• 한국발생생물학회지:발생과생식
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• 제22권1호
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• pp.65-72
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• 2018

Cyclic AMP-response element binding protein zhangfei (CREBZF), a member of ATF/CREB (activating transcription factor/ cAMP response element binding protein) family, regulates numerous cellular functions and development of cells by interacting transcription factors. This study discovered the expression pattern of CREBZF in seminiferous tubule of testes during the postnatal development of mice. In testis, CREBZF mRNA expression was the highest among other organs. Immunofluorescence analyses showed that the CREBZF was specifically expressed on spermatocyte but not in spermatogonia and Sertoli cells in seminiferous epithelium of mouse testis. Semi-quantitative polymerase chain reaction (PCR) analysis showed that CREBZF transcript level was significantly elevated during postnatal development of mouse testis. Confocal imaging analysis indicated that the protein expression of CREBZF in seminiferous tubule remained low until postnatal day (PD) 14, and was dramatically increased in PD 21. Interestingly, only one type of the spermatocyte expressed CREBZF specifically among SCP3-positive spermatocytes. Taken together, these results suggest that CREBZF may be novel putative marker of the spermatocyte and regulate meiosis during postnatal development of mice.

• International Journal of Contents
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• 제15권2호
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• pp.44-52
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• 2019

This paper uses Delphi Method and statistics provided by the State Administration of Market Regulation of China, attempts to develop the scale index of language service industry in China. Coupled with practical investigation and theoretical framework of SCP paradigm, a deep analysis on market behavior, market structure, and market performance of the industry have been explored. First, the study indicates that the scale index of Chinese language services industry has experienced an upward trend from 10.481million RMB in 2008 to 351.403 million RMB in 2017. Second, majority of language services enterprises are situated in Chinese coastal provinces and there are variations in demand for language services. Third, the standardization of language services are minimal while most of the talents involve a single discipline background. Fourth, most enterprises utilize language tools while there is lack of technological innovation for utilization of language resources and enhancement of service quality. The author mainly suggests four strategies which include: cultivating multilingual services, strengthening the development of industrial informatization and technical innovation, and optimizing the industrial talents structure while also adjusting for industrial distribution and regional coordination, which propose the meaningful implications for the development of language service industry in China.

• 지식경영연구
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• 제20권1호
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• pp.231-249
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• 2019

Technology transfer from a multinational company to a local subsidiary is essential for successful local market operations. This study aims to analyze the impact of market, cultural and institutional environmental factors on international technology transfer and innovation performance based on the S-C-P paradigm. We collected data from one hundred ninety-five subsidiaries of Korean parent firms located in seventeen countries and used structural equation modeling to test hypotheses. The analysis findings are as follow; First, both market and cultural environment directly affect international technology transfer. However, institutional environment such as protection of intellectual property does not affect international technology transfer. Due to the less risk of technology disclosure involved in technology transfer within the MNE organization can be not relationship between protection of intellectual property in the host country and the foreign subsidiary's transfer of technology. The risk of infringement of intellectual property is relatively low in intra-firm transfer of technology. Second, the technology introduced from the parent company has a positive effect on the innovation performance of local subsidiaries. This implies that multinational companies that have entered unfamiliar overseas markets should be able to effectively transfer the inherent advantages of the parent company to their overseas subsidiaries, and that their ability to adapt to the local environment is important.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2000년도 연약지반처리위원회 학술세미나
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• pp.32-41
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• 2000

Sand drain as a vertical drainage is widely used in soft ground improvement Recently, sand, the principal source of sand drain, is running out. The laboratory model tests were carried out to utilize gravel as a substitute for sand. Though which the characteristics of gravel are compared to those of sand for engineering purpose. Two cylindrical containers for the model test were filled with marine clayey soil from the west coast of Korea with a column in the center, one with sand, the other with gravel. Vibrating wire type piezometers were installed at the distance of 1.0D, 1.5D and 2.0D from the center of the column. The characteristics of consolidation were studied with data obtained from the measuring instrument place on the surface of the container. The parameter study was performed on the marine clayey soil before and after the test in order to verify the effectiveness of the improvement. The clogging effect was checked at various depth in gravel column after the test. In-situ tests area was divided into two areas by material used. One is Sand Drain(SD) and Sand Compaction Pile(SCP) area, the other is Gravel Drain(GD) and Gravel Compaction Pile(GCP) area. Both areas were monitored to obtain the information on settlement, pore water pressure and bearing capacity by measuring instruments for stage loading caused by embankment. The results of measurements were analyzed. According to the test results, the settlement was found to be smaller in gravel drain than in sand drain. The increase in bearing capacity by gravel pile explains the result. The clogging effect was not found in gravel column. It is assumed that gravel is relatively acceptable as a drainage material. Gravel is considered to be a better material than sand for bearing capacity, and it is found that bearing capacity is larger when gravel is used as a gravel compaction pile than as a gravel drain.

