• Title/Summary/Keyword: SCC model

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Lack of any Impact of Histopathology Type on Prognosis in Patients with Early-Stage Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix

  • Teke, Fatma;Yoney, Adnan;Teke, Memik;Inal, Ali;Urakci, Zuhat;Eren, Bekir;Zincircioglu, Seyit Burhanedtin;Buyukpolat, Muhammed Yakup;Ozer, Ali;Isikdogan, Abdurrahman;Unsal, Mustafa
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.6
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    • pp.2815-2819
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    • 2014
  • Background: The aim of this study was to evaluate the prognosis of patients with stage IA-IIB cervical carcinoma and to investigate a possible correlation of histology with prognosis. Materials and Methods: Two hundred fifty one patients with adenocarcinoma and squamous cell carcinoma (SCC) histology for FIGO (International Federation of Gynecology and Obstetrics) stage IA-IIB uterine cervical carcinomas at the Radiation Oncology Clinic of GH Okmeydan Training and Research Hospital between January 1996 and December 2006 were selected, analyzed retrospectively and evaluated in terms of general characteristics and survival. Disease-free survival (DFS) and overall survival (OS) was calculated using the Kaplan-Meier method and differences were compared with the log-rank test. Multivariate analysis using a Cox-proportional hazards model was used to adjust for prognostic factors and to estimate hazard ratio (HR) with 95% confidence interval (CI). Results: There was no differences between the two tumour types in age, stage, pelvic nodal metastasis, parametrial invasion, surgical margin status, DSI, LVSI, maximal tumor diameter, grade, and treatment modalities. 5-year OS and DFS were 73% and 77%, versus 64% and 69%, for SCC and adenocarcinoma, respectively (p> 0.05). Multivariate analysis revealed independent prognostic factors including pelvic nodal metastasis and resection margin status for OS (p=0.008, p=0.002, respectively). Conclusions: Prognosis of FIGO stage IA-IIB cervical cancer patients was found to be the same for those with adenocarcinoma and SCC.

Composite genotypes of progestogen-associated endometrial protein gene and their association with composition and quality of dairy cattle milk

  • Kolenda, Magdalena;Sitkowska, Beata;Kamola, Dariusz;Lambert, Barry D.
    • Animal Bioscience
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    • v.34 no.8
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    • pp.1283-1289
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    • 2021
  • Objective: The progestogen-associated endometrial protein (PAEP) gene encodes the main whey protein in milk, β-lactoglobulin. The aim of the study was to investigate polymorphism in the PAEP gene and its association with milk yield, composition, and quality. Methods: Test-day records for 782 dairy cows were analysed. A total of 10 single nucleotide polymorphisms (SNP) within the PAEP gene were investigated. The following parameters were recorded: milk yield (MY, kg/d), percent milk fat (%), protein (PP, %), dry matter (DMP, %) and lactose (LP, %), urea content (UC, mg/L) as well as natural logarithm for somatic cell count (LnSCC, ln). Effect on genomic estimated breeding values accuracy was evaluated with pedigree and single step model. Results: Results show that only three SNPs were polymorphic, creating 5 composite genotypes: P1 to P5. Differences in MY between composite genotypes were noted in the two tested herds. Cows with P5 composite genotypes were characterised by the highest PP and LnSCC and the lowest LP and UC (p<0.05). P4 was linked to an increased DMP and UC, while P3 to an increase in LP and decrease in PP and LnSCC. Both factors are important markers in herd management and have high influences on the herds economics. For 5 out of 7 traits the accuracy of prediction was improved by including the haplotype as a fixed effect. Conclusion: Presented results may suggest a new way to optimise breeding programmes and demonstrate the impact of using genomic data during that process.

Ozone Simulations over the Seoul Metropolitan Area for a 2007 June Episode, Part I: Evaluating Volatile Organic Compounds Emissions Speciated for the SAPRC99 Chemical Mechanism (2007년 6월 수도권 오존모사 I - 광화학측정자료를 이용한 SAPRC99 화학종별 휘발성유기물질 배출량 입력자료 평가)

