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Altered Cardiac $Na^{+}$,$K^{+}$-ATPase Activity in Prehypertensive Spontaneously Hypertensive Rat

  • Lee, Shin-Woong-;Lee, Jeung-Soo-
    • 한국응용약물학회:학술대회논문집
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    • 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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    • pp.300-300
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    • 1994
  • $Na^{+}$,$K^{+}$-ATPase activity, $Na^{+}$-dependent phosphorylalion, and [$^3$〕ouabain binding in sarcolemma prepared from 4 week old spontaneously hypertensive rat(SHR) ventricles were compared to the same parameters in sarcolemma from age matched normotensive Wistar-Kyoto(WKY) rat ventricles to examine whether the reduced myocardial $Na^{+}$-pump activity in SHR is an inherited enzymatic defect or a second phenomenon due to sustained hypertension. The total body weights, ventricular weights, and blood pressures were the same for SHR and WKY. No significant differences in sarcolemmal protein content and protein recovery were noted between the two pups. Sarcolemma isolated from SHR ventricles showed sigificantly less $Na^{+}$,$K^{+}$-ATPase activity and number of phosphorylation sites when compared to snrcolemma 1mm the WKY ventricles. Equilibrium binding of [$^3H$〕ouabain and the turnovcr number of myocardial $Na^{+}$,$K^{+}$-ATPast however, wee the same for both groups. These results. indicate that the low affinity(${\alpha}$, or ${\alpha}_1$) isoform for ouabain is reduced in SHR compared to WKY but that the high affinity(${\alpha}$+, or ${\alpha}_2$) isoform is the same in ventricles of SHR and WKY. The reduced amount of at isoform of the $Na^{+}$,$K^{+}$-ATPasc in prehypertensive SHR ventricles may play some pole in the development of hypertension.

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A Study of the Photo-Electric Efficiency of Dye-Sensitized Solar Cells Under Lower Light Intensity

  • Kim, Hee-Je;Kim, Yong-Chul;Hong, Ji-Tae;Kim, Mi-Jeong;Seo, Hyun-Woong;Park, Je-Wook;Choi, Jin-Young
    • Journal of Electrical Engineering and Technology
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    • 제2권4호
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    • pp.513-517
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    • 2007
  • To elucidate possible challenges for outdoor practical use of dye-sensitized solar cells (DSCs), we compared conventional Si solar cells with DSCs. DSC modules still require a larger area than conventional Si solar modules to attain the same rated output because of lower photoelectron-chemical conversion efficiency. However, in backup systems by using batteries, the measured data shows that DSCs generated 15% more electricity than Si solar cells of the same rated output power in the same interval of cloudy daylight. Moreover, the battery charging time of DSCs is about 1 hour faster than the same rate of Si solar cells under outdoor cloudy daylight. This result also indicates that conversion efficiency obtained by the certified condition less than AM 1.5 condition does not always coincide with the electricity generated outdoors daily, and it is not a crucial measure to evaluate the performance of solar cells.

헤드레스트의 형상에 따른 충돌 및 피로해석을 통한 안전성 연구 (A Safety Study Using Impact and Fatigue Analyses According to Headrest Shape)

  • 한문식;조재웅
    • 한국기계가공학회지
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    • 제17권3호
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    • pp.39-44
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    • 2018
  • The automotive headrest is intended to provide comfort, safety, convenience and durability to a vehicle's passengers and driver. In this study, impact and fatigue analyses were carried out for three headrest shape models-A, B and C. These models have the same material properties and the same force was applied to them. Impact and fatigue analyses demonstrated that all of the models obtained almost the exact same result values. This study found that all models had similar equivalent stress, deformation, fatigue life and main damage parts due to the fact that the shared same material properties. Better safety and fatigue life can be anticipated by changing the material of the headrest in order to secure more stable safety. An automotive headrest optimized for safety and durability is thought to have been developed through the impact and fatigue analyses of this study.