• 대한기계학회논문집A
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• 제37권7호
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• pp.857-864
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• 2013

레이저 정밀 가공은 고품질의 집속 광에너지를 이용하여 재료를 미세하게 가공하는 특수 가공으로 정밀 제조 분야에 적용되고 있다. 그러나 레이저 가공 시 열적 효과로 인해 재료 특성을 저하 시킬 수 있다. 또한, 압연 강재 및 강판의 경우 공정 단계에서 강한 압력으로 제작하기 때문에 반드시 잔류응력이 존재한다. 하지만 압연 강재에 존재하는 잔류응력의 양은 정량적인 예측이 불가능하다. 이러한 잔류응력이 존재하는 재료의 레이저 가공 시 레이저에 의한 부가적인 응력 발생 및 재료에 미치는 열적 영향의 예측 및 평가는 정밀 가공에 있어서 반드시 고려해야 하는 사항이다. 본 연구에서는 레이저 홀 가공 시 발생되는 온도 및 응력을 유한요소 해석과 실험적 방법으로 분석하였다. 재료의 열응력을 예측하기 위해 레이저 홀가공 실험을 수행하여 가열 및 냉각 등의 대한 결과를 도출하였다. 또한 냉각 시간에 따른 응력의 변화를 파악하였고 유한요소 해석으로 예측된 응력을 홀드릴링 응력 측정 기법에 의해 도출된 응력과 비교 검증하였다.

• 한국컴퓨터정보학회논문지
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• 제19권10호
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• pp.13-21
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• 2014

집합 커버링 문제는 대표적인 조합 최적화 문제들 중 하나로서 n개의 열로부터 일부를 선택하여 m개의 행을 커버하되 비용을 최소화하는 문제로 정의된다. 본 논문에서는 집합 커버링 문제를 해결하기 위한 정수 계획법 기반 지역 탐색의 적용 방안을 제시하고 있다. 정수계획법 기반 지역 탐색은 이웃해를 탐색하여 현재해를 반복적으로 개선하는 지역 탐색 기법의 일종으로서 이웃해를 생성하기 위한 알고리즘으로 정수계획법을 사용한다. 본 논문에서 제시한 기법의 효과를 검증하기 위해 OR-Library의 테스트 데이터를 대상으로 실험을 수행하였다. 실험 결과, 모든 테스트 데이터에 있어서 정수계획법 기반 지역 탐색을 통해 지금까지 알려진 가장 좋은 해를 탐색할 수 있었다. 특히 4개의 테스트 데이터에 대해서는 지금까지 알려진 가장 좋은 해보다 더 좋은 해를 도출할 수 있음을 확인할 수 있었다.

• 대한한의학회지
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• 제35권4호
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• pp.36-51
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• 2014

