• Parasites, Hosts and Diseases
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• v.43 no.1 s.133
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• pp.19-25
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• 2005

Protective efficacy of vaccination with Neospora caninum multiple recombinant antigens against N. caninum infection was evaluated in vitro and in vivo. Two major immunodominant surface antigens (NcSAG1 and NcSRS2) and two dense granule proteins (NcDG1 and NcDG2) of N. caninum tachyzoites were expressed in E. coli, respectively. An in vitro neutralization assay using polyclonal antisera raised against each recombinant antigen showed inhibitory effects on the invasion of N. caninum tachyzoites into host cells. Separate groups of gerbils were immunized with the purified recombinant proteins singly or in combinations and animals were then challenged with N. caninum. Following these experimental challenges, the protective efficacy of each vaccination was determined by assessing animal survival rate. All experimental groups showed protective effects of different degrees against experimental infection. The highest protection efficacy was observed for combined vaccination with NcSRS2 and NcDG1. Our results indicate that combined vaccination with the N. caninum recombinant antigens, NcSRS2 and NcDG1, induces the highest protective effect against N. caninum infection in vitro and in vivo.

• Journal of Fashion Business
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• v.22 no.2
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• pp.27-39
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• 2018

This study analyzed the body shape of women over 70 years and classified their body shapes in order to provide basic data for the development of pants patterns that can complement the weakness of the body shape of elderly women. It were analyzed using SPSS Ver. 20.0. Five factors were extracted from the lower body: obesity and thigh thickness, lower body length, under knee thickness, ankle height, and hip sag. In type 1, the lower body was obese and the legs were thick, but the hips were not sagging. It was named 'high-hip obesity figure'. Type 2's abdomen, hip, and waist were obese, but the legs were thin and the hip were not sagging. Thus, 'bird-leg middle obesity figure' was the name. Type 3 had a long and slender lower body, but legs were thick and the hips were saggy, it was named 'strong-leg low-hip slender figure'. The elderly women showed less difference in waist, abdomen, and hip circumference. The abdominal circumference was 2-3cm more than the waist and hip circumference; hence there is a need to differentiate the shape and number of darts in the production of bottom-wear patterns for older women. In addition, the leg circumference is gradually reduced by aging compared to the size of the lower body. Therefore, it would be necessary to search for a method that can effectively design the difference between the hip circumference and the leg circumference in relation to the body shape and the aesthetics of older women.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.26 no.4
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• pp.201-212
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• 2023

Purpose: The gastrointestinal system is the most commonly affected organ, followed by the lungs, in patients with primary immunodeficiency disease (PID). Hence, it is common for children with PIDs to present with gastrointestinal symptoms. We aimed to analyze the clinical and histopathological findings of patients who were initially admitted to pediatric gastroenterology/hepatology clinics and subsequently diagnosed with PIDs to identify the clinical clues for PIDs. Methods: The demographic, laboratory, and histopathological findings, treatment modality, and outcomes of patients initially admitted to the pediatric gastroenterology/hepatology unit and subsequently diagnosed with PIDs were recorded. Results: The study included 24 patients (58.3% male; median age [range]: 29 [0.5-204] months). Common clinical presentations included chronic diarrhea (n=8), colitis (n=6), acute hepatitis (n=4), and acute liver failure (n=2). The association of autoimmune diseases, development of malignant diseases, and severe progression of viral diseases was observed in 20.8%, 8.3%, and 16.6% of the patients, respectively. Antibody deficiency was predominantly diagnosed in 29.2% of patients, combined immunodeficiency in 20.8%, immune dysregulation in 12.5%, defects in intrinsic and innate immunity in 4.2%, autoinflammatory disorders in 8.3%, and congenital defects of phagocytes in 4.2%. Five patients remained unclassified (20.8%). Conclusion: Patients with PIDs may initially experience gastrointestinal or liver problems. It is recommended that the association of autoimmune or malignant diseases or severe progression of viral diseases provide pediatric gastroenterologists some suspicion of PIDs. After screening using basic laboratory tests, genetic analysis is mandatory for a definitive diagnosis.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.23 no.2
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• pp.146-153
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• 2020

Purpose: Alpha-1 antitrypsin deficiency (A1ATD) in one of the most common genetic causes of liver disease in children. We aimed to analyze the clinical characteristics and outcomes of patients with A1ATD. Methods: This study included patients with A1ATD from five pediatric hepatology units. Demographics, clinical findings, genetics, and outcome of the patients were recorded (n=25). Results: Eight patients (32.0%) had homozygous PiZZ genotype while 17 (68.0%) had heterozygous genotype. Patients with PiZZ genotype had lower alpha-1 antitrypsin levels than patients with PiMZ genotype (37.6±7.7 mg/dL vs. 66.5±22.7 mg/dL, p=0.0001). Patients with PiZZ genotype were diagnosed earlier than patients with PiMZ genotype, but this was not significant (13±6.8 months vs. 23.7±30.1 months, p=0.192). Follow-up revealed the death of one patient (12.5%) with a homozygous mutation, and revealed that one patient had child A cirrhosis, five patients (62.5%) had chronic hepatitis, and one patient (12.5%) was asymptomatic. Nine of the 17 patients with a heterozygous mutation had chronic hepatitis (52.9%), two (11.7%) had child A cirrhosis, and six (35.2%) were asymptomatic. Overall, 18 (72%) of the 25 children had liver pathology in the long-term. Conclusion: Although prevalence is rare, patients with liver disorders should be checked for alpha-1 antitrypsin levels. Moreover, long-term follow-up is essential because most patients have a liver pathology.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.17 no.1
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• pp.1-9
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• 1995