Sweet Bee Venom과 일반 봉약침 병행 시술 후 발생한 Anaphylaxis에 대한 증례보고 (The case report of an Anaphylaxis occurred when using Sweet Bee Venom and common Bee Venom at the same time)

  • 김채원;이연희;이광호
    • 대한약침학회지
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    • 제14권4호
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    • pp.59-61
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    • 2011
  • Objectives: The purpose of this case report are to introduce an Anaphylaxis occurred when using Sweet Bee Venom (SBV) and common Bee Venom (CBC) at the same time and a risk when used SBV and CBC together without skin test. Methods: A patient, an Anaphylaxis occurred when treated her with SBV and CBC at the same time without additional skin test, we observed the progress of the Anaphylaxis with care for her. Results & Conclusions: The Anaphylaxis in the patient was taken a turn for the better by emergency response. Based on this case, Sometimes the use of SBV and CBC at the same time without skin test can be dangerous, and to avoid the risk when used CBC together, in advance allergy test should be conducted.

Change of Blood Cells' Number from Capillaries and Venous Blood of 20's Healthy Adults

  • Seon, Ji-Yeong;Lee, Jae Sik
    • 대한임상검사과학회지
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    • 제43권4호
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    • pp.156-160
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    • 2011
  • It was confirmed that we got somewhat different results even though we performed same items with same methods from capillaries and venous blood of healthy 72 cases. Items which capillaries blood has higher value than venous blood are the numbers of erythrocyte, lymphocyte, basophil, hematocrit, MCHC and RDW. Total numbers of RBC (p<0.035), lymphocyte and basophil are shown statistically significance. Items which venous blood has higher value than capillary blood are the numbers of platelet (p<0.00) and neutrophil (p<0.01). Fallible items in clinics can be shown the numbers of RBC, platelet, lymphocyte and neutrophil because we got somewhat different results even though we performed same items with same methods from capillaries and venous blood, respectively. It is necessary to choose the clear criteria and normal value depends on clinical specimen as the number of platelets are measured with an abnormal value shown over 40% down. As normal difference according to each item and method is currently acceptable and applicable in clinics, it is considered that a new normal value depends on clinical specimen should be established and is to be useful positively in clinics.

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CISG상 손해배상과 대금감액의 관계에 관한 중국 CIETAC의 중재사례 연구 (A Study on CIETEC Arbitration Case for the Relationship between Damages and Reduction under CISG)

  • 송수련
    • 무역상무연구
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    • 제51권
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    • pp.133-158
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    • 2011
  • The purpose of this study is to analyze one of CIETEC(China International Economic and Trade Arbitration Commission) Award on the dispute arising from Cotton Sale Contact which deals with damages and reduction of the price. Especially this case focused on the effect of reduction of the price to damages. The purpose of damages is to place the aggrieved party in as good a position as if the other party had properly performed the contract. So court costs and attorney's fee should be regarded as the loss, because these are caused by consequence of the breach which is recoverable. With the same reason, overpaid taxes should also regard as the loss. It is not impossible, however, to claim both damages and reduction of the price for same loss at the same time. It means buyer could not claim damages for the same loss, once he already claimed reduction of the price. So Korean companies should consider which remedy is proper to himself under the circumstances. He should choose reduction of the price when market price is down. In case of rising market price, he should consider follows: first, it is better to choose damages based on current price(Art.76), if upswing of non-conformity price is higher then upswing of market price. Second, it is better to choose general rule for measuring damages(Art.74), if upswing of market price is higher then upswing of non-conformity price.

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『보행결장부용약법요(輔行訣臟腑用藥法要)』에 기재된 『상한난병론(傷寒雜病論)』 방제(方劑)에 관한 소고(小考) (Discussion about prescriptions from Sanghanjabbyungron(傷寒雜病論), reported in Bohenggyuljangbuyongyakbubyo(輔行訣臟腑用藥法要))

  • 여민경;윤종화;김기욱
    • 대한한의학원전학회지
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    • 제26권4호
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    • pp.305-323
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    • 2013
  • Through the study of Bohenggyuljangbuyongyakbubyo(輔行訣臟腑用藥法要) focusing on the newly illuminated subject 'The study of Donhuang(敦煌學)' of China, the author analyzed and researched Donhuangzhongyiyakjunseo Bohenggyuljangbuyongyakbubyo(敦煌中醫藥全書 輔行訣臟腑用 藥法要) in order to study and report the origin of prescriptions from Sanghanjabbyungron(傷寒雜病論), which was written by Zhangzhongjing(張仲景). Among around 50 prescriptions included in Bohenggyul, 18 prescriptions similar to Sanghanjabbyungron could be classified in five different manners as follows. 1) There are nine examples whose prescription composition and chief virtue are same but names different. 2) There are five examples whose prescription composition is same but chief virtue and names different. 3) There are two examples whose names are same but prescription composition and chief virtue different. 4) There is one example of prescription as a combination of two or more prescriptions. 5) There is one example whose prescription composition and possible variations of prescription are same but chief virtue different.

