Cox proportional hazard model was used for multivariate analysis. Results: There were 13501 patients diagnosed BJS from 1973 to 2009. The mean follow up time (SD) was 75.6 (90.1) months. Staging was the highest predictive factor of outcome (ROC area of 0.68). SEER stage, histology, primary site and sex were highly significant pre-treatment predictors of CSS. Under multivariate analysis, patients living in low income neighborhoods and rural areas had a 2% and 5% disadvantage in cause specific survival respectively. Conclusions: This study has found 2-5% decrement of CSS of BJS due to SEFs. These data may be used to generate testable hypothesis for future clinical trials to eliminate BJS outcome disparities.

• 지역사회간호학회지
• /
• 제33권2호
• /
• pp.237-246
• /
• 2022

Purpose: The aim of this study was to investigate the relationship between the 5-year survival rate, socioeconomic status, and SEER (Surveillance Epidemiology and End Results) stage of stomach, colorectal, breast and cervical cancer patients. Methods: A total of 11,770 cases of four target cancers, which were diagnosed during 2005-2007, were extracted from the database of Gwangju-Jeonnam Regional Cancer Registry. The subjects of the study were 11,770 including stomach (n=5,479), colorectal (n=3,565), breast (n=1,516) and cervical cancers (n=710). Cox's proportional hazards model was used to obtain the hazards ratio (HR) according to the SEER stage and socioeconomic status. Results: Stomach cancer had a significantly higher HR in the medical aid recipients (HR=1.39), and the group below 20% (HR=1.20) compared to the group with the highest income level. Colorectal cancer had a significantly higher HR in the medical aid recipients (HR=1.26) than in the group with the highest income level. In addition, stomach, colorectal, breast and cervical cancers had a significantly higher HR according to the SEER stage in regional direct (stomach=4.10, colorectal=1.76, breast=12.90, cervical=3.10), regional lymph only(stomach=2.58, colorectal=2.33, breast=4.32, cervical=4.43), regional both (stomach=6.74 colorectal=3.04, breast=15.57 cervical=6.50), and regional NOS (Not Otherwise Specified)/distant (stomach=17.53, colorectal=11.53, breast=25.34, cervical=26.51) than in situ and localized only. Conclusion: In order to increase the cancer survival rate, a support system for early detection and early treatment of cancer should be established for groups with low individual income levels, and regular health checkups and management measures should be actively implemented through the National Cancer Screening Program.

• 시스템엔지니어링워크숍
• /
• 통권1호
• /
• pp.162-164
• /
• 2003

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권9호
• /
• pp.4091-4094
• /
• 2014

Background: This study used the receiver operating characteristic curve (ROC) to analyze Surveillance, Epidemiology and End Results (SEER) bronchioaveolar carcinoma data to identify predictive models and potential disparity in outcomes. Materials and Methods: Socio-economic, staging and treatment factors were assessed. For the risk modeling, each factor was fitted by a Generalized Linear Model to predict cause specific survival. The area under the ROC was computed. Similar strata were combined to construct the most parsimonious models. A random sampling algorithm was used to estimate modeling errors. Risk of cause specific death was computed for the predictors for comparison. Results: There were 7,309 patients included in this study. The mean follow up time (S.D.) was 24.2 (20) months. Female patients outnumbered male ones 3:2. The mean (S.D.) age was 70.1 (10.6) years. Stage was the most predictive factor of outcome (ROC area of 0.76). After optimization, several strata were fused, with a comparable ROC area of 0.75. There was a 4% additional risk of death associated with lower county family income, African American race, rural residency and lower than 25% county college graduate. Radiotherapy had not been used in 2/3 of patients with stage III disease. Conclusions: There are socio-economic disparities in cause specific survival. Under-use of radiotherapy may have contributed to poor outcome. Improving education, access and rates of radiotherapy use may improve outcome.

• Advances in Computational Design
• /
• 제2권3호
• /
• pp.211-223
• /
• 2017

This research presented a numerical and experimental study on the seismic performance of first-generation base-isolated and fixed-base nuclear power plants (NPP). Three types of the base isolation system were applied to rehabilitate the first-generation nuclear power plants: frictional pendulum (FP), high-damping rubber (HDR) and lead-rubber (LR) base isolation. Also, an Excel program was proposed for the design of the abovementioned base isolators in accordance with UBC 97 and the Japan Society of Base Isolation Regulation. The seismic assessment was performed using the pushover and nonlinear time history analysis methods in accordance with the FEMA 356 regulation. To validate the adequacy of the proposed design procedure, two small-scale NPPs were constructed at Universiti Teknologi Malaysia's structural laboratory and subjected to a pushover test for two different base conditions, fixed and HDR-isolated base. The results showed that base-isolated structures achieved adequate seismic performance compared with the fixed-base one, and all three isolators led to a significant reduction in the containment's tension, overturning moment and base shear.