We observed 117 orthognathic surgery cases with dentofacial deformity for 8 years from Jan. 1986 to Dec. 1993. The ratio of male female was 1 : 1.4 and the mean age was 23.0 years ranged from 16 to 35 years. The most dominant group was related to mandibular prognathism (75.0%). Surgery method were divided into 88 cases of mandible surgery, 6 cases of maxilla surgery and 23 cases of two jaw surgery. Sagittal split osteotomy were performed on 84 cases (71.8%). Rigid fixation was increased after 1989 and total percent of rigid fixation was 66%. We used autotransfusion method from 1992 to all orthognathic surgery patient. Lower lip numbness caused by Inferior alveolar nerve injury is the most common problem after operation, and it was 63 cases (53.8%) of total operation cases. In our clinic, we performed 5 cases of re-operation because of segment malalignment, condylar sag, and fixation instability.

• Proceedings of the Korean Vacuum Society Conference
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• 2011.02a
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• pp.143-144
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• 2011

최근 광전자 분야에서는 미래 에너지 자원에 대한 관심과 함께 GaN 기반 발광다이오드에 대한 연구가 활발히 진행되고 있다. 특히 InGaN/GaN 양자 우물 구조는 푸른색, 녹색 발광다이오드 구현에 있어 우수한 물질적 특성을 가지고 있다고 알려져 있다. 하지만 우수한 물질적 특성에도 불구하고 고인듐 고품위 막질 성장의 어려움으로 인해 높은 효율의 녹색 발광다이오드 구현하는 것은 여전히 어려운 실정이다. 이를 극복하기 위한 대안 중에 하나인 선택 영역 박막성장법(Selective Area Growth)은 마스크 패터닝을 통해 열린 영역에서만 박막을 성장하는 방법으로써 인듐 함량을 향상 시킬 수 있는 방법으로 주목 받고 있다. 선택 영역 박막 성장법을 이용하여 GaN를 성장하기 위해 그림 1의 공정을 통하여 n-GaN층 위에 SiO2 마스크를 포토리소그라피와 Reactive Ion Etching (RIE)를 이용한 건식 식각 공정을 통해 형성한 후 Metal Organic Chemical Vapor Deposition (MOCVD) 장비를 이용하여 선택적으로 에피를 성장하였다. 성장된 마이크로 피라미드 발광다이오드 구조는 n-GaN 피라미드 구조위에 양자우물 및 p-GaN을 성장함으로써 p-GaN/MQW/n-GaN 구조를 갖는다. 이렇게 생성된 피라미드 구조의 에피를 이용하여 발광다이오드를 제작한 후 그에 대한 전기적, 광학적 특성을 측정하였다. 2인치 웨이퍼의 중심을 원점 좌표인 (0,0)으로 설정하였을 때 2인치 웨이퍼에서 좌표에 해당하는 위치에서의 Photoluminescence (PL) 측정한 결과 일반적인 구조의 발광다이오드의 경우 첨두치가 441~451nm인데 반해 피라미드 구조의 발광다이오드의 경우 첨두치가 558nm~563nm 임을 알 수 있었다. 이를 통해 피라미드 구조 발광다이오드의 경우 일반적인 구조의 발광다이오드에 비해 인듐의 함유량을 증가시킬 수 있다는 것을 알 수 있다. 본 논문에서는 선택 영역 박막 성장법을 이용하여 마이크로 피라미드 InGaN/GaN 양자 우물 구조 구현과 광 전기적 특성에 대해 더 자세히 논의 하도록 하겠다.