단백질의 제한과 회복으로 인한 골격 근육내의 성분변화 (The Change of Electrolytes Composition in Skeletal Muscles by Protein Restriction and Rehabilitation)

  • 김지현;김숙희
    • Journal of Nutrition and Health
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    • 제14권4호
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    • pp.151-161
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    • 1981
  • The objective of this study was to compare the electrolytes contents in skeletal muscles of two different groups of rats, one for control fed 20% casein diet, and the other experimental group recovered from 7% casein diet as protein restriction feeding for two weeks at the beginning of this experiment. Two different comparison criteria were used in this study, one for comparison between animals at the same age groups and the other between groups weighing same body weight as the control groups. Food consumption of animals for experimental and control groups were ad libitum. Following measurement and samples were collected: body weight, five different muscles-anterior tibialis (A.T.) extensor digitorium longus (E.D.L.) soleus, plantaris, gastrocnemius-for electrolytes and protein analysis. The experimental groups showed lower body weight than that of control group. Same trend was showen in protein content in five different muscles. Magnesium and potassium content in four muscles except gastrocnemius showed lower and sodium higher in experimental groups than those in control group at fourteenth day, after recovery from protein restriction, electrolytes content change showed differently in four muscles. Magnesium and potassium contents were increased as protein content in diet. Sodium content decreased as one week intake of recovery diet started, thereafter it was rather slowly increased. Phosphorus content in gastrocnemius at the second week in experimental group was slightly lower than that of control group, and it recovered rapider while at the same body weight group it was higher in experimental group.

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지반앵커의 인발시험을 위한 개별제어 긴장장치의 적용 사례 연구 (A Case Study on Individually Controlled Pull-out Test for Ground Anchor)

  • 신현철;최용규
    • 한국지반공학회:학술대회논문집
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    • 한국지반공학회 2008년도 춘계 학술발표회 초청강연 및 논문집
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    • pp.545-552
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    • 2008
  • To insure the quality and safety of ground anchors, pull-out test of anchor has to be done. In the individually controlled pull-out test system, pull-out device is used to introduce the same pull-out force to individual tendon that has a different length and a deflection. That is, that device has a separate pull-out oil jack to each tendon, thus the pull-out length of each jack is not the same, but that device introduces each tendon to the same pull-out force. In this study, the in-situ pull-out tests for the compression anchors were performed and its test results were analysed and compared to the results of center hole pull-out tests. In the case of pulling out each tendon using the individually controlled pull-out test device, the pull-out forces were distributed to a individual tendon. That device is excellent one that can solve the cause of unequal pull-out forces of each tendon appearing in the manufacture process and construction of anchors, and unequal pull-out forces due to the deferent length.

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가계의 경제적 안정도: 단기지표와 장기지표의 비교 (Economic Security of Household: The Comparison of Short-term and Long-term Indicators)

  • 김강자
    • 가정과삶의질연구
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    • 제11권1호
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    • pp.107-118
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    • 1993
  • A dimension of well-being economic security was analyzed and compared with economic adequacy. Again it was tested whether two indicators of economic security(short-term vs. long-term) yield same distribution across all household groups. Economic Security was defined as the household ability to sustain a given level of consumption in the case of economic emergency; specifically loss of income. Measure of 8 different kinds of economic security were constructed from household net worth including and excluding home equity. Data were taken from the 1988 U.S. Consumer Expenditure Survey and 2148 households were selected to test hypotheses concerning the economic security of American households Empirical results showed a very low level of economic security in general. The first hypothesis that distribution of economic adequacy and economic security are same across all population groups was rejected. On the average security measure rather than adequacy measure was favor to white female-headed households and households who have old and highly educated house-holder. The second hypothesis that the indicators of long-term and short-term economic security yield the same results across all household was not rejected. In general the level of economic security was relatively higher when long-term indicator was used than short-term indicator was however the direction and relative size of effect of income and each control variable was almost same.

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