• 응용통계연구
• /
• 제34권2호
• /
• pp.255-266
• /
• 2021

본 연구는 미국 국립암연구소의 SEER 프로그램에서 제공하는 위암 3기 자료에 대해 항암치료의 효과를 비교하고 위암 생존율에 유의한 영향을 미치는 요인을 알아보고자 한다. 본 연구에서 분석한 위암 3기 자료는 비례위험 가정이 성립하지 않아 대안으로 제한된 평균 생존시간을 이용한 분석 방법을 자료 분석에 적용하였다. 의사-관측들을 이용하여 제한된 평균 생존시간을 추정하였고, 제한된 평균 생존시간 추정량에 기반한 검정통계량을 이용하여 항암치료의 효과를 파악하였다. 일반화 선형모형을 이용한 회귀모형을 통해 위암 3기 환자의 평균 생존시간에 유의한 영향을 미치는 공변량들의 효과를 추정하였다. 항암치료법에 따라 위암 3기 환자의 평균 생존시간에 유의한 차이가 있음을 확인하였고, 진단연령, 인종, 세분화병기, 분화도, 종양의 크기, 수술여부, 항암치료가 위암 3기 환자의 평균 생존시간에 유의한 영향을 미치는 요인들이였으며, 그 중 수술여부가 위암 3기 환자의 평균 생존시간을 늘리는데 가장 큰 영향을 미치는 요인임을 확인하였다.

• 지능정보연구
• /
• 제17권3호
• /
• pp.63-77
• /
• 2011

월드와이드웹(World Wide Web)은 인터넷에 연결된 컴퓨터를 통해 사람들이 정보를 공유할 수 있는 매우 큰 분산된 정보 공간이다. 웹은 1991년에 시작되어 개인 홈페이지, 온라인 도서관, 가상 박물관 등 다양한 정보 자원들을 웹으로 표현하면서 성장하였다. 이러한 웹은 현재 5천억 페이지 이상 존재할 것이라고 추정한다. 대용량 정보에서 정보를 효과적이며 효율적으로 검색하는 기술을 적용할 수 있다. 현재 존재하는 몇몇 검색 도구들은 초 단위로 gigabyte 크기의 웹을 검사하여 사용자에게 검색 정보를 제공한다. 그러나 검색의 효율성은 검색 시간과는 다른 문제이다. 현재 검색 도구들은 사용자의 질의에 적합한 정보가 적음에도 불구하고 많은 문서들을 사용자에게 검색해준다. 그러므로 대부분의 적합한 문서들은 검색 상위에 존재하지 않는다. 또한 현재 검색 도구들은 사용자가 찾은 문서와 관련된 문서를 찾을 수 없다. 현재 많은 검색 시스템들의 가장 중요한 문제는 검색의 질을 증가 시키는 것이다. 그것은 검색된 결과로 관련 있는 문서를 증가시키고, 관련 없는 문서를 감소시켜 사용자에게 제공하는 것이다. 이러한 문제를 해결하기 위해 CiteSeer는 월드와이드웹에 존재하는 논문에 대해 한정하여 ACI(Autonomous Citation Indexing)기법을 제안하였다. "Citaion Index"는 연구자가 자신의 논문에 다른 논문을 인용한 정보를 기술하는데 이렇게 기술된 논문과 자신의 논문을 연결하여 색인한다. "Citation Index"는 논문 검색이나 논문 분석 등에 매우 유용하다. 그러나 "Citation Index"는 논문의 저자가 다른 논문을 인용한 논문에 대해서만 자신의 논문을 연결하여 색인했기 때문에 논문의 저자가 다른 논문을 인용하지 않은 논문에 대해서는 관련 있는 논문이라 할지 라도 저자의 논문과 연결하여 색인할 수 없다. 또한 인용되지 않은 다른 논문과 연결하여 색인할 수 없기 때문에 확장성이 용이하지 못하다. 이러한 문제를 해결하기 위해 본 논문에서는 검색된 문서에서 단락별 명사와 동사 및 목적어를 추출하여 해당 동사가 명사 및 목적어를 취할 수 있는 가능한 값을 고려하여 하나의 문서를 formal context 형태로 변환한다. 이 표를 이용하여 문서의 계층적 그래프를 구성하고, 문서의 그래프를 이용하여 문서 간 그래프를 통합한다. 이렇게 만들어진 문서의 그래프들은 그래프의 구조를 보고 각각의 문서의 영역을 구하고 그 영역에 포함관계를 계산하여 문서와 문서간의 관계를 표시할 수 있다. 또한 검색된 문서를 트리 형식으로 보여주어 사용자가 원하는 정보를 보다 쉽게 검색할 수 있는 문서의 구조적 통합 방법에 대해 제안한다. 제안한 방법은 루씬 검색엔진이 가지고 있는 순위 계산 공식을 이용하여 문서가 가지는 중요한 단어를 문서의 참조 관계에 적용하여 비교하였다. 제안한 방법이 루씬 검색엔진보다15% 정도 높은 성능을 나타내었다.

• 대한전자공학회:학술대회논문집
• /
• 대한전자공학회 2004년도 하계종합학술대회 논문집(2)
• /
• pp.411-414
• /
• 2004

This paper introduces a modulation method for digital wireless communication based on general DS-QPSK. The design and fabrication is for home networking application to a typical RF transmitter with DS-QPSK modulator. This modulator implemented using VHDL hardware programming language, the fabrication of IC chip $5{\times}5 mm^2$ was carried by 27th IDEC MPW(Multi Project Wafer) process in 0.35${\mu}m$ rule at Samsung Inc. This paper presented the important of this technology for the future application in wireless sensor. This module can be efficient usage for home network to transmit the RF wireless sensor system.