• Journal of the East Asian Society of Dietary Life
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• v.15 no.4
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• pp.450-456
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• 2005

This study was performed to provide basic data that will predict the usefulness of buckwheat sprout as food materials. The quality characteristics of noodles prepared with buckwheat sprout powder were investigated The buckwheat sprout powder was added to the noodles in 0, 2, 4, 6, and $8\%$ in proportion to the weight of wheat flour, respectively. The added amounts of buckwheat sprout powder did not affect the volume of the noodles. The weight of noodles was decreased, whereas tumidity of the soup after cooking the noodles was increased with the increment of the amount of added buckwheat sprout powder. The color of powder mixture, wet noodles, and cooked noodles was changed by the addition of buckwheat sprout powder. Lightness(L) was decreased, whereas yellowness(b) and redness(a) increased as the amount of buckwheat sprout powder increased. In the texture analysis, hardness and chewiness of wet noodles were increased significantly by the addition of buckwheat sprout powder. Hardness, chewiness, and gumminess increased significantly in the cooked noodles with more than $6\%$ substitution of buckwheat sprout powder. Other textural properties did not show any significant changes. The results of sensory evaluation revealed that the overall preference of noodles with 2 to $4\%$ substitution of buckwheat sprout powder was better than other sample groups. Therefore, the appropriate amount of addition for the buckwheat sprout noodles was 2 to $4\%$ buckwheat sprout powder in proportion to the weight of wheat flour.

• Journal of Life Science
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• v.27 no.1
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• pp.100-121
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• 2017

The sexual reproduction of the unicellular green alga Chlamydomonas is reviewed for a comprehensive understanding of the complex processes. The sexual life cycle of C. reinhardtii is distinguished into five main stages: gametogenesis, gamete activation, cell fusion, zygote maturation, and meiosis and germination. Gametogenesis is induced by nitrogen starvation in the environment. C. reinhardtii has two mating types: mating type plus ($mt^+$) and mating type minus ($mt^-$), controlled by a single complex mating type locus ($MT^+$ or $MT^-$) on linkage group VI. In the early gametogenesis agglutinins are synthesized. The $mt^+$ and $mt^-$ agglutinins are encoded by the autosomal genes SAG1 (Sexual AGglutination1) and SAD1 (Sexual ADhesion1), respectively. The agglutinins are responsible for the flagellar adhesion of the two mating type of gametes. The flagellar adhesion initiates a cAMP mediated signal transduction pathways and activates the flagellar tips. In response to the cAMP signal, mating structures between two flagella are activated. The $mt^+$ and $mt^-$ gamete-specific fusion proteins, Fus1 and Hap2/Gcs1, are present on the plasma membrane of the two mating structures. Contact of the two mating structures leads to develop a fertilization tubule forming a cytoplasmic bridge between the two gametes. Upon fusion of nuclei and chloroplasts of $mt^+$ and $mt^-$ cells, the zygotes become zygospores. It is notable that the young zygote shows uniparental inheritance of chloroplast DNA from the $mt^+$ parent and mitochondrial DNA from the $mt^-$ parent. Under the favorable conditions, the zygospores divide meiotically and germinate and then new haploid progenies, vegetative cells, are released.

• Journal of the Optical Society of Korea
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• v.10 no.3
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• pp.124-129
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• 2006

We have developed a compact and cost-effective camera module on the basis of wafer-scale-replica processing. A multiple-layered structure of several aspheric lenses in a mobile-phone camera module is first assembled by bonding multiple glass-wafers on which 2-dimensional replica arrays of identical aspheric lenses are UV-embossed, followed by dicing the stacked wafers and packaging them with image sensor chips. This wafer-scale processing leads to at least 95% yield in mass-production, and potentially to a very slim phone with camera-module less than 2 mm in thickness. We have demonstrated a VGA camera module fabricated by the wafer-scale-replica processing with various UV-curable polymers having refractive indices between 1.4 and 1.6, and with three different glass-wafers of which both surfaces are embossed as aspheric lenses having $230{\mu}m$ sag-height and aspheric-coefficients of lens polynomials up to tenth-order. We have found that precise compensation in material shrinkage of the polymer materials is one of the most technical challenges, in orderto achieve a higher resolution in wafer-scaled lenses for mobile-phone camera modules.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.61 no.2
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• pp.199-208
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• 2012

This paper proposes a quasi Z-source DVR(Dynamic Voltage Restorer) system with a series connection of the output terminals, to compensate the voltage variations in the 6.6[kV]/60[Hz] power distribution system. The conventional DVR using one quasi Z-source AC-AC converter has the advantage which it can compensate the voltage variations without the need for the additional energy storage device such as a battery, but it is impossible to compensate for the 50[%] under voltage sags. To solve this problem, a DVR system using two quasi Z-source AC-AC converters with the series connection of the output terminals is proposed. By controlling the duty ratio D in the buck-boost mode, the proposed system can control the compensation voltage. For case verification of the proposed system, PSIM simulation is achieved. As a result, in case that the voltage sags-swells occur 10[%], 20[%], 60[%] in power distribution system, and, in case that the 50[%] under voltage sags-swells continuously occur, all case could compensate by the proposed system. Especially, the compensated voltage THD was examined under the condition of the 10[%]~50[%] voltage sags and the 20[${\Omega}$]~100[${\Omega}$] load changes. The compensated voltage THD was worse for the higher load resistances and more severe voltage sags. Finally, In case of the voltage swells compensation, the compensation factor has approached nearly 1 regardless of the load resistance changes, while the compensation factor of voltage sags was related to the load variations.