  • Kim, Soon-Tae
    • Journal of Korean Society for Atmospheric Environment
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    • v.27 no.5
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    • pp.580-602
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    • 2011
  • Volatile organic compound (VOC) emissions in the 2007 CAPSS (Clean Air Protection Supporting System) emissions inventory are chemically speciated for the SAPRC99 (Statewide Air Pollution Research Center 99) mechanism, following the Source Classification Code (SCC) matching method to borrow the U.S.EPA's chemical speciation profiles. CMAQ simulations with High-order Direct Decoupled Method (HDDM) are in turn applied to evaluate uncertainty in the method by comparing the simulated model VOC species to the observations in the Seoul Metropolitan Area (SMA) for a 2007 June episode. Simulations under-predicted ALK1 to ALK4 in SAPRC99 by a factor of 2 to 5 and over-predicted ALK5 by a factor of 7.5 while ARO1, ARO2, OLE1, and ethylene (ETH) are comparable to the observations, showing relative difference by 10 to 30%. OLE2 emissions are roughly 4 times overestimated. Emission rates for individual VOC model species are revised referring to the ratio of simulated to observed concentrations. Impact of the VOC emission changes on the overall ozone prediction was insignificant for the days of which 1-hr maximum ozone are lower than 100 ppb. However, simulations showed ozone difference by 5 to 10 ppb when high ozone above 120 ppb was observed in the vicinity of Seoul. This result suggests that evaluations on individual model VOC emissions be necessary to lead ozone control plans to the right direction. Moreover, the simulated ratios of ARO1 and ARO2 to $NO_x$ are roughly 50% lower than the observed ones, which imply that adjustment in $NO_x$ and VOC emission rates may be required to mimic the real VOC/$NO_x$ condition over the area.

Assessment of Changed Input Modules with SMOKE Model (SMOKE 모델의 입력 모듈 변경에 따른 영향 분석)

  • Kim, Ji-Young;Kim, Jeong-Soo;Hong, Ji-Hyung;Jung, Dong-Il;Ban, Soo-Jin;Lee, Yong-Mi
    • Journal of Korean Society for Atmospheric Environment
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    • v.24 no.3
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    • pp.284-299
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    • 2008
  • Emission input modules was developed to produce emission input data and change some profiles for Sparse Matrix Operator Kernel Emissions (SMOKE) using Clean Air Policy Support System (CAPSS)'s activities and previous studies. Specially, this study was focused to improve chemical speciation and temporal allocation profiles of SMOKE. At first, SCC cord mapping was done. 579 SCC cords of CAPSS were matched with EPA's one. Temporal allocation profiles were changed using CAPSS monthly activities. And Chemical speciation profiles were substituted using Kang et al. (2000) and Lee et al. (2005) studies and Kim et al. (2005) study. Simulation in Seoul Metropolitan Area (Seoul, Incheon, Gyeonggi) using MM5, SMOKE and CMAQ modeling system was done for effect analysis of changed input modules of SMOKE. Emission model results adjusted with new input modules were slightly changed as compared to using EPA's default modules. SMOKE outputs shows that aldehyde emissions were decreased 4.78% after changing chemical profiles, increased 0.85% after implementing new temporal profiles. Toluene emissions were decreased 18.56% by changing chemical speciation profiles, increased 0.67% by replacing temporal profiles as well. Simulated results of air quality were also slightly elevated by using new input modules. Continuous accumulation of domestic data and studies to develop input system for air quality modeling would produce more improved results of air quality prediction.

Development of a Prediction Model for Formwork Pressure Exerted by Self-Compacting Concrete (자기충전 콘크리트의 거푸집 측압 예측 모델 개발)

  • Kwon, Seung-Hee
    • Proceedings of the Korea Concrete Institute Conference
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    • 2008.04a
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    • pp.453-456
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    • 2008
  • This study is underway to develop a prediction model for formwork pressure exerted by self-compacting concrete(SCC). Three major mechanisms related to formwork evolution over time were found, and mathematical modelling of each mechanism was made. A calculation method for real formwork pressure by using the mathematical formulae was also established. To verify predictive capability of the prediction model, a parametric study on parameters used in the model was performed. It was confirmed that the proposed model include the essential parameters that can simulate the real formwork pressure evolution over time.

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Neuro-fuzzy based prediction of the durability of self-consolidating concrete to various sodium sulfate exposure regimes

  • Bassuoni, M.T.;Nehdi, M.L.
    • Computers and Concrete
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    • v.5 no.6
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    • pp.573-597
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    • 2008
  • Among artificial intelligence-based computational techniques, adaptive neuro-fuzzy inference systems (ANFIS) are particularly suitable for modelling complex systems with known input-output data sets. Such systems can be efficient in modelling non-linear, complex and ambiguous behaviour of cement-based materials undergoing single, dual or multiple damage factors of different forms (chemical, physical and structural). Due to the well-known complexity of sulfate attack on cement-based materials, the current work investigates the use of ANFIS to model the behaviour of a wide range of self-consolidating concrete (SCC) mixture designs under various high-concentration sodium sulfate exposure regimes including full immersion, wetting-drying, partial immersion, freezing-thawing, and cyclic cold-hot conditions with or without sustained flexural loading. Three ANFIS models have been developed to predict the expansion, reduction in elastic dynamic modulus, and starting time of failure of the tested SCC specimens under the various high-concentration sodium sulfate exposure regimes. A fuzzy inference system was also developed to predict the level of aggression of environmental conditions associated with very severe sodium sulfate attack based on temperature, relative humidity and degree of wetting-drying. The results show that predictions of the ANFIS and fuzzy inference systems were rational and accurate, with errors not exceeding 5%. Sensitivity analyses showed that the trends of results given by the models had good agreement with actual experimental results and with thermal, mineralogical and micro-analytical studies.

