• Journal of Korean Academy of Nursing
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• v.49 no.5
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• pp.526-537
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• 2019

Purpose: The aim of this study was to evaluate the validity and reliability of the Korean version of the Clinical Teaching Behavior Inventory (CTBI). Methods: The English CTBI-23 was translated into Korean with forward and backward translation. Survey data were collected from 280 nurses' preceptors at five acute-care hospitals in Korea. Content validity, construct validity, and criterion-related validity were evaluated. Cronbach's ${\alpha}$ was used to assess reliability. SPSS 24.0 and AMOS 22.0 software was used for data analysis. Results: The CTBI Korean version consists of 22 items in six domains, including being committed to teaching, building a learning atmosphere, using appropriate teaching strategies, guiding inter-professional communication, providing feedback and evaluation, and showing concern and support. One of the items in the CTBI was excluded with a standardized factor loading of less than .05. The confirmatory factor analysis supported good fit and reliable scores for the Korean version of the CTBI model. A six-factor structure was validated ($x^2=366.30$, p<.001, CMIN/df=2.0, RMSEA=.06, RMR=.03, SRMR=.05, GFI=.90, IFI=.94, TLI=.92, CFI=.94). The criterion validity of the core competency evaluation tool for preceptors was .77 (p<.001). The Cronbach's ${\alpha}$ for the overall scale was .93, and the six subscales ranged from .72 to .85. Conclusion: The Korean version CTBI-22 is a valid and reliable instrument for identifying the clinical teaching behaviors of preceptors in Korea. The CTBI-22 also could be used as a guide for the effective teaching behavior of preceptors, which can help new nurses adapt to the practicalities of nursing.

• The Journal of Internal Korean Medicine
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• v.42 no.4
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• pp.605-621
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• 2021

Objectives: The purpose of this review is to assess the efficacy and safety of Hwangryunhaedok-tang for type 2 diabetes without complications by systemic review and meta-analysis of randomized controlled trials (RCTs). Methods: We searched the following up to March 31. 2021: PubMed, EMBASE, The Cochrane Library, CNKI, CiNii, KISS, KMBASE, OASIS, ScienceON. Data extraction and assessment of Cochrane's risk of bias (RoB) tool were performed by two independent authors, and if there was disagreement between two researchers, it was resolved through the intervention of a third researcher. Results: A total of seven trials are included in this systemic review. The treatment group (Hwangryunhaedok-tang plus conventional treatment) showed more statistically significant effects than did the control group (conventional treatment only) in fasting plasma glucose level, 2-hour postprandial plasma glucose level, glycated hemoglobin A1c, fasting insulin level, and HOMA-IR. There was no significant difference between the treatment group (Hwangryunhaedok-tang alone) and the control group (metformin alone). Conclusion: Hwangryunhaedok-tang might have efficacy and safety in controlling blood sugar level and improving insulin-resistance. However, the number of studies included in the meta-analysis was insufficient, and the Hwangryunhaedok-tang used in the included studies was not standardized. Also, the quality of the involved studies was generally low. Therefore, further studies are needed to determine the efficacy and safety of Hwangryunhaedok-tang treatment for type 2 diabetes mellitus.

• Journal of Navigation and Port Research
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• v.45 no.2
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• pp.61-68
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• 2021

Logistics movement using ships has been used for many centuries, but maritime accidents are still difficult to predict and they occur on a large scale. The International Maritime Organization (IMO) made it mandatory to install Electronic Chart Display and Information System (ECDIS) for safe seas, but S-57 standards applied to equipment were not updated over 30 years. In addition, it is difficult to keep the equipment up-to-date and revise standards as ships move around the world. In consideration of the limitations of S-57, the IHO developed the new standard as S-100 rather than an update of the S-57. In this study, the previously developed S-100 tool and S/W were configured as one platform and applied to the S-100 ECDIS. The platform conducts as the S-100 cycle and ecosystem from the creation of standards to release and practical use in ships. The hydrographic information standard is machine-readable as defined in S-100, and it has been validated that the latest standard can be applied using the Plug and Play (PnP) function without software system updates. It is expected that international organization such as the International Hydrographic Office (IHO) and the International Association of Marine Aids to Navigation and Lighthouse Authorities (IALA) shall develop and release standards and mariners can easily apply the latest standards to equipment through the machine-readable platform.