Objectives: cDNA microarray is an effective method to snapshot gene expression. Functional clustering of gene expressions can identify herbal medicine mechanisms. Much microarray data is available for various herbal medicines. This study compares regulated genes with herbal medicines to evaluate the nature of the drugs. Methods: Published microarray data were collected. Total RNAs were prepared from dissociated hippocampal dissociate cultures which were given hypoxic shock in the presence of each herbal medicine. Up- or downregulated genes higher than Global M value 0.5 were selected, clustered in functional groups, and compared with various herbal treatments. Results: 1. Akt2 was upregulated by Acorus gramineus SOLAND, Arisaema amurense var. serratum $N_{AKAI}$ and Coptis chinensis $F_{RANCH}$, and they belong to Araceae herb. 2. Nf-${\kappa}b1$, Cd5, $Gn{\gamma}7$ and Sgne1 were upregulated by Arisaema amurense var. serratum $N_{AKAI}$, Coptis chinensis $F_{RANCH}$ and Rheum coreanum $N_{AKAI}$. 3. Woohwangcheongsim-won, Sohaphyang-won and Scutellaria baicalensis $G_{EORGI}$ downregulated Scp2 and upregulated Tsc2. Woohwangcheongsim-won and Sohaphyang-won upregulated Hba1 and downregulated Myf6. 4. Sohaphyang-won and Scutellaria baicalensis $G_{EORGI}$ downregulated Slc12a1. 5. Woohwangcheongsim-won and Arisaema amurense var. serratum $N_{AKAI}$ upregulated $Rar{\alpha}$, Woohwangcheongsim-won and Coptis chinensis $F_{RANCH}$ downregulated Rab5a and $Pdgfr{\alpha}$, and Woohwangcheongsim-won and Rheum coreanum $N_{AKAI}$ upregulated $Plc{\gamma}1$ and downregulated Pla2g1b and Slc10a1. Conclusions: By clustering microarray, genes are commonly identified to be either up- or downregulated. These results will provide new information to understand the efficacy of herbal medicines and to classify them at the molecular level.

• 한국식품과학회지
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• 제25권2호
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• pp.142-147
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• 1993

일광 에너지를 고정하고 식품공장의 폐수를 이용할 목적으로 56점의 분리원으로부터 광합성 세균 179주를 분리하고 그중 두부유청에서 제일 잘 자라는 균주를 선정하여 동정하고 두부유청을 기질로 하여 배양 최적조건을 조사하였다. 선정균주 B-Ps-106은 Rhodopseudomonas sphaeroides의 변종 또는 근연균으로 동정되었고 호기 배양보다 광혐기 배양에서 더 양호한 성장을 나타냈다. 최적 pH는 $8.5{\sim}9.0$이었고 최적온도는 $30^{\circ}C$ 이었고 최적광량은 $0.72\;ca1/cm^2/min$ 이상이었다. $K_2HPO_4$와 $(NH_4)_2SO_4$ 농도를 달리하여 각각 첨가한 결과 양쪽에서 모두 0.9 g/l 첨가했을 때 비교적 양호한 성장을 나타냈다.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2010년도 추계 학술발표회
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• pp.336-345
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• 2010

GS E&C was awarded the contract for the construction of Hanoi - Hai Phong Expressway Package EX-7 from Station Km 72+000 to Station Km 81+300 in December 2008. This project is the $7^{th}$ contract package of the 105.5 km long expressway near Hai Phong city, which includes a FCM-styled bridge along with high embankments over soft ground. For these high embankments, there is a need to treat the soft soil for improving the overall stability during construction and for reducing the post-construction settlement of the expressway. The Designer of this project had adopted four (4) different types of ground improvement techniques to treat the soft ground, including the prefabricated vertical drains (PVD), sand drains (SD), pack drains (PD, or sometimes called packed sand drains), and sand compaction piles (SCP). The main focus of soft soil treatment should be paid attention to the residual settlement after construction. In current design, however, it appeared that the secondary compression (or creep) of the improved soil layer and the consolidation settlement of the lower untreated compressible soil layer have been neglected in the estimation of the post-construction settlement. These uncalculated residual settlements may not only unsatisfy the design criteria but also raise serious problems during service period of this expressway. In this paper, the subsoil condition and current design were reviewed focusing on the employed soft soil treatment method and expected residual settlement.

• 동력기계공학회지
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• 제16권6호
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• pp.52-58
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• 2012

Roll forming process is one of the most widely used processes in the world for forming metals such as a furniture drawer guide or an up and down slide guide. It can manufacture goods of the uniform cross section on a large scale throughout the continuous processing. In the domestic design and manufacture, roll forming process for production is taking most of the method of 2-point under rail slide. However, this method is vulnerable to the structural strength and stiffness is not suitable for high load conditions. Therefore, through systematic study of high load, low noise 3-point ball type of under rail slide its own design and manufacturing technology is the need to build. In this paper, to make center member of 3-point ball-type under rail slide for the refrigerator doors, the roll forming modeling and simulation are performed. Tensile test is performed about SCP-1 1/2H for determine the mechanical properties of materials. Modeling and simulation of roll forming is used MSC.MARC software of a dedicated analysis program used by rigid plastic finite element method. Interference between the roll and the final shape are predicted from the results of the simulation.