A Comparative Study on the Interim Measures of Protection and the Emergency Arbitrator Systems of International Arbitration Institutions (중재판정부의 임시적 처분과 국제중재기관들의 긴급중재인 제도 비교 연구)

  • Joo, E-Wha;Bae, Sang-Phil;Shim, Sang-Ryul
    • Journal of Arbitration Studies
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    • v.22 no.3
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    • pp.215-238
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    • 2012
  • This paper is to review the interim measures of arbitral tribunals in international commercial arbitration and to compare the emergency arbitrator systems of international arbitration institutions including the ICDR, SCC, SIAC, ACICA, and ICC. Most arbitration legislation and arbitration rules permit the arbitral tribunal to grant orders for interim measures of protection. Orders for interim measures by the arbitral tribunal are not self-enforcing. However, the revised articles with regard to interim measures of UNCITRAL Model Law of 2006 are regarded to contribute significantly to the effectiveness of interim measures in international commercial arbitration. A party that needs urgent interim or conservatory measures that cannot await the constitution of an arbitral tribunal may make an application for such measures. Major international arbitration institutions have their own rules and provisions for the emergency arbitrator system, which was set forth first by the ICRD in 2006. The application requirements for emergency arbitrators are almost the same. However, there are significant differences in details such as appointments and applications for challenging emergency arbitrators, the process and form of the emergency arbitrator's decision, etc. Therefore, it will be necessary to consider these differences for more desirable emergency arbitrator proceedings in Korea.

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국내 기업환경을 고려한 SCM(Supply Chain Management)도입의 성공요인

  • 정인근;이명무
    • Proceedings of the Korean Operations and Management Science Society Conference
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    • 2000.10a
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    • pp.202-205
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    • 2000
  • 본 연구는 국내기업과 선진 외국기업의 SCM 사례를 중심으로 벤치마킹을 통하여 국내 공급사슬관리(Supply Chain Management: SCM)의 도입에 적합한 성공요인을 발견하고자 한다. 참조 모델로는 SCC(Supply Chain Council)의 SCOR(Supply Chain Operations Reference-model)를 적용하여 SCM의 발전단계모형과 성공요인을 제시하고 이를 통해 국내기업의 SCM의 전략적 도입방안과 SCM의 활성화를 위한 정부의 정책에 지침을 제시하고자 한다

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PWSCC Growth Assessment Model Considering Stress Triaxiality Factor for Primary Alloy 600 Components

  • Kim, Jong-Sung;Kim, Ji-Soo;Jeon, Jun-Young;Kim, Yun-Jae
    • Nuclear Engineering and Technology
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    • v.48 no.4
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    • pp.1036-1046
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    • 2016
  • We propose a primary water stress corrosion cracking (PWSCC) initiation model of Alloy 600 that considers the stress triaxiality factor to apply to finite element analysis. We investigated the correlation between stress triaxiality effects and PWSCC growth behavior in cold-worked Alloy 600 stream generator tubes, and identified an additional stress triaxiality factor that can be added to Garud's PWSCC initiation model. By applying the proposed PWSCC initiation model considering the stress triaxiality factor, PWSCC growth simulations based on the macroscopic phenomenological damage mechanics approach were carried out on the PWSCC growth tests of various cold-worked Alloy 600 steam generator tubes and compact tension specimens. As a result, PWSCC growth behavior results from the finite element prediction are in good agreement with the experimental results.

Research on Real-Time Portable Quality Evaluation System for Raw Milk

  • Lee, Dae Hyun;Kim, Yong Joo;Min, Kyu Ho;Choi, Chang Hyun
    • Agribusiness and Information Management
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    • v.6 no.2
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    • pp.32-39
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    • 2014
  • The goal of this research was to develop a portable system that could be used to evaluate the quality of milk in real time at a raw milk production site. A real-time portable quality evaluation system for raw milk was developed to enable non-destructive quality evaluation of somatic cell count (SCC), fat, protein, lactose, and total solid (TS) in milk samples. A prediction model of SCC, fat, protein, lactose, and TS was constructed using partial least squares (PLS) and 200 milk samples were used to evaluate the prediction performance of the portable quality evaluation system and high performance spectroscopy. Through prediction model development and verification, it was found that the accuracy of high performance spectroscopy was 90% for SSC, 96% for fat, 96% for protein, 91% for lactose, and 97% for TS. In comparison, the accuracy of the portable quality evaluation system was relatively low, at 90% for SSC, 95% for fat, 92% for protein, 89% for lactose, 92% for TS. However, the measurement time for high performance spectroscopy was 10 minutes for 1 sample, while for the portable quality evaluation system it was 6 minutes. This means that the high performance spectroscopy system can measure 48 samples per day (8 hours), while the portable quality evaluation system can measure 80 (8 hours). Therefore, it was found that the portable quality evaluation system enables quick on-site quality evaluation of milk samples.