• Journal of Digital Convergence
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• v.16 no.11
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• pp.455-464
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• 2018

Recognizing the shortage of information about business models to generate profit despite the designers' recent interest in 3D printers as a new creative tool, this study set out to make sunglasses for young children, which lacked diversity in sizes according to age due to the small market scope under the old mass production system, by taking advantage of 3D printers' strength in the small batch production of customized products and propose a practical example to be expandable as a small-size business model. For these purposes, the investigator summarized the basic information about the 3D printing technology and the basic structure of sunglasses and made a size table to manufacture sunglasses for young children by analyzing the size table for vision correction. After this series of work, the study presented final product with the production costs and demonstrated that sunglasses for young children made with a 3D printer could be a practical case expandable as a competitive small-size business model in the market.

• The Journal of the Korea Contents Association
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• v.19 no.6
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• pp.192-203
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• 2019

China's urban regeneration, which has been focused on economic growth since the 1950's, has brought about the uniformity of cities. In order to improve on this, the urban regeneration policy has been transformed into a cultural city resource, which is promoting urban regeneration while utilizing the cultural characteristics of each region. However, the specific application methods are still lacking. In this study, I attempt to modify the apartment environment of the city, Hanan-sung, based on the pattern-language of Christopher Alexander, a space planning tool that can be used in urban regeneration. First, 23 patterns were chosen from the primary pattern-language. Next, I investigated the characteristics of the traditional housing culture of Hanan-sung through the literature review, surveyed the opinions of current apartment residents, and summarized the requirements. Finally, a new pattern-language was developed for the regeneration of the old apartments from the viewpoint of the culture, by modifying it according to the characteristics and requirements of housing culture of Hanan-sung which summarizes 23 pattern-languages.

• Tissue Engineering and Regenerative Medicine
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• v.15 no.6
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• pp.761-769
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• 2018

BACKGROUND: Bioprinting has recently appeared as a powerful tool for building complex tissue and organ structures. However, the application of bioprinting to regenerative medicine has limitations, due to the restricted choices of bio-ink for cytocompatible cell encapsulation and the integrity of the fabricated structures. METHODS: In this study, we developed hybrid bio-inks based on acrylated hyaluronic acid (HA) for immobilizing bio-active peptides and tyramine-conjugated hyaluronic acids for fast gelation. RESULTS: Conventional acrylated HA-based hydrogels have a gelation time of more than 30 min, whereas hybrid bio-ink has been rapidly gelated within 200 s. Fibroblast cells cultured in this hybrid bio-ink up to 7 days showed >90% viability. As a guidance cue for stem cell differentiation, we immobilized four different bio-active peptides: BMP-7-derived peptides (BMP-7D) and osteopontin for osteogenesis, and substance-P (SP) and Ac-SDKP (SDKP) for angiogenesis. Mesenchymal stem cells cultured in these hybrid bio-inks showed the highest angiogenic and osteogenic activity cultured in bio-ink immobilized with a SP or BMP-7D peptide. This bio-ink was loaded in a three-dimensional (3D) bioprinting device showing reproducible printing features. CONCLUSION: We have developed bio-inks that combine biochemical and mechanical cues. Biochemical cues were able to regulate differentiation of cells, and mechanical cues enabled printing structuring. This multi-functional bio-ink can be used for complex tissue engineering and regenerative medicine.

• Journal of the Korea Society of Computer and Information
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• v.26 no.5
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• pp.119-126
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• 2021

This study attempted to systematically and comprehensively analyze individual studies in which exercise program on total knee replacement patients. The electronic database for literature search used the Korean educational Academic Information (RISS), Korean Academic Information (KISS) and Nuri Media (DBPIA). We investigated a prior study of exercise program applied to total knee replacement patients from 2015 to February 2021. For meta-analysis, effect size of each individual study was extracted using R project for Statistical computing version 4.0.3. Rob 2.0 tool, developed by the Cochrane group, was used to evaluate the quality of each individual study. The overall effect size exercise program with pain and balance was 0.99 (95% CI=0.53-1.44), which was significantly different than large effect size (p<0.05). The sub-group for pain was analyzed, for effect size of 0.62 and the effect size of balance scale(timed up and go test) was 1.00. Through these results, it was found that exercise program is an effective exercise for total knee replacement patients, and further research is needs.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.34 no.12
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• pp.39-48
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• 2018

In modern architecture, the concept is the central axis of the design process, but it is not yet a building. The concept is modified in the process of realization because it captures only a part of reality. However, in the works of some Japanese architects, the concept seems to have become almost a building. In this study, I tried to find the cause of such a contradictory situation centering on House N of Fujimoto Sou, which is a representative architect of such tendency. Specifically, I analyzed the concept of House N by dividing it into aspects of function and representation. The reason for this was to see if the functional aspects of the concept were not modified in the first place, or if the representational aspects of the concept covered the functional aspects. For this purpose, I used WLVAE, which is a visual analysis tool, to analyze the functions of design concepts, along with the analysis of photographs, drawings, and diagrams. As a result of the analysis, House N was also modified to conditions of reality in the process of building, but the initial purity was emphasized in the representation of the concept, so that the building seemed to be very conceptual. This fact suggests that the architect has divided the functional and representational aspects of the concept and has focused on the latter. In conclusion this can be seen as an expression of the architect's interpretation of the relationship between the house and the city through the building.

• Biomolecules & Therapeutics
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• v.29 no.2
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• pp.135-143
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• 2021

Drug addiction influences most communities directly or indirectly. Increasing studies have reported the relationship between circadian-related genes and drug addiction. Per2 disrupted mice exhibited more vulnerable behavioral responses against some drugs including methamphetamine (METH). However, its roles and mechanisms are still not clear. Transcriptional profiling analysis in Per2 knockout (KO) mice may provide a valuable tool to identify potential genetic involvement and pathways in enhanced behavioral responses against drugs. To explore the potential genetic involvement, we examined common differentially expressed genes (DEGs) in the striatum of drug naïve Per2 KO/wild-type (WT) mice, and before/after METH treatment in Per2 KO mice, but not in WT mice. We selected 9 common DEGs (Ncald, Cpa6, Pklr, Ttc29, Cbr2, Egr2, Prg4, Lcn2, and Camsap2) based on literature research. Among the common DEGs, Ncald, Cpa6, Pklr, and Ttc29 showed higher expression levels in drug naïve Per2 KO mice than in WT mice, while they were downregulated in Per2 KO mice after METH treatment. In contrast, Cbr2, Egr2, Prg4, Lcn2, and Camsap2 exhibited lower expression levels in drug naïve Per2 KO mice than in WT mice, while they were upregulated after METH treatment in Per2 KO mice. qRT-PCR analyses validated the expression patterns of 9 target genes before/after METH treatment in Per2 KO and WT mice. Although further research is required to deeply understand the relationship and roles of the 9 target genes in drug addiction, the findings from the present study indicate that the target genes might play important roles in drug addiction.

• Journal of Korean Society on Water Environment
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• v.27 no.4
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• pp.445-460
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• 2011

The objective of this study was to construct and assess the applicability of the EFDC model for Saemangeum Reservoir as a 3D hydrodynamic and water quality modeling tool that is necessary for the effective management of water quality and establishment of conservation measures. The model grids for both reservoir system only and reservoir-ocean system were created using the most recent survey data to compare the effects of different downstream boundary conditions. The model was applied for the simulations of temperature, salinity, water quality variables including chemical oxygen demand (COD), chlorophyll-a (Chl-a), phosphorus and nitrogen species and algal biomass, and validated using the field data obtained in 2008. Although the model reasonably represented the temporal and spatial variations of the state variables in the reservoir with limited boundary forcing data, the salinity level was underestimated in the middle and upstream of the reservoir when the flow data were used at downstream boundaries; Sinsi and Garyuk Gates. In turn, the error caused to increase the bias of water quality simulations, and inaccurate simulation of density flow regime of river inflow during flood events. It is likely because of the loss of momentum of sea water intrusion at downstream boundaries. In contrast to flow boundary conditions, the mixing between sea water and freshwater was well reproduced when open water boundary condition was applied. Thus, it is required to improve the downstream boundary conditions that can accommodate the real operations of the sluice gates.